• Dr. Baddley is Associate Professor of Medicine in the Division of Infectious Diseases at the University of Alabama at Birmingham. He serves as Director of the Transplant ID Clinic at UAB. He is also Chief of Infectious Diseases at Birmingham VA Medical Center and Director of the VA Infection Control Program. Dr. Baddley’s research interests include the epidemiology, diagnosis and treatment of fungal infections; transplant infectious diseases; and hospital infection control.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Cryptococcosis in solid organ transplantation—Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice 2019
    2019 Perspectives on Scedosporium species and Lomentospora prolificans in lung transplantation: Results of an international practice survey from ESCMID fungal infection study group and study group for infections in compromised hosts, and European Confederation of Medical Mycology 2019
    2018 Mapping Histoplasma capsulatum exposure, United States 2018
    2018 Effect of algorithm-based therapy vs usual care on clinical success and serious adverse events in patients with staphylococcal bacteremia a randomized clinical trial 2018
    2018 ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [I]: anti-tumor necrosis factor-α agents) 2018
    2018 Effect of pulsed xenon ultraviolet room disinfection devices on microbial counts for methicillin-resistant Staphylococcus aureus and aerobic bacterial colonies 2018
    2018 Human polyomavirus-7–associated eruption successfully treated with acitretin 2018
    2018 Pneumocystis and glucocorticoid use: To prophylax or not to prophylax (and when?); That is the question 2018
    2018 Central nervous system histoplasmosis 2018
    2018 Epidemiology of Histoplasmosis 2018
    2018 Two cases and a review of graft-versus-host disease and the role of hepatitis C treatment in liver transplant patients 2018
    2017 Community characteristics and regional variations in sepsis 2017
    2017 Association of baseline steroid use with long-term rates of infection and sepsis in the REGARDS cohort 2017
    2017 Longterm effectiveness of herpes zoster vaccine among patients with autoimmune and inflammatory diseases 2017
    2017 Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: a retrospective population-based cohort study 2017
    2017 Safety of biologic and nonbiologic disease-modifying antirheumatic drug therapy in veterans with rheumatoid arthritis and hepatitis c virus infection 2017
    2017 Association of Diabetes and Insulin Therapy With Risk of Hospitalization for Infection and 28-Day Mortality Risk. 2017
    2017 Association of diabetes and insulin therapy with risk of hospitalization for infection and 28-day mortality risk 2017
    2017 Herpes Zoster and the Risk of Stroke in Patients With Autoimmune Diseases 2017
    2017 Opportunistic Infections in Biological Therapy, Risk and Prevention 2017
    2017 A Mycoses Study Group International Prospective Study of Phaeohyphomycosis: An Analysis of 99 Proven/Probable Cases. 2017
    2016 The epidemiology and outcomes of invasive Candida infections among organ transplant recipients in the United States: results of the Transplant-Associated Infection Surveillance Network (TRANSNET) 2016
    2016 Hemostasis biomarkers and risk of sepsis: the REGARDS cohort 2016
    2016 Antistaphylococcal β-lactams versus vancomycin for treatment of infective endocarditis due to methicillin-susceptible coagulase-negative staphylococci: A prospective cohort study from the international collaboration on endocarditis 2016
    2016 The risk of hospitalized infection following initiation of biologic agents versus methotrexate in the treatment of juvenile idiopathic arthritis 2016
    2016 Analysis of health care claims during the peri-transfer stage of transition from pediatric to adult care among juvenile idiopathic arthritis patients 2016
    2016 Risk of Herpes Zoster in Autoimmune and Inflammatory Diseases: Implications for Vaccination 2016
    2016 Approach to the Solid Organ Transplant Patient with Suspected Fungal Infection 2016
