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Jianbo Wang Ph.D.
Associate Professor
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E-mail
j18wang@uab.edu
Phone
205-996-9594
Visualizations
Co-author Network
Map of Science
Co-investigator Network
Jianbo Wang Ph.D.
Associate Professor
Positions
Scientist
,
Cancer Cell Biology
,
O'Neal Comprehensive Cancer Center
Assistant Professor (S)
,
Genetics
,
Academic Joint Departments
2007 -
Associate Professor (P)
,
Cell, Developmental and Integrative Biology (CDIB)
,
Academic Joint Departments
2012 -
Scientist (C)
,
Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED)
,
School of Dentistry
2017 -
Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
2019 -
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2020
A conserved aromatic moiety in the ectodomain is a key determinant for structural integrity and protein trafficking of TNFR superfamily
.
The FASEB Journal
. 34:15687-15700.
2020
2019
Planar cell polarity signaling regulates polarized second heart field morphogenesis to promote both arterial and venous pole septation
2019
2018
Planar Cell Polarity Signaling in Mammalian Cardiac Morphogenesis.
.
Pediatric Cardiology
. 39:1052-1062.
2018
2017
Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis
.
Human Molecular Genetics
. 26:2053-2061.
2017
2016
Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice
.
Cardiovascular Research
. 112:532-542.
2016
2016
Spatial regulation of cell cohesion by Wnt5a during second heart field progenitor deployment.
.
Developmental Biology
. 412:18-31.
2016
2015
Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndrome
.
Human Molecular Genetics
. 24:1704-1716.
2015
2015
Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse development
.
Developmental Biology
. 398:177-192.
2015
2012
Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis
.
Developmental Biology
. 370:135-144.
2012
2012
Wnt signaling in mammalian development: Lessons from mouse genetics
.
Cold Spring Harbor perspectives in biology
. 4:6.
2012
2011
Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B
.
Human Molecular Genetics
. 20:271-285.
2011
2010
Planar polarization of node cells determines the rotational axis of node cilia
.
Nature Cell Biology
. 12:170-176.
2010
2008
Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development
.
PLoS Genetics
. 4:e1000259-e1000259.
2008
2007
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions
2007
2006
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
2006
2005
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway
.
Nature Genetics
. 37:980-985.
2005
2004
The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation
.
Current Opinion in Genetics and Development
. 14:533-539.
2004
2002
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure
2002
2002
Identification of a Wnt/Dvl/β-Catenin → Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development
.
Cell
. 111:673-685.
2002
2002
The mouse PcG gene eed is required for Hox gene repression and extraembryonic development
.
Mammalian Genome
. 13:493-503.
2002
2002
Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1
.
Neuron
. 35:489-505.
2002
2001
Imprinted X inactivation maintained by a mouse Polycomb group gene
.
Nature Genetics
. 28:371-375.
2001
2000
Mouse homolog of the Drosophila Pc-G gene esc exerts a dominant negative effect in Drosophila
2000
Chapter
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Year
Title
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2006
The Wnt Signaling Pathways in Mammalian Development and Morphogenesis
2006
Research
Research Overview
Cell polarity and signaling mechanisms in animal development and human diseases.
Principal Investigator On
The Role of Planar Cell Polarity Signaling in Outflow Tract Malformation in 22q11.2 Deletion Syndrome
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2017 - 2021
Planar Cell Polarity Signaling in Second Heart Field Development
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2011 - 2018
Mechanism of Vangl2-Mediated Planar Cell Polarity Signaling in Heart Development
awarded by
American Heart Association (Southeast Affiliate)
2014 - 2017
The Role of the Planar Cell Polarity Pathway in the Second Heart Field During Outflow Tract Morphogenesis
awarded by
American Heart Association
2012 - 2014
UAB Core Center for Basic Skeletal Research - P&F1
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2010 - 2012
Planar Cell Polarity Signaling in Mouse Second Heart Field Development
awarded by
American Heart Association (Southeast Affiliate)
2011
Characterizing the Mouse Dv12 Mediated Planar Cell Polarity/Convergent Extension Pathway in Heart Morphogenesis
awarded by
American Heart Association
2007 - 2011
Investigator On
Functional and Mechanistic Characterization of YWHAZ Variants Associated with Human Diseases
awarded by
National Institute of Child Health and Human Development/NIH/DHHS
2020 - 2024
UAB Core Center for Basic Skeletal Research
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2010 - 2012
Teaching
Teaching Activities
GBS717 - Methods & Sci Logic (Summer Term 2020)
2020
GBS710 - Cell Signaling (Spring Term 2020)
2020
GBS717 - Methods & Sci Logic (Summer Term 2019)
2019
GBS710 - Cell Signaling (Spring Term 2019)
2019
GBS717 - Methods & Sci Logic (Summer Term 2018)
2018
GBS717 - Methods & Sci Logic (Summer Term 2017)
2017
GBS717 - Methods & Sci Logic (Summer Term 2016)
2016
GBS717 - Methods & Sci Logic (Summer Term 2015)
2015
GBS717 - Methods & Sci Logic (Summer Term 2014)
2014
GBS717 - Methods & Sci Logic (Summer Term 2013)
2013
GBS717 - Methods & Sci Logic (Summer Term 2012)
2012
GBS717 - Methods & Sci Logic (Spring Term 2011)
2011
Background
Education And Training
Doctor of Philosophy in Genetics,
Case Western Reserve University
2001
Bachelor of Science or Mathematics in Cell Biology and Anatomy,
1992
Awards And Honors
Scientist Development Grant
,
2006
Beginning Grant-In-Aid
,
2006
Scholarship
,
2005
Scholarship
,
2004
Postdoctoral Fellowship
,
2004
Clifford & Evelyn Cherry Fellowship Award
,
2002
Pete Lopiccola Fellowship in Cancer Research
,
2001
The Verhosek Fund
,
1999
Scholarship for Best Academic Performance
,
1989
Contact
Full Name
Jianbo
Wang