Positions

Overview

  • Irshad H. Chaudry was born on May 2, 1945. He received a B.S. as well as M.S. with honors from Sind University, and a Ph.D. from Monash University, Australia. After his postdoctoral training at Toronto University, Canada, he was an appointed as an Instructor and subsequently as an Assistant Professor at the Jewish Hospital and Washington University School of Medicine. He then moved to Yale University as an Associate Professor and subsequently became a Professor. He moved to Michigan State University in 1986 as Professor and Director of Research and in 1996 became the Director of the Center for Surgical Research at Brown University. In 2000, he became the Director of the Center for Surgical Research at the University of Alabama at Birmingham. His has over 600 publications to his credit and is a recipient of the NIH MERIT award.

    Current research interests include determining the mechanisms responsible for cellular and subcellular alterations following soft tissue trauma, bone fracture, hemorrhage and sepsis. Additionally, the use of novel, readily available, FDA approved inexpensive therapeutic agents to attenuate such alterations in patients following trauma is planned. Other areas include evaluation of: (1) gender dimorphism and the mechanisms responsible for producing cardiovascular and hepatocellular dysfunction and immunological alterations following trauma-hemorrhage; (2) trauma-induced changes in the hypothalamus-pituitary-adrenal axis; (3) apoptosis of immune cells; and (4) wound healing. Specific research interests include determining the mechanism of regulation of estradiol levels by hypothalamic/pituitary factors, adrenals and steroidogenic enzyme activity and how differences in estradiol levels or the estradiol: androgen ratio due to the estrus cycle, ovariectomy, and age affect immune responses after trauma. Studies of T lymphocytes, macrophages and Kupffer cell functions using molecular biological techniques are being conducted to determine why low estradiol fails to maintain immune functions in aged females after trauma. The use of estradiol, Raloxifene, prolactin, metoclopramide, or flutamide to restore immune/cardiovascular functions following trauma should yield novel information and provide an innovative approach for improving the host responses and reducing mortality from sepsis following trauma in postmenopausal and in surgically ovariectomized patients with low estrogen activity. Additional interests encompass the mechanisms by which androgen depletion/androgen antagonists improve cardiac performance and other organ functions after trauma. These studies also examine whether androgen depletion/androgen antagonists affect the adrenals and modify the response of the heart, liver and vascular smooth muscle to catecholamines. The hemodynamic parameters and organ functions being measured include blood flow, circulating blood volume, cardiac output, left ventricular performance, vascular reactivity, liver, gut, adrenal and pulmonary functions. The integration of cardiac function with other organ functions and detailed mechanistic studies at the cellular and subcellular levels using physiological, pharmacological and molecular biology techniques to identify targets for novel treatment modalities using sex steroid antagonists/agonists or hormones should provide new information for the improved treatment of trauma victims with major blood loss and for decreasing the susceptibility to sepsis following trauma.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Part III: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Fluid Resuscitation and Antimicrobial Therapy Endpoints 2019
    2019 Premise for Standardized Sepsis Models 2019
    2018 Gender differences in trauma, shock and sepsis 2018
    2018 Minimum quality threshold in pre-clinical sepsis studies (mqtipss): An international expert consensus initiative for improvement of animal modeling in sepsis 2018
    2017 Hepatoprotective effects of corilagin following hemorrhagic shock are through Akt-dependent pathway 2017
    2016 The Role and Use of Estrogens Following Trauma 2016
    2015 Hepatoprotective effect of casodex after trauma hemorrhage in a rodent model 2015
    2015 Expression of Concern 2015
    2015 Inflammatory response to traumatic injury: Clinical and animal researches in inflammation 2015
    2015 The ERRor of our ways: Estrogen-related receptors are about energy, not hormones, and are potential new targets for trauma and shock 2015
    2014 Abandon the mouse research ship? Not just yet! 2014
    2014 Efficacy of 17α-ethynylestradiol-3-sulfate for severe hemorrhage in minipigs in the absence of fluid resuscitation 2014
    2014 Gender differences in sepsis: Cardiovascular and immunological aspects 2014
    2014 Gender-specific effects on immune response and cardiac function after trauma hemorrhage and sepsis 2014
    2014 Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model 2014
    2014 The august krogh principle: Seeking unity in diversity: Reply 2014