    2016 Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): A phase 3, randomised-controlled, non-inferiority trial 2016
    2016 Association of hyperlipidaemia, inflammation and serological status and coronary heart disease among patients with rheumatoid arthritis: Data from the National Veterans Health Administration 2016
    2016 Comparative Risk of Hospitalized Infection Associated with Biologic Agents in Rheumatoid Arthritis Patients Enrolled in Medicare 2016
    2016 Comparative effectiveness of echinocandins versus fluconazole therapy for the treatment of adult candidaemia due to Candida parapsilosis: A retrospective observational cohort study of the Mycoses Study Group (MSG-12) 2016
    2016 Inpatient mortality among solid organ transplant recipients hospitalized for sepsis and severe sepsis 2016
    2016 Validated risk score for predicting 6-month mortality in infective endocarditis 2016
    2015 Opportunistic infections and biologic therapies in immune-mediated inflammatory diseases: Consensus recommendations for infection reporting during clinical trials and postmarketing surveillance 2015
    2015 Pneumocystis Pneumonia in Solid Organ Transplant Recipients 2015
    2015 Black-white racial disparities in sepsis: A prospective analysis of the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort 2015
    2015 Fungal Infections in the Era of Biologic Therapies 2015
    2015 Safety of biologic and nonbiologic disease-modifying antirheumatic drug therapy in veterans with rheumatoid arthritis and hepatitis B virus infection: A retrospective cohort study 2015
    2015 Candida infective endocarditis: An observational cohort study with a focus on therapy 2015
    2015 An evolving plaque in an immunosuppressed patient with psoriasis 2015
    2015 Discharge diagnoses versus medical record review in the identification of community-acquired sepsis 2015
    2015 One-year outcome following biological or mechanical valve replacement for infective endocarditis 2015
    2015 Association between surgical indications, operative risk, and clinical outcome in infective endocarditis a prospective study from the international collaboration on endocarditis 2015
    2015 Hospital-onset Clostridium difficile infection among solid organ transplant recipients 2015
    2015 Impact of early valve surgery on outcome of staphylococcus aureus prosthetic valve infective endocarditis: Analysis in the international collaboration of endocarditis-prospective cohort study 2015
    2015 Loss of vancomycin-resistant enterococcus fecal dominance in an organ transplant patient with Clostridium difficile colitis after fecal microbiota transplant 2015
    2015 Ocular bartonellosis in transplant recipients: Two case reports and review of the literature 2015
    2015 Phaeohyphomycosis in transplant recipients: Results from the Transplant Associated Infection Surveillance Network (TRANSNET) 2015
    2015 Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus 2015
    2015 Risks of herpes zoster in patients with rheumatoid arthritis according to biologic disease-modifying therapy 2015
    2014 Non-viral opportunistic infections in new users of tumour necrosis factor inhibitor therapy: Results of the SAfety assessment of biologic ThERapy (SABER) study 2014
    2014 Risk of hospitalised infection in rheumatoid arthritis patients receiving biologics following a previous infection while on treatment with anti-TNF therapy 2014
    2014 Antibiotic utilization for acute respiratory tract infections in U.S. emergency departments 2014
    2014 Immunosuppression regimen and the risk of acute rejection in HIV-infected kidney transplant recipients 2014
    2014 A case report of progressive multifocal leucoencephalopathy (PML) associated with adalimumab 2014
    2014 Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET) 2014
    2014 Epidemiology of invasive mold infections in lung transplant recipients 2014
    2014 Histoplasmosis in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS): Multicenter study of outcomes and factors associated with relapse 2014
    2014 Mollaret's meningitis 2014
    2014 Physical inactivity and long-term rates of community-acquired sepsis 2014
