Positions

Overview

  • Jianyi “Jay” Zhang, M.D., Ph.D., F.A.H.A., is an international leader in myocardial bioenergetics, biomaterials, and stem cells for cardiac repair. He is tenured Professor of Medicine and of Engineering; T. Michael and Gillian Goodrich Endowed Chair of Engineering Leadership; and the Chair of the Department of Biomedical Engineering (BME), a joint department of the School of Medicine and School of Engineering, at the University of Alabama at Birmingham (UAB).

    He came to UAB in October 2015 after he was chosen in a national search to lead the UAB BME department from the University of Minnesota Medical School, where he was the Engdahl Family Foundation Chair in Cardiovascular Regenerative Therapies, in addition to being a tenured professor of medicine, of biomedical engineering, of electrical engineering, and computer engineering. Among his recent honors and awards is the prestigious George E. Brown Memorial Lectureship for the 2014 AHA Scientific Sessions. He is also the recipient of an Established Investigator Award from the American Heart Association (1996) and a First Award from the National Institutes of Health (1993).

    Zhang earned his M.D. from Shanghai Medical University in 1983 and his Ph.D. in biomedical engineering from the University of Minnesota in 1992. He also earned a master of science in engineering (1987) and a certificate of business administration (1987) from Tufts University. Prior to joining the faculty at the University of Minnesota, Zhang completed postdoctoral work in that university’s cardiovascular division. Since his arrival at UAB, the Department of Biomedical Engineering rose to the rank of 4th in the nation in NIH funding, with $4.3 million in FY16 under Zhang’s leadership. Dr. Zhang’s research interests include tissue engineering, myocardial energetics in hearts with postinfarction left-ventricle remodeling, heart failure, biomaterials, and stem cells for cardiac repair. He is currently the principal investigator of three R01 NIH grants in the fields of myocardial bioenergetics, biomaterials, and stem cells for cardiac repair, and an NIH U01 grant for the NHLBI Progenitor Cell Translational Consortium (PCTC) on cardiovascular tissue engineering, which continuous through 2022.

