Positions

Overview

  • Dr. Mountz is a Professor of Medicine and Director of the UAB Recombinant Inbred Strain Facility. Dr. Mountz is the Co-Director of the UAB Bone Center, the UAB Center for Aging, Basic Biology Component, and is a Physician at the Birmingham Veterans Administration Medical Center. Dr. Mountz is the recipient of the J. W. & Virginia Goodwin-Warren D. Blackburn, Jr. Research Chair in Rheumatology (2002) and recipient of the Max Cooper Award for Excellence in Research (2003). Dr. Mountz was designated one of 50 Arthritis Foundation ¡§Heroes¡¨for outstanding contributions for research in Rheumatology (2002). Dr. Mountz was Co-Chair of the National Institutes on Aging Task Force on Immunology and Aging and Co-Chair of the ¡§Leukocyte Trafficking in Inflammatory Disease¡¨ symposium at the 2004 annual meeting of the American Association of Immunologists. Dr. Mountz received a Ph.D. in High Energy Physics and graduated Summa Cum Laude before carrying out a post-doctoral fellowship in the area of biophysics studying bilayer lipid membranes. Dr. Mountz then received an MD from Ohio State University and carried out an internship of residency and a one-year fellowship in Internal Medicine in Rheumatology. Dr. Mountz was a research staff fellow at the National Institutes of Health for five years and also an Assistant Professor of Medicine at the Naval Bethesda Medical Center. During this time, Dr. Mountz was the first investigator to identify that Onco genes were elevated in autoimmune mice and humans. Dr. Mountz became an Assistant Professor of Medicine at The University of Alabama at Birmingham in 1987, where he produced the first transgenic mouse expressing Fas in T cells and ameliorated the lymphoproliferative autoimmune disease in /lpr (Fas mutant mice). Dr. Mountz then identified the Fas mutation in MRL-lpr/lpr mice as being an insertion of the Etn retrotransposon. Dr. Mountz also was the first investigator to study clono-deletion and energy induction in PCR transgenic mice on the lpr/lpr background. Dr. Mountz continues an active research program in lupus, arthritis, molecular nuclear imaging, immune response to virus and poxvirus and gene therapy, as well as T-cell senescence in aging in both mice and humans.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Dysregulation of T follicular helper cells in lupus 2019
    2018 Cutting edge: Intracellular IFN-β and distinct type i IFN expression patterns in circulating systemic lupus erythematosus B cells 2018
    2018 Editorial: STATus of STAT3 in Psoriatic Arthritis 2018
    2018 Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and Diseases 2018
    2018 Role of production of type I interferons by B cells in the mechanisms and pathogenesis of systemic lupus erythematosus 2018
    2017 Cutting Edge: Endogenous IFN-β regulates survival and development of transitional B cells 2017
    2015 General approach for tetramer-based identification of autoantigen-reactive B cells: Characterization of La- and snRNP-reactive B cells in autoimmune BXD2 mice 2015
    2015 Identification of follicular T helper cells in tissue sections 2015
    2015 Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus 2015
    2015 Odanacatib, a cathepsin K-specific inhibitor, inhibits inflammation and bone loss caused by periodontal diseases 2015
    2014 Dysregulated cytokine production by dendritic cells modulates B cell responses in the NZM2410 mouse model of lupus 2014
    2014 IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt 2014
    2014 Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen-induced arthritis 2014
    2014 Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice 2014
    2013 The Dynamic Duo-Inflammatory M1 macrophages and Th17 cells in Rheumatic Diseases. 2013
    2013 Death receptor 5-targeted depletion of interleukin-23-producing macrophages, Th17, and Th1/17 associated with defective tyrosine phosphatase in mice and patients with rheumatoid arthritis 2013
    2013 Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice 2013
    2013 Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction 2013
    2013 The interdependent, overlapping, and differential roles of type i and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis 2013
    2013 IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells 2013
    2013 Cutting edge: Defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice 2013
    2013 Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging. 2013
