Positions

Selected Publications

Academic Article

Year Title Altmetric
2016 Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignanciesLeukemia.  30:2364-2372. 2016
2016 Pillars Article: Identification of a Putative Second T-cell Receptor. Nature. 1986. 322: 145-149Journal of Immunology.  196:3509-3513. 2016
2012 Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles.Journal of Translational Medicine.  10:72. 2012
2010 Pathway modulators and inhibitorsCurrent protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]2010
2010 Analysis of proteins: IntroductionCurrent protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]2010
2010 Current Protocols in Molecular Biology: PrefaceCurrent protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]2010
2009 Pathway modulators and inhibitors.Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.].  Appendix 6:6. 2009
2008 Diagnosis of thrombotic thrombocytopenic purpura with normal ADAMTS13 activity and absence of its inhibitor (anti-ADAMTS13 antibodies)American Journal of Hematology.  83:256. 2008
2007 Performance of the Sebia CAPILLARYS 2 for detection and immunotyping of serum monoclonal paraproteinsAmerican Journal of Clinical Pathology.  128:293-299. 2007
2007 Bio*Medical informatics and genomic medicine: Research and training 2007
2007 Electrospray ionisation-cleavable tandem nucleic acid mass tag-peptide nucleic acid conjugates: Synthesis and applications to quantitative genomic analysis using electrospray ionisation-MS/MSNucleic Acids Research.  35. 2007
2006 Timing of plasma exchange and rituximab for the treatment of thrombotic thrombocytopenic purpura [1]American Journal of Clinical Pathology.  126:965. 2006
2006 Solution radioimmunoassay of proteins and peptides.Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.].  Chapter 10. 2006
2006 Spectrophotometric and colorimetric determination of protein concentration.Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.].  Chapter 10. 2006
2002 Electroelution of proteins from stained gels. 2002
2001 Column chromatography of antibodies and fragments. 2001
1999 Continuous quality improvement for point-of-care testing using background monitoring of duplicate specimensArchives of Pathology and Laboratory Medicine.  123:824-828. 1999
1999 Cost analysis for decision support: The case of comparing centralized versus distributed methods for blood gas testingJournal of Healthcare Management.  44:207-215. 1999
1999 Curbing overutilization: the silver lining to HCFA compliance. 1999
1999 Estimating costs and turnaround times: presenting a user-friendly tool for analyzing costs and performance. 1999
1998 Evaluating stat testing options in an academic health center: Therapeutic turnaround time and staff satisfaction 1998
1998 Stark choices for AHCsAcademic Medicine.  73:839-841. 1998
1997 A N(alpha)-acetyltransferase selectively transfers an acetyl group to NH2-terminal methionine residues: purification and partial characterization. 1997
1997 A N(α)-acetyltransferase selectively transfers an acetyl group to NH2-terminal methionine residues: Purification and partial characterization 1997
1997 Streptococcus pyogenes type 5 M protein is an antigen, not a superantigen, for human T cellsHuman Immunology.  53:206-215. 1997
1997 Training of doctors in the UK. 1997
1997 Using patient satisfaction as an indicator of the quality of laboratory services. Applying social science methods to evaluate outcomes in laboratory medicine. 1997
1996 Acetyl-CoA hydrolase involved in acetate utilization in Saccharomyces cerevisiae 1996
1996 Automating clinical practice guidelines: A corporate-academic partnership 1996
1995 Different forms of Streptolysin O produced by Streptococcus pyogenes and by Escherichia coli expressing recombinant toxin: Cleavage by streptococcal cysteine proteaseInfection and Immunity.  63:2776-2779. 1995
1993 Immunodominance: A single amino acid substitution within an antigenic site alters intramolecular selection of T cell determinantsJournal of Immunology.  151:1852-1858. 1993
1993 Isolation of a membrane-associated cathepsin D-like enzyme from the model antigen presenting cell, A20, and its ability to generate antigenic fragments from a protein antigen in a cell-free systemArchives of Biochemistry and Biophysics.  305:298-306. 1993
