Positions

Overview

  • Dr. Meador-Woodruff received his BS in Chemistry from the University of Richmond, and his MD from the Medical College of Virginia. He then moved to Ann Arbor, and completed a combined residency in psychiatry and a research fellowship at the University of Michigan. After completing his research training, he joined the faculty of the Department of Psychiatry and the Mental Health Research Institute at the University of Michigan, where he held administrative positions including Associate Chair for Research and Vice Chair. He left Michigan in April 2006 to become the Heman E. Drummond Professor and Chairman of the Department of Psychiatry of University of Alabama at Birmingham (UAB). He moved his lab largely intact to UAB.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Abnormal ER quality control of neural GPI-anchored proteins via dysfunction in ER export processing in the frontal cortex of elderly subjects with schizophrenia 2019
    2019 Fractionation of subcellular compartments from human brain tissue 2019
    2019 Intracellular compartment-specific proteasome dysfunction in postmortem cortex in schizophrenia subjects 2019
    2019 Kinase network dysregulation in a human induced pluripotent stem cell model of DISC1 schizophrenia 2019
    2018 Abnormal expression of ER quality control and ER associated degradation proteins in the dorsolateral prefrontal cortex in schizophrenia 2018
    2017 Abnormalities of signal transduction networks in chronic schizophrenia 2017
    2017 Actin polymerization is reduced in the anterior cingulate cortex of elderly patients with schizophrenia 2017
    2017 Pre-clinical Medical Students as the Primary Longitudinal Provider of Psychiatric Care in the Outpatient Setting: A Novel Training Model 2017
    2017 Altered fucosyltransferase expression in the superior temporal gyrus of elderly patients with schizophrenia 2017
    2017 Abnormalities of signal transduction networks in chronic schizophrenia. 2017
    2016 Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia 2016
    2016 Cell-specific abnormalities of glutamate transporters in schizophrenia: Sick astrocytes and compensating relay neurons? 2016
    2016 Shaping plasticity: Alterations in glutamate transporter localization as a pathophysiological mechanism in severe mental illness. 2016
    2016 Changes in cortical N-methyl-d-aspartate receptors and post-synaptic density protein 95 in schizophrenia, mood disorders and suicide 2016
    2016 Protein Expression of Proteasome Subunits in Elderly Patients with Schizophrenia 2016
    2016 Decreased expression of cortactin in the schizophrenia brain 2016
    2016 Cortical PGC-1?-dependent transcripts are reduced in postmortem tissue from patients with schizophrenia 2016
    2015 Abnormal subcellular localization of GABA A receptor subunits in schizophrenia brain 2015
    2015 Glutamate transporter splice variant expression in an enriched pyramidal cell population in schizophrenia 2015
    2015 Abnormal N-acetylglucosaminyltransferase expression in prefrontal cortex in schizophrenia 2015
    2015 Corrigenda - Postmortem Brain: An Underutilized Substrate for Studying Severe Mental Illness (Neuropsychopharmacology Reviews (2014) 39, (65-87) DOI: 10.1038/npp.2013.239) 2015
    2014 Altered serine/threonine kinase activity in schizophrenia 2014
    2014 Evolutionarily conserved pattern of AMPA receptor subunit glycosylation in mammalian frontal cortex 2014
    2014 N-glycosylation of GABAA receptor subunits is altered in schizophrenia 2014
    2014 Abnormal partitioning of hexokinase 1 suggests disruption of a glutamate transport protein complex in schizophrenia 2014
    2014 Alterations of the myristoylated, alanine-rich C kinase substrate (MARCKS) in prefrontal cortex in schizophrenia 2014
    2014 Increased G protein-coupled receptor kinase (GRK) expression in the anterior cingulate cortex in schizophrenia 2014
    2014 Postmortem brain: An underutilized substrate for studying severe mental illness 2014
    2013 Dysfunction of the ubiquitin proteasome and ubiquitin-like systems in schizophrenia 2013
    2013 N-linked glycosylation of cortical N-methyl-D-aspartate and kainate receptor subunits in schizophrenia 2013
    2013 Erratum: Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy (Epilepsia (2013) 54 228-238) 2013
    2013 Transmembrane AMPA receptor regulatory protein (TARP) dysregulation in anterior cingulate cortex in schizophrenia 2013
    2013 Abnormal N-linked glycosylation of cortical AMPA receptor subunits in schizophrenia 2013
    2013 Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia 2013
    2013 Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy 2013
    2012 Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia 2012
    2012 Ampa receptor subunit expression in the endoplasmic reticulum in frontal cortex of elderly patients with schizophrenia 2012
