Positions

Overview

  • John Chatham received his D.Phil. in 1987 from John Chatham received his D.Phil. in 1987 from the Department of Biochemistry at the University of Oxford in the UK. He completed his post-doctoral training at Johns Hopkins School of Medicine in 1989. He is currently Professor of Pathology in the Division of Molecular and Cellular Pathology at the University of Alabama at Birmingham.
  • Research Overview

  • His recent research has focused on the role of the glucose-dependent, post-translational modifications of proteins by O-linked beta-N-acetylglucosamine moiety (O-GlcNAc) in mediating cardiomyocyte stress responses. Work from his laboratory has demonstrated that acute increases of O-GlcNAc levels are cardioprotective; conversely, in the setting of diabetes where O-GlcNAc levels are chronically elevated cardiomyocytes cell survival pathways such as autophagy are impaired in an O-GlcNAc dependent manner. Additional interests include the role of store-operated calcium entry (SOCE) in cardiomyocytes and how this is regulated by O-GlcNAc.
  • Principal Investigator On

  • STIM1 and its Role in Regulating Cardiac Metabolism  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2020 - 2024
  • The Role of Protein O-Linked N-Acetylglucosamine in Regulating Cardiac Physiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2020 - 2022
  • Disruption of the Clock O-GlcNAc Axis in Diabetic Cardiomyopathy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2019
  • The Role of Cardiac O-GlcNAcylation on the Function of Stromal Interaction Molecule 1 and its Impact on Cardiac Metabolism  awarded by American Diabetes Association, Inc. 2016 - 2018
  • STIMulating Stress: A Novel Role of the ER Ca2+Sensor STIM1 in the Adult Heart  awarded by American Heart Association (Southeast Affiliate) 2015 - 2017
  • Protein O-GlcNAcylation and the Regulation of Cardiac Function  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2010 - 2016
  • The Role of O-Linked-Beta-N-Acetyl-Glucosamine Protein Modification Impairs Autophagy in the Diabetic Heart  awarded by United Negro College Fund 2013 - 2015
  • STIM1 Mediated Calcium Entry: A New Paradigm of Metabolic Regulation of Cardiomyocyte Calcium Signaling  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2012 - 2015
  • Mechanisms of Glucosamine Ischemic Cardioprotection  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2006 - 2013
  • Private Grant  awarded by DISCOVERY BIOMED, LLC ^ 2012
  • SCCOR in Cardiac Dysfunction and Disease - Project 3  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2005 - 2008
  • Investigator On

  • Consequences of Noradrenergic Degeneration in the Novel TgF344-AD Rat Model  awarded by National Institute on Aging/NIH/DHHS 2020 - 2025
  • Kidney Undergraduate Research Experience (KURE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Circadian Regulation of Vascular Aging  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2022
  • Aberrant Circadian Regulation Of Autophagy In The Heart During Diabetes  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2022
  • Rapid modulation of hippocampal GABAergic Inhibition by O-GlcNAcylation  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2019 - 2021
  • O-GlcNAc Regulation of Protein Clearance in the Context of AD and DLB  awarded by National Institute on Aging/NIH/DHHS 2019 - 2021
  • O-GlcNAcylation Regulates Vascular Smooth Muscle Cells in Diabetic Vasculopathy  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • O-GlcNAcylation and Hippocampal Synaptic Plasticity  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2011 - 2017
  • The Role of PPARdelta Signaling in Diabetic Cardiomyopathy  awarded by American Diabetes Association, Inc. 2012 - 2016
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2015
  • Influence of the Cardiomyocyte Circadian Clock on Cardiac Hypertrophy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2012 - 2015
  • Exploring Barriers to PHER Grant Fund Expenditures  awarded by CDC - Centers for Disease Control and Prevention/DHHS 2011 - 2012
  • SCCOR in Cardiac Dysfunction and Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2005 - 2010
  • Education And Training

  • Doctorate Level Degree in Biochemistry, University of Oxford 1987
  • Full Name

  • John Chatham