• Dr. James Donahue is an associate professor of surgery and the section chief of thoracic surgery at the University of Alabama at Birmingham. Dr. Donahue comes to UAB from the University of Maryland School of Medicine where he had an active clinical practice focused on thoracic surgical oncology and served as chief of thoracic surgery at the Baltimore VA Medical Center. He is committed to resident education and served as the associate program director for the University of Maryland cardiothoracic surgical residency program. Dr. Donahue is a former Navy reservist and was deployed with a forward surgical team in Afghanistan in 2013. In addition to his clinical interests, Dr. Donahue also runs a basic science research laboratory.

    Dr. Donahue is certified by the American Board of Surgery and the American Board of Thoracic Surgery. He is a fellow in the American College of Surgeons. He is also a member of the American Association of Cancer Research and the Society of Thoracic Surgeons.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Cost-benefit analysis of a patient engagement technology (PET) in cardiac, thoracic, and colorectal surgeryThe American Journal of Surgery.  224:979-986. 2022
    2022 Encapsulation of miRNA and siRNA into Nanomaterials for Cancer TherapeuticsPharmaceutics.  14. 2022
    2022 Evolution of technique and results after permanent open repair for pectus deformities 2022
    2022 Analysis of Applicants’ Perspectives of Cardiothoracic Surgery Fellowship Program WebsitesAnnals of Thoracic Surgery2022
    2021 A prediction model for postoperative urinary retention after thoracic surgery 2021
    2021 MicroRNA-141-3p regulates cellular proliferation, migration, and invasion in esophageal cancer by targeting tuberous sclerosis complex 1Molecular Carcinogenesis.  60:125-137. 2021
    2020 Mechanical or chemical and mechanical pleurodesis for spontaneous pneumothorax: What is the most effective approach in preventing recurrence? A systematic review and meta-analysisEuropean Journal of Cardio-Thoracic Surgery.  58:682-691. 2020
    2020 Reasons for extended length of stay following chest tube removal in general thoracic surgical patientsJournal of Thoracic Disease.  12:5700-5708. 2020
    2019 Morbidity and 30-day mortality after decortication for parapneumonic empyema and pleural effusion among patients in the Society of Thoracic Surgeons' General Thoracic Surgery DatabaseJournal of Thoracic and Cardiovascular Surgery.  157:1288-1297.e4. 2019
    2019 Lymph Node Size Predicts for Asymptomatic Brain Metastases in Patients With Non–small-cell Lung Cancer at DiagnosisClinical Lung Cancer.  20:e107-e114. 2019
    2018 MiR-199a-3p decreases esophageal cancer cell proliferation by targeting p21 activated kinase 4Oncotarget.  9:28391-28407. 2018
    2018 Implications of Pathologic Complete Response Beyond Mediastinal Nodal Clearance With High-Dose Neoadjuvant Chemoradiation Therapy in Locally Advanced, Non-Small Cell Lung CancerInternational Journal of Radiation: Oncology - Biology - Physics.  101:445-452. 2018
    2018 Restrictive Transfusion Practices after Esophagectomy Are Associated with Improved Outcome: A Review of the Society of Thoracic Surgeons General Thoracic DatabaseAnnals of Surgery.  267:886-891. 2018
    2018 Corrigendum to “Clinical outcomes of black vs. non-black patients with locally advanced non–small cell lung cancer” [Lung Cancer 114, (December 2017) 44–49] (S016950021730555X) (10.1016/j.lungcan.2017.10.016))Lung Cancer.  116:105. 2018
    2018 Editorial for economic impact of an enhanced recovery pathway for lung resectionJournal of Thoracic Disease.  10:7-9. 2018
    2017 Clinical outcomes of black vs. non-black patients with locally advanced non–small cell lung cancerLung Cancer.  114:44-49. 2017
    2017 The Society of Thoracic Surgeons General Thoracic Surgery Database: 2017 Update on ResearchAnnals of Thoracic Surgery.  104:1450-1455. 2017
    2017 Oncological outcomes from trimodality therapy receiving definitive doses of neoadjuvant chemoradiation (≥60 Gy) and factors influencing consideration for surgery in stage III non-small cell lung cancerAdvances in Radiation Oncology.  2:259-269. 2017
    2016 The Society of Thoracic Surgeons General Thoracic Surgery Database: 2016 Update on ResearchAnnals of Thoracic Surgery.  102:1444-1451. 2016
