John Chatham received his D.Phil. in 1987 from John Chatham received his D.Phil. in 1987 from the Department of Biochemistry at the University of Oxford in the UK. He completed his post-doctoral training at Johns Hopkins School of Medicine in 1989. He is currently Professor of Pathology in the Division of Molecular and Cellular Pathology at the University of Alabama at Birmingham.
His recent research has focused on the role of the glucose-dependent, post-translational modifications of proteins by O-linked beta-N-acetylglucosamine moiety (O-GlcNAc) in mediating cardiomyocyte stress responses. Work from his laboratory has demonstrated that acute increases of O-GlcNAc levels are cardioprotective; conversely, in the setting of diabetes where O-GlcNAc levels are chronically elevated cardiomyocytes cell survival pathways such as autophagy are impaired in an O-GlcNAc dependent manner. Additional interests include the role of store-operated calcium entry (SOCE) in cardiomyocytes and how this is regulated by O-GlcNAc.