Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein 2019
2019 Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo 2019
2019 Novel mutations in NSP2 abolish Chikungunya virus-induced transcriptional shutoff and make the virus less cytopathic without affecting its replication rates 2019
2019 Molecular Virology of Chikungunya Virus. 2019
2018 Multiple host factors interact with the hypervariable domain of chikungunya virus nsP3 and determine viral replication in cell-specific mode 2018
2018 Novel insect-specific Eilat virus-based chimeric vaccine candidates provide durable, mono- and multivalent, single-dose protection against lethal alphavirus challenge 2018
2018 β-D-N 4 -Hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome 2018
2018 Sindbis virus infection causes cell death by NSP2-induced transcriptional shutoff or by Nsp3-dependent translational shutoff 2018
2017 Aspicilia goettweigensis (Megasporaceae, lichenized Ascomycetes) – a poorly known and overlooked species in Europe and Russia 2017
2017 Hypervariable domain of eastern equine encephalitis virus nsP3 redundantly utilizes multiple cellular proteins for replication complex assembly 2017
2017 A chikungunya fever vaccine utilizing an insect-specific virus platform 2017
2016 New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes 2016
2016 The extensive geographical range of several species of Teloschistaceae: Evidence from Russia 2016
2016 Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode 2016
2016 The SD1 subdomain of venezuelan equine encephalitis virus capsid protein plays a critical role in nucleocapsid and particle assembly 2016
2015 Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya Infection 2015
2015 IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon 2015
2015 Long-term Socioeconomic Challenges for Russia and Demand for New Technology 2015
2015 Long-term Socioeconomic Challenges for Russia and Demand for New Technology 2015
2015 Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype 2015
2014 Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs 2014
2014 Interferon-stimulated poly(ADP-ribose) polymerases are potent inhibitors of cellular translation and virus replication 2014
2013 Hypervariable domain of nonstructural protein nsp3 of venezuelan equine encephalitis virus determines cell-specific mode of virus replication 2013
2013 Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions 2013
2013 Hypervariable Domains of nsP3 Proteins of New World and Old World Alphaviruses Mediate Formation of Distinct, Virus-Specific Protein Complexes 2013
2013 A chimeric Sindbis-based vaccine protects cynomolgus macaques against a lethal aerosol challenge of eastern equine encephalitis virus 2013
2013 IRES-driven Expression of the Capsid Protein of the Venezuelan Equine Encephalitis Virus TC-83 Vaccine Strain Increases Its Attenuation and Safety 2013
2013 Pseudoinfectious Venezuelan Equine Encephalitis Virus: A New Means of Alphavirus Attenuation 2013
2013 The amino-terminal domain of alphavirus capsid protein is dispensable for viral particle assembly but regulates RNA encapsidation through cooperative functions of its subdomains 2013
2012 New PARP gene with an anti-alphavirus function 2012
2012 Early events in alphavirus replication determine the outcome of infection 2012
2011 Chimeric chikungunya viruses are nonpathogenic in highly sensitive mouse models but efficiently induce a protective immune response 2011
2011 Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution. 2011
2011 Characterization of the replivax platform for replication-defective flavivirus vaccines 2011
2011 Novel chikungunya vaccine candidate with an ires-based attenuation and host range alteration mechanism 2011
2011 Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype 2011
2011 Conservation of a packaging signal and the Vira genome RNA packaging mechanism in alphavirus evolution 2011
2010 Functional sindbis virus replicative complexes are formed at the plasma membrane 2010
2010 Efficient, trans-complementing packaging systems for chimeric, pseudoinfectious dengue 2/yellow fever viruses 2010
2010 Infection, dissemination, and transmission of a west nile virus green fluorescent protein infectious clone by culex pipiens quinquefasciatus mosquitoes 2010
2010 Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid protein 2010
2009 Structural and functional elements of the promoter encoded by the 5′ untranslated region of the Venezuelan equine encephalitis virus genome 2009
2009 Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription 2009
2009 Chimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus 2009
2009 The 5′UTR-specific mutation in VEEV TC-83 genome has a strong effect on RNA replication and subgenomic RNA synthesis, but not on translation of the encoded proteins 2009