    2012 Recent advances in targeting the ionotropic glutamate receptors in treating schizophrenia 2012
    2012 Abnormalities of the Duo/Ras-related C3 botulinum toxin substrate 1/p21-activated kinase 1 pathway drive myosin light chain phosphorylation in frontal cortex in schizophrenia 2012
    2012 Expression of equilibrative nucleoside transporter type 1 protein in elderly patients with schizophrenia 2012
    2012 Abnormal activity of the MAPK- and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia 2012
    2012 Regional differences in expression of β-tubulin isoforms in schizophrenia 2012
    2012 Glutamate receptor abnormalities in schizophrenia: Implications for innovative treatments 2012
    2011 Glutamatergic gene expression is specifically reduced in thalamocortical projecting relay neurons in schizophrenia 2011
    2011 Endosomal trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia 2011
    2011 Novel approaches to the study of postmortem brain in psychiatric illness: Old limitations and new challenges 2011
    2011 Innovative approach to research training: Research colloquium for junior investigators 2011
    2010 Increased cortical expression of an RNA editing enzyme occurs in major depressive suicide victims 2010
    2010 Evidence for abnormal forward trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia 2010
    2010 Expression of the NR2B-NMDA receptor subunit and its Tbr-1/CINAP regulatory proteins in postmortem brain suggest altered receptor processing in schizophrenia 2010
    2010 Expression of the NR2B-NMDA receptor trafficking complex in prefrontal cortex from a group of elderly patients with schizophrenia 2010
    2010 Parvalbumin deficiency and GABAergic dysfunction in mice lacking PGC-1α 2010
    2010 Late emerging effects of prenatal and early postnatal nicotine exposure on the cholinergic system and anxiety-like behavior 2010
    2010 Abnormal glycosylation of EAAT1 and EAAT2 in prefrontal cortex of elderly patients with schizophrenia 2010
    2009 Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia 2009
    2009 Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia 2009
    2009 Expression of four housekeeping proteins in elderly patients with schizophrenia 2009
    2009 Identification of novel targets for PGC-1α and histone deacetylase inhibitors in neuroblastoma cells 2009
    2009 Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers 2009
    2008 Abnormal expression of glutamate transporter and transporter interacting molecules in prefrontal cortex in elderly patients with schizophrenia 2008
    2008 Role of glutamate in schizophrenia: Integrating excitatory avenues of research 2008
    2008 Cortical expression of glial fibrillary acidic protein and glutamine synthetase is decreased in schizophrenia 2008
    2008 Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder 2008
    2008 Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine 2008
    2008 Altered Vesicular Glutamate Transporter Expression in the Anterior Cingulate Cortex in Schizophrenia 2008
    2007 Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders 2007
    2007 Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia 2007
    2007 NMDA receptors and schizophrenia 2007
    2007 Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder 2007
    2006 Lamina-specific abnormalities of AMPA receptor trafficking and signaling molecule transcripts in the prefrontal cortex in schizophrenia 2006
    2006 Dopamine receptor signaling molecules are altered in elderly schizophrenic cortex 2006
    2006 Plasma copper, iron, ceruloplasmin and ferroxidase activity in schizophrenia 2006
    2006 Altered NMDA receptor expression in schizophrenia 2006
    2006 Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia 2006
    2006 Up-regulation of NMDA receptor subunit and post-synaptic density protein expression in the thalamus of elderly patients with schizophrenia 2006
    2006 Serine racemase protein expression in cortex and hippocampus in schizophrenia 2006
    2006 Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia 2006
    2006 Glutamatergic mechanisms in schizophrenia: Current concepts 2006
    2006 Reply to Balcar and Nanitsos. Reply: Autoradiography of [ 3H]aspartate and glutamate transport in schizophrenia [2] 2006
    2005 Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression 2005
    2005 Dopaminergic abnormalities in select thalamic nuclei in schizophrenia: Involvement of the intracellular signal integrating proteins calcyon and spinophilin 2005
    2005 Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia 2005
    2005 Cortical glutamatergic markers in schizophrenia 2005
    2005 Dopaminergic regulation of orexin neurons 2005
    2005 Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia 2005
    2005 Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains 2005
    2005 Distribution of the NMDA receptor NR3A subunit in the adult pig-tail macaque brain 2005