    2012 Emerging optical and nuclear medicine imaging methods in rheumatoid arthritis 2012
    2012 Managing macrophages in rheumatoid arthritis by reform or removal 2012
    2012 Systemic autoimmunity caused by fas deficiency in macrophages: A new perspective on the first identified autoimmunity gene 2012
    2012 Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model. 2012
    2011 Longitudinal assessment of cognitive and psychosocial functioning after Hurricanes Katrina and Rita: Exploring disaster impact on middle-aged, older, and oldest-old adults 2011
    2011 mRNA editing, FAS, and systemic lupus erythematosus. 2011
    2011 Reply 2011
    2011 Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice 2011
    2011 Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages 2011
    2011 Alloantigen specific deletion of primary human T cells by Fas ligand (CD95L)-transduced monocyte-derived killer-dendritic cells 2011
    2011 Type i interferon-dependent CD86high marginal zone precursor b cells are potent T cell costimulators in mice 2011
    2011 Emerging MRI methods in rheumatoid arthritis 2011
    2011 Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease. 2011
    2010 Metabolic syndrome, hormones, and maintenance of T cells during aging 2010
    2010 IL-17 activates the canonical NF-κB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16 2010
    2010 IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells 2010
    2010 Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3 2010
    2010 Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity 2010
    2010 Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model 2010
    2009 Assessment of genetic shielding for adenovirus vectors 2009
    2009 Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis 2009
    2008 Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach 2008
    2008 Therapeutic potential of mesenchymal stem cells producing interferon-α in a mouse melanoma lung metastasis model 2008
    2008 Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession 2008
    2008 Cancer gene therapy using mesenchymal stem cells expressing interferon-β in a mouse prostate cancer lung metastasis model 2008
    2008 Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice 2008
    2007 Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice 2007
    2007 Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies 2007
    2007 Quantitative trait locus (QTL) mapping in aging systems 2007
    2007 Quantitative trait locus (QTL) mapping in aging systems. 2007
    2006 Principal component analysis of quantitative trait loci for immune response to adenovirus in mice 2006
    2006 Targeted and shielded adenovectors for cancer therapy 2006
    2006 Phenotype of genetically regulated thymic involution in young BXD RI strains of mice 2006
    2006 Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor α 2006
    2006 In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, Fas ligand, and perforin 2006
    2006 CD8 T-cell immune phenotype of successful aging 2006
    2006 Determination of specific CD4 and CD8 T cell epitopes after AAV2- and AAV8-hF.IX gene therapy 2006
    2006 Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritis 2006
    2006 Tumor necrosis factor ligand-receptor superfamily and arthritis. 2006
    2005 Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function 2005
    2005 Rheumatoid arthritis: safe and sound. 2005
    2005 Safe and sound 2005
    2005 Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis 2005
    2005 Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation 2005
    2005 Genetic analysis of the antibody response to AAV2 and factor IX 2005
    2005 Impaired apoptosis and immune senescence - Cause or effect? 2005
    2005 Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice 2005
    2005 Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts 2005
    2005 Genetic regulation of thymic involution 2005
    2004 Nur77 family of nuclear hormone receptors 2004
    2004 Defective clearance of adenovirus in IRF-1-/- mice associated with defects in NK and T cells but not macrophages 2004
    2004 Regulation of apoptosis proteins in cancer cells by ubiquitin 2004
    2004 IL-12 Inhibits Thymic Involution by Enhancing IL-7- and IL-2-Induced Thymocyte Proliferation 2004
    2004 Novel Tumor Necrosis Factor α-Regulated Genes in Rheumatoid Arthritis 2004
    2004 Chebyshev's inequality for nonparametric testing with small N and α in microarray research 2004
