Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Kir5.1-dependent CO2/H+-sensitive currents contribute to astrocyte heterogeneity across brain regions.  Glia.  69:310-325. 2021
2020 GSK3β inhibition restores cortical gamma oscillation and cognitive behavior in a mouse model of NMDA receptor hypofunction relevant to schizophrenia.  Neuropsychopharmacology.  45:2207-2218. 2020
2020 A Role for PGC-1α in Transcription and Excitability of Neocortical and Hippocampal Excitatory Neurons.  Neuroscience.  435:73-94. 2020
2018 Optogenetic dissection of roles of specific cortical interneuron subtypes in GABAergic network synchronization 2018
2018 Developmental changes in HCN channel modulation of neocortical layer 1 interneurons.  Frontiers in Cellular Neuroscience.  12. 2018
2017 HCN channel modulation of synaptic integration in GABAergic interneurons in malformed rat Neocortex.  Frontiers in Cellular Neuroscience.  11. 2017
2016 Transcriptional dysregulation causes altered modulation of inhibition by haloperidol.  Neuropharmacology.  111:304-313. 2016
2016 Dynamic DNA methylation regulates neuronal intrinsic membrane excitability.  Science Signaling.  9. 2016
2015 Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K+ channels and Ih.  Frontiers in Cellular Neuroscience.  9. 2015
2015 DNA methylation regulates neuronal glutamatergic synaptic scaling.  Science Signaling.  8. 2015
2015 Interneuron transcriptional dysregulation causes frequency-dependent alterations in the balance of inhibition and excitation in hippocampus 2015
2015 Science signaling podcast: 23 June 2015.  Science Signaling.  8. 2015
2014 Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.  Frontiers in Cellular Neuroscience.  8. 2014
2014 PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons 2014
2014 Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortex.  Neuroscience.  271:137-148. 2014
2014 Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cells.  Neurobiology of Disease.  62:160-171. 2014
2014 Transcriptional and epigenetic regulation of Hebbian and non-Hebbian plasticity.  Neuropharmacology.  80:3-17. 2014
2013 Regulation of epileptiform discharges in rat neocortex by HCN channels.  Journal of Neurophysiology.  110:1733-1743. 2013
2013 Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus.  Neuroscience.  248:602-619. 2013
2011 Decreased hyperpolarization-activated currents in layer 5 pyramidal neurons enhances excitability in focal cortical dysplasia.  Journal of Neurophysiology.  106:2189-2200. 2011
2011 Baclofen and adenosine inhibition of synaptic transmission at CA3-CA1 synapses display differential sensitivity to K+ channel blockade.  Cellular and Molecular Neurobiology.  31:587-596. 2011
2011 Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging.  Journal of Neurophysiology.  105:1768-1784. 2011
2011 Presynaptic NMDA receptors mediate IPSC potentiation at GABaergic synapses in developing rat neocortex.  PLoS ONE.  6. 2011
2010 Abnormal pyramidal cell morphology and HCN channel expression in cortical dysplasia.  Epilepsia.  51:52-55. 2010
2009 GABA vesicles at synapses: Are there 2 distinct pools? 2009
2008 Decreased glutamate transport enhances excitability in a rat model of cortical dysplasia.  Neurobiology of Disease.  32:254-261. 2008
2008 Calcium release via activation of presynaptic IP3 receptors contributes to kainate-induced IPSC facilitation in rat neocortex.  Neuropharmacology.  55:106-116. 2008
2008 Kainate modulates presynaptic GABA release from two vesicle pools 2008
2007 Pre- and postsynaptic effects of kainate on layer II/III pyramidal cells in rat neocortex.  Neuropharmacology.  53:37-47. 2007
2007 Dopaminergic modulation of local network activity in rat prefrontal cortex.  Journal of Neurophysiology.  97:4120-4128. 2007
2006 NR2B antagonists restrict spatiotemporal spread of activity in a rat model of cortical dysplasia.  Epilepsy Research.  72:127-139. 2006
2006 Functional expression of Kir4.1 channels in spinal cord astrocytes.  Glia.  53:516-528. 2006
2006 Endogenous acetylcholine enhances synchronized interneuron activity in rat neocortex.  Journal of Neurophysiology.  95:1908-1916. 2006
2005 Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex.  Journal of Neurophysiology.  94:2073-2085. 2005
2005 Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons 2005
2005 Modification of epileptiform discharges in neocortical neurons following glutamate uptake inhibition.  Epilepsia.  46:129-133. 2005
2005 Horizontal spread of activity in neocortical inhibitory networks 2005
2005 Dopamine enhances spatiotemporal spread of activity in rat prefrontal cortex.  Journal of Neurophysiology.  93:864-872. 2005
2005 Ectopic action potential generation in cortical interneurons during synchronized GABA responses.  Neuroscience.  131:833-842. 2005