    2016 Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1Oncogene.  35:2087-2097. 2016
    2016 Overexpression of miR-199a-5p decreases esophageal cancer cell proliferation through repression of mitogen-activated protein kinase kinase kinase-11 (MAP3K11)Oncotarget.  7:8756-8770. 2016
    2015 Competition between RNA-binding proteins CELF1 and HuR modulates MYC translation and intestinal epithelium renewalMolecular Biology of the Cell.  26:1797-1810. 2015
    2014 Src-mediated caveolin-1 phosphorylation regulates intestinal epithelial restitution by altering Ca2+ influx after woundingAmerican Journal of Physiology: Gastrointestinal and Liver Physiology.  306. 2014
    2014 Invited commentaryAnnals of Thoracic Surgery.  97:1013-1014. 2014
    2014 Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancerOncogene.  33:1181-1189. 2014
    2014 Role of p53 and EGFR as prognostic biomarkers in stage i non-small cell lung cancerJournal of Surgical Oncology.  110:97-98. 2014
    2013 Predictors of anastomotic leak after esophagectomy: An analysis of the society of thoracic surgeons general thoracic databaseAnnals of Thoracic Surgery.  96:1919-1926. 2013
    2013 Sphingosine kinase 1 overexpression stimulates intestinal epithelial cell proliferation through increased c-Myc translationAmerican Journal of Physiology: Cell Physiology.  304. 2013
    2013 Concurrent chemotherapy inhibits herpes simplex virus-1 replication and oncolysisCancer Gene Therapy.  20:133-140. 2013
    2012 The RNA-binding protein CUG-BP1 increases survivin expression in oesophageal cancer cells through enhanced mRNA stabilityBiochemical Journal.  446:113-123. 2012
    2012 Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosisAmerican Journal of Physiology: Cell Physiology.  303. 2012
    2012 Oncologic efficacy of anatomic segmentectomy in stage IA lung cancer patients with T1a tumorsAnnals of Thoracic Surgery.  93:381-388. 2012
    2011 The RNA-binding protein HuR stabilizes survivin mRNA in human oesophageal epithelial cellsBiochemical Journal.  437:89-96. 2011
    2010 Loss of p53, rather than beta-catenin overexpression, induces survivin-mediated resistance to apoptosis in an esophageal cancer cell lineJournal of Thoracic and Cardiovascular Surgery.  140:225-232. 2010
    2010 Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell growth after polyamine depletionAmerican Journal of Physiology: Cell Physiology.  298. 2010
    2010 The prognostic importance of pathologically involved celiac node metastases in node-positive patients with carcinoma of the distal esophagus or gastroesophageal junction: A surgical series from the Mayo ClinicDiseases of the Esophagus.  23:232-239. 2010
    2009 Lung Volume Reduction Surgery for Patients with Alpha-1 Antitrypsin Deficiency EmphysemaThoracic Surgery Clinics.  19:201-208. 2009
    2009 Complete Pathologic Response After Neoadjuvant Chemoradiotherapy for Esophageal Cancer Is Associated With Enhanced SurvivalAnnals of Thoracic Surgery.  87:392-399. 2009
    2008 Extra-adrenal pheochromocytoma involving the organ of ZuckerkandlSurgery.  143:830-832. 2008
    2005 Mouse models of subcutaneous spleen reservoir for multiple portal venous injections to treat liver malignanciesCancer Research.  65:3823-3827. 2005
    2004 Oncolysis by viral replication and inhibition of angiogenesis by a replication-conditional herpes simplex virus that expresses mouse endostatinCancer.  101:869-877. 2004
    2004 Selectivity of an Oncolytic Herpes Simplex Virus for Cells Expressing the DF3/MUC1 AntigenCancer Research.  64:2561-2567. 2004
    2002 Regulation of herpes simplex virus 1 replication using tumor-associated promotersAnnals of Surgery.  236:502-513. 2002
    2002 Viral oncolysisSurgical Oncology Clinics of North America.  11:661-680. 2002
    2002 Regulation of herpes simplex virus γ134.5 expression and oncolysis of diffuse liver metastases by Myb34.5Journal of Clinical Investigation.  109:871-882. 2002


    Year Title Altmetric
    2012 Complications of thoracoscopy 2012
    2011 Primary mediastinal tumors and cysts and diagnostic investigation of mediastinal masses.  5841-5854. 2011

    Education And Training

  • Massachusetts General Hospital, Residency
  • Mayo Clinic, Postdoctoral Fellowship
  • Doctor of Medicine, Harvard University 1998
  • Full Name

  • James Donahue