Selected Publications

Academic Article

Year Title Altmetric
2021 High-resolution yeast quiescence profiling in human-like media reveals complex influences of auxotrophy and nutrient availabilityGeroscience.  43:941-964. 2021
2021 A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolismJournal of Biological Chemistry.  296. 2021
2020 Interplay of mitochondrial fission-fusion with cell cycle regulation: Possible impacts on stem cell and organismal agingExperimental Gerontology.  135. 2020
2019 Slowing ribosome velocity restores folding and function of mutant CFTRJournal of Clinical Investigation.  129:5236-5253. 2019
2019 A humanized yeast phenomic model of deoxycytidine kinase to predict genetic buffering of nucleoside analog cytotoxicityGenes.  10. 2019
2019 A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin.Cancer & Metabolism.  7:9. 2019
2016 Gene-nutrient interaction markedly influences yeast chronological lifespanExperimental Gerontology.  86:113-123. 2016
2015 Yeast phenomics: An experimental approach for modeling gene interaction networks that buffer diseaseGenes.  6:24-45. 2015
2014 Aging and energetics' 'Top 40' future research opportunities 2010-2013F1000Research.  3. 2014
2014 Conserved allosteric hot spots in the transmembrane domains of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channels and Multidrug Resistance Protein (MRP) pumpsJournal of Biological Chemistry.  289:19942-19957. 2014
2014 Phenomic assessment of genetic buffering by kinetic analysis of cell arraysMethods in Molecular Biology.  1205:187-208. 2014
2012 A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis 2012
2011 A screen to identify small molecule inhibitors of protein-protein interactions in mycobacteriaASSAY and Drug Development Technologies.  9:299-310. 2011
2010 Global analysis of phase locking in gene expression during cell cycle: The potential in network modelingBMC Systems Biology.  4. 2010
2010 Recursive expectation-maximization clustering: A method for identifying buffering mechanisms composed of phenomic modules 2010
2009 Genomewide analysis reveals novel pathways affecting endoplasmic eticulum homeostasis, protein modification and quality control 2009
2009 Stringent mating-type-regulated auxotrophy increases the accuracy of systematic genetic interaction screens with Saccharomyces cerevisiae mutant arrays 2009
2007 High throughput drug screening for human immunodeficiency virus type 1 reactivating compoundsASSAY and Drug Development Technologies.  5:181-189. 2007
2007 Accurate, precise modeling of cell proliferation kinetics from time-lapse imaging and automated image analysis of agar yeast culture arraysBMC Systems Biology.  1. 2007
2004 Systematic quantification of gene interactions by phenotypic array analysis.Genome Biology.  5. 2004
1996 Functional reconstitution in situ of 5-hydroxytryptamine(2c) (5HT(2c)) receptors with α(q) and inverse agonism of 5HT(2c) receptor antagonistsJournal of Biological Chemistry.  271:22591-22597. 1996
1994 Cystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide bindingJournal of Clinical Investigation.  94:228-236. 1994
1992 Affinity purification of insoluble recombinant fusion proteins containing glutathione‐S‐transferaseBiotechnology and Bioengineering.  39:828-832. 1992
1992 Recombinant synthesis, purification, and nucleotide binding characteristics of the first nucleotide binding domain of the cystic fibrosis gene productJournal of Biological Chemistry.  267:6455-6458. 1992


Year Title Altmetric
2006 Genetic and Molecular Buffering of Phenotypes.  105-134. 2006

Education And Training

  • Doctor of Medicine, University of Alabama at Birmingham 1995
  • Bachelor of Science or Mathematics in Zoological Medicine Residency Program, Duke University 1989
  • Full Name

  • John Hartman