Our team conducts research on Alzheimer’s disease (AD) and Frontotemporal dementia (FTD) and is committed to identifying better therapeutic targets and finding more effective treatments for these devastating disorders. We formulate and test mechanistic hypotheses on AD and FTD pathogenesis by incorporating cellular and animal models with synergistic studies using postmortem human brain tissue samples. The lab addresses basic science questions and performs preclinical studies on therapeutic targets for AD and FTD.