1993 Mapping of the glycoprotein 330 (gp330) gene to mouse chromosome 2Genomics.  17:780-781. 1993
1992 Immunodominance: Intermolecular competition between MHC class II molecules by covalently linked T cell epitopesJournal of Immunology.  148:3034-3041. 1992
1992 Molecular cloning, sequencing, deletion, and overexpression of a methionine aminopeptidase gene from Saccharomyces cerevisiaeJournal of Biological Chemistry.  267:8007-8011. 1992
1992 Silencing of immunodominant epitopes by contiguous sequences in complex synthetic peptidesCellular Immunology.  143:284-297. 1992
1991 Optimization of the Fragmentation in a Frit-Fast Atom Bombardment Ion Source for the Sequencing of Peptides at the Picomole LevelAnalytical Chemistry.  63:1978-1983. 1991
1991 Comparison of class I‐ and II‐restricted T cell recognition of the identical peptideEuropean Journal of Immunology.  21:2781-2789. 1991
1991 Immunodominance: Intramolecular competition between T cell epitopesJournal of Immunology.  146:2137-2144. 1991
1991 Primary Structure Determination of Peptides and Enzymatically Digested Proteins Using Capillary Liquid Chromatography/Mass Spectrometry and Rapid Linked-Scan TechniquesAnalytical Chemistry.  63:1091-1097. 1991
1991 Single amino acid substitution alters T cell determinant selection during antigen processing of Staphylococcus aureus nucleaseJournal of Immunology.  146:438-443. 1991
1990 Purification and characterization of a methionine aminopeptidase from Saccharomyces cerevisiaeJournal of Biological Chemistry.  265:19892-19897. 1990
1990 Model peptides reveal specificity of N(α)-acetyltransferase from Saccharomyces cerevisiaeJournal of Biological Chemistry.  265:11576-11580. 1990
1990 A glucose-repressible gene encodes acetyl-CoA hydrolase from Saccharomyces cerevisiaeJournal of Biological Chemistry.  265:7413-7418. 1990
1990 Identification of methionine N(α)-acetyltransferase from Saccharomyces cerevisiaeJournal of Biological Chemistry.  265:3603-3606. 1990
1990 Freshly isolated Thy-1+ dendritic epidermal cells express T cell receptor γδ-CD3Journal of Dermatological Science.  1:459-464. 1990
1990 Immunological activity of covalently linked T-cell epitopesNature.  343:381-383. 1990
1989 N alpha acetylation is required for normal growth and mating of Saccharomyces cerevisiae.Journal of Bacteriology.  171:5795-5802. 1989
1989 Nα-acetyltransferase deficiency alters protein synthesis in Saccharomyces cerevisiaeFEBS Letters.  256:139-142. 1989
1989 Structural organization of the rat acyl-peptide hydrolase gene.Nucleic Acids Research.  17:4397-4400. 1989
1989 Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptorScience.  244:1163-1165. 1989
1989 Cloning and sequence analysis of a rat liver cDNA encoding acyl-peptide hydrolaseJournal of Biological Chemistry.  264:8892-8899. 1989
1989 High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons 1989
1989 Identical peptides recognized by MHC class I- and II-restricted T cellsJournal of Experimental Medicine.  170:279-289. 1989
1989 Molecular cloning and sequencing of a cDNA encoding N(α)-acetyltransferase from Saccharomyces cerevisiaeJournal of Biological Chemistry.  264:12339-12343. 1989
1989 Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiaeJournal of Biological Chemistry.  264:6979-6983. 1989
1989 Murine MHC polymorphism and T cell specificitiesScience.  244:572-575. 1989
1989 N(α) acetylation is required for normal growth and mating of Saccharomyces cerevisiaeJournal of Bacteriology.  171:5795-5802. 1989
1989 Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis 1989
1989 Purification and characterization of an acetyl‐CoA hydrolase from Saccharomyces cerevisiae 1989
1989 Relative contribution of 'determinant selection' and 'holes in the T-cell repertoire' to T-cell responses 1989
1988 Rapid separation of DNA restriction fragments using capillary electrophoresis 1988
1988 Structural characteristics of an antigen required for its interaction with Ia and recognition by T cellsNature.  328:395-399. 1988
1988 Identification of distinct C3B and C4B recognition sites in the human C3B/C4B receptor (Cri, Cd35) by deletion mutagenesisJournal of Experimental Medicine.  168:1699-1717. 1988
1988 T cell receptor gene usage in the response to γ repressor cI protein: An apparent bias in the usage of a Vα gene elementJournal of Experimental Medicine.  168:1081-1097. 1988