    Over the years, the Zhang research lab has trained more than 60 trainees (Ph.D. students, post-docs, residents, and cardiology fellows), and led 11 Ph.D. students in biomedical engineering, physiology, or electrical engineering. Dr. Zhang is currently advisor to five students earning their Ph.D. in Biomedical Engineering, Pathology, or Electrical Engineering, respectively. Professional Organizations: Fellow, American Physiological Society; Fellow, American Heart Association. Reviewer on NIH study sections (MIM, charter member, others); scientific journal editorial board member for Circulation Research, Circulation, American Journal of Physiology, and others.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Scaffold-free bioprinter utilizing layer-by-layer printing of cellular spheroids.  Micromachines.  10. 2019
    2019 Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision.  Biophysical Journal.  117:631-645. 2019
    2019 Functionally Competent DNA Damage-Free Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair.  Circulation.  140:520-522. 2019
    2019 OBG-like ATPase 1 inhibition attenuates angiotensin II-induced hypertrophic response in human ventricular myocytes via GSK-3beta/beta-catenin signalling.  Clinical and Experimental Pharmacology and Physiology.  46:743-751. 2019
    2019 Enhancing the engraftment of human induced pluripotent stem cell-derived cardiomyocytes via a transient inhibition of rho kinase activity.  Journal of Visualized Experiments.  2019. 2019
    2019 HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injury.  Journal of Molecular and Cellular Cardiology.  130:36-48. 2019
    2019 Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice.  Cardiovascular Research.  115:343-356. 2019
    2019 Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.  Circulation Research.  124:161-169. 2019
    2019 Assessing stem cell DNA integrity for cardiac cell therapy.  Journal of Visualized Experiments.  2019. 2019
    2019 Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells.  Science Advances.  5. 2019
    2019 Correction: Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation (PLoS ONE (2019) 14: 7 (e0219442) DOI: 10.1371/journal.pone.0219442).  PLoS ONE.  14. 2019
    2019 Direct in vivo application of induced pluripotent stem cells is feasible and can be safe.  Theranostics.  9:290-310. 2019
    2019 Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation.  PLoS ONE.  14. 2019
    2019 Nanoscale Technologies for Prevention and Treatment of Heart Failure: Challenges and Opportunities.  Chemical Reviews.  2019
    2018 Human leukocyte antigen class I and II knockout human induced pluripotent stem cell–derived cells: Universal donor for cell therapy.  Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  7. 2018
    2018 The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways.  Stem Cell Research and Therapy.  9:313. 2018
    2018 Transactivation domain of p53 regulates DNA repair and integrity in human ips cells.  AJP - Heart and Circulatory Physiology.  315:H512-H521. 2018
    2018 Mitochondrial-mediated oxidative Ca2+/calmodulin-dependent kinase II activation induces early afterdepolarizations in Guinea pig cardiomyocytes: An in silico study.  Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  7. 2018
    2018 Spheroids of cardiomyocytes derived from human-induced pluripotent stem cells improve recovery from myocardial injury in mice.  AJP - Heart and Circulatory Physiology.  315:H327-H339. 2018
    2018 Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman Primates.  Circulation Research.  122:958-969. 2018
    2018 VEGF nanoparticles repair the heart after myocardial infarction.  AJP - Heart and Circulatory Physiology.  314:H278-H284. 2018
    2018 CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle.  Circulation Research.  122:88-96. 2018
    2018 Can we engineer a human cardiac patch for therapy?.  Circulation Research.  123:244-265. 2018
    2018 Corrigendum to “the transcription factor Bach1 suppresses the developmental angiogenesis of zebrafish” (Oxidative Medicine and Cellular Longevity (2017) (2143875) DOI: 10.1155/2017/2143875).  Oxidative Medicine and Cellular Longevity.  2018. 2018
    2018 Early regenerative capacity in the porcine heart.  Circulation.  138:2798-2808. 2018
    2018 Effective metabolic approaches for the energy starved failing heart: Bioenergetic resiliency via redundancy or something else?.  Circulation Research.  123:329-331. 2018
    2018 Large cardiac muscle patches engineered from human induced-pluripotent stem cell-derived cardiac cells improve recovery from myocardial infarction in swine.  Circulation.  137:1712-1730. 2018
