American Journal of Respiratory Cell and Molecular Biology

Does UCP2 Couple Hyperoxia to Lung Injury? 2021

Carbonic anhydrase ix and hypoxia promote rat pulmonary endothelial cell survival during infection.  65:630-645. 2021

DOCK-t(w)o Pleural Fibrosis. 2021

Targeting Asporin in Lung Fibrosis: A New Approach to An Old Concept. 2021

Extracellular vesicles: Progress and challenges in the study of human immunodeficiency virus and cocaine-associated pulmonary arterial hypertension.  65:341-342. 2021

Transglutaminase-2: Nature’s glue in lung fibrosis?.  65:243-244. 2021

The big impact of small Airway pH.  65:123-125. 2021

Influenza Antiviral Subversion: Now the Host Is in on the Act.  65:1-3. 2021

Novel correctors and potentiators enhance translational readthrough in CFTR nonsense mutations.  64:604-616. 2021

Lung myofibroblasts promote macrophage profibrotic activity through lactate-induced histone lactylation.  64:115-125. 2021

Opsin 3–Gas promotes airway smooth muscle relaxation modulated by G protein receptor kinase 2.  64:59-68. 2021

Extracellular vesicles: Bidirectional accelerators of cellular senescence in fibrosis?.  63:547-548. 2020

ATF4 mediates mitochondrial unfolded protein response in alveolar epithelial cells.  63:478-489. 2020

Metabolomics to Predict Antiviral Drug Efficacy in COVID-19.  63:396-398. 2020

Novel therapy of bicarbonate, glutathione, and ascorbic acid improves cystic fibrosis mucus transport.  63:362-373. 2020

CD70 activation decreases pulmonary fibroblast production of extracellular matrix proteins.  63:255-265. 2020

a-tocopherol attenuates the severity of pseudomonas aeruginosa-induced pneumonia.  63:234-243. 2020

C(C)Learing the role of chemokines in pulmonary fibrosis.  62:546-547. 2020

PAI-1 regulation of TGF-β1-induced alveolar Type II cell senescence, SASP secretion, and SASP-mediated activation of alveolar macrophages.  62:319-330. 2020

Inhibition of glutaminase 1 attenuates experimental pulmonary fibrosis.  61:492-500. 2019

Vaporized e-cigarette liquids induce ion transport dysfunction in airway epithelia.  61:162-173. 2019

What lies beneath: Preformed autoantibodies and lung transplantation.  60:613-614. 2019

Fibronectin on the surface of extracellular vesicles mediates fibroblast invasion.  60:279-288. 2019

Impairment of fatty acid oxidation in alveolar epithelial cells mediates acute lung injury.  60:167-178. 2019

Betting on novel treatments for asthma: Bromodomain 4 inhibitors.  60:7-8. 2019

Beyond fibroblast heterogeneity: What single-cell RNA sequencing tells us.  61:7-8. 2019

Glutaminolysis epigenetically regulates antiapoptotic gene expression in idiopathic pulmonary fibrosis fibroblasts.  60:49-57. 2019

Modeling fibrosis in three-dimensional organoids reveals new epithelial restraints on fibroblasts.  61:556-557. 2019

Proline-glycine-proline peptides are critical in the development of smoke-induced emphysema.  61:560-566. 2019

Can a Vitamin A day keep tuberculosis away?.  59:523-524. 2018

Mechanisms of ventilator-induced lung injury: Is the elafin in the room?.  59:531-532. 2018

Whole-genome sequencing in severe chronic obstructive pulmonary disease.  59:614-622. 2018

Cellular senescence in chronic obstructive pulmonary disease: Multifaceted and multifunctional.  59:135-136. 2018

Collagen biosynthesis in pulmonary fibrosis: Unraveling the metabolic web.  58:545-546. 2018

LPS-induced acute lung injury involves NF-kB–mediated downregulation of SOX18.  58:614-624. 2018

Most good, least harm: Isoform-specific targeting of ROCK in pulmonary fibrosis.  58:421-422. 2018

Systemic markers of adaptive and innate immunity are associated with chronic obstructive pulmonary disease severity and spirometric disease progression.  58:500-509. 2018

Glutaminolysis promotes collagen translation and stability via a-ketoglutarate-mediated mTOR activation and proline hydroxylation.  58:378-390. 2018

