Positions

Overview

  • Dr. Juan Jose Calix obtained his Bachelor of Science Degree from Loyola University New Orleans in 2005. After working a year in Hurricane Katrina relief efforts, he earned his MD and PhD in Microbiology from the Medical Scientist Training Program at the University of Alabama at Birmingham (UAB) between 2006-2014. He performed his doctoral thesis work in the laboratory of Moon Nahm, MD with the support of a NIAID F31 Fellowship. He subsequently joined the Physician Scientist Training Program at Washington University in St. Louis (WUSTL) to perform his Internal Medicine residency and Infectious Diseases fellowship. During this training he worked in the laboratories of Mario Feldman, PhD (2017-2019) and then Gautam Dantas, PhD (2019-2021). In March 2020 he became an Instructor of Medicine at WUSTL. In August 2021, he returned to UAB to open his own laboratory as an Assistant Professor in the Division of Infectious Diseases and the Division of Pulmonology/Allergy/Critical Care, where he is continues to conduct his NIAID K08-funded research studying the propagation of bacterial pathogens among at-risk hosts.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Staphylococcus aureus injection drug use-associated bloodstream infections are propagated by community outbreaks of diverse lineages 2021
    2019 Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genesNature Communications.  10. 2019
    2019 Comparison of the Clinical Characteristics of Hospital-Acquired and Non-Hospital-Acquired Acinetobacter calcoaceticus-baumannii Complex in a Large Midwest US Health Care System.Open Forum Infectious Diseases.  6:ofz423. 2019
    2019 Seasonal Changes in the Prevalence of Antibiotic-Susceptible Acinetobacter calcoaceticus-baumannii Complex Isolates Result in Increased Multidrug Resistance Rates During Winter Months.Open Forum Infectious Diseases.  6:ofz245. 2019
    2014 Low invasiveness of pneumococcal serotype 11A is linked to ficolin-2 recognition of O-acetylated capsule epitopes and lectin complement pathway activationJournal of Infectious Diseases.  210:1155-1165. 2014
    2014 Spectrum of pneumococcal serotype 11A variants results from incomplete loss of capsule O-acetylationJournal of Clinical Microbiology.  52:758-765. 2014
    2013 Elucidation of structural and antigenic properties of pneumococcal serotype 11A, 11B, 11C, and 11F polysaccharide capsulesJournal of Bacteriology.  195:4552. 2013
    2013 Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating unitsJournal of Biological Chemistry.  288:21945-21954. 2013
    2012 Biochemical, genetic, and serological characterization of two capsule subtypes among Streptococcus pneumoniae serotype 20 strains: Discovery of a new pneumococcal serotypeJournal of Biological Chemistry.  287:27885-27894. 2012
    2012 Structural characterization of Streptococcus pneumoniae serotype 9A capsule polysaccharide reveals role of glycosyl 6-O-acetyltransferase wcjE in serotype 9V capsule biosynthesis and immunogenicityJournal of Biological Chemistry.  287:13996-14003. 2012
    2012 Differential occurrence of Streptococcus pneumoniae serotype 11E between asymptomatic carriage and invasive pneumococcal disease isolates reflects a unique model of pathogen microevolutionClinical Infectious Diseases.  54:794-799. 2012
    2012 Elucidation of structural and antigenic properties of pneumococcal serotype 11A, 11B, 11C, and 11F polysaccharide capsulesJournal of Bacteriology.  194:206. 2012
    2011 Streptococcus pneumoniae serotype 9A isolates contain diverse mutations to wcjE that result in variable expression of serotype 9v-specific epitopeJournal of Infectious Diseases.  204:1585-1595. 2011
    2011 Elucidation of structural and antigenic properties of pneumococcal serotype 11A, 11B, 11C, and 11F polysaccharide capsulesJournal of Bacteriology.  193:5271-5278. 2011
    2010 A new pneumococcal serotype, 11E, has a variably inactivated wcjE GeneJournal of Infectious Diseases.  202:29-38. 2010
    2010 Survey of nonsusceptible nasopharyngeal streptococcus pneumoniae isolates in children attending day-care centers in Brazil 2010

    Research Overview

  • "To cause an infection somewhere, the microbe must first be able to get there. The incidental journey microbes take on their way to causing infections is imprinted in, and thus can be unraveled from, the genomes of clinical isolates."

    The Calix lab (Est. 2021) focuses on the microbial and environmental determinants that facilitate the propagation (transmission, niche colonization, population persistence, etc.) of pathogenic bacteria among individuals at risk of eventual opportunistic infections. Our goal is to identify key pathobiological "choke points" that can be targeted by preventative efforts against modern-day bacterial pathogens, with current focus on Carbapenem-resistant Acinetobacter and non-vaccine serotypes of Streptococcus pneumoniae.

    Our translational research strategy begins with elucidating the molecular epidemiology of infections through next-generation sequencing of clinical isolates supplemented by clinical metadata. This aids in identifying microbial factors of interest and the building of clinically-relevant hypotheses. We subsequently investigate these factors using clinical isolates, and combining benchtop immunological/ biochemical/ molecular microbiology techniques and non-animal models. We have special interests in bacterial surfaces and microbial glycobiology.
  • Education And Training

  • Doctor of Medicine in Microbiology, University of Alabama at Birmingham 2014
  • Bachelor of Science or Mathematics in Biology / Biological Sciences, Loyola University New Orleans 2005
  • Full Name

  • Juan J. Calix