2004 Glutamate transporters regulate excitability in local networks in rat neocortex.  Neuroscience.  127:625-635. 2004
2004 Regulation of circuits and excitability: implications for epileptogenesis..  Epilepsy Currents.  4:151-153. 2004
2003 Dopamine enhances EPSCs in layer II-III pyramidal neurons in rat prefrontal cortex 2003
2003 GABAB receptor-mediated heterosynaptic depression of excitatory synaptic transmission in rat frontal neocortex.  Brain Research.  959:39-49. 2003
2001 Chloride accumulation and depletion during GABAA receptor activation in neocortex.  NeuroReport.  12:2537-2541. 2001
2001 Dopamine inhibition of evoked IPSCs in rat prefrontal cortex.  Journal of Neurophysiology.  86:2911-2918. 2001
2001 Electrophysiological characteristics of reactive astrocytes in experimental cortical dysplasia.  Journal of Neurophysiology.  85:1719-1731. 2001
2000 Nicotinic acetylcholine receptor-mediated synaptic potentials in rat neocortex.  Brain Research.  887:399-405. 2000
2000 Cellular abnormalities and synaptic plasticity in seizure disorders of the immature nervous system.  Mental Retardation and Developmental Disabilities Research Reviews.  6:258-267. 2000
2000 Potassium-coupled chloride cotransport controls intracellular chloride in rat neocortical pyramidal neurons 2000
2000 Reactive astrocytes show enhanced inwardly rectifying K+ currents in situ.  NeuroReport.  11:3151-3155. 2000
2000 Quisqualate induces an inward current via mGluR activation in neocortical pyramidal neurons.  Brain Research.  879:88-92. 2000
2000 Alterations in NMDA receptors in a rat model of cortical dysplasia.  Journal of Neurophysiology.  83:315-321. 2000
2000 Altered receptor subunit expression in rat neocortical malformations.  Epilepsia.  41. 2000
2000 Cellular abnormalities and synaptic plasticity in seizure disorders of the immature nervous system..  Mental Retardation and Developmental Disabilities Research Reviews.  6:258-267. 2000
2000 Modulation of intrinsic circuits in developing neocortex.  Epilepsia.  41:1082-1084. 2000
1999 Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex.  Journal of Neurophysiology.  82:2989-2999. 1999
1999 Dopamine modulation of membrane and synaptic properties of interneurons in rat cerebral cortex.  Journal of Neurophysiology.  81:967-976. 1999
1999 Reduction of zolpidem sensitivity in a freeze lesion model of neocortical dysgenesis.  Journal of Neurophysiology.  81:404-407. 1999
1998 Excitability changes in freeze-induced neocortical microgyria.  Epilepsy Research.  32:75-82. 1998
1998 Depletion of intracellular CA2+ stores or lowering extracellular calcium alters intracellular Ca2+ changes during cerebral energy deprivation.  Brain Research.  796:125-131. 1998
1998 AMPA receptor-mediated EPSCs in rat neocortical layer II/III interneurons have rapid kinetics.  Brain Research.  780:166-169. 1998
1998 AMPA receptor-mediated EPSCs in rat neocortical layer II/III interneurons have rapid kinetics.  Brain Research.  780:164-167. 1998
1998 Activation of group I mGluRs increases spontaneous IPSC frequency in rat frontal cortex.  Journal of Neurophysiology.  80:621-627. 1998
1998 Zinc and zolpidem modulate mIPSCs in rat neocortical pyramidal neurons.  Journal of Neurophysiology.  80:1670-1677. 1998
1997 Metabotropic glutamate receptor enhancement of spontaneous IPSCs in neocortical interneurons.  Journal of Neurophysiology.  78:2287-2295. 1997
1997 Rapid kinetics and inward rectification of miniature EPSCs in layer I neurons of rat neocortex.  Journal of Neurophysiology.  77:2416-2426. 1997
1996 Morphological properties of intracellularly labeled layer I neurons in rat neocortex.  Journal of Comparative Neurology.  376:198-213. 1996
1996 Morphological properties of intracellularly labeled layer I neurons in rat neocortex..  Journal of Comparative Neurology.  376:198-213. 1996
1996 Tetraethylammonium-induced synaptic plasticity in rat neocortex.  Cerebral Cortex.  6:771-780. 1996
1996 G-protein activation by metabotropic glutamate receptors reduces spike frequency adaptation in neocortical neurons.  Neuroscience.  75:123-131. 1996
1996 Postnatal development of membrane properties of layer I neurons in rat neocortex 1996
1996 Layer I neurons of rat neocortex. I. Action potential and repetitive firing properties.  Journal of Neurophysiology.  76:651-667. 1996
1996 Layer I neurons of the rat neocortex. II. Voltage-dependent outward currents.  Journal of Neurophysiology.  76:668-682. 1996
1996 NMDA and non-NMDA synaptic currents in rat neocortex during early postnatal development. 1996
1995 Modulation of epileptiform activity by metabotropic glutamate receptors in immature rat neocortex.  Journal of Neurophysiology.  73:205-217. 1995