The lung likes the little fella miR-29.  57:637-638. 2017

Multiomics approach to asthma: Navigating the network.  57:381-382. 2017

Effect of prenatal versus postnatal Vitamin D deficiency on pulmonary structure and function in mice.  56:383-392. 2017

Sex-based genetic association study identifies celsr1 as a possible chronic obstructive pulmonary disease risk locus among women.  56:332-341. 2017

MIR-34a inhibits lung fibrosis by inducing lung fibroblast senescence.  56:168-178. 2017

Epigenetic regulation of caveolin-1 gene expression in lung fibroblasts.  56:50-61. 2017

Susceptibility to childhood pneumonia: A genome-wide analysis.  56:20-28. 2017

The cystic fibrosis transmembrane conductance regulator potentiator ivacaftor augments mucociliary clearance abrogating cystic fibrosis transmembrane conductance regulator inhibition by cigarette smoke.  56:99-108. 2017

Transplantation of airway epithelial stem/progenitor cells: A future for cell-based therapy.  56:1-10. 2017

Bone morphogenic protein type 2 receptor mutation-independent mechanisms of disrupted bone morphogenetic protein signaling in idiopathic pulmonary arterial hypertension.  55:564-575. 2016

Endothelial monocyte-activating polypeptide II mediates macrophage migration in the development of hyperoxia-induced lung disease of prematurity.  55:602-612. 2016

Airway progenitor clone formation is enhanced by Y-27632-dependent changes in the transcriptome.  55:323-336. 2016

Thioredoxin reductase inhibition attenuates neonatal hyperoxic lung injury and enhances nuclear factor E2-related factor 2 activation.  55:419-428. 2016

Cu,Zn-superoxide dismutase-mediated redox regulation of Jumonji domain containing 3 modulates macrophage polarization and pulmonary fibrosis.  55:58-71. 2016

Matrix remodeling in pulmonary fibrosis and emphysema.  54:751-760. 2016

MicroRNA-27a-3p is a negative regulator of lung fibrosis by targeting myofibroblast differentiation.  54:843-852. 2016

Bik mediates caspase-dependent cleavage of viral proteins to promote influenza a virus infection.  54:664-673. 2016

Toll-like receptor 4 engagement mediates prolyl endopeptidase release from airway epithelia via exosomes.  54:359-369. 2016

Novel mechanisms for the antifibrotic action of nintedanib.  54:51-59. 2016

Alterations in gene expression and DNA methylation during murine and human lung alveolar septation.  53:60-73. 2015

Noninvasive imaging of experimental lung fibrosis.  53:8-13. 2015

Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs.  52:683-694. 2015

Early exposure to hyperoxia or hypoxia adversely impacts cardiopulmonary development.  52:594-602. 2015

Sarcoendoplasmic Reticulum Ca21 ATPase A critical target in chlorine inhalation-induced cardiotoxicity.  52:492-502. 2015

IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.  52:365-376. 2015

Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model.  52:106-115. 2015

Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.  51:678-687. 2014

An autoregulatory mechanism governing mucociliary transport is sensitive to mucus load.  51:485-493. 2014

Antifibrinolytic mechanisms in acute airway injury after sulfur mustard analog inhalation.  51:559-567. 2014

Endothelin-1 Induces a Glycolytic Switch in Pulmonary Arterial Endothelial Cells via the Mitochondrial Translocation of Endothelial Nitric Oxide Synthase.  50:1084-1095. 2014

Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury..  50:614-625. 2014

Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis.  50:549-558. 2014

Inter-a-inhibitor blocks epithelial sodium channel activation and decreases nasal potential differences in DF508 mice.  50:953-962. 2014

Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor.  50:805-816. 2014

Human tracheobronchial basal cells: Normal versus remodeling/repairing phenotypes in vivo and in vitro.  49:1127-1134. 2013

In utero exposure to second-hand smoke aggravates the response to ovalbumin in adult mice.  49:1102-1109. 2013

Ephrin-B2 reverse signaling increases α5β1 integrin-mediated fibronectin deposition and reduces distal lung compliance.  49:680-687. 2013

Chlorine induces the unfolded protein response in murine lungs and skin.  49:197-203. 2013

