Jeremy Herskowitz

Jeremy Herskowitz
Associate Professor

Associate Professor (P), Neurology , School of Medicine
Associate Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Associate Scientist (C), Neurodegeneration and Experimental Therapeutics (CNET) , Neurology
Scientist (C), Alzheimer's Disease Center , Neurology
Investigator (C), Evelyn F. McKnight Brain Institute , Neurology
Associate Scientist (C), Civitan International Research Center , Academic Joint Departments
Assistant Professor (S), Neurobiology , Academic Joint Departments

Selected Publications

Academic Article

Year	Title	Altmetric
2021	Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease 2021
2021	Perspectives on ROCK2 as a Therapeutic Target for Alzheimer’s Disease. Frontiers in Cellular Neuroscience. 15. 2021
2021	Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice. Neuroscience. 455:195-211. 2021
2020	Identifying Mechanisms of Normal Cognitive Aging Using a Novel Mouse Genetic Reference Panel. Frontiers in Cell and Developmental Biology. 8. 2020
2020	Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia. Cell Reports. 32. 2020
2020	The SETD6 Methyltransferase Plays an Essential Role in Hippocampus-Dependent Memory Formation. Biological Psychiatry. 87:577-587. 2020
2019	Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors. Behavioural Brain Research. 373. 2019
2019	Klotho deficiency affects the spine morphology and network synchronization of neurons. Molecular and Cellular Neuroscience. 98:1-11. 2019
2019	Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging. Neurobiology of Aging. 73:92-103. 2019
2019	Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid. Science Signaling. 12. 2019
2018	Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity 2018
2018	α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons. Acta Neuropathologica Communications. 6:35. 2018
2017	Dendritic spines provide cognitive resilience against Alzheimer's disease. Annals of Neurology. 82:602-614. 2017
2016	Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain. Journal of Neurochemistry. 525-531. 2016
2016	Rho kinase inhibition as a therapeutic for progressive supranuclear palsy and corticobasal degeneration 2016
2013	Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model 2013
2013	AAV2 production with optimized N/P ratio and PEI-mediated transfection results in low toxicity and high titer for in vitro and in vivo applications. Journal of Virological Methods. 193:270-277. 2013
2013	RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells. Neurobiology of Disease. 54:264-279. 2013
2012	Neuronal LR11 expression does not differentiate between clinically-defined Alzheimer's disease and control brains. PLoS ONE. 7. 2012
2012	Asparaginyl endopeptidase cleaves TDP-43 in brain. Proteomics. 12:2455-2463. 2012
2012	GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production 2012
2012	Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards. Journal of Proteome Research. 11:2721-2738. 2012
2012	Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling. Journal of Neuroinflammation. 9. 2012
2011	The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells (Journal of Virology (2005) 79, 4, (2261-2273)). Journal of Virology. 85:3041. 2011
2011	Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-β production. Journal of Biological Chemistry. 286:6117-6127. 2011
2010	Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration. Journal of Proteome Research. 9:6368-6379. 2010
2008	Systematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infection. Journal of Virology. 82:3295-3310. 2008
2008	The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiation. PLoS Pathogens. 4. 2008
2005	The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells. Journal of Virology. 79:2261-2273. 2005

Research Overview

Our team conducts research on Alzheimer’s disease (AD) and Frontotemporal dementia (FTD) and is committed to identifying better therapeutic targets and finding more effective treatments for these devastating disorders. We formulate and test mechanistic hypotheses on AD and FTD pathogenesis by incorporating cellular and animal models with synergistic studies using postmortem human brain tissue samples. The lab addresses basic science questions and performs preclinical studies on therapeutic targets for AD and FTD.