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John Hartman IV M.D.
Associate Professor
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E-mail
jhartman@uab.edu
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John Hartman IV M.D.
Associate Professor
Positions
Senior Scientist (C)
,
Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC)
,
School of Medicine
Scientist (C)
,
Comprehensive Diabetes Center
,
School of Medicine
Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
Scientist (C)
,
Integrative Center for Aging Research
,
School of Medicine
Associate Scientist (C)
,
Cystic Fibrosis Research Center
,
School of Medicine
Scientist
,
Cancer Cell Biology
,
O'Neal Comprehensive Cancer Center
Scholar (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
Associate Professor (S)
,
Medicine - Hematology & Oncology
,
Department of Medicine
Associate Scientist (C)
,
Neurodegeneration and Experimental Therapeutics (CNET)
,
Neurology
Scientist (C)
,
Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED)
,
School of Dentistry
Scientist (C)
,
Nutrition Obesity Res Center (NORC)
,
Nutrition Sciences Research
Associate Professor (S)
,
Biochemistry & Molecular Genetics
,
Academic Joint Departments
Associate Professor (S)
,
Pharmacology and Toxicology
,
Academic Joint Departments
Associate Professor (P)
,
Genetics Research Division
,
Genetics
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2021
High-resolution yeast quiescence profiling in human-like media reveals complex influences of auxotrophy and nutrient availability
.
Geroscience
. 43:941-964.
2021
2021
A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism
.
Journal of Biological Chemistry
. 296.
2021
2020
A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism
2020
2020
Interplay of mitochondrial fission-fusion with cell cycle regulation: Possible impacts on stem cell and organismal aging
.
Experimental Gerontology
. 135.
2020
2020
High-resolution yeast quiescence profiling in human-like media reveals interacting influences of auxotrophy and nutrient availability
2020
2019
Slowing ribosome velocity restores folding and function of mutant CFTR
.
Journal of Clinical Investigation
. 129:5236-5253.
2019
2019
A humanized yeast phenomic model of deoxycytidine kinase to predict genetic buffering of nucleoside analog cytotoxicity
.
Genes
. 10.
2019
2019
A humanized yeast phenomic model of deoxycytidine kinase to predict genetic buffering of nucleoside analog cytotoxicity
2019
2019
A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin
2019
2019
A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin.
2019
2016
Gene-nutrient interaction markedly influences yeast chronological lifespan
.
Experimental Gerontology
. 86:113-123.
2016
2016
Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect
.
PLoS Biology
. 14.
2016
2016
Long-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channels
2016
2015
Yeast phenomics: An experimental approach for modeling gene interaction networks that buffer disease
.
Genes
. 6:24-45.
2015
2014
Aging and energetics' 'Top 40' future research opportunities 2010-2013
.
F1000Research
. 3.
2014
2014
Conserved allosteric hot spots in the transmembrane domains of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channels and Multidrug Resistance Protein (MRP) pumps
.
Journal of Biological Chemistry
. 289:19942-19957.
2014
2014
Phenomic assessment of genetic buffering by kinetic analysis of cell arrays
.
Methods in Molecular Biology
. 1205:187-208.
2014
2013
The SWI/SNF Chromatin Remodeling Complex Influences Transcription by RNA Polymerase I in Saccharomyces cerevisiae
.
PLoS One
. 8.
2013
2012
A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis
2012
2011
A screen to identify small molecule inhibitors of protein-protein interactions in mycobacteria
.
Assay and Drug Development Technologies
. 9:299-310.
2011
2010
Global analysis of phase locking in gene expression during cell cycle: The potential in network modeling
.
BMC Systems Biology
. 4.
2010
2010
Recursive expectation-maximization clustering: A method for identifying buffering mechanisms composed of phenomic modules
2010
2009
Genomewide analysis reveals novel pathways affecting endoplasmic eticulum homeostasis, protein modification and quality control
2009
2009
Stringent mating-type-regulated auxotrophy increases the accuracy of systematic genetic interaction screens with Saccharomyces cerevisiae mutant arrays
2009
2008
Defining genetic interaction
2008
2007
Buffering of deoxyribonucleotide pool homeostasis by threonine metabolism
2007
2007
High throughput drug screening for human immunodeficiency virus type 1 reactivating compounds
.
Assay and Drug Development Technologies
. 5:181-189.
2007
2007
Accurate, precise modeling of cell proliferation kinetics from time-lapse imaging and automated image analysis of agar yeast culture arrays
.
BMC Systems Biology
. 1.
2007
2005
The case for strategic international alliances to harness nutritional genomics for public and personal health
2005
2005
The case for strategic international alliances to harness nutritional genomics for public and personal health
2005
2004
Systematic quantification of gene interactions by phenotypic array analysis.
.
Genome Biology
. 5.
2004
2001
Cell Biology: Principles for the buffering of genetic variation
.
Science
. 291:1001-1004.
2001
1996
Functional reconstitution in situ of 5-hydroxytryptamine(2c) (5HT(2c)) receptors with α(q) and inverse agonism of 5HT(2c) receptor antagonists
.
Journal of Biological Chemistry
. 271:22591-22597.
1996
1994
Cystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide binding
.