    2014 Pneumocystis jirovecii Pneumonia in Patients Receiving Tumor-Necrosis-Factor-Inhibitor Therapy: Implications for Chemoprophylaxis 2014
    2014 Race and invasive fungal infection in solid organ transplant recipients 2014
    2014 Reduction in false-positive aspergillus serum galactomannan enzyme immunoassay results associated with use of piperacillin-tazobactam in the United States 2014
    2014 Reply to "acute sinusitis and pharyngitis as inappropriate indications for antibiotic use" 2014
    2014 Risk of hospitalized bacterial infections associated with biologic treatment among US veterans with rheumatoid arthritis 2014
    2014 Transmission of Balamuthia mandrillaris through solid organ transplantation: Utility of organ recipient serology to guide clinical management 2014
    2013 Epidemiologic research of invasive fungal infections using large healthcare databases 2013
    2013 Histoplasmosis after solid organ transplant 2013
    2013 Infectious complications of immune modulatory agents 2013
    2013 Sexual history taking and sexually transmitted infection screening in patients initiating erectile dysfunction medication therapy 2013
    2013 HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort 2013
    2013 Reply to oude lashof and vogelaers 2013
    2013 Brief report: Incidence of selected opportunistic infections among children with juvenile idiopathic arthritis 2013
    2013 Predictors of Mortality and Differences in Clinical Features among Patients with Cryptococcosis According to Immune Status 2013
    2013 Association between the initiation of anti-tumor necrosis factor therapy and the risk of herpes zoster 2013
    2013 Cryptococcosis in solid organ transplantation 2013
    2013 Aspergillosis in Intensive Care Unit (ICU) patients: Epidemiology and economic outcomes 2013
    2013 Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke 2013
    2013 Antifungal therapy and length of hospitalization in transplant patients with invasive aspergillosis 2013
    2013 How i treat histoplasmosis 2013
    2013 Initiation of anti-TNF therapy and the risk of optic neuritis: From the safety assessment of biologic ThERapy (SABER) study 2013
    2013 Mycobacterial diseases and antitumour necrosis factor therapy in USA 2013
    2012 Cross-reactivity of Aspergillus galactomannan in an HIV-infected patient with histoplasmosis 2012
    2012 Pneumocystis pneumonia in hospitalized patients: A detailed examination of symptoms, management, and outcomes in human immunodeficiency virus (HIV)-infected and HIV-uninfected persons 2012
    2012 Use of a disease risk score to compare serious infections associated with anti-tumor necrosis factor therapy among high-versus lower-risk rheumatoid arthritis patients 2012
    2012 Reply to Anaissie and Nucci and to Cisneros et al 2012
    2012 Fatal burkholderia gladioli infection misidentified as empedobacter brevis in a lung transplant recipient with cystic fibrosis 2012
    2012 Rates of hospitalized bacterial infection associated with juvenile idiopathic arthritis and its treatment 2012
    2012 Association between Vaccination for Herpes Zoster and Risk of Herpes Zoster Infection among Older Patients with Selected Immune-Mediated Diseases 2012
    2012 Association between Vancomycin-resistant enterococci bacteremia and ceftriaxone usage 2012
    2012 Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: A patient-level quantitative review of randomized trials 2012
    2012 Incidence and risk factors for progressive multifocal leukoencephalopathy among patients with selected rheumatic diseases 2012
    2012 In response 2012
    2012 Subcutaneous fungal infections 2012
    2011 Pulmonary cryptococcosis 2011
    2011 Pulmonary fungal infections 2011
    2011 Fungal endocarditis 2011
    2011 Initiation of tumor necrosis factor-αantagonists and the risk of hospitalization for infection in patients with autoimmune diseases 2011
    2011 The use, safety, and effectiveness of herpes zoster vaccination in individuals with inflammatory and autoimmune diseases: A longitudinal observational study 2011
    2011 Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis 2011