1988 Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1Journal of Experimental Medicine.  167:1271-1280. 1988
1988 Characterization of the catalytic domain of bovine adrenal tyrosine hydroxylaseBiochemical and Biophysical Research Communications.  151:1446-1453. 1988
1988 Structure of the human B lymphocyte receptor for C3d and the epstein-barr virus and relatedness to other members of the family of C3/C4 binding proteinsJournal of Experimental Medicine.  167:1047-1066. 1988
1988 Eosinophil granule cationic proteins: Major basic protein is distinct from the smaller subunit of eosinophil peroxidaseJournal of Leukocyte Biology.  43:1-4. 1988
1988 Eosinophilic Chemotactic Factors of AnaphylaxisMethods in Enzymology.  162:170-174. 1988
1988 Purification and characterization of an N alpha-acetyltransferase from Saccharomyces cerevisiae.Journal of Biological Chemistry.  263:14948-14955. 1988
1988 Rapid separation and purification of oligonucleotides by high-performance capillary gel electrophoresis 1988
1988 Sequence determination of the mumps virus HN geneVirology.  164:318-325. 1988
1987 T lymphocyte response to bacteriophage λ repressor cI protein. Recognition of the same peptide presented by Ia molecules of different haplotypesJournal of Immunology.  139:3973-3980. 1987
1987 Acyl-peptide hydrolase from rat liver. Characterization of enzyme reaction.Journal of Biological Chemistry.  262:11435-11445. 1987
1987 Human C3B/C4B receptor (CR1): Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristic of C3/C4 binding proteinsJournal of Experimental Medicine.  165:1095-1112. 1987
1987 A peptide binding protein which plays a role in antigen presentation.Advances in Experimental Medicine and Biology.  225:161-164. 1987
1987 A rat histone H4 gene closely associated with the testis-specific H1t geneExperimental Cell Research.  173:534-545. 1987
1987 Complete Amino Acid Sequences of the Heavy and Light Chain Variable Regions from Two A/J Mouse Antigen Nonbinding Monoclonal Antibodies Bearing the Predominant p-Azophenyl Arsonate IdiotypeBiochemistry.  26:604-612. 1987
1987 High-Performance Capillary Electrophoretic Separation of Bases, Nucleosides, and Oligonucleotides: Retention Manipulation via Micellar Solutions and Metal AdditivesAnalytical Chemistry.  59:1021-1027. 1987
1987 Immune recognition of proteins: Conclusions, dilemmas and enigmasBioEssays.  6:112-116. 1987
1987 Immunological self, nonself discriminationScience.  235:865-870. 1987
1987 Reactive sulfhydryl groups of α39, a guanine nucleotide-binding protein from brain. Location and functionJournal of Biological Chemistry.  262:4501-4507. 1987
1987 Site-directed mutagenesis of stahphylococcal nuclease: Role of tyrosine residues in substrate binding and catalysis 1987
1987 T cell activation by processed antigen is equally blocked by I‐E and I‐A‐restricted immunodominant peptidesEuropean Journal of Immunology.  17:1605-1609. 1987
1986 Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: Homology with the receptor for fragments C3b and C4b of the third and fourth components of complement 1986
1986 Identification of a putative second T-cell receptorNature.  322:145-149. 1986
1986 Interaction of peptide antigens and class II major histocompatibility complex antigensNature.  324:260-262. 1986
1986 Molecular cloning and characterization of cDNA encoding the GTP-binding protein α(i) and identification of a related protein, α(h) 1986
1986 The T cell repertoire for recognition of a phylogenetically distant protein antigen: Peptide specificity and mhc restriction of staphylococcal nuclease-specific T cell clonesJournal of Experimental Medicine.  164:897-910. 1986
1986 Purification of the B lymphocyte receptor for the C3d fragment of complement and the Epstein-Barr virus by monoclonal antibody affinity chromatography, and assessment of its functional capacitiesJournal of Immunological Methods.  92:79-87. 1986
1986 Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains) 1986
1986 Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor 1986
1986 Identification of functional regions on the I-Ab molecule by site-directed mutagenesis 1986
1986 Molecular cartography of globular proteins with application to antigenic sitesBiopolymers.  25:863-883. 1986
