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Craig Maynard Ph.D.
Associate Professor
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E-mail
clmaynard@uab.edu
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Craig Maynard Ph.D.
Associate Professor
Positions
Scientist (C)
,
UAB Immunology Institute
,
School of Medicine
Associate Scientist (C)
,
UWIRC Microbiome Center
,
School of Medicine
Associate Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
Associate Scientist
,
Inflammation, Immunology and Immunotherapeutics
,
O'Neal Comprehensive Cancer Center
Associate Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
Assistant Professor (S)
,
Medicine - Gastroenterology
,
Department of Medicine
Associate Scientist (C)
,
Nutrition Obesity Res Center (NORC)
,
Nutrition Sciences Research
Associate Professor (P)
,
Molecular & Cellular Pathology
,
Joint Pathology
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2022
Hedgehog blockade remodels the gut microbiota and the intestinal effector CD8
+
T cells in a mouse model of mammary carcinoma
.
Laboratory Investigation
. 102:1236-1244.
2022
2022
Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models
.
JCI Insight
. 7.
2022
2022
Mucus, commensals, and the immune system
.
Gut Microbes
. 14.
2022
2021
CD4
+
T cell activation and concomitant mTOR metabolic inhibition can ablate microbiota-specific memory cells and prevent colitis
.
Science Immunology
. 5.
2021
2021
Early life stress in mice alters gut microbiota independent of maternal microbiota inheritance
2021
2021
ICOS ligand and IL-10 synergize to promote host–microbiota mutualism
2021
2020
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity
.
Nature Communications
. 11.
2020
2020
Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10
.
JCI Insight
. 5.
2020
2019
Cutting edge: ICOS-deficient regulatory T cells display normal induction of IL10 but readily downregulate expression of Foxp3
.
Journal of Immunology
. 202:1039-1044.
2019
2018
Intestinal microbiota and the immune system in metabolic diseases
2018
2017
TCR-independent functions of Th17 cells mediated by the synergistic actions of cytokines of the IL-12 and IL-1 families
.
PLoS One
. 12.
2017
2017
T Cell-derived IL-10 impairs host resistance to mycobacterium tuberculosis infection
.
Journal of Immunology
. 199:613-623.
2017
2016
Colonization potential to reconstitute a microbe community in patients detected early after fecal microbe transplant for recurrent C. difficile
.
BMC Microbiology
. 16.
2016
2015
Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis
2015
2013
IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis
2013
2013
Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to porphyromonas gingivalis
.
Journal of Leukocyte Biology
. 93:21-31.
2013
2012
Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses
.
Science
. 337:1553-1556.
2012
2012
Reciprocal interactions of the intestinal microbiota and immune system
.
Nature
. 489:231-241.
2012
2011
Immunology: Context is key in the gut
.
Nature
. 471:169-170.
2011
2011
Lineage-specific effects of 1,25-dihydroxyvitamin D
3
on the development of effector CD4 T cells
.
Journal of Biological Chemistry
. 286:997-1004.
2011
2009
Intestinal Effector T Cells in Health and Disease
.
Immunity
. 31:389-400.
2009
2009
Contrasting roles for all-trans retinoic acid in TGF-β-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells
.
Journal of Experimental Medicine
. 206:343-357.
2009
2009
Late Developmental Plasticity in the T Helper 17 Lineage
.
Immunity
. 30:92-107.
2009
2008
Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation
.
Immunological Reviews
. 226:219-233.
2008
2007
Regulatory T cells expressing interleukin 10 develop from Foxp3
+
and Foxp3
-
precursor cells in the absence of interleukin 10
.
Nature Immunology
. 8:931-941.
2007
Chapter
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Year
Title
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2015
Effector CD4+ T Cells in the Intestines
. 721-732.
2015
Research
Principal Investigator On
Immune Interaction with the Mucus-Associated Microbiota
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Interaction Of Early Life Stress And The Immune System In Promoting Susceptibility To Intestinal Inflammation
awarded by
American Association of Immunologists
T Cell Co-Stimulation and the Resistance of Regulatory T Cells to Gut Inflammation
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
Investigator On
(Environmental Triggers) Molecular Mechanisms of Early Life Stress and Risk of Inflammatory Bowel Disease
awarded by
Crohn's & Colitis Foundation of America
Age-Related Dysbiosis and Physical Resilience
awarded by
National Institute on Aging/NIH/DHHS
Innate and Adaptive Immunity in IBD
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
Innate and Adaptive Immunity in IBD - Project 3
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
Interactions Between AHR Ligands and the Gut Microbiota in Murine Arthritis
awarded by
National Institute of Environmental Health Sciences/NIH/DHHS
Mechanisms Controlling IL-10 Producing Intestinal Regulatory T Cells
awarded by
Crohn's & Colitis Foundation of America
Microbiota Flagellin Specific Antibodies in IBD Pathogenesis and Prevention
awarded by
Crohn's & Colitis Foundation of America
Molecular Mechanisms of Early Life Stress and Risk of Inflammatory Bowel Disease
awarded by
Crohn's & Colitis Foundation of America
Oxalate-Driven Host Responses in Kidney Stone Disease
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
Regulation of IL-10 Expression by Intestinal T Cells
awarded by
Crohn's & Colitis Foundation of America
Teaching
Teaching Activities
GBS744 - Mucosal Immunology (Spring Term 2018)
GBS744 - Mucosal Immunology (Spring Term 2019)
GBS744 - Mucosal Immunology (Spring Term 2020)
GBS744 - Mucosal Immunology (Spring Term 2021)
GBS744 - Mucosal Immunology (Spring Term 2022)
Background
Education And Training
Doctor of Philosophy in Microbiology,
University of Alabama at Birmingham
2007
Bachelor of Science or Mathematics in Biology,
Midwestern State University
2001
Contact
Full Name
Craig
Maynard