    2011 Antifungal susceptibilities of Cryptococcus neoformans cerebrospinal fluid isolates from AIDS patients in Kenya 2011
    2011 Geographic distribution of endemic fungal infections among older persons, United States 2011
    2011 Observational study of the epidemiology and outcomes of vancomycin-resistant Enterococcus bacteraemia treated with newer antimicrobial agents 2011
    2011 In Vitro echinocandin susceptibility of Aspergillus isolates from patients enrolled in the transplant-associated infection surveillance network 2011
    2011 The comparative risk of serious infections among rheumatoid arthritis patients starting or switching biological agents 2011
    2011 Comparison of in vitro susceptibility characteristics of Candida species from cases of invasive candidiasis in solid organ and stem cell transplant recipients: Transplant-Associated Infections Surveillance Network (TRANSNET), 2001 to 2006 2011
    2011 Antifungal prophylaxis in solid organ transplant recipients 2011
    2011 Clinical risk factors for invasive aspergillosis 2011
    2011 Histoplasma antigen clearance during treatment of histoplasmosis in patients with AIDS determined by a quantitative antigen enzyme immunoassay 2011
    2011 Transmission of Cryptococcus neoformans by organ transplantation 2011
    2011 Aspergillus terreus accessory conidia are multinucleated, hyperpolarizing structures that display differential dectin staining and can induce heightened inflammatory responses in a pulmonary model of aspergillosis 2011
    2011 Aspergillus terreus accessory conidia are multinucleated, hyperpolarizing structures that display differential dectin staining and can induce heightened inflammatory responses in a pulmonary model of aspergillosis. 2011
    2011 Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006 2011
    2010 Epidemiology of emerging fungi and fungi-like organisms 2010
    2010 Factors associated with mortality in transplant patients with invasive aspergillosis 2010
    2010 Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: Overview of the transplant- associated infection surveillance network (TRANSNET) database 2010
    2010 The prevalence, clinical features, risk factors and outcome associated with cryptococcal meningitis in HIV positive patients in Kenya. 2010
    2009 Molecular identification of Aspergillus species collected for the transplant-associated infection surveillance network 2009
    2009 Patterns of susceptibility of Aspergillus isolates recovered from patients enrolled in the transplant-associated infection surveillance network 2009
    2009 Cryptococcal disease presenting as necrotizing cellulitis in transplant recipients: Case report 2009
    2009 Pinpointing prognostic indicators of fungal infections in transplant patients 2009
    2009 A multicenter, double-blind trial of a high-dose caspofungin treatment regimen versus a standard caspofungin treatment regimen for adult patients with invasive candidiasis 2009
    2009 Authors' reply 2009
    2009 Aspergillus alabamensis, a new Clinically relevant species in the section terre 2009
    2009 Cryptococcal lung disease 2009
    2008 Histoplasmosis in HIV-infected patients in a southern regional medical center: poor prognosis in the era of highly active antiretroviral therapy 2008
    2008 Pulmonary cryptococcosis in patients without HIV infection: Factors associated with disseminated disease 2008
    2008 Association of fluconazole pharmacodynamics with mortality in patients with candidemia 2008
    2008 Candida infective endocarditis 2008
    2008 Active surveillance to determine the impact of methicillin-resistant Staphylococcus aureus colonization on patients in intensive care units of a veterans affairs medical center 2008
    2008 Prevention of Invasive Aspergillosis in High-Risk Patients: Universal Versus Preemptive, Targeted Treatment. 2008
    2008 Dissemination of community-associated methicillin-resistant Staphylococcus aureus in a tertiary care hospital 2008
    2007 Combination antifungal therapy for the treatment of invasive yeast and mold infections 2007