    2004 Elimanation of activated but not resting primary human CD4+ and CD8+ T cells by Fas ligand (FasL/Cd95L)-expressing Killer-dendritic cells 2004
    2004 Identification of multiple genetic loci that regulate adenovirus gene therapy 2004
    2004 Power and sample size estimation in high dimensional biology 2004
    2003 CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis 2003
    2003 CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis. 2003
    2003 The nature and identification of quantitative trait loci: A community's view 2003
    2003 Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10 2003
    2003 Randomization tests for small samples: An application for genetic expression data 2003
    2003 TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis 2003
    2003 Erratum: Cellular mechanism of thymic involution (Scandinavian Journal of Immunology (2003) 57 (410-422)) 2003
    2003 Mature but not immature Fas Ligand (CD95L)-transduced human monocyte-derived dendritic cells are protected from Fas-mediated apoptosis and can be used as killer APC 2003
    2003 Cellular mechanism of thymic involution 2003
    2003 Impact of immune senescence on human aging 2003
    2003 Monkey see, monkey do 2003
    2003 Origin of late-onset autoimmune disease 2003
    2002 Addition of six-His-tagged peptide to the C terminus of adeno-associated virus VP3 does not affect viral tropism or production 2002
    2002 Molecular imaging: New applications for biochemistry 2002
    2002 Immunobiology of tumor necrosis factor receptor superfamily 2002
    2002 Specific deletion of autoreactive T cells by adenovirus-transfected, Fas ligand-producing antigen-presenting cells 2002
    2002 Significance of increased circulating proteasome in autoimmune disease 2002
    2002 BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model 2002
    2002 Different role of Apaf-1 in positive selection, negative selection and death by neglect in foetal thymic organ culture 2002
    2002 Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver 2002
    2002 Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11 2002
    2002 Beneficial influences of systemic cooperation and sociological behavior on longevity 2002
    2002 Local production of complement proteins in rheumatoid arthritis synovium 2002
    2002 Depletion of collagen II-reactive T cells and blocking of B cell activation prevents collagen II-induced arthritis in DBA/1j mice 2002
    2002 A universal distribution for component failure times 2002
    2002 Molecular imaging: new applications for biochemistry. 2002
    2002 Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-α production by Kupffer cells 2002
    2001 "Inverse wrap": An improved implantation technique for virus-transduced synovial fibroblasts in the SCID mouse model for rheumatoid arthritis 2001
    2001 Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles 2001
    2001 Activated CD8+ T cells from aged mice exhibit decreased activation-induced cell death 2001
    2001 Defective Fas Ligand-Mediated Apoptosis Predisposes to Development of a Chronic Erosive Arthritis Subsequent to Mycoplasma pulmonis Infection 2001
    2001 Defective Fas ligand-mediated apoptosis predisposes to development of a chronic erosive arthritis subsequent to Mycoplasma pulmonis infection. 2001
    2001 Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity 2001
    2001 Regulation of tumor necrosis factor α-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt 2001
    2001 Decreased T cell stimulatory capacity of monocyte-derived human macrophages following herpes simplex virus type 1 infection 2001
    2001 Genetic dissection of age-related changes of immune function in mice 2001
    2001 Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt. 2001
    2001 Recombinant adenovirus expressing adeno-associated virus cap and rep proteins supports production of high-titer recombinant adeno-associated virus 2001
    2001 "Inverse wrap": an improved implantation technique for virus-transduced synovial fibroblasts in the SCID mouse model for rheumatoid arthritis. 2001
    2001 Aged mice exhibit in vivo defective peripheral clonal deletion of Db/H-Y reactive CD8+ T cells 2001
    2001 Treatment of chronic sialadenitis in a murine model of Sjögren's syndrome by local fasL gene transfer 2001
    2001 Treatment of chronic sialadenitis in a murine model of Sjögren's syndrome by local fasL gene transfer. 2001
