American Journal of Respiratory Cell and Molecular Biology

Extracellular Vesicles: Bidirectional Accelerators of Cellular Senescence in Fibrosis? 2020

CD70 Activation Decreases Pulmonary Fibroblast Production of Extracellular Matrix Proteins.  63:255-265. 2020

α-Tocopherol Attenuates the Severity of Pseudomonas aeruginosa-induced Pneumonia.  63:234-243. 2020

ATF4 Mediates Mitochondrial Unfolded Protein Response (UPRmt) in Alveolar Epithelial Cells. 2020

Novel Therapy of Bicarbonate, Glutathione and Ascorbic Acid Improves Cystic Fibrosis Mucus Transport. 2020

C(C)Learing the role of chemokines in pulmonary fibrosis.  62:546-547. 2020

Impaired Myofibroblast Dedifferentiation Contributes to Nonresolving Fibrosis in Aging.  62:633-644. 2020

PAI-1 regulation of TGF-β1-induced alveolar Type II cell senescence, SASP secretion, and SASP-mediated activation of alveolar macrophages.  62:319-330. 2020

Inhibition of glutaminase 1 attenuates experimental pulmonary fibrosis.  61:492-500. 2019

Vaporized e-cigarette liquids induce ion transport dysfunction in airway epithelia.  61:162-173. 2019

What lies beneath: Preformed autoantibodies and lung transplantation.  60:613-614. 2019

Fibronectin on the surface of extracellular vesicles mediates fibroblast invasion.  60:279-288. 2019

Impairment of fatty acid oxidation in alveolar epithelial cells mediates acute lung injury.  60:167-178. 2019

Betting on novel treatments for asthma: Bromodomain 4 inhibitors.  60:7-8. 2019

Beyond fibroblast heterogeneity: What single-cell RNA sequencing tells us.  61:7-8. 2019

Glutaminolysis epigenetically regulates antiapoptotic gene expression in idiopathic pulmonary fibrosis fibroblasts.  60:49-57. 2019

Modeling fibrosis in three-dimensional organoids reveals new epithelial restraints on fibroblasts.  61:556-557. 2019

Proline-glycine-proline peptides are critical in the development of smoke-induced emphysema.  61:560-566. 2019

Can a Vitamin A day keep tuberculosis away?.  59:523-524. 2018

Mechanisms of ventilator-induced lung injury: Is the elafin in the room?.  59:531-532. 2018

Whole-genome sequencing in severe chronic obstructive pulmonary disease.  59:614-622. 2018

Cellular senescence in chronic obstructive pulmonary disease: Multifaceted and multifunctional.  59:135-136. 2018

Collagen biosynthesis in pulmonary fibrosis: Unraveling the metabolic web.  58:545-546. 2018

LPS-induced acute lung injury involves NF-kB–mediated downregulation of SOX18.  58:614-624. 2018

Most good, least harm: Isoform-specific targeting of ROCK in pulmonary fibrosis.  58:421-422. 2018

Systemic markers of adaptive and innate immunity are associated with chronic obstructive pulmonary disease severity and spirometric disease progression.  58:500-509. 2018

Glutaminolysis promotes collagen translation and stability via a-ketoglutarate-mediated mTOR activation and proline hydroxylation.  58:378-390. 2018

The lung likes the little fella miR-29.  57:637-638. 2017

Multiomics approach to asthma: Navigating the network.  57:381-382. 2017

An official American thoracic society workshop report: Use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis.  56:667-679. 2017

Effect of prenatal versus postnatal Vitamin D deficiency on pulmonary structure and function in mice.  56:383-392. 2017

Sex-based genetic association study identifies celsr1 as a possible chronic obstructive pulmonary disease risk locus among women.  56:332-341. 2017

MIR-34a inhibits lung fibrosis by inducing lung fibroblast senescence.  56:168-178. 2017

Epigenetic regulation of caveolin-1 gene expression in lung fibroblasts.  56:50-61. 2017

Susceptibility to childhood pneumonia: A genome-wide analysis.  56:20-28. 2017

The cystic fibrosis transmembrane conductance regulator potentiator ivacaftor augments mucociliary clearance abrogating cystic fibrosis transmembrane conductance regulator inhibition by cigarette smoke.  56:99-108. 2017

