Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 FK506-binding protein 12.6/1b, a negative regulator of [Ca 2+ ], rescues memory and restores genomic regulation in the hippocampus of aging ratsJournal of Neuroscience.  38:1030-1041. 2018
2018 Inhibition of amyloid Aβ aggregation by high pressures or specific d-enantiomeric peptidesChemical Communications.  54:3294-3297. 2018
2017 Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampusBMC Neuroscience.  18. 2017
2017 The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathologyScientific Reports.  7. 2017
2017 Optimization of d -Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ OligomersACS Chemical Neuroscience.  8:1889-1900. 2017
2017 Vitamin A and retinoic acid combination attenuates neonatal hyperoxia-induced neurobehavioral impairment in adult miceNeurobiology of Learning and Memory.  141:209-216. 2017
2016 Dietary composition affects the development of cognitive deficits in WT and Tg AD model miceExperimental Gerontology.  86:39-49. 2016
2016 Observational research rigour alone does not justify causal inferenceEuropean Journal of Clinical Investigation.  46:985-993. 2016
2016 Blood-brain barrier penetration of an Aβ-targeted, arginine-rich, D-enantiomeric peptideBBA - Biomembranes.  1858:2717-2724. 2016
2016 Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer's disease transgenic female micePharmacological Research.  113:781-787. 2016
2016 Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d -Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ SpeciesACS Chemical Neuroscience.  7:1088-1096. 2016
2016 Allelic series of Huntington's disease knock-in mice reveals expression discorrelatesHuman Molecular Genetics.  25:1619-1636. 2016
2015 QIAD assay for quantitating a compounds efficacy in elimination of toxic Aβ oligomersScientific Reports.  5. 2015
2015 Reversal of aging-related neuronal Ca2+ dysregulation and cognitive impairment by delivery of a transgene encoding FK506-binding protein 12.6/1b to the hippocampusJournal of Neuroscience.  35:10878-10887. 2015
2015 Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer's disease mouse modelScientific Reports.  5. 2015
2015 A novel 1,4-dihydropyridine derivative improves spatial learning and memory and modifies brain protein expression in wild type and transgenic APPSweDI MicePLoS ONE.  10. 2015
2014 FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca 2+ dysregulation?European Journal of Pharmacology.  739:74-82. 2014
2014 Mildronate improves cognition and reduces amyloid-β pathology in transgenic Alzheimer's disease miceJournal of Neuroscience Research.  92:338-346. 2014
2014 Axonal tract tracing for delineating interacting brain regions: Implications for Alzheimer's disease-associated memoryFuture Neurology.  9:89-98. 2014
2013 Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 ratsNeurobiology of Aging.  34:1977-1987. 2013
2013 Glucocorticoid-dependent hippocampal transcriptome in male rats: Pathway-specific alterations with agingEndocrinology.  154:2807-2820. 2013
2013 Hunger in the Absence of Caloric Restriction Improves Cognition and Attenuates Alzheimer's Disease Pathology in a Mouse ModelPLoS ONE.  8. 2013
2013 Neurodevelopmental impairment following neonatal hyperoxia in the mouseNeurobiology of Disease.  50:69-75. 2013
2013 In vivo and in vitro effects of an apolipoprotein E mimetic peptide on amyloid-β pathologyJournal of Alzheimer's Disease.  36:335-347. 2013
2013 Treatment with D3 removes amyloid deposits, reduces inflammation, and improves cognition in aged AβPP/PS1 double transgenic miceJournal of Alzheimer's Disease.  34:609-620. 2013
2012 Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of alzheimer's diseaseJournal of Alzheimer's Disease.  30:943-961. 2012
2012 Treatment with Aβ42 binding d-amino acid peptides reduce amyloid deposition and inflammation in APP/PS1 double transgenic miceAdvances in Protein Chemistry and Structural Biology.  88:133-152. 2012
2011 Age-related brain pathology in Octodon degu: Blood vessel, white matter and Alzheimer-like pathologyNeurobiology of Aging.  32:1651-1661. 2011
2011 Insufficient DNA methylation affects healthy aging and promotes age-related health problemsClinical Epigenetics.  2:349-360. 2011
2011 Disrupting function of FK506-binding protein 1b/12.6 induces the Ca 2+-dysregulation aging phenotype in hippocampal neuronsJournal of Neuroscience.  31:1693-1703. 2011
2011 Transgenic AD model mice, effects of potential anti-AD treatments on inflammation, and pathologyJournal of Alzheimer's Disease.  24:301-313. 2011
2010 Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of alzheimer's disease transgenic miceACS Chemical Neuroscience.  1:639-648. 2010