1985 Expression of murine 21-hydroxylase in mouse adrenal glands and in transfected Y1 adrenocortical tumor cells 1985
1985 Identification of a partial cDNA clone for the human receptor for complement fragments C3b/C4b 1985
1985 Purification and amino-terminal protein sequence analysis of the mumps virus fusion proteinVirology.  144:373-383. 1985
1985 Combinational diversity within variable regions bearing the predominant anti-ρ-azophenylarsonate idiotype of strain a miceJournal of Immunology.  134:2740-2747. 1985
1985 Conformation of the eosinophil chemotactic tetrapeptides and analogues in dimethyl sulfoxide. 1H n.m.r. studiesInternational journal of peptide and protein research.  25:337-346. 1985
1985 Molecular studies of the atrial natriuretic factor geneHypertension.  7:31-34. 1985
1985 Rapid purification of the human C3b/C4b receptor (CR1) by monoclonal antibody affinity chromatographyJournal of Immunological Methods.  82:303-313. 1985
1985 Rat epidermal growth factor: complete amino acid sequence: Homology with the correspondence murine and human proteins; isolation of a form truncated at both ends with full in vitro biological activity 1985
1985 Turns in Peptides and ProteinsAdvances in Protein Chemistry.  37:1-109. 1985
1984 Complete Amino Acid Sequence of the Heavy-Chain Variable Region from an A/J Mouse Antigen-Nonbinding Monoclonal Antibody Bearing the Predominant Arsonate ldiotypeBiochemistry.  23:4726-4732. 1984
1984 Nucleotide sequences of the human and mouse atrial natriuretic factor genesScience.  226:1206-1209. 1984
1984 The structure of rat preproatrial natriuretic factor as defined by a complementary DNA cloneScience.  225:324-326. 1984
1983 Structural Correlates of Idiotypy in the Arsonate SystemAnnals of the New York Academy of Sciences.  418:48-64. 1983
1982 Hollow visceral myopathy. A light- and electron-microscopic studyAmerican Journal of Surgical Pathology.  6:269-275. 1982
1981 CONFORMATIONAL CHARACTERISTICS OF THE N‐ACETYL‐N‘‐METHYLAMIDES OF THE FOUR (LYS, TYR) DIPEPTIDESInternational journal of peptide and protein research.  17:575-592. 1981
1980 Polydispersity of rat mast cell heparin. Implications for proteoglycan assemblyJournal of Biological Chemistry.  255:11753-11758. 1980
1979 The red blood cell lithium/plasma lithium ratio. Significance in recurrent affective illness.Medical Journal of Australia.  1:631-632. 1979
1978 Elimination of nonspecific adsorption of serum proteins by Sepharose-bound antigensAnalytical Biochemistry.  87:299-305. 1978
1978 Aspects of Membrane Structure: Updated for the ClinicianAustralian and New Zealand Journal of Medicine.  8:89-99. 1978
1978 The detection of five antigenically reactive regions in the soybean leghemoglobin a moleculeMolecular Immunology.  15:297-302. 1978
1977 A controlled comparative trial of clorazepate (Tranxene) and diazepam (Valium) for anxietyMedical Journal of Australia.  2:525-528. 1977
1977 A novel method for delineating antigenic determinants: Peptide synthesis and radioimmunoassay using the same solid supportImmunochemistry.  14:565-568. 1977
1977 Conformational integrity of myoglobin after immunization with Freund's adjuvantJournal of Immunology.  118:226-228. 1977
1977 Cross-reactivity between mammalian myoglobins: Linear vs spatial antigenic determinantsImmunochemistry.  14:283-288. 1977
1977 Fragmentation patterns by fast linked electric and magnetic field scanningJournal of Mass Spectrometry.  12:264-265. 1977
1977 Immunological Measurements of Conformational Motility in Regions of the Myoglobin MoleculeBiochemistry.  16:175-185. 1977
1976 Evaluation of the fluorescamine test for monitoring completion of coupling on nitrochloromethylated resinAnalytical Biochemistry.  74:477-483. 1976
1972 THERMAL PERTURBATION DIFFERENCE SPECTROSCOPY OF PROTEINSInternational journal of peptide and protein research.  4:11-19. 1972

Education And Training

  • Master of Science in Health / Health Care Administration / Management, Tulane University 1998
  • Doctor of Philosophy in Biochemistry, University of Melbourne 1978
  • Doctor of Medicine, University of Missouri System : Columbia 1974
  • Brigham & Women's Hospital, Internship 1981
  • Massachusetts General Hospital, Residency 1983
  • Brigham & Women's Hospital, Residency 1982
  • Brigham & Women's Hospital, Residency 1980
  • Full Name

  • John Smith