    2001 Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to γ-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice 2001
    2001 Apoptosis and rheumatoid arthritis: past, present, and future directions. 2001
    2001 Re: "collagen-induced arthritis in TNF receptor-1-deficient mice: TNF receptor-2 can modulate arthritis in the absence of TNF receptor 1" 2001
    2001 Regulation of apoptosis of synovial fibroblasts. 2001
    2001 The Fas signaling connection between autoimmunity and embryonic lethality 2001
    2000 Adeno-associated virus production of soluble tumor necrosis factor receptor neutralizes tumor necrosis factor α and reduces arthritis 2000
    2000 The prodomain of caspase-1 enhances Fas-mediated apoptosis through facilitation of caspase-8 activation 2000
    2000 Gene therapy that inhibits nuclear translocation of nuclear factor kappaB results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts. 2000
    2000 Gene therapy that inhibits nuclear translocation of nuclear factor κB results in tumor necrosis factor α-induced apoptosis of human synovial fibroblasts 2000
    2000 Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand-deficient mice 2000
    2000 Serum levels of soluble Fas correlate with indices of organ damage in systemic lupus erythematosus 2000
    1999 Apoptosis and cell death in the endocrine system 1999
    1999 Specific targeting of activated endothelium in rat adjuvant arthritis with a 99mTc-radiolabeled E-selectin-binding peptide. 1999
    1999 Specific targeting of activated endothelium in rat adjuvant arthritis with a 99mTc-radiolabeled e-selectin-binding peptide 1999
    1999 Construction of a recombinant adenovirus vector encoding Fas ligand with a CRE/Loxp inducible system 1999
    1999 Induction of specific T cell tolerance by Fas ligand-expressing antigen- presenting cells 1999
    1999 Herpes simplex virus type 2 infection induced apoptosis in peritoneal macrophages independent of Fas and tumor necrosis factor-receptor signaling 1999
    1999 Regulation of Fas-mediated apoptosis in CD2-fas transgenic mice 1999
    1998 Murine cytomegalovirus induces a Sjogren's syndrome-like disease in C57B1/6-lpr/lpr mice 1998
    1998 Murine cytomegalovirus induces a Sjögren's syndrome-like disease in C57Bl/6-lpr/lpr mice. 1998
    1998 Induction of specific T-cell tolerance by adenovirus-transfected, Fas ligand - Producing antigen presenting cells 1998
    1998 Familial painful restless legs syndrome correlates with pain dependent variation of blood flow to the caudate, thalamus, and anterior cingulate gyrus 1998
    1998 Apoptosis mediated by Fas but not tumor necrosis factor receptor 1 prevents chronic disease in mice infected with murine cytomegalovirus 1998
    1998 Inhibition of tumor necrosis factor α decreases inflammation and prolongs adenovirus gene expression in lung and liver 1998
    1998 Calmodulin antagonists inhibit apoptosis of CD4+ T-cells from patients with AIDS 1998
    1998 Increased susceptibility to apoptosis induced by anti-Fas antibody in a Rothmund-Thomson syndrome lymphoblastoid cell line 1998
    1998 Autocrine and paracrine apoptosis are mediated by differential regulation of Fas ligand activity in two distinct Jurkat T cell populations 1998
    1998 Effect of age and apoptosis on the mouse homologue of the huWRN gene 1998
    1998 Cell death mediated by Fas-FasL interaction between glial cells and MBP- reactive T cells 1998
    1998 Fas/Fas ligand signaling during gestational T cell development 1998
    1998 Application of a Fas ligand encoding a recombinant adenovirus vector for prolongation of transgene expression 1998
    1998 Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5) 1998
    1998 Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptor 1998
    1998 Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptor. 1998
    1997 Cell death and longevity: Implications of Fas-mediated apoptosis in T-cell senescence 1997
    1997 Increased Lymphocyte Apoptosis in Fas Ligand Transgenic Mice 1997
    1997 Increased Acute-Phase Response and Renal Amyloidosis in Aged CD2-fas-Transgenic Mice 1997
    1997 Increased apoptosis of CD45RO- T cells with aging 1997
    1997 Kinetics of Fas-induced apoptosis in thymic organ culture 1997
    1997 Clinical features associated with correction of T-cell senescence: Increased acute-phase response, amyloidosis and arthritis 1997
    1997 Lymphoid cell accumulation in salivary glands of autoimmune MRL mice can be due to impaired apoptosis 1997