    2018 Regenerative potential of neonatal porcine hearts.  Circulation.  138:2809-2816. 2018
    2018 Relationship between the efficacy of cardiac cell therapy and the inhibition of differentiation of human iPSC-Derived nonmyocyte cardiac cells into Myofibroblast-like cells.  Circulation Research.  123:1313-1325. 2018
    2018 Transplanted mesenchymal stem cells reduce autophagic flux in infarcted hearts via the exosomal transfer of miR-125b.  Circulation Research.  123:564-578. 2018
    2017 Pathologic Stimulus Determines Lineage Commitment of Cardiac C-kit+ Cells.  Circulation.  136:2359-2372. 2017
    2017 Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes.  Stem Cell Research and Therapy.  8. 2017
    2017 Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering.  Journal of the American College of Cardiology.  70:766-775. 2017
    2017 Effect of densely ionizing radiation on cardiomyocyte differentiation from human-induced pluripotent stem cells.  Physiological Reports.  5. 2017
    2017 Meeting Report for the 2017 National Institutes of Health National Heart, Lung, and Blood Institute Progenitor Cell Biology Consortium: Cardiovascular Bioengineering Workshop and Symposium.  Circulation Research.  120:1709-1712. 2017
    2017 Quantitative Proteomics and Immunohistochemistry Reveal Insights into Cellular and Molecular Processes in the Infarct Border Zone One Month after Myocardial Infarction.  Journal of Proteome Research.  16:2101-2112. 2017
    2017 Myocardial Tissue Engineering with Cells Derived from Human-Induced Pluripotent Stem Cells and a Native-Like, High-Resolution, 3-Dimensionally Printed Scaffold.  Circulation Research.  120:1318-1325. 2017
    2017 Pluripotent stem cell derived cardiac cells for myocardial repair.  Journal of Visualized Experiments.  2017. 2017
    2017 From Microscale Devices to 3D Printing: Advances in Fabrication of 3D Cardiovascular Tissues.  Circulation Research.  120:150-165. 2017
    2017 Lactate promotes synthetic phenotype in vascular smooth muscle cells.  Circulation Research.  121:1251-1262. 2017
    2017 The Transcription Factor Bach1 Suppresses the Developmental Angiogenesis of Zebrafish.  Oxidative Medicine and Cellular Longevity.  2017. 2017
    2016 Nox2 and Nox4 regulate self-renewal of murine induced-pluripotent stem cells.  Biochemistry and Molecular Biology International.  68:963-970. 2016
    2016 2D Pulses using spatially dependent frequency sweeping.  Magnetic Resonance in Medicine.  76:1364-1374. 2016
    2016 Meeting Report for NIH 2016 Progenitor Cell Biology Consortium Cardiovascular Tissue Engineering 2016.  Circulation Research.  119:981-983. 2016
    2016 Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction.  Biomaterials.  105:52-65. 2016
    2016 Nox2 contributes to the arterial endothelial specification of mouse induced pluripotent stem cells by upregulating Notch signaling.  Scientific Reports.  6. 2016
    2016 31P NMR 2D mapping of creatine kinase forward flux rate in hearts with postinfarction left ventricular remodeling in response to cell therapy.  PLoS ONE.  11. 2016
    2016 Distilling complexity to advance cardiac tissue engineering.  Science Translational Medicine.  8. 2016
    2016 Transmurally differentiated measurement of ATP hydrolysis rates in the in vivo porcine hearts.  Magnetic Resonance in Medicine.  75:1859-1866. 2016
    2016 A large-scale investigation of hypoxia-preconditioned allogeneic mesenchymal stem cells for myocardial repair in nonhuman primates: Paracrine activity without remuscularization.  Circulation Research.  118:970-983. 2016
    2016 ATP sensitive K+ channels are critical for maintaining myocardial perfusion and high energy phosphates in the failing heart.  Journal of Molecular and Cellular Cardiology.  92:116-121. 2016
    2016 Bach1 induces endothelial cell apoptosis and cell-cycle arrest through ROS generation.  Oxidative Medicine and Cellular Longevity.  2016. 2016
    2016 Differentiation of human induced-pluripotent stem cells into smooth-muscle cells: Two novel protocols.  PLoS ONE.  11. 2016
    2015 Functional effects of a tissue-engineered cardiac patch from human induced pluripotent stem cell-derived cardiomyocytes in a rat infarct model.  Stem Cells Translational Medicine.  4:1324-1332. 2015
    2015 Early detection of myocardial bioenergetic deficits: A 9.4 tesla complete non invasive 31P MR spectroscopy study in mice with muscular dystrophy.  PLoS ONE.  10. 2015
    2015 Engineered Tissue Patch for Cardiac Cell Therapy.  Current Treatment Options in Cardiovascular Medicine.  17. 2015
    2015 Quantitative proteomics reveals differential regulation of protein expression in recipient myocardium after trilineage cardiovascular cell transplantation.  Proteomics.  15:2560-2567. 2015
