Positions

Overview

  • Dr. Locke completed her undergraduate degree in biology and chemistry at Duke University and her medical degree at East Carolina University prior to matriculating to Johns Hopkins Hospital where she received training in general surgery and multi-visceral abdominal transplantation. Dr. Locke completed her Master of Public Health degree with an emphasis in biostatistics and epidemiology at the Johns Hopkins Bloomberg School of Public Health. She joined the surgical faculty at UAB upon completion of her training at Johns Hopkins Hospital. Dr. Locke is a well-funded investigator, and currently holds an NIH K23 Career Development Award and a Clinical Science Faculty Development Grant through the American Society of Transplantation. She has authored 52 articles in peer-reviewed journals and 11 book chapters. Dr. Locke is frequently invited to present her research as a visiting professor at many prestigious academic centers around the US and at international transplant meetings, including the World Transplant Congress, the British Transplantation Society, the American Transplant Congress, and the National Kidney Foundation. In addition, Dr. Locke is an Associate Editor for Transplantation and is a regular peer reviewer for several journals, including the American Journal of Transplantation and the Journal of the American Society of Nephrology to name a few. She is an invited member of the ASTS Providing Better Access to Organs Task Force and Diversity Affairs Committee, the AST Kidney-Pancreas Committee, The Transplantation Society Young Member Committee, and the United Network for Organ Sharing Pediatric Transplant Committee. Dr. Locke is the recipient of numerous honors and has most recently received the American Transplant Congress Young Investigator Award, the Birmingham Business Journal’s Top 40 under 40 Award, and was named one of AL.com’s 2015 Women Who Shape the State.