Differential regulation of pulmonary vascular cell growth by hypoxia-inducible transcription factor-1a and hypoxia-inducible transcription factor-2α.  49:78-85. 2013

Defining lung injury in animals.  48:267. 2013

Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2.  48:94-104. 2013

In utero exposure to second-hand smoke aggravates adult responses to irritants adult second-hand smoke.  47:843-851. 2012

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability.  47:445-453. 2012

Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction.  47:340-348. 2012

Thy-1 signals through PPARγ to promote lipofibroblast differentiation in the developing lung.  46:765-772. 2012

Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways.  46:790-796. 2012

Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation.  46:599-606. 2012

Regulation of alveolar epithelial Na ⁺ channels by ERK1/2 in chlorine-breathing mice.  46:342-354. 2012

Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis.  46:87-95. 2012

Hypoxia-inducible factor regulates expression of surfactant protein in alveolar type II cells in vitro.  45:938-945. 2011

Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide.  45:874-881. 2011

Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa - Induced lung injury in mice.  45:632-641. 2011

Ascorbate and deferoxamine administration after chlorine exposure decrease mortality and lung injury in mice.  45:386-392. 2011

Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling.  45:419-425. 2011

Epigenetic regulation of Thy-1 by histone deacetylase inhibitor in rat lung fibroblasts.  45:16-23. 2011

Postexposure administration of a β2-agonist decreases chlorine-induced airway hyperreactivity in mice.  45:88-94. 2011

Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: Potential use as a biomarker of ΔF508 cystic fibrosis transmembrane conductance regulator rescue.  43:607-616. 2010

Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel.  43:99-108. 2010

Respiratory syncytial virus impairs macrophage IFN-α/β- and IFN-γ-stimulated transcription by distinct mechanisms.  42:404-414. 2010

Functional stability of rescued ΔF508 cystic fibrosis transmembrane conductance regulator in airway epithelial cells.  42:363-372. 2010

Repeated bouts of moderate-intensity aerobic exercise reduce airway reactivity in a murine asthma model.  42:243-249. 2010

Highlights of the December issue.  41:629-630. 2009

Highlights of the October issue.  41:377-378. 2009

Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis.  41:367-375. 2009

α1-Antitrypsin inhibits epithelial Na⁺ transport in vitro and in vivo.  41:261-270. 2009

Highlights of the August issue.  41:125-126. 2009

Participation of mammalian target of rapamycin complex 1 in toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury.  41:237-245. 2009

Highlights of the July issue.  41:1-2. 2009

Influenza exerts continued pressure in an era of modern medicine.  41:3-7. 2009

Expression and regulation of epithelial Na⁺ channels by nucleotides in pleural mesothelial cells.  40:543-554. 2009

Inhibition of Na⁺ transport in lung epithelial cells by respiratory syncytial virus infection.  40:588-600. 2009

Search and rescue finding ways to correct ΔF508 CFTR.  40:385-387. 2009

Highlights of the march issue.  40:249-250. 2009

Acute exercise decreases airway inflammation, but not responsiveness, in an allergic asthma model.  40:83-89. 2009

Role of small GTPases and αvβ5 integrin in Pseudomonas aeruginosa-induced increase in lung endothelial permeability.  40:108-118. 2009

α1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro.  39:631-637. 2008

Role of oxygen availability in CFTR expression and function.  39:514-521. 2008

Thy-1 promoter hypermethylation: A novel epigenetic pathogenic mechanism in pulmonary fibrosis.  39:610-618. 2008

Activation of the unfolded protein response by ΔF508 CFTR.  39:448-457. 2008

Activation of the unfolded protein response by F508 cystic fibrosis transmembrane conductance regulator.  39:448-457. 2008

Developmental regulation of NO-mediated VEGF-induced effects in the lung.  39:420-430. 2008

DETANO and nitrated lipids increase chloride secretion across lung airway cells.  39:150-162. 2008

Asbestos-induced MKP-3 expression augments TNF-α gene expression in human monocytes.  39:113-123. 2008

Human metapneumovirus inhibits IFN-α signaling through inhibition of STAT1 phosphorylation.  38:661-670. 2008

The role of red blood cells and hemoglobin-nitric oxide interactions on blood flow.  38:125-126. 2008

Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae.  38:105-113. 2008

Post-infection A77-1726 blocks pathophysiologic sequelae of respiratory syncytial virus infection.  37:379-386. 2007

Differential expression and oxidation of MKP-1 modulates TNF-α gene expression.  37:366-374. 2007

Restoration of W1282X CFTR activity by enhanced expression.  37:347-356. 2007

No detectable improvements in cystic fibrosis transmembrane conductance regulator by nasal aminoglycosides in patients with cystic fibrosis with stop mutations.  37:57-66. 2007

VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator.  36:706-714. 2007

NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I.  36:263-269. 2007

Enhanced myofibroblastic differentiation and survival in thy-1(-) lung fibroblasts.  36:226-235. 2007

Surfactant dysfunction in SP-A^-/- and iNOS^-/- mice with mycoplasma infection.  36:103-113. 2007

Unlocking the mysteries of Na⁺-K⁺-ATPase endocytosis: Phosphorylation is the key.  35:1-2. 2006

Bactericidal function of alveolar macrophages in mechanically ventilated rabbits.  34:719-726. 2006

Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epithelia.  34:600-608. 2006

4-Hydroxynonenal induces rat γ-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling.  34:174-181. 2006

Involvement of calpain-calpastatin in cigarette smoke-induced inhibition of lung endothelial nitric oxide synthase.  33:513-520. 2005

Thrombin increases lung water by decreasing Na,K-ATPase activity.  33:317-318. 2005

American Journal of Respiratory Cell and Molecular Biology: Editors' notes.  32:363. 2005

Role of hypoxia-inducible factor-1α in hypoxia-induced apoptosis of primary alveolar epithelial type II cells.  32:395-403. 2005

Altered airway responsiveness in CD38-deficient mice.  32:149-156. 2005

Surfactant proteins and inflammation: The Yin and the Yang.  31:585-586. 2004

Activation of airway Cl^- secretion in human subjects by adenosine.  31:140-146. 2004

High levels of catalase and glutathione peroxidase activity dampen H 2O2 signaling in human alveolar macrophages.  31:43-53. 2004

Regulation of amiloride-sensitive Na⁺ transport by basal nitric oxide.  30:720-728. 2004

Role of Surfactant Protein-A in Nitric Oxide Production and Mycoplasma Killing in Congenic C57BL/6 Mice.  30:319-325. 2004

Gene Expression Analysis in response to lung toxicants I. sequencing and microarray development.  30:296-310. 2004

Hyperoxia impairs antibacterial function of macrophages through effects on actin.  28:443-450. 2003

Increased susceptibility to rsv infection by exposure to inhaled diesel engine emissions.  28:451-463. 2003

Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: Role of phosphatidylinositol 3-kinase.  28:179-187. 2003

Pseudomonas aeruginosa and tumor necrosis factor-α attenuate Clara cell secretory protein promoter function.  26:216-223. 2002

4-Hydroxy-2-nonenal increases γ-glutamylcysteine synthetase gene expression in alveolar epithelial cells.  24:499-505. 2001

Early events in naphthalene-induced acute Clara cell toxicity II. Comparison of glutathione depletion and histopathology by airway location.  24:272-281. 2001

GM-CSF increases AP-1 DNA binding and Ref-1 amounts in human alveolar macrophages.  25:254-259. 2001

Geldanamycin inhibits NF-κB activation and interleukin-8 gene expression in cultured human respiratory epithelium.  25:92-97. 2001

Modification of sodium transport and alveolar fluid clearance by hypoxia: Mechanisms and physiological implications.  25:538-541. 2001

Na,K-ATPase gene transfer mitigates an oxidant-induced decrease of active sodium transport in rat fetal ATII cells.  24:245-252. 2001

A CD36 synthetic peptide inhibits bleomycin-induced pulmonary inflammation and connective tissue synthesis in the rat.  23:204-212. 2000

Could asthma be worsened by stimulating the T-helper type 1 immune response?.  22:143-146. 2000

Decreased expression of aquaporin (AQP)1 and AQP5 in mouse lung after acute viral infection.  22:34-44. 2000

Pulmonary fibrosis. Pathways are slowly coming into light.  22:520-523. 2000

Three-dimensional organization of the lamina reticularis in the rat tracheal basement membrane zone.  22:393-397. 2000