    2004 NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder 2004
    2004 Thalamic dysfunction in schizophrenia: Neurochemical, neuropathological, and in vivo imaging abnormalities 2004
    2004 Abnormalities of the NMDA receptor and associated intracellular molecules in the thalamus in schizophrenia and bipolar disorder 2004
    2004 Molecular abnormalities of the hippocampus in severe psychiatric illness: Postmortem findings from the Stanley Neuropathology Consortium 2004
    2004 Molecular abnormalities of the hippocampus in severe psychiatric illness: Postmortem findings from the Stanley Neuropathology Consortium 2004
    2004 Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia 2004
    2004 Effects of 6-Cyano-7-nitroquinoxaline-2,3-dione on Nicotinic Receptor Subunit Transcript Expression in the Rat Brain 2004
    2004 Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophrenia 2004
    2004 Gender-Specific Gene Expression in Post-Mortem Human Brain: Localization to Sex Chromosomes 2004
    2004 Expression of Transcripts Encoding AMPA Receptor Subunits and Associated Postsynaptic Proteins in the Macaque Brain 2004
    2004 Calcyon Transcript Expression in Macaque Brain 2004
    2004 Neurofilament subunit protein abnormalities in the thalamus in schizophrenia 2004
    2003 Differential effects of antipsychotics on haloperidol-induced vacuous chewing movements and subcortical gene expression in the rat 2003
    2003 Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia 2003
    2003 DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles 2003
    2002 Ontogeny of ionotropic glutamate receptor subunit expression in the rat hippocampus 2002
    2002 Striatal Excitatory Amino Acid Transporter Transcript Expression in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder 2002
    2002 Nucleus-specific expression of NMDA receptor-associated postsynaptic density proteins in primate thalamus 2002
    2001 Gene expression in schizophrenia [9] 2001
    2001 Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia 2001
    2001 Vesicular glutamate transporter transcript expression in the thalamus in schizophrenia 2001
    2001 Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder 2001
    2001 Ontogeny of ionotropic glutamate receptor expression in human fetal brain 2001
    2001 Abnormal kainate receptor expression in prefrontal cortex in schizophrenia 2001
    2000 Ionotropic glutamate receptor modulation preferentially affects NMDA receptor expression in rat hippocampus 2000
    2000 Ionotropic glutamate receptor binding and subunit mRNA expression in thalamic nuclei in schizophrenia 2000
    2000 New initiative: Neuropsychopharmacology online rapid publication 2000
    2000 Nucleus-specific expression of ionotropic glutamate receptor subunit mRNAs and binding sites in primate thalamus 2000
    2000 Metabotropic glutamate receptor mRNA expression in the schizophrenic thalamus 2000
    1999 Ionotropic glutamate receptor modulation of 5-HT6 and 5-HT7 mRNA expression in rat brain 1999
    1999 Nicotine withdrawal and psychiatric symptoms in cigarette smokers with schizophrenia 1999
    1999 Effects of clozapine and haloperidol on 5-HT6 receptor mRNA levels in rat brain 1999
    1999 On the distribution patterns of D1, D2, tyrosine hydroxylase and dopamine transporter immunoreactivities in the ventral striatum of the rat 1999
    1999 Acute feasibility and safety of a smoking reduction strategy for smokers with schizophrenia 1999
    1998 AMPA receptor binding and subunit mRNA expression in prefrontal cortex and striatum of elderly schizophrenics 1998
    1998 Differential prevalence of cigarette smoking in patients with schizophrenic vs mood disorders 1998
    1998 The role of life events in onset and recurrent episodes of schizophrenia and schizoaffective disorder 1998
    1998 Tardive dyskinesia, clozapine, and treatment response 1998
    1998 Nicotine dependence in schizophrenia: Clinical phenomena and laboratory findings 1998
    1997 Clozapine-reserpine combination for refractory psychosis 1997
    1997 Antipsychotic regulation of hippocampal dopamine receptor messenger RNA expression 1997
    1997 Clozapine and haloperidol differentially affect AMPA and kainate receptor subunit mRNA levels in rat cortex and striatum 1997
    1997 Linking the family of D2 receptors to neuronal circuits in human brain: Insights into schizophrenia 1997
    1997 Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex: Focal abnormalities in orbitofrontal cortex in schizophrenia 1997
    1997 Editorial 1997
    1997 Serotonin transporter mRNA in schizophrenia (multiple letters) [1] 1997
    1996 Lack of dopamine receptor agonists effect on striatal dopamine transporter binding sites 1996
    1996 Differential regulation of hippocampal AMPA and kainate receptor subunit expression by haloperidol and clozapine 1996
    1996 Smoking, smoking withdrawal and schizophrenia: Case reports and a review of the literature 1996