    Dr. Locke is an abdominal transplant surgeon who specializes in innovative strategies for the transplantation of incompatible organs, disparities in access to and outcomes after solid organ transplantation, and transplantation of HIV-infected end-stage patients. Her research interests include complex statistical analysis and modeling of transplant outcomes and behavioral research focused on health disparities.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Patient Perspectives on Weight Management for Living Kidney Donation 2019
    2019 Mitigating Racial and Sex Disparities in Access to Living Donor Kidney Transplantation: Impact of the Nation's Longest Single-center Kidney Chain 2019
    2019 Obesity and long-term mortality risk among living kidney donors 2019
    2019 Patient-reported outcome measures for life participation in kidney transplantation: A systematic review 2019
    2019 Center Variation and Risk Factors for Failure to Complete 6 Month Postdonation Follow-up Among Obese Living Kidney Donors 2019
    2019 Ethnic and Age Disparities in Outcomes Among Liver Transplant Waitlist Candidates 2019
    2019 Time for reform in transplant program–specific reporting: AST/ASTS transplant metrics taskforce 2019
    2019 Establishing a Core Outcome Measure for Life Participation: A Standardized Outcomes in Nephrology-kidney Transplantation Consensus Workshop Report 2019
    2019 Mortality and Kidney Transplantation Outcomes Among Hepatitis C Virus–Seropositive Maintenance Dialysis Patients: A Retrospective Cohort Study 2019
    2019 Optimal timing of hepatitis C treatment among HIV/HCV coinfected ESRD patients: Pre- vs posttransplant 2019
    2019 Kidney transplantation in a HIV-positive recipient 2019
    2019 Disparity in access to kidney allograft offers among transplant candidates with human immunodeficiency virus 2019
    2019 CYP3A5 genotype affects time to therapeutic tacrolimus level in pediatric kidney transplant recipients 2019
    2019 Donation approval among obese living kidney donor candidates: The impact of metabolic syndrome 2019
    2019 Get on with it!—A novel allocation strategy to reduce kidney discards 2019
    2018 Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop 2018
    2018 Population Health, Ethnicity, and Rate of Living Donor Kidney Transplantation 2018
    2018 Can you hear me now? Patient preferences for evaluating kidney transplant centers 2018
    2018 Population level outcomes and cost-effectiveness of hepatitis C treatment pre- vs postkidney transplantation 2018
    2018 Response to “It is time to revise the kidney allocation system to restore the pediatric advantage” 2018
    2018 Expand the pool of living donors for kidney transplantation 2018
    2018 Impact of the new kidney allocation system A2/A2B → B policy on access to transplantation among minority candidates 2018
    2018 Decreasing deceased donor transplant rates among children (≤6 years) under the new kidney allocation system 2018
    2018 In Reply to ‘Core Assessment of Predonation Kidney Function: Clarification of the 2017 KDIGO Living Donor Guideline’ 2018
    2018 Apolipoprotein L1 and Chronic Kidney Disease Risk in Young Potential Living Kidney Donors 2018
    2018 Expanding clarity or confusion? Volatility of the 5-tier ratings assessing quality of transplant centers in the United States 2018
    2018 Response to: Regarding “HIV protease inhibitors and mortality following kidney transplantation” 2018
    2018 Redefining the Influence of Ethnicity on Simultaneous Kidney and Pancreas Transplantation Outcomes: A 15-Year Single-Center Experience. 2018
    2018 Evaluation of Kidney Donors: Core Curriculum 2018 2018
    2018 Assessing emergency department utilization in the era of population health 2018
    2018 Kidney transplantation and waitlist mortality rates among candidates registered as willing to accept a hepatitis C infected kidney 2018
    2018 Landscape of ABO-Incompatible Live Donor Kidney Transplantation in the US 2018
    2018 Long Cold Ischemia Times in Same Hospital Deceased Donor Transplants 2018
    2018 Race but not Hepatitis C co-infection affects survival of HIV+ individuals on dialysis in contemporary practice 2018
    2018 Patient and Kidney Allograft Survival in Recipients with End-Stage Renal Disease from Amyloidosis 2018
    2018 Living Kidney Donor Phenotype and Likelihood of Postdonation Follow-up 2018
    2018 Urologic malignancies in kidney transplantation 2018
    2017 Impact of Protease Inhibitor–Based Anti-Retroviral Therapy on Outcomes for HIV+ Kidney Transplant Recipients 2017
    2017 Apolipoprotein L1 Gene Effects on Kidney Transplantation 2017
    2017 Expanding the use of hepatitis C–viremic kidney donors 2017
    2017 PROviding Better ACcess To ORgans: A comprehensive overview of organ-access initiatives from the ASTS PROACTOR Task Force 2017
    2017 Quantifying postdonation risk of ESRD in living kidney donors 2017
    2017 Effect of kidney donor hepatitis C virus serostatus on renal transplant recipient and allograft outcomes. 2017
    2017 Patterns of primary care utilization before and after living kidney donation 2017
    2017 Risk of End-Stage Renal Disease in HIV-Positive Potential Live Kidney Donors 2017
    2017 The Authors Reply 2017
    2017 Abdominal lean muscle is associated with lower mortality among kidney waitlist candidates 2017
    2017 Obesity increases the risk of end-stage renal disease among living kidney donors 2017
    2017 Survival benefit of kidney transplantation in HIV-infected patients 2017
    2017 Lymphocyte-depleting induction therapy lowers the risk of acute rejection in African American pediatric kidney transplant recipients 2017
    2017 Access to kidney transplantation among HIV-infected waitlist candidates 2017
    2017 Increased Mortality and Graft Loss With Kidney Retransplantation Among Human Immunodeficiency Virus (HIV)–Infected Recipients 2017
    2017 Kidney transplantation of highly sensitized recipients under the new kidney allocation system: A reflection from five different transplant centers across the United States 2017
    2017 Survival benefit of transplantation with a deceased diabetic donor kidney compared with remaining on the waitlist 2017
    2016 Dosing Eculizumab for Antibody-Mediated Rejection in Kidney Transplantation: A Case Report 2016
    2016 Insurance Type and Solid Organ Transplantation Outcomes: A Historical Perspective on How Medicaid Expansion Might Impact Transplantation Outcomes 2016