    2013 Trauma-associated human neutrophil alterations revealed by comparative proteomics profiling 2013
    2013 Tranexamic acid and trauma: Current status and knowledge gaps with recommended research priorities 2013
    2013 Hepatic gene expression patterns following trauma-hemorrhage: Effect of posttreatment with estrogen 2013
    2012 Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1 2012
    2011 Liver X receptor protects against liver injury in sepsis caused by rodent cecal ligation and puncture 2011
    2011 Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury 2011
    2011 Lidocaine suppresses mouse Peyer's Patch T cell functions and induces bacterial translocation 2011
    2010 Single photon emission computed tomography demonstrated efficacy of 17β-estradiol therapy in male rats after trauma-hemorrhage and extended hypotension 2010
    2010 Lidocaine enhances apoptosis and suppresses mitochondrial functions of human neutrophil in vitro 2010
    2010 Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotension 2010
    2010 Hypoxia-induced alteration of mitochondrial genes in cardiomyocytes: Role of Bnip3 and Pdk1 2010
    2010 Mechanism of the anti-inflammatory effect of 17β-estradiol on brain following trauma-hemorrhage 2010
    2009 Erratum: Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels (Shock (2008) 30 (372-378)) 2009
    2009 Analysis of the relationship between longitudinal gene expressions and ordered categorical event data 2009
    2009 Inflammation and the host response to injury, a large-scale collaborative project: Patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients 2009
    2009 Estrogen suppresses cardiac IL-6 after trauma-hemorrhage via a hypoxia-inducible factor 1α-mediated pathway 2009
    2009 Therapy of hemorrhagic shock : New strategies based on experimental results 2009
    2009 The role of estrogen and receptor agonists in maintaining organ function after trauma-hemorrhage 2009
    2009 When apoptosis meets autophagy: deciding cell fate after trauma and sepsis 2009
    2009 Role of extracellular signal-regulated protein kinase (ERK) in 17β-estradiol-mediated attenuation of lung injury after trauma-hemorrhage 2009
    2008 Estradiol's salutary effects on keratinocytes following trauma-hemorrhage are mediated by estrogen receptor (ER)-α and ER-β 2008
    2008 Estrogen: A novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations (Molecular Medicine (2008) 14, 3-4, (213-221)) 2008
    2008 Systematic analysis of the salutary effect of estrogen on cardiac performance after trauma-hemorrhage 2008
    2008 Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels 2008
    2008 Acute alcohol intoxication potentiates neutrophil-mediated intestinal tissue damage after burn injury 2008
    2008 Effect of 17β-estradiol on signal transduction pathways and secondary damage in experimental spinal cord trauma 2008
    2008 Estrogen: A novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations 2008
    2008 Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice 2008
    2008 17β-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-α 2008
    2007 Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhage 2007
    2007 V. Guidelines for sedation and analgesia during mechanical ventilation general overview 2007
    2007 Regulation of the postburn wound inflammatory response by γδ T-cells 2007
    2007 17β-Estradiol normalizes Toll receptor 4, mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhage 2007
    2007 TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage 2007
    2007 The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels 2007
    2007 17β-Estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage 2007
    2007 Influence of sex and age on mods and cytokines after multiple injuries 2007
    2006 Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways 2006
    2006 High dynamic range characterization of the trauma patient plasma proteome 2006
    2006 17β-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-α 2006
    2006 Glucosamine administration during resuscitation improves organ function after trauma hemorrhage 2006
    2006 MyD88 and Src are differentially regulated in Kupffer cells of males and proestrus females following hypoxia 2006
    2006 Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury 2006
    2005 Cecal ligation and puncture 2005
    2005 Erratum: A network-based analysis of systemic inflammation in humans (Nature (2005) 437 (1032-1037) DOI: 10.1038/nature03985) 2005
    2005 Gender differences in acute response to trauma-hemorrhage 2005
    2005 Dehydroepiandrosterone modulates toll-like receptor expression on splenic macrophages of mice after severe polymicrobial sepsis 2005
    2005 Salutary effects of androstenediol on hepatic function after trauma-hemorrhage are mediated via peroxisome proliferators-activated receptor gamma 2005
    2005 L-arginine improves wound healing after trauma-hemorrhage by increasing collagen synthesis 2005
    2005 Mechanism responsible for the salutary effects of flutamide on cardiac performance after trauma-hemorrhagic shock: Upregulation of cardiomyocyte estrogen receptors 2005