2008 Chapter 2 Third-Generation Flavivirus Vaccines Based on Single-Cycle, Encapsidation-Defective Viruses 2008
2008 Different types of nsP3-containing protein complexes in sindbis virus-infected cells 2008
2008 Chimeric alphavirus vaccine candidates for chikungunya 2008
2008 IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells 2008
2008 A new role for ns polyprotein cleavage in Sindbis virus replication 2008
2008 Identification of mutated cyclization sequences that permit efficient replication of West Nile virus genomes: Use in safer propagation of a novel vaccine candidate 2008
2008 Structural and nonstructural protein genome regions of eastern equine encephalitis virus are determinants of interferon sensitivity and murine virulence 2008
2008 Venezuelan equine encephalitis virus capsid protein inhibits nuclear import in mammalian but not in mosquito cells 2008
2008 Experimental infection of aedes sollicitans and Aedes taeniorhynchus with two chimeric sindbis/eastern equine encephalitis virus vaccine candidates 2008
2007 Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcription 2007
2007 Production of pseudoinfectious yellow fever virus with a two-component genome 2007
2007 Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection 2007
2007 Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice 2007
2007 Comparative analysis of the alphavirus-based vectors expressing Rift Valley fever virus glycoproteins 2007
2007 Adaptation of Venezuelan equine encephalitis virus lacking 51-nt conserved sequence element to replication in mammalian and mosquito cells 2007
2007 Development of Sindbis viruses encoding nsP2/GFP chimeric proteins and their application for studying nsP2 functioning 2007
2007 Recombinant alphaviruses are safe and useful serological diagnostic tools 2007
2007 The old world and new world alphaviruses use different virus-specific proteins for induction of transcriptional shutoff 2007
2006 Production and characterization of vaccines based on flaviviruses defective in replication 2006
2006 Evaluation of replicative capacity and genetic stability of West Nile virus replicons using highly efficient packaging cell lines 2006
2006 Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcription 2006
2006 Formation of nsP3-specific protein complexes during Sindbis virus replication 2006
2006 Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses 2006
2006 The efficient packaging of Venezuelan equine encephalitis virus-specific RNAs into viral particles is determined by nsP1-3 synthesis 2006
2005 Inhibition of transcription and translation in Sindbis virus-infected cells 2005
2005 Noncytopathic replication of Venezuelan equine encephalitis virus and eastern equine encephalitis virus replicons in mammalian cells 2005
2005 Dual mechanisms of pestiviral superinfection exclusion at entry and RNA replication 2005
2005 Venezuelan equine encephalitis virus in the guinea pig model: Evidence for epizootic virulence determinants outside the E2 envelope glycoprotein gene 2005
2005 Sindbis virus with a tricomponent genome 2005
2004 Gene therapy for malignant glioma using Sindbis vectors expressing a fusogenic membrane glycoprotein 2004
2004 PKR-dependent and -independent mechanisms are involved in translational shutoff during sindbis virus infection 2004
2004 Changes of the Secondary Structure of the 5′ End of the Sindbis Virus Genome Inhibit Virus Growth in Mosquito Cells and Lead to Accumulation of Adaptive Mutations 2004
2004 Analysis of the 3′ cis-Acting Elements of Rubella Virus by Using Replicons Expressing A Puromycin Resistance Gene 2004
2004 Uncleaved NS2-3 Is Required for Production of Infectious Bovine Viral Diarrhea Virus 2004
2004 Persistent infection and suppression of host response by alphaviruses. 2004
2004 Selection of Functional 5′ cis-Acting Elements Promoting Efficient Sindbis Virus Genome Replication 2004
2003 Recombinant Sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic 2003
2002 Roles of nonstructural protein nsP2 and alpha/beta interferons in determining the outcome of Sindbis virus infection 2002
2001 Cis-acting RNA elements at the 5′ end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis 2001
2001 Efficient translation initiation is required for replication of bovine viral diarrhea virus subgenomic replicons 2001
2000 Infection of human dendritic cells by a Sindbis virus replicon vector is determined by a single amino acid substitution in the E2 glycoprotein 2000
1999 Selection of RNA replicons capable of persistent noncytopathic replication in mammalian cells 1999
1999 Stable alphavirus packaging cell lines for Sindbis virus-and Semliki Forest virus-derived vectors 1999