Journal of Clinical Investigation
. 94:228-236.
1994
1992
Affinity purification of insoluble recombinant fusion proteins containing glutathione‐S‐transferase
.
Biotechnology and Bioengineering
. 39:828-832.
1992
1992
Hypothyroidism in adults with sickle cell anemia
.
American Journal of Medicine
. 92:567-570.
1992
1992
Hypothyroidism in adults with sickle cell anemia
.
American Journal of Medicine
. 92:567-570.
1992
1992
Intrinsic anion channel activity of the recombinant first nucleotide binding fold domain of the cystic fibrosis transmembrane regulator protein
1992
1992
Recombinant synthesis, purification, and nucleotide binding characteristics of the first nucleotide binding domain of the cystic fibrosis gene product
.
Journal of Biological Chemistry
. 267:6455-6458.
1992
1990
Regulation of Tissue Plasminogen Activator in Sickle Cell Anemia
.
American Journal of Hematology
. 35:167-170.
1990
1988
Totally implantable intravenous catheters in the management of sickle cell anemia.
.
American Journal of Hematology
. 29:134-138.
1988
1988
Chronic granulocytic leukemia in a patient with sickle cell anemia.
.
American Journal of Medicine
. 85:567-569.
1988
Nutritional Genomics: Discovering the Path to Personalized Nutrition
Chapter
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Year
Title
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2006
Genetic and Molecular Buffering of Phenotypes
. 105-134.
2006
Research
Principal Investigator On
A Phenomic Model for N1303K-CFTR
awarded by
Cystic Fibrosis Foundation ^
Assays for Premature Termination Codon Suppression
awarded by
Emory University
Comparative Bioenergetics of Aging - Core B - Research Development Core
awarded by
National Institute on Aging/NIH/DHHS
Constructing Gene-Regulatory Networks to Reveal the Metabolic Basis of Lifespan in Yeast
awarded by
National Institute on Aging/NIH/DHHS
Discovery of Novel Mechanisms that Impact CFTR Translation and Contribute to Cystic Fibrosis Pathogenesis
awarded by
Emory University
Genetic Analysis of X-mutation Read Through: Targets and Mechanisms
awarded by
Cystic Fibrosis Foundation ^
Molecular Buffering of dNTP Metabolism by Target of Rapamycin Signaling
awarded by
American Cancer Society, Inc.
New Reagents for Understanding and Overcoming CFTR Defects
awarded by
Emory University
Quantitative, Global Analyis of Gene Interaction Networks that Buffer DNA Replication by Regulation of Threonine Metabolic Flux.
awarded by
Hughes (Howard) Medical Institute
Ribosomal Perturbation as a Mechanism to Prevent Misfolding of CFTR
awarded by
Emory University
Ribosomal Perturbation to Increase Functional Expression of F508del-CFTR
awarded by
Cystic Fibrosis Foundation ^
Systems Level Analysis of the Interplay Between Metabolism, Cell-Cell Communication, and Aging
awarded by
National Institute on Aging/NIH/DHHS
Investigator On
Comparative Bioenergetics of Aging
awarded by
National Institute on Aging/NIH/DHHS
Comparative Bioenergetics of Aging - Core B - Research Development Core
awarded by
National Institute on Aging/NIH/DHHS
Comparative Energetics and Aging
awarded by
National Institute on Aging/NIH/DHHS
Comparative Energetics and Aging - Research Development Core B
awarded by
National Institute on Aging/NIH/DHHS
Comparative Energetics and Aging - Research Development Core B
awarded by
National Institute on Aging/NIH/DHHS
New Paradigms of CFTR Regulation
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
Research Development Program - Component II
awarded by
Cystic Fibrosis Foundation ^
Teaching
Teaching Activities
GBS708 - Basic Genetics/Mole BIo (Fall Term 2010)
GBS708 - CORE COURSE II: GENETICS/MOLECULAR BIOLOGY (Fall Term 2010)
GBS708 - CORE COURSE II: GENETICS/MOLECULAR BIOLOGY (Fall Term 2011)
GBS723 - Model Sys for Gen & Epi Analys (Spring Term 2013)
GBS723 - Model Sys for Gen & Epi Analys (Spring Term 2014)
GBS723 - Model Sys for Genetic Analyses (Spring Term 2015)
GBS723 - Model Sys for Genetic Analyses (Spring Term 2016)
GBS723 - Model Sys for Genetic Analyses (Spring Term 2022)
GBS788 - Special Topics (Fall Term 2013)
GBS788 - Special Topics (Spring Term 2014)
GBSC700 - Journal Clubs (Fall Term 2014)
GBSC700 - Journal Clubs (Fall Term 2018)
GBSC711 - Advanced Genetics Study (Spring Term 2016)
GGSC320 - Colloquium-Genetics/Genomics (Fall Term 2020)
GGSC320 - Colloquium-Genetics/Genomics (Fall Term 2021)
GGSC320 - Colloquium-Genetics/Genomics (Fall Term 2022)
Background
Education And Training
Doctor of Medicine,
University of Alabama at Birmingham
1995
Bachelor of Science or Mathematics in Zoological Medicine Residency Program,
Duke University
1989
Contact
Full Name
John
Hartman