    2016 Anti–Blood Group Antibodies in Intravenous Immunoglobulin May Complicate Interpretation of Antibody Titers in ABO-Incompatible Transplantation 2016
    2016 Identification of Optimal Donor–Recipient Combinations Among Human Immunodeficiency Virus (HIV)–Positive Kidney Transplant Recipients 2016
    2016 Induction Immunosuppression and Clinical Outcomes in Kidney Transplant Recipients Infected With Human Immunodeficiency Virus 2016
    2016 A systematic review of the use of expandable cages in the cervical spine 2016
    2016 Inpatient mortality among solid organ transplant recipients hospitalized for sepsis and severe sepsis 2016
    2016 Long-Term outcomes after liver transplantation among human immunodeficiency virus-infected recipients 2016
    2015 Center-Level Experience and Kidney Transplant Outcomes in HIV-Infected Recipients 2015
    2015 The biomechanics of pedicle screw augmentation with cement 2015
    2015 A Systematic Assessment of the Use of Platelet-Rich Plasma in Spinal Fusion 2015
    2015 A national study of outcomes among HIV-infected kidney transplant recipients 2015
    2015 Center-Level Experience and Kidney Transplant Outcomes in HIV-Infected Recipients 2015
    2015 Hospital-onset Clostridium difficile infection among solid organ transplant recipients 2015
    2015 Identification of strategies to facilitate organ donation among african americans using the nominal group technique 2015
    2015 The impact of proposed changes in liver allocation policy on cold ischemia times and organ transportation costs 2015
    2014 The authors' reply 2014
    2014 Resource utilization associated with procurement of transplantable organs from donors that do not meet OPTN eligible death criteria 2014
    2014 Immunosuppression regimen and the risk of acute rejection in HIV-infected kidney transplant recipients 2014
    2014 Eculizumab and splenectomy as salvage therapy for severe antibody-mediated rejection after HLA-incompatible kidney transplantation 2014
    2014 Is there a role for detection of complement-binding antibodies in kidney transplantation? 2014
    2014 To whom goes the kidney? 2014
    2013 What liver transplant outcomes can be expected in the uninsured who become insured via the affordable care act? 2013
    2012 Donor-derived organ transplant transmission of coccidioidomycosis 2012
    2012 Re: Desensitization in HLA-incompatible kidney recipients and survival 2012
    2012 In vitro and ex vivo delivery of short hairpin RNAs for control of hepatitis C viral transcript expression 2012
    2011 Late graft loss among pediatric recipients of DCD kidneys 2011
    2011 Outcomes of renal transplants from centers for disease control and prevention high-risk donors with prospective recipient viral testing: A single-center experience 2011
    2011 Desensitization in HLA-incompatible kidney recipients and survival 2011
    2011 Evolving concepts in the selection of immunosuppression regimen for liver transplant recipients. 2011
    2010 Stem cell mobilization is life saving in an animal model of acute liver failure 2010
    2010 Eculizumab, bortezomib and kidney paired donation facilitate transplantation of a highly sensitized patient without vascular access 2010
    2010 Proinflammatory events and HLA antibodies. 2010
    2010 Renal transplantation in HIV-positive recipients 2010
    2009 Impact of medicare coverage on disparities in access to simultaneous pancreas and kidney transplantation 2009
    2009 Increased risk of graft loss from hepatic artery thrombosis after liver transplantation with older donors 2009
    2009 Stem Cells and the Liver: Clinical Applications in Transplantation 2009
    2009 Successful liver transplantation for Budd-Chiari syndrome in a patient with paroxysmal nocturnal hemoglobinuria treated with the anti-complement antibody eculizumab 2009
    2009 Rapid accomodation of an a1 renal allograft after preconditioning for ABO-incompatible transplantation 2009
    2009 Recruitment of host progenitor cells in rat liver transplants 2009
    2009 ABO incompatible renal transplantation: A paradigm ready for broad implementation 2009
    2009 ABO-incompatible deceased donor liver transplantation in the United States: A national registry analysis 2009
    2009 C4d deposition without rejection correlates with reduced early scarring in ABO-incompatible renal allografts 2009
    2009 Proinflammatory events are associated with significant increases in breadth and strength of HLA-specific antibody 2009
    2009 Renal transplant in HIV-positive patients: Long-term outcomes and risk factors for graft loss 2009
    2009 The use of antibody to complement protein C5 for salvage treatment of severe antibody-mediated rejection 2009
    2008 Prolonged waiting times for liver transplantation in obese patients 2008
    2008 Donor ethnicity influences outcomes following deceased-donor kidney transplantation in black recipients 2008
    2008 Generation of humanized animal livers using embryoid body-derived stem cell transplant 2008
    2008 Can Machine Perfusion Decrease the Likelihood of Discard Among Biopsied Kidneys? 2008
    2008 Declining outcomes in simultaneous liver-kidney transplantation in the MELD era: Ineffective usage of renal allografts 2008
    2008 Effect modification in liver allografts with prolonged cold ischemic time 2008
    2008 Obesity impacts access to kidney transplantation 2008
    2007 ABO-incompatible transplantation: Less may be more 2007
    2007 Minimizing risk associated with elderly liver donors by matching to preferred recipients 2007
    2007 Twenty years of liver transplantation for Budd-Chiari syndrome: A national registry analysis 2007
    2007 Desensitization protocols for crossing human leukocyte antigen and ABO incompatible barriers 2007
    2007 Outcomes of kidneys from donors after cardiac death: Implications for allocation and preservation 2007
    2007 The utility of splenectomy as rescue treatment for severe acute antibody mediated rejection 2007
    2007 Cold ischemia time and allograft outcomes in live donor renal transplantation: Is live donor organ transport feasible? 2007
    2006 Factors affecting graft survival after liver transplantation from donation after cardiac death donors 2006
    2006 Biliary cystic disease 2006
    2006 Rescue splenectomy for severe acute antibody-mediated rejection. 2006
    2005 Inflammatory pseudotumor of the liver 2005