Transplantation of airway epithelial stem/progenitor cells: A future for cell-based therapy.  56:1-10. 2017

Bone morphogenic protein type 2 receptor mutation-independent mechanisms of disrupted bone morphogenetic protein signaling in idiopathic pulmonary arterial hypertension.  55:564-575. 2016

Endothelial monocyte-activating polypeptide II mediates macrophage migration in the development of hyperoxia-induced lung disease of prematurity.  55:602-612. 2016

Airway progenitor clone formation is enhanced by Y-27632-dependent changes in the transcriptome.  55:323-336. 2016

Cu,Zn-superoxide dismutase-mediated redox regulation of Jumonji domain containing 3 modulates macrophage polarization and pulmonary fibrosis.  55:58-71. 2016

Matrix remodeling in pulmonary fibrosis and emphysema.  54:751-760. 2016

MicroRNA-27a-3p is a negative regulator of lung fibrosis by targeting myofibroblast differentiation.  54:843-852. 2016

Bik mediates caspase-dependent cleavage of viral proteins to promote influenza a virus infection.  54:664-673. 2016

Toll-like receptor 4 engagement mediates prolyl endopeptidase release from airway epithelia via exosomes.  54:359-369. 2016

Novel mechanisms for the antifibrotic action of nintedanib.  54:51-59. 2016

Alterations in gene expression and DNA methylation during murine and human lung alveolar septation.  53:60-73. 2015

Noninvasive imaging of experimental lung fibrosis.  53:8-13. 2015

Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs.  52:683-694. 2015

Early exposure to hyperoxia or hypoxia adversely impacts cardiopulmonary development.  52:594-602. 2015

IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.  52:365-376. 2015

Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model.  52:106-115. 2015

Sarcoendoplasmic Reticulum Ca21 ATPase A critical target in chlorine inhalation-induced cardiotoxicity.  52:492-502. 2015

Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.  51:678-687. 2014

Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury..  50:614-625. 2014

An autoregulatory mechanism governing mucociliary transport is sensitive to mucus load.  51:485-493. 2014

Antifibrinolytic mechanisms in acute airway injury after sulfur mustard analog inhalation.  51:559-567. 2014

Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis.  50:549-558. 2014

Inter-a-inhibitor blocks epithelial sodium channel activation and decreases nasal potential differences in DF508 mice.  50:953-962. 2014

Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor.  50:805-816. 2014

Human tracheobronchial basal cells: Normal versus remodeling/repairing phenotypes in vivo and in vitro.  49:1127-1134. 2013

In utero exposure to second-hand smoke aggravates the response to ovalbumin in adult mice.  49:1102-1109. 2013

Ephrin-B2 reverse signaling increases α5β1 integrin-mediated fibronectin deposition and reduces distal lung compliance.  49:680-687. 2013

Chlorine induces the unfolded protein response in murine lungs and skin.  49:197-203. 2013

Differential regulation of pulmonary vascular cell growth by hypoxia-inducible transcription factor-1a and hypoxia-inducible transcription factor-2α.  49:78-85. 2013

Defining lung injury in animals.  48:267. 2013

Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2.  48:94-104. 2013

In utero exposure to second-hand smoke aggravates adult responses to irritants adult second-hand smoke.  47:843-851. 2012

Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction.  47:340-348. 2012

NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy.  47:288-297. 2012

Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice.  47:28-36. 2012

Thy-1 signals through PPARγ to promote lipofibroblast differentiation in the developing lung.  46:765-772. 2012

Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways.  46:790-796. 2012

Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation.  46:599-606. 2012

Regulation of alveolar epithelial Na ⁺ channels by ERK1/2 in chlorine-breathing mice.  46:342-354. 2012

Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis.  46:87-95. 2012

Hypoxia-inducible factor regulates expression of surfactant protein in alveolar type II cells in vitro.  45:938-945. 2011

Enhancement of Respiratory Mucosal Antiviral Defenses by the Oxidation of Iodide.  45:874-881. 2011

Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa - Induced lung injury in mice.  45:632-641. 2011