    1997 Persistent expression of a soluble form of Fas/APO1 in continuously activated T cells from a patient with SLE 1997
    1996 CD2-FAS transgene increases t cell immune response and elevates amyloidosis in the kidney of aged CD-I mice 1996
    1996 Fas and tumor necrosis factor-receptor i-mediated activation-induced cell death of macrophages 1996
    1996 HCP-deficient motheaten mice exhibit T cell apoptosis defect 1996
    1996 Improved survival and decreased inflammatory lung and skin diseases in motheaten mice by treatment of tnf binding protein 1996
    1996 Intracellular il-ib is an inhibitor of the ICE pathway of FAS-mediated apoptosis 1996
    1996 Oncogene c-myb is a direct transcriptional activator of the human fas gene 1996
    1996 The cloning and identification of two novel isoforms of human ICE 1996
    1996 The possible role of fas/fas-l mediated apoptosis in early thymocyte development 1996
    1996 Autoimmunity due to defective Nur77, Fas, and TNF-RI apoptosis 1996
    1996 Intracellular IL-1β Is an Inhibitor of Fas-Mediated Apoptosis 1996
    1996 Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease 1996
    1996 Role of calmodulin in HIV-potentiated fas-mediated apoptosis 1996
    1996 The role of programmed cell death as an emerging new concept for the pathogenesis of autoimmune diseases. 1996
    1996 Inhibition of Superantigen-Induced Proinflammatory Cytokine Production and Inflammatory Arthritis in MRL-Ipr/Ipr Mice by a Transcriptional Inhibitor of TNF-α 1996
    1996 Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect 1996
    1996 Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I 1996
    1996 Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells 1996
    1996 Autoimmune disease results from multiple interactive defects in apoptosis induction molecules and signaling pathways. 1996
    1996 Increased t cell apoptosis in thymus and lymph node of fas ligand transgenic mice 1996
    1996 Oncogene c-myb is a direct transcriptional activator of the human fas gene 1996
    1996 Use of sensitive assays to detect soluble Fas in patients with systemic lupus erythematosus: comment on the article by Knipping et al and the article by Goel et al. 1996
    1995 Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice 1995
    1995 A fas antigen receptor mutation allows development of toxic shock syndrome toxin-1 -induced lethal shock in Vβ8.2T-cell receptor transgenic mice 1995
    1995 Autoimmunity, apoptosis defects and retroviruses 1995
    1995 Characterization of human Fas gene: Exon/intron organization and promoter region 1995
    1995 Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis 1995
    1995 Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation 1995
    1995 Fibromyalgia in women 1995
    1995 Increased susceptability of fas mutant MRL-lpr/lpr mice to staphylococcal enterotoxin B-induced septic shock 1995
    1995 Regulation of apoptosis in immune cells 1995
    1994 Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule 1994
    1994 Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice 1994
    1994 Apoptosis defects analyzed in tcr transgenic and fas transgenic ipr mice 1994
    1994 Autoimmune disease. a problem of defective apoptosis 1994
    1994 Defective clonal deletion and anergy induction in tcr transgenic lpr/lpr mice 1994
    1994 T Cell Influence on Superantigen‐Induced Arthritis in MRL‐lpr/lpr Mice 1994
    1994 T cells of staphylococcal enterotoxin B‐tolerized autoimmune MRL‐lpr/lpr mice require co‐stimulation through the B7‐CD28/CTLA‐4 pathway for activation and can be reanergized in vivo by stimulation of the T cell receptor in the absence of this co‐stimulatory signal 1994
    1993 Autoinnnune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene 1993
    1993 Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse. 1993
    1993 Murine models of autoimmune disease and Sjogren's syndrome 1993
    1993 Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice: Clues from a T cell receptor β transgenic mouse 1993
    1993 Regulation of c-myb oncogene expression in immature and mature murine T cells 1993
    1993 Retroviruses, apoptosis and autogenes 1993
    1993 Retroviruses, apoptosis and autogenes 1993
    1992 Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr mice 1992
    1992 Molecular studies of mouse medium and long-chain acyl-CoA dehydrogenase genes for site-directed mutagenesis of embryonic stem cells. 1992
    1992 Murine models of autoimmune disease 1992