    Chapter

    Year Title Altmetric
    2015 Management of Portal Hypertensive Hemorrhage.  510-513. 2015
    2012 Consider parvovirus B19 infection in patients with anemia or pancytopenia 2012
    2012 Keep patients with dural tears flat for 24-48 hours 2012
    2012 Place the tip of a central venous catheter at the junction of the superior vena cava and atrium 2012

    Research Overview

  • abdominal transplantation, incompatible organ transplantation, transplantation of HIV-infected end-stage patients, outcomes and behavioral research focused on health disparities
  • Investigator On

  • Private Grant  awarded by ASTELLAS PHARMA GLOBAL DEVELOPMENT, INC. - NEW 2018 - 2025
  • Short-Term Research Experiences Advancing Medical Students (STREAMS)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2024
  • APOL1 Long-Term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2022
  • APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • Private Grant  awarded by UNITED THERAPEUTICS CORPORATION 2015 - 2021
  • Private Grant  awarded by ASTELLAS PHARMA US, INC. 2017 - 2021
  • Private Grant  awarded by QUARK PHARMACEUTICALS, INC. 2015 - 2020
  • Effects of Inhibiting Early Inflammation in Kidney Transplant Patients - Equipment  awarded by Mount Sinai School of Medicine 2015 - 2020
  • Identification of Drugs that Induce Terminal Transcriptional Silencing of Latent HIV-1 Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2017 - 2020
  • Impact of CCR5 Blockade in HIV + Kidney Transplant Recipients  awarded by University of California, San Francisco 2016 - 2020
  • Evaluating the Implementation and Effectiveness of the Living Donor Navigator Program  awarded by American Society of Nephrology 2018 - 2020
  • HOPE in Action: A Clinical Trial of HIV-to-HIV Deceased Donor Kidney Transplantation  awarded by Johns Hopkins University 2018 - 2019
  • Prospective Observational Study of HIV+ Deceased Donor Transplant for HIV+ Recipients  awarded by Johns Hopkins University 2018 - 2019
  • Comparison of Immune Globulin Intravenous (Human), 10% (IVIG), plus Rituximab vs. IVIG 10% + Placebo (Normal Saline) as Agents to Reduce Donor Specific Antibodies, Improve Transplant Rates and Outcomes in Highly-HLA Sensitized Patients Awaiting Deceased Donor Kidney Transplantation  awarded by Cedars - Sinai Medical Center 2014 - 2019
  • Private Grant  awarded by ASTELLAS PHARMA US, INC. 2013 - 2017
  • Private Grant  awarded by ALEXION PHARMACEUTICALS, INC. 2014 - 2017
  • Preserving Renal Function & Protective Immunity via Anti-LFA-1-Based CNI Avoidance  awarded by Emory University 2009 - 2016
  • Private Grant  awarded by ALEXION PHARMACEUTICALS, INC. 2013 - 2016
  • Comparison of Immune Globulin Intravenous (Human), 10% (IVIG), plus Rituximab vs. IVIG 10% + Placebo (Normal Saline) as Agents to Reduce Donor Specific Antibodies, Improve Transplant Rates and Outcomes in Highly-HLA Sensitized Patients Awaiting Deceased Donor Kidney Transplantation  awarded by Cedars - Sinai Medical Center 2014
  • Education And Training

  • Johns Hopkins Hospital, Residency 2010
  • Johns Hopkins Hospital, Postdoctoral Fellowship 2012
  • Full Name

  • Jayme Locke