    2015 The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart.  Cell Reports.  12:15-22. 2015
    2015 Bach1 represses Wnt/β-catenin signaling and angiogenesis.  Circulation Research.  117:364-375. 2015
    2015 Fabrication of a myocardial patch with cells differentiated from human-induced pluripotent stem cells 2015
    2015 Derivation and high engraftment of patient-specific cardiomyocyte sheet using induced pluripotent stem cells generated from adult cardiac fibroblast.  Circulation: Heart Failure.  8:156-166. 2015
    2015 Erratum: Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells (Cell Stem Cell (2014) 15 (750-761)).  Cell Stem Cell.  16:102. 2015
    2015 Myocardial ATP hydrolysis rates in vivo: A porcine model of pressure overload-induced hypertrophy.  AJP - Heart and Circulatory Physiology.  309:H450-H458. 2015
    2015 New mass-spectrometry-compatible degradable surfactant for tissue proteomics.  Journal of Proteome Research.  14:1587-1599. 2015
    2015 Safety and efficacy of intracoronary hypoxia-preconditioned bone marrow mononuclear cell administration for acute myocardial infarction patients: The CHINA-AMI randomized controlled trial.  International Journal of Cardiology.  184:446-451. 2015
    2015 The structural basis of functional improvement in response to human umbilical cord blood stem cell transplantation in hearts with postinfarct lv remodeling.  Cell Transplantation.  24:971-983. 2015
    2014 Synthetic phosphopeptides enable quantitation of the content and function of the four phosphorylation states of phospholamban in cardiac muscle.  Journal of Biological Chemistry.  289:29397-29405. 2014
    2014 Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes.  Stem Cell Reports.  3:594-605. 2014
    2014 Myocytes oxygenation and high energy phosphate levels during hypoxia.  PLoS ONE.  9. 2014
    2014 Intra-myocardial injection of both growth factors and heart derived Sca-1+/CD31- cells attenuates post-MI LV remodeling more than does cell transplantation Alone: Neither intervention enhances functionally significant cardiomyocyte regeneration.  PLoS ONE.  9. 2014
    2014 Functional consequences of a tissue-engineered myocardial patch for cardiac repair in a rat infarct model.  Tissue Engineering: Parts A, B, and C.  20:1325-1335. 2014
    2014 The influence of a spatiotemporal 3D environment on endothelial cell differentiation of human induced pluripotent stem cells.  Biomaterials.  35:3786-3793. 2014
    2014 Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells.  Cell Stem Cell.  15:750-761. 2014
    2013 Patching the heart: Cardiac repair from within and outside.  Circulation Research.  113:922-932. 2013
    2013 Thymosin β4 increases the potency of transplanted mesenchymal stem cells for myocardial repair.  Circulation.  128. 2013
    2013 Mechanisms of cell therapy for clinical investigations: An urgent need for large-animal models.  Circulation.  128:92-94. 2013
    2013 Reduced expression of mitochondrial electron transport chain proteins from hibernating hearts relative to ischemic preconditioned hearts in the second window of protection.  Journal of Molecular and Cellular Cardiology.  60:90-96. 2013
    2013 Induced pluripotent stem cells and their potential for basic and clinical sciences.  Current Cardiology Reviews.  9:63-72. 2013
    2013 Preface.  Current Cardiology Reviews.  9:1. 2013
    2013 Functional consequences of human induced pluripotent stem cell therapy: Myocardial ATP turnover rate in the in vivo swine heart with postinfarction remodeling.  Circulation.  127:997-1008. 2013
    2013 Effective Cardiac Myocyte Differentiation of Human Induced Pluripotent Stem Cells Requires VEGF.  PLoS ONE.  8. 2013
    2012 Bioenergetic and functional consequences of cellular therapy: Activation of endogenous Cardiovascular progenitor cells.  Circulation Research.  111:455-468. 2012
    2012 Increased angiogenesis and improved left ventricular function after transplantation of myoblasts lacking the MyoD gene into infarcted myocardium.  PLoS ONE.  7. 2012
    2012 Satellite cell heterogeneity revealed by G-Tool, an open algorithm to quantify myogenesis through colony-forming assays.  Skeletal Muscle.  2. 2012
    2012 Aging kit mutant mice develop cardiomyopathy.  PLoS ONE.  7. 2012
    2012 Fetal myocardium in the kidney capsule: An in vivo model of repopulation of myocytes by bone marrow cells.  PLoS ONE.  7. 2012
    2012 Cellular therapy promotes endogenous stem cell repair..  Canadian Journal of Physiology and Pharmacology.  90:1335-1344. 2012
    2011 Seamless networks of myocardial bioenergetics.  Journal of Physiology.  589:5013-5014. 2011