    2007 Clinical practice guidelines for the management of patients with histoplasmosis: 2007 Update by the Infectious Diseases Society of America 2007
    2006 Clinical research in the lay press: Irresponsible journalism raises a huge dose of doubt 2006
    2006 Phase II, randomized, double-blind, multicenter study comparing the safety and pharmacokinetics of tefibazumab to placebo for treatment of Staphylococcus aureus bacteremia 2006
    2006 Phaeoacremonium parasiticum infections confirmed by β-tubulin sequence analysis of case isolates 2006
    2006 Avian influenza: what PAs need to know. 2006
    2005 Antifungal combination therapy: Clinical potential 2005
    2005 Initial management of candidemia at an academic medical center: Evaluation of the IDSA guidelines 2005
    2004 Utility of real-time antifungal susceptibility testing for fluconazole in the treatment of candidemia 2004
    2004 Emerging fungal resistance 2004
    2004 Other viral bioweapons: Ebola and Marburg hemorrhagic fever 2004
    2004 Surgical treatment of multiple skull abscesses associated with coccidioidomycosis 2004
    2003 Epidemiology of Aspergillus terreus at a University Hospital 2003
    2003 Polymicrobial septic arthritis in a patient with Wilson's disease [12] 2003
    2002 Fungal brain abscess in transplant recipients: Epidemiologic, microbiologic, and clinical features 2002
    2001 Invasive mold infections in allogeneic bone marrow transplant recipients 2001
    2001 Implantable cardioverter-defibrillator endocarditis secondary to Candida albicans 2001
    2001 Trends in frequency and susceptibilities of Candida glabrata bloodstream isolates at a University Hospital 2001
    2000 Microascus cinereus (anamorph Scopulariopsis) brain abscess in a bone marrow transplant recipient 2000
    2000 Fungal infections in ventricular assist devices 2000
    1999 Crohn's disease presenting as septic thrombophlebitis of the portal vein (pylephlebitis): case report and review of the literature. 1999
    1999 Crohn's disease presenting as septic thrombophlebitis of the portal vein (pylephlebitis): Case report and review of the literature 1999
    1998 Insulinoma masquerading as factitious hypoglycemia 1998


    Year Title Altmetric
    2018 Vaccinations in rheumatology.  411-426. 2018
    2018 Systemic antifungals.  425-450. 2018
    2011 Chromoblastomycosis.  427-433. 2011
    2011 Cryptococcosis.  207-226. 2011
    2011 Infections due to miscellaneous fungi.  455-461. 2011

    Principal Investigator On

  • Phase II Multi-Center, Prospective, Randomized, Double-Blind Study of Nitazoxanide in Acute and Chronic Norovirus in Hematpoietic Stem Cell and Solid Organ Transplant Recipients  awarded by Northwestern University 2016 - 2021
  • Private Grant  awarded by CONTRAFECT CORPORATION 2018 - 2021
  • Private Grant  awarded by MERCK & COMPANY, INC. 2018 - 2020
  • Private Grant  awarded by VICAL, INC. 2018 - 2020
  • Private Grant  awarded by SHIRE PHARMACEUTICALS DEVELOPMENT, INC. 2017 - 2020
  • Global Survey of Bloodstream Infections in High Risk Neutropenic Cancer Patients  awarded by UNIVERSITY OF NEBRASKA MEDICAL CENTER - NEW 2016 - 2019
  • Private Grant  awarded by SHIRE HUMAN GENETIC THERAPIES 2017 - 2019
  • A Multi-Centered, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of a Treatment Algorithm to Reduce the Use of Vancomycin in Patients with Intravenous Catheter-Associated Blood Stream Infections due to Staphylococci  awarded by Duke University 2011 - 2017
  • Private Grant  awarded by ASTELLAS PHARMA US, INC. 2013 - 2015
  • Training in Primary Care Medicine and Dentistry: Physician Assistant Training in Primary Care  awarded by Health Resources and Services Administration/DHHS 2013 - 2015
  • Private Grant  awarded by CEREXA, INC. 2013 - 2014
  • Mortality in Transplant Patients with Aspergillosis  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2005 - 2011
  • Private Grant  awarded by Pfizer Pharmaceuticals 2008 - 2010
  • Private Grant  awarded by Pfizer Pharmaceuticals 2008 - 2010
  • Education And Training

  • LSU Affiliated Hospitals, Residency 1998
  • UAB Hospital, Postdoctoral Fellowship 2001
  • Full Name

  • John Baddley