Primary laboratory research interests concern the regulation of fetal and neonatal pulmonary vascular tone and remodeling during normal development and in the pathophysiology of major diseases of neonates, such as persistent pulmonary hypertension, bronchopulmonary dysplasia, and sepsis. Whole animal models are used to elucidate the mechanisms of Group B streptococcus and hypoxia-induced pulmonary hypertension and to test potential remedies. Tissue culture is used to explore the role of oxygen tension, pH, and peptide growth factors and other signaling molecules in pulmonary vascular smooth muscle cell growth and remodeling. Clinical research interests include persistent pulmonary hypertension of the newborn, bronchopulmonary dysplasia, sepsis, neonatal immunity, necrotizing enterocolitis, and controlled clinical trials.