    1992 Murine models of autoimmunity: T-cell and B-cell defects 1992
    1991 Nonhomologous recombination at sites within the mouse J(H)-C(δ) locus accompanies Cμ deletion and switch to immunoglobulin D secretion 1991
    1991 Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice 1991
    1991 Murine models for systemic lupus erythematosus and Sjogren's syndrome 1991
    1990 Transgenic Rearranged T Cell Receptor Gene Inhibits Lymphadenopathy and Accumulation of CD4-CD8- B220 + T Cells in lpr/lpr Mice 1990
    1990 The in vivo generation of murine IgD-secreting cells is accompanied by deletion of the Cμ gene and occasional deletion of the gene for the Cδ1 domain 1990
    1990 Altered expression of self-reactive T cell receptor Vβ regions in autoimmune mice 1990
    1990 Animal models of systemic lupus erythematosus and Sjogren's syndrome 1990
    1990 Elucidating the pathogenesis of autoimmune disease: recent advances at the molecular level and relevance to oral mucosal disease 1990
    1990 Production of trangenic mice and application to immunology and autoimmunity 1990
    1989 Studies of c-myb gene regulation in MRL-1pr/1pr mice. Identification of a 5' c-myb nuclear protein binding site and high levels of binding factors in nuclear extracts of 1pr/1pr lymph node cells 1989
    1988 Expression of the murine proto-oncogene bcl-2 is stage specific and cell-type specific. 1988
    1988 Activation of CD 4-, CD 8-thymocytes with IL 4 vs IL 1 + IL 2 1988
    1988 Characteristics and functions of CD4-, CD8- T cells in normal and autoimmune mice. 1988
    1988 Characterization and differentiation of CD4-, CD8- thymocytes sorted with the Ly-24 marker 1988
    1988 Prevention of lymphadenopathy in MRL-lpr/lpr mice by blocking peripheral lymph node homing with Mel-14 in vivo 1988
    1988 The expression and modulation of IL-1α in murine keratinocytes 1988
    1987 Genetic and molecular genetic studies of murine and human lupus. 1987
    1987 CS-A therapy in MRL-lpr/lpr mice: Amelioration of immunopathology despite autoantibody production 1987
    1987 IL-2 Modulation of Murine T-Cell Oncogene Expression 1987
    1987 Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response 1987
    1987 Polyclonal activation of the murine immune system by an antibody to IgD. VIII. Stimulation of IgD secretion 1987
    1987 Subpopulations of CD4, CD8 thymocytes 1987
    1986 T cell receptor gene expression in autoimmune mice 1986
    1986 Oncogene expression in autoimmune and normal peripheral blood mononuclear cells 1986
    1986 Studies of the Effects of Y Chromosome Factors on the Expression of Autoimmune Disease 1986
    1986 pks, a raf-related sequence in humans 1986
    1985 Modulation of c-myb transcription in autoimmune disease by cyclophosphamide 1985
    1985 Oncogene expression in autoimmune mice 1985
    1985 Unusual expression of IL 2 receptors and both the c-myb and c-raf oncogenes in T cell lines and clones derived from autoimmune MRL-lpr/lpr mice 1985
    1985 Altered myb expression is associated with abnormal T cell development in the thymus of MRL-lpr/lpr mice 1985
    1985 Antinucleic acid antibodies, gene expression, and autoimmune mice 1985
    1985 Differential gene expression in autoimmune mice. 1985
    1985 Effects of UV radiation on autoimmune strains of mice: Increased mortality and accelerated autoimmunity in BXSB male mice 1985
    1984 Abnormal T cell proliferation in MRL-lpr/lpr mice is associated with high c-myb expression 1984
    1984 Autoimmunity and increased c-myb transcription 1984
    1984 Recent advances in SLE 1984
    1984 Rheumatoid arthritis and small airways function 1984
    1984 Studies of immune defective RII AnN mice 1984
    1983 Neutrophil migration in response to chemotactic factors - Effects of generation conditions and chemotherapeutic agents 1983
    1983 An autopsy study of the prevalence of monosodium urate and calcium pyrophosphate dihydrate crystal deposition in first metatarsophalangeal joints 1983
    1983 Bleomycin‐induced cutaneous toxicity in the rat: analysis of histopathology and ultrastructure compared with progressive systemic sclerosis (scleroderma 1983
    1981 Analysis of double-scattering mechanisms in pd annihilation processes between 1.09 and 1.43 GeV/c 1981
    1981 Ethambutol-Induced Toxic Epidermal Necrolysis 1981
    1981 Rheumatoid arthritis therapeutic agent effects on chemotaxis 1981
    1979 PHOTOELECTRIC EFFECTS IN DYE‐SENSITIZED ARTIFICIAL LIPID MEMBRANES 1979