Ascorbate and deferoxamine administration after chlorine exposure decrease mortality and lung injury in mice.  45:386-392. 2011

Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling.  45:419-425. 2011

miR-29 is a major regulator of genes associated with pulmonary fibrosis.  45:287-294. 2011

Epigenetic regulation of Thy-1 by histone deacetylase inhibitor in rat lung fibroblasts.  45:16-23. 2011

Postexposure administration of a β2-agonist decreases chlorine-induced airway hyperreactivity in mice.  45:88-94. 2011

Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: Potential use as a biomarker of ΔF508 cystic fibrosis transmembrane conductance regulator rescue.  43:607-616. 2010

Characterization of the epithelial sodium channel δ-subunit in human nasal epithelium.  42:498-505. 2010

Respiratory syncytial virus impairs macrophage IFN-α/β- and IFN-γ-stimulated transcription by distinct mechanisms.  42:404-414. 2010

Functional stability of rescued ΔF508 cystic fibrosis transmembrane conductance regulator in airway epithelial cells.  42:363-372. 2010

Repeated bouts of moderate-intensity aerobic exercise reduce airway reactivity in a murine asthma model.  42:243-249. 2010

Highlights of the December issue.  41:629-630. 2009

Endothelin-1 and transforming growth factor-β1 independently induce fibroblast resistance to apoptosis via AKT activation.  41:484-493. 2009

Highlights of the October issue.  41:377-378. 2009

Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis.  41:367-375. 2009

α1-Antitrypsin inhibits epithelial Na⁺ transport in vitro and in vivo.  41:261-270. 2009

Highlights of the August issue.  41:125-126. 2009

Participation of mammalian target of rapamycin complex 1 in toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury.  41:237-245. 2009

Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity.  41:114-123. 2009

Highlights of the July issue.  41:1-2. 2009

Influenza exerts continued pressure in an era of modern medicine.  41:3-7. 2009

Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure.  40:710-716. 2009

Expression and regulation of epithelial Na⁺ channels by nucleotides in pleural mesothelial cells.  40:543-554. 2009

Inhibition of Na⁺ transport in lung epithelial cells by respiratory syncytial virus infection.  40:588-600. 2009

Oxygen in the evolution of complex life and the price we pay.  40:507-510. 2009

Search and rescue finding ways to correct ΔF508 CFTR.  40:385-387. 2009

Highlights of the march issue.  40:249-250. 2009

Acute exercise decreases airway inflammation, but not responsiveness, in an allergic asthma model.  40:83-89. 2009

α1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro.  39:631-637. 2008

Role of oxygen availability in CFTR expression and function.  39:514-521. 2008

Thy-1 promoter hypermethylation: A novel epigenetic pathogenic mechanism in pulmonary fibrosis.  39:610-618. 2008

Activation of the unfolded protein response by ΔF508 CFTR.  39:448-457. 2008

Activation of the unfolded protein response by F508 cystic fibrosis transmembrane conductance regulator.  39:448-457. 2008

Developmental regulation of NO-mediated VEGF-induced effects in the lung.  39:420-430. 2008

DETANO and nitrated lipids increase chloride secretion across lung airway cells.  39:150-162. 2008

Asbestos-induced MKP-3 expression augments TNF-α gene expression in human monocytes.  39:113-123. 2008

Human metapneumovirus inhibits IFN-α signaling through inhibition of STAT1 phosphorylation.  38:661-670. 2008

The role of red blood cells and hemoglobin-nitric oxide interactions on blood flow.  38:125-126. 2008

Decreased asbestos-induced lung inflammation and fibrosis after radiation and bone marrow transplant.  38:16-25. 2008

Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae.  38:105-113. 2008

Plasminogen activation-induced pericellular fibronectin proteolysis promotes fibroblast apoptosis.  38:78-87. 2008

Post-infection A77-1726 blocks pathophysiologic sequelae of respiratory syncytial virus infection.  37:379-386. 2007

Differential expression and oxidation of MKP-1 modulates TNF-α gene expression.  37:366-374. 2007

Restoration of W1282X CFTR activity by enhanced expression.  37:347-356. 2007

No detectable improvements in cystic fibrosis transmembrane conductance regulator by nasal aminoglycosides in patients with cystic fibrosis with stop mutations.  37:57-66. 2007

VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator.  36:706-714. 2007

NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I.  36:263-269. 2007

Enhanced myofibroblastic differentiation and survival in thy-1(-) lung fibroblasts.  36:226-235. 2007

Surfactant dysfunction in SP-A^-/- and iNOS^-/- mice with mycoplasma infection.  36:103-113. 2007

Unlocking the mysteries of Na⁺-K⁺-ATPase endocytosis: Phosphorylation is the key.  35:1-2. 2006

Bactericidal function of alveolar macrophages in mechanically ventilated rabbits.  34:719-726. 2006

4-Hydroxynonenal induces rat γ-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling.  34:174-181. 2006

Involvement of calpain-calpastatin in cigarette smoke-induced inhibition of lung endothelial nitric oxide synthase.  33:513-520. 2005

Thrombin increases lung water by decreasing Na,K-ATPase activity.  33:317-318. 2005

American Journal of Respiratory Cell and Molecular Biology: Editors' notes.  32:363. 2005

Role of hypoxia-inducible factor-1α in hypoxia-induced apoptosis of primary alveolar epithelial type II cells.  32:395-403. 2005

Altered airway responsiveness in CD38-deficient mice.  32:149-156. 2005

Surfactant proteins and inflammation: The Yin and the Yang.  31:585-586. 2004

Activation of airway Cl^- secretion in human subjects by adenosine.  31:140-146. 2004

High levels of catalase and glutathione peroxidase activity dampen H 2O2 signaling in human alveolar macrophages.  31:43-53. 2004

Regulation of amiloride-sensitive Na⁺ transport by basal nitric oxide.  30:720-728. 2004

Role of Surfactant Protein-A in Nitric Oxide Production and Mycoplasma Killing in Congenic C57BL/6 Mice.  30:319-325. 2004

Trafficking of Th1 Cells to Lung: A Role for Selectins and a P-Selectin Glycoprotein-1-Independent Ligand.  30:220-227. 2004

Gene Expression Analysis in response to lung toxicants I. sequencing and microarray development.  30:296-310. 2004

Prostaglandin E2 Inhibits Fibroblast to Myofibroblast Transition via E. Prostanoid Receptor 2 Signaling and Cyclic Adenosine Monophosphate Elevation.  29:537-544. 2003

Hyperoxia impairs antibacterial function of macrophages through effects on actin.  28:443-450. 2003

Increased susceptibility to rsv infection by exposure to inhaled diesel engine emissions.  28:451-463. 2003

Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: Role of phosphatidylinositol 3-kinase.  28:179-187. 2003

Pseudomonas aeruginosa and tumor necrosis factor-α attenuate Clara cell secretory protein promoter function.  26:216-223. 2002

4-Hydroxy-2-nonenal increases γ-glutamylcysteine synthetase gene expression in alveolar epithelial cells.  24:499-505. 2001

Early events in naphthalene-induced acute Clara cell toxicity II. Comparison of glutathione depletion and histopathology by airway location.  24:272-281. 2001

GM-CSF increases AP-1 DNA binding and Ref-1 amounts in human alveolar macrophages.  25:254-259. 2001

Modification of sodium transport and alveolar fluid clearance by hypoxia: Mechanisms and physiological implications.  25:538-541. 2001

Na,K-ATPase gene transfer mitigates an oxidant-induced decrease of active sodium transport in rat fetal ATII cells.  24:245-252. 2001

A CD36 synthetic peptide inhibits bleomycin-induced pulmonary inflammation and connective tissue synthesis in the rat.  23:204-212. 2000

Could asthma be worsened by stimulating the T-helper type 1 immune response?.  22:143-146. 2000

Decreased expression of aquaporin (AQP)1 and AQP5 in mouse lung after acute viral infection.  22:34-44. 2000

Pulmonary fibrosis. Pathways are slowly coming into light.  22:520-523. 2000

Three-dimensional organization of the lamina reticularis in the rat tracheal basement membrane zone.  22:393-397. 2000

Both Erk and p38 kinases are necessary for cytokine gene transcription.  20:751-758. 1999