    2011 Effect of acute xanthine oxidase inhibition on myocardial energetics during basal and very high cardiac workstates.  Journal of Cardiovascular Translational Research.  4:504-513. 2011
    2011 Cellular fusion for gene delivery to SCA1 affected Purkinje neurons.  Molecular and Cellular Neuroscience.  47:61-70. 2011
    2011 Getting to the heart of myocardial stem cells and cell therapy.  Circulation.  123:1771-1779. 2011
    2011 ATP production rate via creatine kinase or ATP synthase in Vivo: A novel superfast magnetization saturation transfer method.  Circulation Research.  108:653-663. 2011
    2011 Long-term preservation of myocardial energetic in chronic hibernating myocardium.  AJP - Heart and Circulatory Physiology.  300. 2011
    2011 A fibrin patch-based enhanced delivery of human embryonic stem cell-derived vascular cell transplantation in a porcine model of postinfarction left ventricular remodeling.  STEM CELLS.  29:367-375. 2011
    2010 Stem cell therapy for ischemic heart disease.  Antioxidants and Redox Signaling.  13:1879-1897. 2010
    2010 Long-term functional improvement and gene expression changes after bone marrow-derived multipotent progenitor cell transplantation in myocardial infarction.  AJP - Heart and Circulatory Physiology.  298. 2010
    2009 Stem cells for myocardial repair with use of a transarterial catheter.  Circulation.  120. 2009
    2009 Novel strategy for measuring creatine kinase reaction rate in the in vivo heart.  AJP - Heart and Circulatory Physiology.  297. 2009
    2009 Heart failure management: The present and the future.  Antioxidants and Redox Signaling.  11:1989-2010. 2009
    2009 Myocardial energetics in left ventricular hypertrophy.  Current Cardiology Reviews.  5:243-250. 2009
    2009 Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism.  Proceedings of the National Academy of Sciences.  106:7143-7148. 2009
    2008 Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischaemic hearts.  Journal of Physiology.  586:4193-4208. 2008
    2008 Enhancing efficacy of stem cell transplantation to the heart with a PEGylated fibrin biomatrix.  Tissue Engineering: Parts A, B, and C.  14:1025-1036. 2008
    2008 Transmural distribution of metabolic abnormalities and glycolytic activity during dobutamine-induced demand ischemia.  AJP - Heart and Circulatory Physiology.  294. 2008
    2008 Relationships between regional myocardial wall stress and bioenergetics in hearts with left ventricular hypertrophy.  AJP - Heart and Circulatory Physiology.  294. 2008
    2007 The energetic state within hibernating myocardium is normal during dobutamine despite inhibition of ATP-dependent potassium channel opening with glibenclamide.  AJP - Heart and Circulatory Physiology.  293. 2007
    2007 Erratum: Multipotent adult progenitor cells from swine bone marrow (Stem Cells (2006) 24 (2355-2366) DOI: 10.1634/stemcells.2005-0551).  STEM CELLS.  25:2387. 2007
    2007 Functional and bioenergetic modulations in the infarct border zone following autologous mesenchymal stem cell transplantation.  AJP - Heart and Circulatory Physiology.  293. 2007
    2007 Controlled release of stromal cell-derived factor-1alpha in situ increases C-kit+ cell homing to the infarcted heart.  Tissue Engineering -Larchmont-.  13:2063-2071. 2007
    2007 Multipotent adult progenitor cell transplantation increases vascularity and improves left ventricular function after myocardial infarction.  Journal of Tissue Engineering and Regenerative Medicine.  1:325. 2007
    2007 Cellular therapy for myocardial repair.  Current Cardiology Reviews.  3:121-135. 2007
    2007 Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling.  Circulation.  115:1866-1875. 2007
    2007 The host immune response is essential for the beneficial effect of adult stem cells after myocardial ischemia.  Experimental Hematology.  35:682-690. 2007
    2007 Xenotransplantation of long-term-cultured swine bone marrow-derived mesenchymal stem cells.  STEM CELLS.  25:612-620. 2007
    2007 Multipotent adult progenitor cell transplantation increases vascularity and improves left ventricular function after myocardial infarction.  Journal of Tissue Engineering and Regenerative Medicine.  1:51-59. 2007
    2006 Open-chest 31P magnetic resonance spectroscopy of mouse heart at 4.7 Tesla.  Journal of Magnetic Resonance Imaging.  24:1269-1276. 2006
    2006 Acute effects of febuxostat, a nonpurine selective inhibitor of xanthine oxidase, in pacing induced heart failure.  Journal of Cardiovascular Pharmacology.  48:255-263. 2006
    2006 Profound bioenergetic abnormalities in peri-infarct myocardial regions.  AJP - Heart and Circulatory Physiology.  291. 2006