    1996 Differential effects of clozapine and haloperidol on dopamine receptor mRNA expression in rat striatum and cortex 1996
    1996 Dopamine receptor gene expression in hippocampus is differentially regulated by the NMDA receptor antagonist MK-801 1996
    1996 Differential regulation, by MK-801, of dopamine receptor gene expression in rat nigrostriatal and mesocorticolimbic systems 1996
    1996 Dopamine receptor mRNA expression in human striatum and neocortex 1996
    1996 Frequency of neuropathology in a brain bank from a long-term, domiciliary population 1996
    1995 Effects of cocaine on D3 and D4 receptor expression in the human striatum 1995
    1995 The Human Dopamine D5 Receptor Gene: Cloning and Characterization of the 5′-Flanking and Promoter Region 1995
    1995 Neocortical Abnormalities in Schizophrenia 1995
    1994 Differential expression of autoreceptors in the ascending dopamine systems of the human brain 1994
    1994 Ventricular enlargement, neuropsychological status, and premorbid function in schizophrenia 1994
    1994 Dopamine receptor gene expression in the human medial temporal lobe 1994
    1994 Human brain receptors, V: Binding and message 1994
    1994 Prodynorphin-derived peptide expression in primate cortex and striatum 1994
    1994 Update on dopamine receptors 1994
    1993 Effects of cocaine on dopamine receptor gene expression: A study in the postmortem human brain 1993
    1993 Characterization of pro-opiomelanocortin processing in heterologous neuronal cells that express PC2 mRNA 1993
    1993 Expression of prodynorphin-derived peptides and mRNA in guinea-pig cortex 1993
    1992 Distribution of D5 dopamine receptor mRNA in rat brain 1992
    1992 Site-directed mutagenesis of the human dopamine D2 receptor 1992
    1992 A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques 1992
    1991 Comparison of the distributions of D1 and D2 dopamine receptor mRNAs in the rat brain 1991
    1991 Expression of the dopamine D2 receptor gene in brain 1991
    1991 Dexamethasone suppression test in schizophrenia: Relationship to symptomatology, ventricular enlargement, and outcome 1991
    1991 Basal ganglia mineralization in schizophrenia 1991
    1991 A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques 1991
    1991 Distribution of D2 dopamine receptor mRNA in the primate brain 1991
    1991 Opiate Receptors: Opioid Agonist‐Antagonist Effects 1991
    1990 Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: An in situ hybridization-receptor autoradiographic analysis 1990
    1990 Multiplicity of depressive episodes: Phenomenological and neuroendocrine correlates 1990
    1990 Differential effects of haloperidol on the rat pituitary: Decreased biosynthesis, processing and release of anterior lobe pro-opiomelanocortin 1990
    1990 Psychiatric side effects of tricyclic antidepressants 1990
    1990 Severity of depression and hypothalamic‐pituitary‐adrenal axis dysregulation: identification of contributing factors 1990
    1990 The effects of nigrostriatal 6-hydroxydopamine lesions on dopamine D2 receptor mRNA and opioid systems. 1990
    1989 γ-melanotropin and β-endorphin after dexamethasone 1989
    1989 Positive and negative symptoms in schizophrenia and the dexamethasone suppression test 1989
    1989 Distribution of D2 dopamine receptor mRNA in rat brain 1989
    1988 Behavioral and cognitive toxicity related to elevated plasma tricyclic antidepressant levels 1988
    1988 Dexamethasone suppression test status and severity of depression 1988
    1988 Doxepin-induced cardiac dysrhythmia 1988
    1988 Effects of psychotropic medications on hypothalamic-pituitary-adrenal regulation 1988
    1988 Effects of psychotropic medications on hypothalamic-pituitary-adrenal regulation 1988
    1988 Plasma postdexamethasone cortisol levels in schizoaffective disorder 1988
    1988 Regional processing of the N- and C-terminal domains of proopiomelanocortin in monkey pituitary and brain 1988
    1987 Gamma-melanotropin response to ovine corticotropin releasing factor in normal humans 1987
    1987 Multiple depressive episodes and plasma postdexamethasone cortisol levels 1987
    1987 Postdexamethasone plasma cortisol and β-endorphin levels in depression: Relationship to severity of illness 1987
    1986 Gamma-3-MSH and beta-endorphin in monkey pituitary. 1986
    1986 Profound behavioral toxicity due to tricyclic antidepressants 1986
    1985 Differential proliferative responses of cultured Schwann cells to axolemma and myelin-enriched fractions. II. Morphological studies 1985
    1984 Differential proliferative responses of cultured Schwann cells to axolemma- and myelin-enriched fractions. I. Biochemical studies 1984
    1984 Cyclic AMP and calcium as potential mediators of stimulation of cultured Schwann cell proliferation by axolemma-enriched and myelin-enriched membrane fractions 1984