1995 N-methyl-d-aspartate receptor-mediated calcium accumulation in neocortical neurons.  Neuroscience.  69:351-362. 1995
1994 Developmental changes in the voltage-dependence of neocortical NMDA responses 1994
1994 Metabortropic glutamate receptor activation decreases epileptiform activity in rat neocortex.  Neuroscience Letters.  174:29-33. 1994
1994 Altered desensitization produces enhancement of EPSPs in neocortical neurons.  Journal of Neurophysiology.  72:1032-1036. 1994
1994 Paired-pulse facilitation in the dentate gyrus: A patch-clamp study in rat hippocampus in vitro.  Journal of Neurophysiology.  72:326-336. 1994
1994 Presynaptic depression of synaptic transmission mediated by activation of metabotropic glutamate receptors in rat neocortex 1994
1994 Spread of epileptiform activity in the immature rat neocortex studied with voltage-sensitive dyes and laser scanning microscopy.  Journal of Neurophysiology.  72:1756-1768. 1994
1993 Influence of barium on rectification in rat neocortical neurons.  Neuroscience Letters.  157:62-66. 1993
1993 Developmental changes in NMDA and non-NMDA receptor-mediated synaptic potentials in rat neocortex.  Journal of Neurophysiology.  69:230-240. 1993
1993 Local anesthetics block transient outward potassium currents in rat neocortical neurons.  Journal of Neurophysiology.  69:1966-1975. 1993
1993 NMDA receptor-mediated components of miniature excitatory synaptic currents in developing rat neocortex.  Journal of Neurophysiology.  70:1841-1852. 1993
1993 Zinc enhances GABAergic transmission in rat neocortical neurons.  Journal of Neurophysiology.  70:1264-1269. 1993
1992 Kinetic properties of a transient outward current in rat neocortical neurons.  Journal of Neurophysiology.  68:1133-1142. 1992
1992 NMDA receptor involvement in epileptogenesis in the immature neocortex. 1992
1992 Voltage‐dependence of GABAA‐receptor desensitization in cultured chick cerebral neurons 1992
1991 Excitatory synaptic involvement in epileptiform bursting in the immature rat neocortex.  Journal of Neurophysiology.  66:1894-1901. 1991
1991 Initiation of epileptiform activity by excitatory amino acid receptors in the disinhibited rat neocortex.  Journal of Neurophysiology.  65:87-95. 1991
1990 Nystatin-perforated patch recordings disclose NMDA-induced outward currents in cultured neocortical neurons.  Brain Research.  535:318-322. 1990
1990 Activation of subconductance states by γ-aminobutyric acid and its analogs in chick cerebral neurons 1990
1990 Effect of APV and ketamine on epileptiform acitivity in the CA1 and CA3 regions of the hippocampus.  Epilepsy Research.  6:87-94. 1990
1990 Excitatory postsynaptic potentials in rat neocortical neurons in vitro. III. Effects of a quinoxalinedione non-NMDA receptor antagonist.  Journal of Neurophysiology.  64:1282-1290. 1990
1989 Involvement of non-NMDA receptors in picrotoxin-induced epileptiform activity in the hippocampus.  Neuroscience Letters.  107:129-134. 1989
1989 Chronic exposure of developing cortical neurons to GABA down-regulates GABA/benzodiazepine receptors and GABA-gated chloride currents.  Brain Research.  501:332-338. 1989
1989 Alterations in the microenvironment during spreading depression associated with epileptiform activity in the immature neocortex 1989
1989 Cholinergic modulation of epileptiform activity in the developing rat neocortex 1989
1989 Long-term potentiation in frontal cortex: Role of NMDA-modulated polysynaptic excitatory pathways.  Neuroscience Letters.  97:111-117. 1989
1989 EPSPs in rat neocortical neurons in vitro II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs.  Journal of Neurophysiology.  61:621-634. 1989
1989 EPSPs in rat neocortical neurons in vitro. I. Electrophysiological evidence for two distinct EPSPs.  Journal of Neurophysiology.  61:607-620. 1989
1989 Zinc and glycine do not modify low-magnesium-induced epileptiform activity in the immature neocortex in vitro.  Epilepsy Research.  3:174-177. 1989
1989 cAMP increases the rate of GABAA receptor desensitization in chick cortical neurons 1989
1988 Whole-cell and single-channel recordings of GABA-gated currents in cultured chick cerebral neurons.  Journal of Neurophysiology.  59:495-513. 1988
1987 Extracellular K+ and Ca2+ changes during epileptiform discharges in the immature rat neocortex 1987
1987 Glutamate-induced ionic currents in cultured neurons from the rat superior colliculus.  Brain Research.  420:182-187. 1987
1987 Conductance changes underlying a late synaptic hyperpolarization in hippocampal CA3 neurons.  Journal of Neurophysiology.  58:160-179. 1987
1987 Extracellular K+ and Ca2+ changes during epileptiform discharges in the immature rat neocortex..  Brain Research.  433:299-303. 1987