1999 Construction of recombinant sindbis-based expression vectors for the study of HCV genes and their products. 1999
1998 cis-acting RNA elements required for replication of bovine viral diarrhea virus-hepatitis C virus 5' nontranslated region chimeras 1998
1998 Noncytopathic sindbis virus RNA vectors for heterologous gene expression 1998
1997 Packaging Signals in Alohaviruses 1997
1997 Sindbis virus replicons and sindbis virus: Assembly of chimeras and of particles deficient in virus RNA 1997
1996 Alphavirus-based expression vectors: Strategies and applications 1996
1996 Preparation and study of recombinant strains of Venezuelan equine encephalomyelitis virus expressing the PreS2-S gene of the hepatitis B virus 1996
1996 Translation of Sindbis virus mRNA: Analysis of sequences downstream of the initiating AUG codon that enhance translation 1996
1996 Construction and investigation of recombinant strains of Venezuelan equine encephalomyelitis virus expressing preS2-S gene of hepatitis B virus 1996
1995 Study of the structure-function organization of the variola virus genome. IV. Sequencing and analysis of the nucleotide sequence of the right terminus of the India-1967 strain genome 1995
1994 Translation of sindbis virus mRNA: Effects of sequences downstream of the initiating codon 1994
1994 Comparison of the effects of Sindbis virus and Sindbis virus replicons on host cell protein synthesis and cytopathogenicity in BHK cells 1994
1994 Localization of four antigenic sites involved in Venezuelan equine encephalomyelitis virus protection 1994
1994 A cell line that expresses a reporter gene in response to infection by Sindbis virus: A prototype for detection of positive strand RNA viruses 1994
1994 Study of structure-function organization of variola virus genome. III. Sequencing and analysis of the nucleotide sequence of conservative region of HindIII F, N and A genome fragments of India-1967 strain 1994
1993 Immunogenic properties of a recombinant vaccinia virus with incorporated cDNA copy of 26S RNA of Venezuelan equine encephalomyelitis virus 1993
1993 Sindbis virus expression vectors: Packaging of RNA replicons by using defective helper RNAs 1993
1993 Recombinant equine Venezuelan encephalomyelitis virus, expressing HBsAg 1993
1993 Nucleotide sequence analysis of variola virus HindIII M, L, I genome fragments 1993
1992 Effect of mutations in genes of Venezuelan equine encephalomyelitis virus structural proteins on its attenuation 1992
1992 Obtaining infectious Venezuelan equine encephalomyelitis virus based on a full length DNA copy of its genome 1992
1992 Study of the prospects for creating vector systems based on the alpha-virus genome 1992
1992 The study of structure-functional organization of variola virus genome. I. Cloning of viral HindIII and XhoI DNA fragments and sequencing of HindIII M, L, I fragments 1992
1991 Variants of the Venezuelan equine encephalomyelitis virus resistant to the neutralizing action of monoclonal antibodies 1991
1991 Comparison of the amino acid sequence of structural proteins from attenuated and pathogenic strains of the Venezuelan equine encephalomyelitis virus 1991
1990 A comparison of the primary structures of the 26S RNA in variants of the eastern equine encephalomyelitis virus 1990
1989 Primary structure of the avian influenza virus A/FVP/Weybridge hemagglutinin gene 1989

Principal Investigator On

  • Mechanistic Understanding of SH3 Domain-containing Protein Function in Alphavirus Replication  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2021
  • Mechanism of Alphavirus Packaging: Designing of Pseudoinfectious Viruses  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2020
  • Revolutionary Eilat-based Chikungunya Vaccine Vector  awarded by UNIVERSITY OF TEXAS MEDICAL BRANCH (GALVESTON) 2017 - 2019
  • Single Round Infection Chikungunya Virus as a New Vaccine Candidate  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2019
  • Development of a Ribonucleoside Analog to Treat VEEV Infections  awarded by Emory University 2015 - 2018
  • Evaluation of Recombinant Eilat Virus as Viral Vector for Expression of the Heterologous Antigen Genes Canine Parainfluenza Virus HN and F Protein Genes and Rabies G Protein Gene  awarded by University of Texas Medical Branch 2015 - 2016
  • The Molecular Basis of VEEV Pathogenesis  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2015
  • New Generation of Efficient Vaccines Against Encephalitogenic Alphaviruses  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2014
  • Chimeric Alphavirus Vaccines for Chikungunya  awarded by UNIVERSITY OF TEXAS MEDICAL BRANCH (GALVESTON) 2009 - 2012
  • Interaction of Sindbis Virus with Cellular Processes  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2011
  • Full Name

  • Ilya Frolov