    Book

    Year Title Altmetric
    2004 Schizophrenia as a disorder of neuroplasticity.  Ed. 59.  2004

    Chapter

    Year Title Altmetric
    2014 Evidence of glutamatergic dysfunction in the pathophysiology of schizophrenia.  265-294. 2014
    2008 A role for glutamate receptors, transporters, and interacting proteins in cortical dysfunction in schizophrenia.  113-147. 2008

    Research Overview

  • Dr. Meador-Woodruff's research has been continuously funded by NIH since 1989. His laboratory’s primary research interest is on understanding how different parts of the brain communicate with other parts via a variety of chemical signals, and how this communication is disrupted in schizophrenia. His current focus is on studying the expression of genes associated with glutamatergic neurotransmission within individual cells in the nervous system.

    • Principal Investigator On

    Investigator On

    Teaching Overview

  • Dr. Meador-Woodruff has a longstanding interest in teaching and mentorship, and nearly 100 trainees have rotated through his lab. He was director of the University of Michigan’s Psychiatry Residency Research Track, and was the PI of one of the earliest NIMH R25 grants to fund such research exposure during residency training. He is the Editor-in-Chief of the journal Neuropsychopharmacology.

    • Education And Training

  • University of Michigan Hospitals & Health Centers, Internship 1985
  • University of Michigan Hospitals & Health Centers, Residency 1989
  • University of Michigan Hospitals & Health Centers, Postdoctoral Fellowship 1989

    • Full Name

  • James Meador-Woodruff