Both Erk and p38 kinases are necessary for cytokine gene transcription.  20:751-758. 1999

Cloning and characterization of KPL2, a novel gene induced during ciliogenesis of tracheal epithelial cells.  20:675-683. 1999

Components of human papillomavirus that activate transcription and support plasmid replication in human airway cells.  20:1001-1006. 1999

In vitro culture of microdissected rat nasal airway tissues.  20:1274-1285. 1999

Iron regulates hyperoxia-dependent human heme oxygenase 1 gene expression in pulmonary endothelial cells.  20:797-804. 1999

Restoration of the mucous phenotype by retinoic acid in retinoid-deficient human bronchial cell cultures: Changes in mucin gene expression.  20:43-52. 1999

Surfactant protein B deficiency worsens hyperoxic injury to the alveolar epithelium.  21:449-450. 1999

The attenuated fibroblast sheath of the respiratory tract epithelial-mesenchymal trophic unit.  21:655-657. 1999

Endothelial exposure to Pseudomonas aeruginosa proteases increases the vulnerability of the alveolar epithelium to a second injury.  18:129-135. 1998

Inhibition of cell proliferation and induction of apoptosis by the retinoid AHPN in human lung carcinoma cells.  18:323-333. 1998

Lipopolysaccharide-induced NF-κB activation and cytokine release in human alveolar macrophages is PKC-independent and TK- and PC-PLC-dependent.  18:384-391. 1998

Modulation of monocyte chemotactic protein-1 production by hyperoxia: Importance of RNA stability in control of cytokine production.  18:521-525. 1998

Identification of Novel Inducible Genes in Airway Epithelium.  17:106-113. 1997

Modulation of Adenovirus-mediated Gene Transfer by Nitric Oxide.  16:501-509. 1997

Phenotyping and Cytokine Regulation of the BEAS-2B Human Bronchial Epithelial Cell: Demonstration of Inducible Expression of the Adhesion Molecules VCAM-1 and ICAM-1.  17:571-582. 1997

Pulmonary Cytochrome P450 Monooxygenase and Clara Cell Differentiation in Mice.  17:302-314. 1997

Characterization of a Neutrophil Inhibitor Peptide Harvested from Human Bronchial Lavage: Homology to Influenza A Nucleoprotein.  15:207-215. 1996

Differential Enhancement of γ-Glutamyl Transpeptidase and γ-Glutamylcysteine Synthetase by Tert-butylhydroquinone in Rat Lung Epithelial L2 Cells.  14:186-191. 1996

Increased γ-Glutamylcysteine Synthetase and γ-Glutamyl Transpeptidase Activities Enhance Resistance of Rat Lung Epithelial L2 Cells to Quinone Toxicity.  14:192-197. 1996

Quantitation of the Alveolar Distribution of Surfactant Mixtures in Normal and Injured Lungs.  15:451-459. 1996

erbB-2 Knockout Employing an Intracellular Single-chain Antibody (sFv) Accomplishes Specific Toxicity in erbB-2-expressing Lung Cancer Cells.  15:348-354. 1996

Pleural mesothelial cell expression of C-C (monocyte chemotactic peptide) and C-X-C (interleukin 8) chemokines..  12:581-588. 1995

Differential responsiveness of human bronchial epithelial cells, lung carcinoma cells, and bronchial fibroblasts to interferon-gamma in vitro..  11:147-152. 1994

Manganese superoxide dismutase expression in alveolar type II epithelial cells from nonventilated and hypoperfused lungs..  11:366-371. 1994

gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells..  11:586-592. 1994

Homeobox 1.3 expression: induction by retinoic acid in human bronchial fibroblasts..  7:3-9. 1992

Mesothelial cell response to pleural injury: thrombin-induced proliferation and chemotaxis of rat pleural mesothelial cells..  6:421-425. 1992

Regulation of type I and type II transglutaminase in normal human bronchial epithelial and lung carcinoma cells..  7:10-18. 1992

Production of tumor necrosis factor-alpha by blood and lung mononuclear phagocytes from patients with human immunodeficiency virus-related lung disease..  5:144-148. 1991

Human alveolar macrophages release a factor that inhibits phagocyte function..  1:407-416. 1989