    2006 The role of the Sca-1+/CD31- cardiac progenitor cell population in postinfarction left ventricular remodeling.  STEM CELLS.  24:1779-1788. 2006
    2006 Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling.  Journal of Cardiovascular Pharmacology.  47:686-694. 2006
    2006 Bioenergetic and functional consequences of stem cell-based VEGF delivery in pressure-overloaded swine hearts.  AJP - Heart and Circulatory Physiology.  290. 2006
    2006 A PEGylated fibrin patch for mesenchymal stem cell delivery.  Tissue Engineering -Larchmont-.  12:9-19. 2006
    2006 Multipotent adult progenitor cells from swine bone marrow.  STEM CELLS.  24:2355-2366. 2006
    2005 Nitric oxide regulation of myocardial O2 consumption and HEP metabolism.  AJP - Heart and Circulatory Physiology.  288. 2005
    2004 Autologous stem cell transplantation for myocardial repair.  AJP - Heart and Circulatory Physiology.  287. 2004
    2004 Interstitial purine metabolites in hearts with LV remodeling.  AJP - Heart and Circulatory Physiology.  286. 2004
    2004 Molecular biology of myocardial recovery.  Surgical Clinics of North America.  84:223-242. 2004
    2003 Myocardial oxygenation and high-energy phosphate levels during K ATPchannel blockade.  AJP - Heart and Circulatory Physiology.  285. 2003
    2003 Oxidative capacity in failing hearts.  AJP - Heart and Circulatory Physiology.  285. 2003
    2002 Nicorandil improves myocardial high-energy phosphates in postinfarction porcine hearts.  Clinical and Experimental Pharmacology and Physiology.  29:639-645. 2002
    2002 Myocardial creatine kinase expression after left ventricular assist device support.  Journal of the American College of Cardiology.  39:1773-1779. 2002
    2002 Myocardial energetics in cardiac hypertrophy.  Clinical and Experimental Pharmacology and Physiology.  29:351-359. 2002
    2001 Effects of augmented delivery of pyruvate on myocardial high-energy phosphate metabolism at high workstate.  AJP - Heart and Circulatory Physiology.  281. 2001
    2001 Myocardial creatine kinase kinetics and isoform expression in hearts with severe LV hypertrophy.  AJP - Heart and Circulatory Physiology.  281. 2001
    2001 Mitochondrial ATPase and high-energy phosphates in failing hearts.  AJP - Heart and Circulatory Physiology.  281. 2001
    2001 Selective blockade of mitochondrial KATP channels does not impair myocardial oxygen consumption.  AJP - Heart and Circulatory Physiology.  281. 2001
    2001 Myocardial oxygenation and high-energy phosphate levels during graded coronary hypoperfusion.  AJP - Heart and Circulatory Physiology.  280. 2001
    2001 Noninvasive measurements of transmural myocardial metabolites using 3-D 31 P NMR spectroscopy.  AJP - Heart and Circulatory Physiology.  280. 2001
    2001 High-energy phosphate metabolism and creatine kinase in failing hearts: A new porcine model.  Circulation.  103:1570-1576. 2001
    2000 Signaling and expression for mitochondrial membrane proteins during left ventricular remodeling and contractile failure after myocardial infarction.  Journal of the American College of Cardiology.  36:282-287. 2000
    2000 Use of magnetic resonance spectroscopy for in vivo evaluation of high- energy phosphate metabolism in normal and abnormal myocardium.  Journal of Cardiovascular Magnetic Resonance.  2:23-32. 2000
    1999 The molecular energetics of the failing heart from animal models - Large animal models.  Heart Failure Reviews.  4:255-267. 1999
    1999 An efficient MR phosphorous spectroscopic localization technique for studying ischemic heart.  Journal of Magnetic Resonance Imaging.  10:892-898. 1999
    1999 An efficient MR phosphorous spectroscopic localization technique for studying ischemic heart.  Journal of Magnetic Resonance Imaging.  10:892-898. 1999
    1999 In vitro and in vivo studies of1H NMR visibility to detect deoxyhemoglobin and deoxymyoglobin signals in myocardium.  Magnetic Resonance in Medicine.  42:1-5. 1999
    1999 Oxygen delivery does not limit cardiac performance during high work states.  AJP - Heart and Circulatory Physiology.  277. 1999
    1999 Transmural metabolic heterogeneity at high cardiac work states.  AJP - Heart and Circulatory Physiology.  277. 1999
    1999 Myocardial oxygenation at high workstates in hearts with left ventricular hypertrophy.  Cardiovascular Research.  42:616-626. 1999
    1999 Myocardial creatine kinase kinetics in hearts with postinfarction left ventricular remodeling.  AJP - Heart and Circulatory Physiology.  276. 1999
    1999 Myocardial oxygenation during high work states in hearts with postinfarction remodeling.  Circulation.  99:942-948. 1999