    1979 PHOTOGALVANOVOLTAIC CELLS AND PHOTOVOLTAIC CELLS USING GLASSY CARBON ELECTRODES. 1979
    1978 Bilayer lipid membranes (BLM): Study of antigen-antibody interactions 1978
    1978 PHOTOEFFECTS OF PIGMENTED LIPID MEMBRANES IN A MICROPOROUS FILTER 1978
    1978 Photo‐galvano‐voltaic cell: A new approach to the use of solar energy 1978
    1978 Study of the reaction pn+ - Between 1.09 and 1.43 GeV/c 1978
    1978 The Photogalvanic Effect in a Modified Iron Thionine System 1978
    1978 The photogalvanovoltaic cell 1978
    1977 Study of double-scattering effects in p̄d annihilation processes 1977
    1976 ρ{variant}0ρ{variant}0π- formation in the reaction pn → 3π-+ near 2190 MeV c.m. energy 1976
    1975 Some features of the reaction p p→Δ+ +(1236) n at 6 GeV/c 1975
    1974 An isospin analysis of the reaction pN→NNπ from threshold to 2.90 GeV/c 1974

    Chapter

    Year Title Altmetric
    2017 Regulation of negative selection in the thymus by cytokines: Novel Role of IL-23 to Regulate RORγt.  41-52. 2017
    2009 Gene therapy and immune senescence.  1629-1646. 2009

    Principal Investigator On

  • B Cell Intrinsic Interferon-beta Regulates Autoreactive B Cell Development  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2023
  • Follicular Exclusion of Self Antigens Prevents Development of Autoantibodies  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2020
  • B-Cell Control Point Dysregulation in African Americans with SLE  awarded by LUPUS RESEARCH ALLIANCE 2018 - 2020
  • Next Generation Cell Sorting to Streamline Core Operation in CFCC  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2017 - 2019
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core A: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core B: Comprehensive Flow Cytometry Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Next Generation Flow Cytometer to Streamline Core Operation in CFCC  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2015 - 2017
  • Laser and Filter Upgrade for the Flow Cytometers in CFCC at Shelby  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2014 - 2016
  • Induction of Apoptotic Cell Reactive B Cells by Type I IFN in BXD2 Mice  awarded by Lupus Foundation of America, Inc. 2015
  • Optimal Approach to Block M1 Macrophages/Th17 Inflammation in Arthritis  awarded by American College of Rheumatology 2012 - 2014
  • Suppression of Pathogenic Autoantibodies in Lupus by Inhibition of AID  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2008 - 2014
  • DR5 Glycosylation Mediates Apoptosis Resistance in RA Synovial Fibroblasts  awarded by Arthritis Foundation 2010 - 2013
  • Rheumatic Diseases Core Center: Pilot Project - P & F 6  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Rheumatic Diseases Core Center: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Rheumatic Diseases Core Center: Core C - Analytic and Preparative Cytometry Facility  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Disruption of Autoreactive Germinal Centers as a Novel Therapy for Lupus  awarded by LUPUS RESEARCH ALLIANCE 2008 - 2011
  • Investigator On

  • Cbfß Mediates Articular Cartilage Regeneration and Repair in Aging  awarded by National Institute on Aging/NIH/DHHS 2019 - 2024
  • Characterizing the Mechanism by which Endogenous Negative Regulators of Osteoclasts Control Bone Homeostasis under Physiological and Pathological Conditions in Mouse Models  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • Improving Resolution and Throughput on the HRIF Institutional Core  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2018 - 2020
  • REduCing Immunogenicity to PegloticasE (RECIPE)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2020
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • CbfB Mediates Articular Cartilage Regeneration and Repair in Aging  awarded by National Institute on Aging/NIH/DHHS 2017 - 2019
  • UAB Multidisciplinary Clinical Research Center (P60)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • Inhibiting Periodontitis by Targeting Cathepsin K and Attenuating TLR Signaling  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2014 - 2019
  • Repopulation of Tolerogenic B Cells Post B Cell Depletion Therapy in Lupus  awarded by LUPUS RESEARCH ALLIANCE 2016 - 2019
  • Flow Cytometry Core Enhancement: ISS PC1 Photon Counting Spectrofluorimeter  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2011 - 2014
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Full Name

  • John Mountz