Selected Publications

Academic Article

Year Title Altmetric
2022 Comparison of Golgi-Cox and Intracellular Loading of Lucifer Yellow for Dendritic Spine Density and Morphology Analysis in the Mouse BrainNeuroscience.  498:1-18. 2022
2021 Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neuronsMolecular Brain.  14. 2021
2021 Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease 2021
2021 Perspectives on ROCK2 as a Therapeutic Target for Alzheimer’s DiseaseFrontiers in Cellular Neuroscience.  15. 2021
2021 Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy MiceNeuroscience.  455:195-211. 2021
2020 Identifying Mechanisms of Normal Cognitive Aging Using a Novel Mouse Genetic Reference PanelFrontiers in Cell and Developmental Biology.  8. 2020
2020 Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's DementiaCell Reports.  32. 2020
2020 The SETD6 Methyltransferase Plays an Essential Role in Hippocampus-Dependent Memory FormationBiological Psychiatry.  87:577-587. 2020
2019 Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviorsBehavioural Brain Research.  373. 2019
2019 Klotho deficiency affects the spine morphology and network synchronization of neuronsMolecular and Cellular Neuroscience.  98:1-11. 2019
2019 Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal agingNeurobiology of Aging.  73:92-103. 2019
2019 Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloidScience Signaling.  12. 2019
2018 Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticityBrain Structure and Function.  223:4227-4241. 2018
2018 α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neuronsActa Neuropathologica Communications.  6:35. 2018
2017 Dendritic spines provide cognitive resilience against Alzheimer's diseaseAnnals of Neurology.  82:602-614. 2017
2016 Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brainJournal of Neurochemistry.  525-531. 2016
2016 Rho kinase inhibition as a therapeutic for progressive supranuclear palsy and corticobasal degeneration 2016
2013 Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model 2013
2013 AAV2 production with optimized N/P ratio and PEI-mediated transfection results in low toxicity and high titer for in vitro and in vivo applicationsJournal of Virological Methods.  193:270-277. 2013
2013 RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cellsNeurobiology of Disease.  54:264-279. 2013
2012 Neuronal LR11 expression does not differentiate between clinically-defined Alzheimer's disease and control brainsPLoS One.  7. 2012
2012 Asparaginyl endopeptidase cleaves TDP-43 in brainProteomics.  12:2455-2463. 2012
2012 GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionMolecular Biology of the Cell.  23:2645-2657. 2012
2012 Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standardsJournal of Proteome Research.  11:2721-2738. 2012
2012 Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signalingJournal of Neuroinflammation.  9. 2012
2011 The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells (Journal of Virology (2005) 79, 4, (2261-2273))Journal of Virology.  85:3041. 2011
2011 Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-β productionJournal of Biological Chemistry.  286:6117-6127. 2011
2010 Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degenerationJournal of Proteome Research.  9:6368-6379. 2010
2008 Systematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infectionJournal of Virology.  82:3295-3310. 2008
2008 The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiationPLoS Pathogens.  4. 2008
2005 The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cellsJournal of Virology.  79:2261-2273. 2005

Research Overview

  • Our team conducts research on Alzheimer’s disease (AD) and Frontotemporal dementia (FTD) and is committed to identifying better therapeutic targets and finding more effective treatments for these devastating disorders. We formulate and test mechanistic hypotheses on AD and FTD pathogenesis by incorporating cellular and animal models with synergistic studies using postmortem human brain tissue samples. The lab addresses basic science questions and performs preclinical studies on therapeutic targets for AD and FTD.
  • Education And Training

  • Doctor of Philosophy in Microbiology, Emory University 2007
  • Full Name

  • Jeremy Herskowitz