    1999 In vitro and in vivo studies of 1H NMR visibility to detect deoxyhemoglobin and deoxymyoglobin signals in myocardium.  Magnetic Resonance in Medicine.  42:1-5. 1999
    1998 ATP-sensitive K+ channels, adenosine, and nitric oxide-mediated mechanisms account for coronary vasodilation during exercise.  Circulation Research.  82:346-359. 1998
    1997 Myocardial bioenergetics during acute hibernation.  AJP - Heart and Circulatory Physiology.  273. 1997
    1997 Myocardial bioenergetics during acute hibernation.  AJP - Heart and Circulatory Physiology.  273. 1997
    1997 Determination of deoxymyoglobin changes during graded myocardial ischemia: An in vivo 1H NMR spectroscopy study.  Magnetic Resonance in Medicine.  38:193-197. 1997
    1997 Post-infarction left ventricular remodeling induces changes in creatine kinase mRNA and protein subunit levels in porcine myocardium.  American Journal of Pathology.  151:257-264. 1997
    1997 Relationships between myocardial bioenergetic and left ventricular function in hearts with volume-overload hypertrophy.  Circulation.  96:334-343. 1997
    1997 Cardiac troponin I and T alterations in hearts with severe left ventricular remodeling.  Clinical Chemistry.  43:990-995. 1997
    1996 Coronary hyperperfusion augments myocardial oxygen consumption.  AJP - Heart and Circulatory Physiology.  271. 1996
    1996 Coronary hyperperfusion augments myocardial oxygen consumption.  AJP - Heart and Circulatory Physiology.  271. 1996
    1996 Functional and bioenergetic consequences of postinfarction left ventricular remodeling in a new porcine model MRI and 31P-MRS study.  Circulation.  94:1089-1100. 1996
    1995 Bioenergetic consequences of left ventricular remodeling.  Circulation.  92:1011-1019. 1995
    1995 Effect of exercise on coronary pressure-flow relationship in hypertrophied left ventricle.  AJP - Heart and Circulatory Physiology.  269. 1995
    1995 Effect of left ventricular hypertrophy secondary to chronic pressure overload on transmural myocardial 2-deoxyglucose uptake: A 31P NMR spectroscopic study.  Circulation.  92:1274-1283. 1995
    1995 Effects of dobutamine on myocardial blood flow, contractile function, and bioenergetic responses distal to coronary stenosis: Implications with regard to dobutamine stress testing.  American Heart Journal.  129:330-342. 1995
    1995 Regional myocardial blood volume and flow: First‐pass MR imaging with polylysine‐Gd‐DTPA.  Journal of Magnetic Resonance Imaging.  5:227-237. 1995
    1995 Transmural bioenergetic responses of normal myocardium to high workstates.  AJP - Heart and Circulatory Physiology.  268. 1995
    1995 Transmural distribution of 2‐deoxyglucose uptake in normal and post‐ischemic canine myocardium.  NMR in Biomedicine.  8:9-18. 1995
    1995 α1-Adrenergic tone does not influence the transmural distribution of myocardial blood flow during exercise in dogs with pressure overload left ventricular hypertrophy.  Basic Research in Cardiology.  90:73-83. 1995
    1994 Myocardial bioenergetic abnormalities in a canine model of left ventricular dysfunction.  Journal of the American College of Cardiology.  23:786-793. 1994
    1994 High-energy phosphate responses to tachycardia and inotropic stimulation in left ventricular hypertrophy.  AJP - Heart and Circulatory Physiology.  266. 1994
    1994 Hyperperfusion and cardioplegia effects on myocardial high-energy phosphate distribution and energy expenditure.  AJP - Heart and Circulatory Physiology.  267. 1994
    1993 Bioenergetic abnormalities associated with severe left ventricular hypertrophy.  Journal of Clinical Investigation.  92:993-1003. 1993
    1993 Contrast‐enhanced first pass myocardial perfusion imaging: Correlation between myocardial blood flow in dogs at rest and during hyperemia.  Magnetic Resonance in Medicine.  29:485-497. 1993
    1993 Coronary pressure-flow relation in left ventricular hypertrophy: Importance of changes in back pressure versus changes in minimum resistance.  Circulation Research.  72:579-587. 1993
    1993 Responses of myocardial high energy phosphates and wall thickening to prolonged regional hypoperfusion induced by subtotal coronary stenosis.  Magnetic Resonance in Medicine.  30:28-37. 1993
    1992 B1 voxel shifting of phase-modulated spectroscopic localization techniques.  Journal of Magnetic Resonance (1969).  97:486-497. 1992
    1990 Correlation between transmural high energy phosphate levels and myocardial blood flow in the presence of graded coronary stenosis.  Circulation Research.  67:660-673. 1990
    1989 Metabolic consequences of coronary stenosis. Transmurally heterogeneous myocardial ischemia studied by spatially localized 31P NMR spectroscopy.  NMR in Biomedicine.  2:317-328. 1989