1987 Spontaneous ictal-like discharges and sustained potential shifts in the developing rat neocortex.  Journal of Neurophysiology.  58:1052-1065. 1987
1986 N-methyl-D-aspartate receptor antagonists reduce synaptic excitation in the hippocampus 1986
1986 Prenatal exposure to alcohol alters short-term plasticity in hippocampus.  Experimental Neurology.  93:423-427. 1986
1986 Step reductions in extracellular Ca2+ activate a transient inward current in chick dorsal root ganglion cells.  Biophysical Journal.  50:753-757. 1986
1985 Action of excitatory amino acids and their antagonists on hippocampal neurons.  Cellular and Molecular Neurobiology.  5:389-405. 1985
1985 Role of uptake in γ-aminobutyric acid (GABA)-mediated responses in guinea pig hippocampal neurons.  Cellular and Molecular Neurobiology.  5:353-371. 1985
1984 Interaction of penicillin and pentobarbital with inhibitory synaptic mechanisms in neocortex.  Cellular and Molecular Neurobiology.  4:301-317. 1984
1984 Picrotoxin-induced epileptiform activity in hippocampus: Role of endogenous versus synaptic factors.  Journal of Neurophysiology.  51:1011-1027. 1984
1982 Conductance changes induced by DL-homocysteic acid and N-methyl-DL-aspartic acid in hippocampal neurons.  Brain Research.  247:149-153. 1982
1982 Effect of sodium ions on penicillin-induced epileptiform activity in vitro.  Experimental Brain Research.  47:154-157. 1982
1982 Excitation of hippocampal pyramidal cells by glutamate in the guinea‐pig and rat. 1982
1982 Antagonism of GABA-mediated responses by d-tubocurarine in hippocampal neurons.  Journal of Neurophysiology.  48:622-632. 1982
1981 Endogenous nature of spontaneous bursting in hippocampal pyramidal neurons.  Cellular and Molecular Neurobiology.  1:325-334. 1981
1981 Altered burst responses in hippocampal CA3 neurons injected with EGTA.  Experimental Brain Research.  42:483-485. 1981
1981 Reversal potential for glutamate responses in hippocampal pyramidal cells.  Neuroscience Letters.  23:61-65. 1981
1981 Effects of intracellular injections of chloride and EGTA on postepileptiform-burst hyperpolarizations in hippocampal neurons.  Neuroscience Letters.  22:159-163. 1981
1981 Hippocampal excitability and changes in extracellular potassium.  Experimental Neurology.  71:410-420. 1981
1981 Synaptic triggering of epileptiform discharges in CA1 pyramidal cells in vitro 1981
1980 Voltage clamp discloses slow inward current in hippocampal burst-firing neurones.  Nature.  286:391-393. 1980
1980 Pathological behavior of pyramidal cell dentrites as a major epileptogenic mechanism.  Epilepsia.  21:191-192. 1980
1978 Selective amplitude histograms: A statistical approach to EEG-single unit relationships in generalized epilepsy.  Brain Research.  154:317-329. 1978
1978 Chronically Isolated Cerebral Hemisphere in the Cat: Effects of Parenteral Administration of Penicillin.  Epilepsia.  19:637-642. 1978
1978 Focal penicillin epilepsy in an isolated cerebral hemisphere.  Experimental Neurology.  62:463-474. 1978
1977 Alterations in cerebellar unit activity during intramuscular penicillin epilepsy.  Epilepsia.  18:287. 1977
1977 Cerebellar unit activity during generalized penicillin epilepsy in the awake cat.  Experimental Neurology.  56:189-199. 1977
1977 Modulation of cerebellar electrical and unit activity by low-frequency stimulation of caudate nucleus in chronic cats.  Experimental Neurology.  55:289-294. 1977
1977 Neuronal firing patterns during generalized penicillin epilepsy in the awake cat.  Brain Research Bulletin.  2:317-321. 1977
1976 Cerebellar inhibition of intramuscular penicillin epilepsy in the cat.  Electroencephalography and clinical neurophysiology.  40:310-311. 1976
1976 Cerebellar nuclear stimulation in generalized penicillin epilepsy.  Brain Research Bulletin.  1:599-601. 1976
1976 Intramuscular penicillin epilepsy in the cat: Effects of chronic cerebellar stimulation.  Experimental Neurology.  50:505-514. 1976
1975 Cortical seizures following cerebellar stimulation in primates.  Electroencephalography and clinical neurophysiology.  38:423-426. 1975
1974 Electroencephalographic changes induced by cerebellar stimulation in freely moving primates.  Brain Research.  75:305-308. 1974
1974 A technique for recording the electroretinogram (ERG) from chronically implanted electrodes in animals.  Vision Research.  14. 1974
1973 Operant conditioning and slow potential changes from monkey cortex.  Electroencephalography and clinical neurophysiology.  34:399-408. 1973
1973 Use of a simple visual display to reduce eye movement artifacts in CNV recordings.  Electroencephalography and clinical neurophysiology.  34:433-436. 1973
1972 Adrenalin, sodium amobarbital, and the kamin effect in the albino rat.  Learning and Motivation.  3:51-58. 1972

