Positions

Overview

  • Dr. Mountz is a Professor of Medicine and Director of the UAB Recombinant Inbred Strain Facility. Dr. Mountz is the Co-Director of the UAB Bone Center, the UAB Center for Aging, Basic Biology Component, and is a Physician at the Birmingham Veterans Administration Medical Center. Dr. Mountz is the recipient of the J. W. & Virginia Goodwin-Warren D. Blackburn, Jr. Research Chair in Rheumatology (2002) and recipient of the Max Cooper Award for Excellence in Research (2003). Dr. Mountz was designated one of 50 Arthritis Foundation ¡§Heroes¡¨for outstanding contributions for research in Rheumatology (2002). Dr. Mountz was Co-Chair of the National Institutes on Aging Task Force on Immunology and Aging and Co-Chair of the ¡§Leukocyte Trafficking in Inflammatory Disease¡¨ symposium at the 2004 annual meeting of the American Association of Immunologists. Dr. Mountz received a Ph.D. in High Energy Physics and graduated Summa Cum Laude before carrying out a post-doctoral fellowship in the area of biophysics studying bilayer lipid membranes. Dr. Mountz then received an MD from Ohio State University and carried out an internship of residency and a one-year fellowship in Internal Medicine in Rheumatology. Dr. Mountz was a research staff fellow at the National Institutes of Health for five years and also an Assistant Professor of Medicine at the Naval Bethesda Medical Center. During this time, Dr. Mountz was the first investigator to identify that Onco genes were elevated in autoimmune mice and humans. Dr. Mountz became an Assistant Professor of Medicine at The University of Alabama at Birmingham in 1987, where he produced the first transgenic mouse expressing Fas in T cells and ameliorated the lymphoproliferative autoimmune disease in /lpr (Fas mutant mice). Dr. Mountz then identified the Fas mutation in MRL-lpr/lpr mice as being an insertion of the Etn retrotransposon. Dr. Mountz also was the first investigator to study clono-deletion and energy induction in PCR transgenic mice on the lpr/lpr background. Dr. Mountz continues an active research program in lupus, arthritis, molecular nuclear imaging, immune response to virus and poxvirus and gene therapy, as well as T-cell senescence in aging in both mice and humans.
  • Selected Publications

    Principal Investigator On

  • B Cell Intrinsic Interferon-beta Regulates Autoreactive B Cell Development  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2023
  • Training Program in Rheumatic and Musculoskeletal Diseases Research  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2020 - 2022
  • High Dimension Single Cell Omics in CFCC  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2020 - 2021
  • Follicular Exclusion of Self Antigens Prevents Development of Autoantibodies  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2020
  • B-Cell Control Point Dysregulation in African Americans with SLE  awarded by LUPUS RESEARCH ALLIANCE 2018 - 2020
  • Next Generation Cell Sorting to Streamline Core Operation in CFCC  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2017 - 2019
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core A: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core B: Comprehensive Flow Cytometry Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Next Generation Flow Cytometer to Streamline Core Operation in CFCC  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2015 - 2017
  • Laser and Filter Upgrade for the Flow Cytometers in CFCC at Shelby  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2014 - 2016
  • Induction of Apoptotic Cell Reactive B Cells by Type I IFN in BXD2 Mice  awarded by Lupus Foundation of America, Inc. 2015
  • Optimal Approach to Block M1 Macrophages/Th17 Inflammation in Arthritis  awarded by American College of Rheumatology 2012 - 2014
  • Suppression of Pathogenic Autoantibodies in Lupus by Inhibition of AID  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2008 - 2014
  • DR5 Glycosylation Mediates Apoptosis Resistance in RA Synovial Fibroblasts  awarded by Arthritis Foundation 2010 - 2013
  • Rheumatic Diseases Core Center: Pilot Project - P & F 6  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Rheumatic Diseases Core Center: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Rheumatic Diseases Core Center: Core C - Analytic and Preparative Cytometry Facility  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Disruption of Autoreactive Germinal Centers as a Novel Therapy for Lupus  awarded by LUPUS RESEARCH ALLIANCE 2008 - 2011
  • Investigator On

  • Characterizing the Negative Signaling in Dendritic Cells and Macrophages to Attenuate Inflammation and Bone Destruction in Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2020 - 2024
  • Cbfß Mediates Articular Cartilage Regeneration and Repair in Aging  awarded by National Institute on Aging/NIH/DHHS 2019 - 2024
  • Cytokine Immunoregulatory Strategy to Target SLE Autoreactive B Cells  awarded by LUPUS RESEARCH ALLIANCE 2019 - 2022
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • Characterizing the Mechanism by which Endogenous Negative Regulators of Osteoclasts Control Bone Homeostasis under Physiological and Pathological Conditions in Mouse Models  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • Improving Resolution and Throughput on the HRIF Institutional Core  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2018 - 2020
  • REduCing Immunogenicity to PegloticasE (RECIPE)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2020
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • CbfB Mediates Articular Cartilage Regeneration and Repair in Aging  awarded by National Institute on Aging/NIH/DHHS 2017 - 2019
  • UAB Multidisciplinary Clinical Research Center (P60)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • Inhibiting Periodontitis by Targeting Cathepsin K and Attenuating TLR Signaling  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2014 - 2019
  • Repopulation of Tolerogenic B Cells Post B Cell Depletion Therapy in Lupus  awarded by LUPUS RESEARCH ALLIANCE 2016 - 2019
  • Flow Cytometry Core Enhancement: ISS PC1 Photon Counting Spectrofluorimeter  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2011 - 2014
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Education And Training

  • Doctor of Medicine, Ohio State University System : Columbus 1978
  • Doctor of Philosophy, Michigan State University 1974
  • Full Name

  • John Mountz