J. Bart Rose

Faculty Member
Dr. J. Bart Rose joined the faculty of the UAB Department of Surgery Division of Surgical Oncology in 2017 as an Assistant Professor. He has a combined research and clinical appointment. He has been engaged in scientific research for fifteen years. Over this time he contributed to scientific knowledge in the fields of molecular genetics, enzymology, oncologic biomarkers, and clinical outcomes. His focus since entering the field of surgery has been on biomarker research for hepatopancreatobiliary cancers. He has presented on novel uses of established biomarkers in pancreatic cancer and was the first to investigate the clinical utility of a bile based biomarker in patients with bile duct cancer (cholangiocarcinoma).

He is originally from a small logging town in Northern California, but has enjoyed his time during training in the Midwest and Pacific Northwest. He is excited to explore everything Alabama has to offer with his wife and two daughters. His hobbies include working on classic cars, hiking, and has recently started fly fishing.

Selected Publications

Academic Article

Year Title Altmetric
2021 Preoperative anthropomorphic radiographic measurements can predict postoperative pancreatic fistula formation following pancreatoduodenectomy 2021
2020 Synthetic Makaluvamine Analogs Decrease c-Kit Expression and Are Cytotoxic to Neuroendocrine Tumor CellsMolecules.  25. 2020
2020 Sustained Carbohydrate Antigen 19-9 Response to Neoadjuvant Chemotherapy in Borderline Resectable Pancreatic Cancer Predicts Progression and Survival 2020
2020 Gemcitabine-Based Neoadjuvant Treatment in Borderline Resectable Pancreatic Ductal Adenocarcinoma: A Meta-Analysis of Individual Patient DataFrontiers in Oncology.  10. 2020
2020 Is radical ever too radical? 2020
2020 Biochemical Predictors of Response to Neoadjuvant Therapy in Pancreatic Ductal AdenocarcinomaFrontiers in Oncology.  10. 2020
2020 A growth model of neuroendocrine tumor surrogates and the efficacy of a novel somatostatin-receptor–guided antibody-drug conjugate: Perspectives on clinical response?Surgery.  167:197-203. 2020
2020 Gamma Secretase Inhibitors in Cancer: A Current Perspective on Clinical Performance 2020
2019 Heterogeneity of Vascular Endothelial Cells, De Novo Arteriogenesis and Therapeutic Implications in Pancreatic Neuroendocrine Tumors.Journal of Clinical Medicine.  8. 2019
2019 Significance of radiographic splenic vessel involvement in the pancreatic ductal adenocarcinoma of the body and tail of the glandJournal of Surgical Oncology.  120:262-269. 2019
2019 Management of Gastrointestinal Neuroendocrine TumorsClinical Medicine Insights : Endocrinology and Diabetes.  12. 2019
2018 Gallbladder Ejection Fraction and Biliary Scintigraphy: In Reply to Richmond and Fanelli.Journal of The American College of Surgeons.  227:296. 2018
2018 The Role of Notch3 in Cancer 2018
2018 Poor Reproducibility of Gallbladder Ejection Fraction by Biliary Scintigraphy for Diagnosis of Biliary Dyskinesia.Journal of The American College of Surgeons.  226:155-159. 2018
2018 Prospective Evaluation of Pasireotide in Patients Undergoing Pancreaticoduodenectomy: The Washington University Experience.Journal of The American College of Surgeons.  226:147-154.e1. 2018
2017 Diagnosis and management of biliary injuries.Current Problems in Surgery.  54:406-435. 2017
2016 The role of biliary carcinoembryonic antigen-related cellular adhesion molecule 6 (CEACAM6) a sa biomarker in cholangiocarcinomaPLoS ONE.  11. 2016
2016 Pattern of CA19-9 response to neoadjuvant chemotherapy in locally advanced, borderline resectable pancreatic cancer to predict progression.Journal of Clinical Oncology.  34:321-321. 2016
2014 Erratum to: Extended Neoadjuvant Chemotherapy for Borderline Resectable Pancreatic Cancer Demonstrates Promising Postoperative Outcomes and Survival (Annals of Surgical Oncology, DOI: 10.1245/S10434-014-3486-Z)Annals of Surgical Oncology.  21:1538. 2014
2014 Extended neoadjuvant chemotherapy for borderline resectable pancreatic cancer demonstrates promising postoperative outcomes and survivalAnnals of Surgical Oncology.  21:1530-1537. 2014
2014 Posterior 'superior mesenteric artery first' approach for resection of locally advanced pancreatic cancerAnnals of Surgical Oncology.  21:1927-1928. 2014
2013 Use the duodenum, it’s right there: a retrospective cohort study comparing biliary reconstruction using either the jejunum or the duodenum.JAMA Surgery.  148:860-865. 2013
2013 Tu1573 A Comparative Analysis of Plastic Versus Metal Endoscopic Biliary Stents in Borderline Resectable Pancreatic Cancer Patients Undergoing Extended Neoadjuvant ChemotherapyGastroenterology.  144:S-1129. 2013
2013 Extended neoadjuvant chemotherapy (CT) in borderline resectable pancreas cancer (BRPC): Is preoperative chemoradiation (CRT) essential?Journal of Clinical Oncology.  31:236-236. 2013
2013 Role of biliary CEACAM6 as a biomarker for cholangiocarcinoma.Journal of Clinical Oncology.  31:177-177. 2013
2012 Tu2049 Use the Duodenum, It's Already There: A Retrospective Cohort Study Comparing Biliary Reconstruction to the Either the Jejunum or DuodenumGastroenterology.  142:S-1105. 2012
2009 Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease 2009
2007 Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation 2007
2007 Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrateMolecular Pharmacology.  71:83-91. 2007
2007 The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysisMolecular Pharmacology.  71:73-82. 2007
2006 Cerebrolysin decreases amyloid-β production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's diseaseJournal of Neuroscience Research.  83:1252-1261. 2006

Chapter

Year Title Altmetric
2014 Intraoperative and laparoscopic ultrasound during pancreatic surgery.  5161-5176. 2014

Research Overview

  • diseases of the stomach, small bowel, liver, pancreas, gallbladder, and bile duct, Notch signaling pathways in gastroenteropancreatic neuroendocrine tumors
  • Education And Training

  • Doctor of Medicine, University of Illinois at Chicago 2010
  • Virginia Mason Medical Center, Residency 2016
  • Washington University, Postdoctoral Fellowship 2017