Chapter

Year Title Altmetric
2009 Neurotransmitter Function: Dopamine Modulation of Neurotransmission: Relationship to Epilepsy.  882-887. 2009

Principal Investigator On

  • Training Program in the Neurobiology of Cognition and Cognitive Disorders  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • UAB Neuroscience Core Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2021
  • UAB Neuroscience Core Center - Core D: Administrative Core  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2021
  • Cellular Mechanism of Synchrony Impairments in Schizophrenia  awarded by SOUTHERN RESEARCH INSTITUTE 2018 - 2021
  • Acquired HCN Channelopathies in Cortical Dysplasia  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2019
  • Training Program in the Neurobiology of Cognition and Cognitive Disorders  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2018
  • UAB Neuroscience Core Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2011 - 2016
  • UAB Neuroscience Core Center - Core D  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2011 - 2016
  • Neocortical Epilepsy During Development  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2007 - 2013
  • Presynaptic NMDA Receptors and GABA Release in Cortical Dysplasia  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2008 - 2011
  • UAB Neuroscience Core Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2005 - 2011
  • UAB Neurroscience Core Center - Core D  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2005 - 2011

    • Investigator On

  • Transcriptional Regulation of Metabolism in Neurons  awarded by SOUTHERN RESEARCH INSTITUTE 2017 - 2022
  • UAB Neuroscience Core Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2021
  • Cellular Mechanism of Synchrony Impairments in Schizophrenia  awarded by National Institute of Mental Health/NIH/DHHS 2016 - 2018
  • UAB Research and Education Program in Neurology, Neurosurgery, and Neuropathology  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2012 - 2017
  • Transcriptional Regulation of Metabolism in Neurons  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2017
  • Molecular Neuropharmacology and Signaling of Histone H2A.Z  awarded by National Institute of Mental Health/NIH/DHHS 2016 - 2017
  • Training Program in the Neurobiology of Cognition and Cognitive Disorders  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2016
  • Biochemical Mechanisms of Neural Plasticity  awarded by National Institute of Mental Health/NIH/DHHS 2015 - 2016
  • Role of CL-Channels and Transporters in Tumor-Associated Epilepsy  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2016
  • GSK3 Regulation of Suprachiasmatic Neuronal Excitability and Light Entrainment  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2015
  • Amino Acid Transport and the Biology of Human Gliomas  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2011 - 2015
  • Training Program in the Neurobiology of Cognition and Cognitive Disorders  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2008 - 2013

    • Education And Training

  • Doctor of Philosophy in Psychology, University of Houston System : Clear Lake 1972

    • Full Name

  • John Hablitz