Cloning and characterization of KPL2, a novel gene induced during ciliogenesis of tracheal epithelial cells.  20:675-683. 1999

Components of human papillomavirus that activate transcription and support plasmid replication in human airway cells.  20:1001-1006. 1999

In vitro culture of microdissected rat nasal airway tissues.  20:1274-1285. 1999

Iron regulates hyperoxia-dependent human heme oxygenase 1 gene expression in pulmonary endothelial cells.  20:797-804. 1999

Restoration of the mucous phenotype by retinoic acid in retinoid-deficient human bronchial cell cultures: Changes in mucin gene expression.  20:43-52. 1999

Surfactant protein B deficiency worsens hyperoxic injury to the alveolar epithelium.  21:449-450. 1999

The attenuated fibroblast sheath of the respiratory tract epithelial-mesenchymal trophic unit.  21:655-657. 1999

Inhibition of cell proliferation and induction of apoptosis by the retinoid AHPN in human lung carcinoma cells.  18:323-333. 1998

Lipopolysaccharide-induced NF-κB activation and cytokine release in human alveolar macrophages is PKC-independent and TK- and PC-PLC-dependent.  18:384-391. 1998

Modulation of monocyte chemotactic protein-1 production by hyperoxia: Importance of RNA stability in control of cytokine production.  18:521-525. 1998

Identification of Novel Inducible Genes in Airway Epithelium.  17:106-113. 1997

Modulation of Adenovirus-mediated Gene Transfer by Nitric Oxide.  16:501-509. 1997

Phenotyping and Cytokine Regulation of the BEAS-2B Human Bronchial Epithelial Cell: Demonstration of Inducible Expression of the Adhesion Molecules VCAM-1 and ICAM-1.  17:571-582. 1997

Pulmonary Cytochrome P450 Monooxygenase and Clara Cell Differentiation in Mice.  17:302-314. 1997

Characterization of a Neutrophil Inhibitor Peptide Harvested from Human Bronchial Lavage: Homology to Influenza A Nucleoprotein.  15:207-215. 1996

Differential Enhancement of γ-Glutamyl Transpeptidase and γ-Glutamylcysteine Synthetase by Tert-butylhydroquinone in Rat Lung Epithelial L2 Cells.  14:186-191. 1996

Increased γ-Glutamylcysteine Synthetase and γ-Glutamyl Transpeptidase Activities Enhance Resistance of Rat Lung Epithelial L2 Cells to Quinone Toxicity.  14:192-197. 1996

Quantitation of the Alveolar Distribution of Surfactant Mixtures in Normal and Injured Lungs.  15:451-459. 1996

erbB-2 Knockout Employing an Intracellular Single-chain Antibody (sFv) Accomplishes Specific Toxicity in erbB-2-expressing Lung Cancer Cells.  15:348-354. 1996

Pleural mesothelial cell expression of C-C (monocyte chemotactic peptide) and C-X-C (interleukin 8) chemokines..  12:581-588. 1995

Release of hydrogen peroxide in response to hypoxia-reoxygenation: role of an NAD(P)H oxidase-like enzyme in endothelial cell plasma membrane..  12:41-49. 1995

Differential responsiveness of human bronchial epithelial cells, lung carcinoma cells, and bronchial fibroblasts to interferon-gamma in vitro..  11:147-152. 1994

Manganese superoxide dismutase expression in alveolar type II epithelial cells from nonventilated and hypoperfused lungs..  11:366-371. 1994

gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells..  11:586-592. 1994

Homeobox 1.3 expression: induction by retinoic acid in human bronchial fibroblasts..  7:3-9. 1992

Mesothelial cell response to pleural injury: thrombin-induced proliferation and chemotaxis of rat pleural mesothelial cells..  6:421-425. 1992

Regulation of type I and type II transglutaminase in normal human bronchial epithelial and lung carcinoma cells..  7:10-18. 1992

Production of tumor necrosis factor-alpha by blood and lung mononuclear phagocytes from patients with human immunodeficiency virus-related lung disease..  5:144-148. 1991

Human alveolar macrophages release a factor that inhibits phagocyte function..  1:407-416. 1989