    Chapter

    Year Title Altmetric
    2015 Cell transplantation for ischemic heart disease.  733-749. 2015
    2015 Current Perspectives on Methods for Administering Human Pluripotent Stem Cell-Derived Cells for Myocardial Repair.  297-308. 2015
    2012 Myocardial regeneration: The role of progenitor cells derived from bone marrow and heart.  195-215. 2012
    2008 Postnatal stem cells for myocardial repair.  221-262. 2008
    2005 Cell transplantation for ischemic heart disease.  613-629. 2005
    2005 Experimental cell transplantation for myocardial repair.  427-438. 2005

    Research Overview

  • Dr. Zhang's seminal contributions to cardiovascular physiology and cell therapy are:

    Use of in vivo NMR spectroscopy to study myocardial bioenergetic abnormality in hypertrophied and failing hearts;
    Cardiac cell therapy using adult or human pluripotent stem cells; and
    Design of scaffolds to enhance delivery of stem cells for cardiac repair.
    Using a canine model of severe LVH secondary to pressure overload, the Zhang lab was the first to demonstrate that in vivo LVH hearts are associated with myocardial bioenergetic inefficiency; the severity of this bioenergetic abnormality is linearly related to the severity of hypertrophy, but is independent from a persistent myocardial ischemia. The recent report from the Zhang lab of quantitatively measuring myocardial ATP hydrolysis rate in the in vivo heart using NMR spectroscopy has had a significant impact on the field of bioenergetics in vivo, not only to the cardiovascular sciences, but also to other important organ systems.

    In the past two decades, the Zhang lab’s active research areas have involved cell therapy for myocardial repair using autologous, allogenic adult stem cells, or human pluripotent stem cell (PSC) derived cardiac cells, and large-animal models of severe left-ventricular dysfunction with or without ischemic coronary artery disease. Dr. Zhang’s lab has been designing and fabricating myocardial tissue patches to examine the mechanisms and the functional outcomes of myocardial contractile-, bioenergetic-, and gene/protein expression changes in hearts receiving different types of cell transplantation (adult progenitor cells or iPSC-derivatives) using tissue engineering and molecular biochemistry tools.

    • Principal Investigator On

  • Development and Functional Assessment of Cardiovascular Tissue Engineering Therapy  awarded by National Institute of Biomedical Imaging and Bioengineering/NIH/DHHS 2018 - 2023
  • Deciphering the Neonatal Cardiac Regenerative Potential and Regulators in Large Animals  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2023
  • Integrated Cellular and Tissue Engineering for Ischemic Heart Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2023
  • Cell Therapy in Hypertrophied and Remodeled Left Ventricle  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2021
  • Improved Myocardial Infarct Repair via Implantation of Inducible Cyclin D2 Expressing iPS-derived Cardiomyocytes  awarded by American Heart Association 2019 - 2020
  • Maturing Cyclin-D2 Overexpressed Human Induced Pluripotent Stem Cell Derived Cardiomyocyte Spheroid Tissues For The Improvement of Left Ventricular Function After Myocardial Infarction  awarded by American Heart Association 2019 - 2020
  • Stem Cell Therapy for Myocardial Repair  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2020
  • Cardiovascular Bioengineering (CVBE) Symposium - 2019  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2020
  • PCTC Administrative Coordinating Center  awarded by University of Maryland 2018 - 2019
  • Myocardial Repair Using Human iPSC Derived Cardiac Muscle Patch  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2018
  • Progenitor Cell Biology Administrative Coordinating Center  awarded by University of Maryland 2016 - 2018
  • Bioenergetics in Hypertropied and Remodeled Left Ventricle  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2017
  • Midwestern Progenitor Cell Consortium  awarded by University of Minnesota 2015 - 2017

    • Investigator On

    Education And Training

  • Doctor of Philosophy in Biomedical Technology / Technician, University of Minnesota System : Crookston 1992
  • Master of Engineering in Biomedical / Medical Engineering, Tufts University 1987
  • Doctor of Medicine, Shanghai University 1983

    • Full Name

  • Jay Zhang