2009 Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's diseaseNeurobiology of Disease.  34:525-534. 2009
2009 DNA methylation impacts on learning and memory in agingNeurobiology of Aging.  30:549-560. 2009
2009 In vitro and in vivo staining characteristics of small, fluorescent, Aβ42-binding D-enantiomeric peptides in transgenic AD mouse modelsChemMedChem.  4:276-282. 2009
2009 Hippocampal and cognitive aging across the lifespan: A bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairmentJournal of Neuroscience.  29:1805-1816. 2009
2009 Lesion-induced hippocampal plasticity in transgenic alzheimer's disease mouse models: Influences of age, genotype, and estrogenJournal of Alzheimer's Disease.  18:429-445. 2009
2009 Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary SyndromeGastroenterology.  136:1070-1080. 2009
2008 Reduction of Alzheimer's disease amyloid plaque load in transgenic mice by D3, a D-enantiomeric peptide identified by mirror image phage displayChemMedChem.  3:1848-1852. 2008
2008 Subfield and layer-specific depletion in calbindin-D28K, calretinin and parvalbumin immunoreactivity in the dentate gyrus of amyloid precursor protein/presenilin 1 transgenic miceNeuroscience.  155:182-191. 2008
2007 Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged ratsJournal of Neuroscience.  27:3098-3110. 2007
2006 Deposition of mouse amyloid β in human APP/PS1 double and single AD model transgenic miceNeurobiology of Disease.  23:653-662. 2006
2005 Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's modelsJournal of Neuroscience.  25:4649-4658. 2005
2005 Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: Statistical reliability and functional correlationAgeing Research Reviews.  4:481-512. 2005
2005 Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathologyBrain Research Reviews.  48:370-378. 2005
2004 Retrosplenial cortex lesions of area Rgb (but not of area Rga) impair spatial learning and memory in the ratBehavioural Brain Research.  154:483-491. 2004
2004 Erratum: Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice (Neurobiology of Disease (2003) 14 (318-327) DOI: 10.1016/j.nbd.2003.08.009)Neurobiology of Disease.  16:290. 2004
2003 Age-related decline in spatial learning and memory: Attenuation by captoprilClinical and experimental hypertension.  25:455-474. 2003
2003 Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesionsNeuroscience.  119:1185-1197. 2003
2003 The entorhinal cortex of the mouse: Organization of the projection to the hippocampal formationHippocampus.  13:133-149. 2003
2003 Differences in lesion-induced hippocampal plasticity between mice and ratsNeuroscience.  116:499-509. 2003
2003 Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic miceNeurobiology of Disease.  14:318-327. 2003
2002 The role of the laterodorsal nucleus of the thalamus in spatial learning and memory in the ratBehavioural Brain Research.  136:329-337. 2002
2002 Old rats remember old tricks; memories of the water maze persist for 12 monthsBehavioural Brain Research.  136:247-255. 2002
2002 Low Levels of Estrogen Significantly Diminish Axonal Sprouting after Entorhinal Cortex Lesions in the MouseJournal of Neuroscience.  22:4095-4102. 2002
2002 Role of the anterodorsal and anteroventral nuclei of the thalamus in spatial memory in the ratBehavioural Brain Research.  132:19-28. 2002
2002 Transgenic mice expressing the human presenilin 1 gene demonstrate enhanced hippocampal reorganization following entorhinal cortex lesionsBrain Research Bulletin.  57:587-594. 2002
2002 Species differences in the projections from the entorhinal cortex to the hippocampusBrain Research Bulletin.  57:553-556. 2002
2001 Chronic, severe hypertension does not impair spatial learning and memory in Sprague-Dawley ratsLearning and Memory.  8:104-111. 2001
2000 Age-related decline in water maze learning and memory in rats: Strain differencesNeurobiology of Aging.  21:671-681. 2000
1999 Efferent connections of the anteromedial nucleus of the thalamus of the ratBrain Research Reviews.  30:1-26. 1999
1999 Distribution of neurons in the anterior hypothalamic nucleus activated by blood pressure changes in the ratBrain Research Bulletin.  49:163-172. 1999

Chapter

Year Title Altmetric
2014 The limbic system plays a significant role in epilepsy.  1-20. 2014
2014 Ongoing studies of deimination in neurodegenerative diseases using the F95 antibody.  257-280. 2014
2010 Aging and non-sirtuin histone modifications.  41-50. 2010
2008 Disorders of the limbic system.  397-399. 2008
2008 The limbic system.  379-396. 2008

Education And Training

  • Doctor of Philosophy in Neuroscience, 2002
  • Full Name

  • Inga Kadisha