    2005 Surgical trauma and immunosuppression: Pathophysiology and potential immunomodulatory approaches 2005
    2005 Quantitative proteome analysis of human plasma following in vivo lypopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach 2005
    2005 Application of genome-wide expression analysis to human health and disease 2005
    2005 Genetic variability in the immune-inflammatory response after major burn injury 2005
    2004 The role of the mitochondrion in trauma and shock 2004
    2004 Enhanced isolated pancreatic islet recovery and functionality in rats by 17β-estradiol treatment of brain death donors 2004
    2004 Metabolic disturbances in shock, and the role of ATP-MgCl2 and sex steroids 2004
    2003 Endocrine targets in experimental shock. 2003
    2003 Age-related gender differential in outcome after blunt or penetrating trauma. 2003
    2003 Differential fluid regulation during and after soft tissue trauma and hemorrhagic shock in males and proestrus females. 2003
    2003 Regulation of macrophage IL-10 production postinjury via beta2 integrin signaling and the P38 MAP kinase pathway. 2003
    2003 The association between gender and mortality among trauma patients as modified by age 2003
    2002 A universal distribution for component failure times 2002
    2002 Differential alterations in cardiovascular responses during the progression of polymicrobial sepsis in the mouse 2002
    2002 Gender differences in mortality following burn injury 2002
    2002 Scientific priorities and strategic planning for resuscitation research and life saving therapy following traumatic injury: Report of the PULSE Trauma Work Group 2002
    2001 Continuous resuscitation after hemorrhage and acute fluid replacement improves cardiovascular responses 2001
    2001 Cyclooxygenase-2-mediated regulation of Kupffer cell interleukin-6 production following trauma-hemorrhage and subsequent sepsis 2001
    2001 DHEA: A novel adjunct for the treatment of male trauma patients 2001
    2001 Evolution of an immune suppressive macrophage phenotype as a product of p38 MAPK activation in polymicrobial sepsis 2001
    2001 Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis 2001
    2000 Androgen and estrogen receptors in splenic T lymphocytes: Effects of flutamide and trauma-hemorrhage 2000
    2000 Critical role of oxygen radicals in the initiation of hepatic depression after trauma hemorrhage 2000
    2000 Does burn wound excision after thermal injury attenuate subsequent macrophage hyperactivity and immunosuppression? 2000
    2000 Effect of gender and sex hormones on immune responses following shock 2000
    2000 IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis 2000
    2000 Insight into the mechanism by which estradiol improves organ functions after trauma-hemorrhage 2000
    2000 The aromatase inhibitor, 4-hydroxyandrostenedione, restores immune responses following trauma-hemorrhage in males and decreases mortality from subsequent sepsis 2000
    2000 Upregulation of inducible nitric oxide synthase and nitric oxide occurs later than the onset of the hyperdynamic response during sepsis 2000
    1999 Reply: Letters to the editor 1999
    1999 Differential alterations in systemic and regional oxygen delivery and consumption during the early and late stages of sepsis 1999
    1999 Does fas ligand or endotoxin contribute to thymic apoptosis during polymicrobial sepsis? 1999
    1999 Gender dimorphism in trauma-hemorrhage-induced thymocyte apoptosis 1999
    1999 Trauma-hemorrhage delays wound healing potentially by increasing pro- inflammatory cytokines at the wound site 1999
    1999 What is the role of interleukin 10 in polymicrobial sepsis: Anti- inflammatory agent or immunosuppressant? 1999
    1998 Trauma-hemorrhage activates signal transduction pathways in mouse splenic T cells 1998
    1998 Cardiac contractility and structure are not significantly compromised even during the late, hypodynamic stage of sepsis 1998
    1998 L-arginine restores the depressed cardiac output and regional perfusion after trauma-hemorrhage 1998
    1998 Lymphocyte Apoptosis in Sepsis 1998
    1998 The contribution of soft-tissue trauma and/or bone fracture to depressed immunity following hemorrhagic shock in an experimental setting 1998
    1998 Up-regulation of a novel potent vasodilatory peptide adrenomedullin during polymicrobial sepsis 1998
    1997 Impaired enterocyte triglyceride synthesis after trauma-hemorrhage and resuscitation. 1997
    1997 Intestinal alkaline phosphatase: role in the depressed gut lipid transport after trauma-hemorrhagic shock. 1997
    1997 Flutamide: A novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock 1997
    1996 Immune dysfunction in murine polymicrobial sepsis: Mediators, macrophages, lymphocytes and apoptosis 1996
    1996 Impaired enterocyte triglyceride synthesis after trauma-hemorrhage and resuscitation 1996
    1996 Intestinal alkaline phosphatase: Role in the depressed gut lipid transport after trauma-hemorrhagic shock 1996
    1996 Depressed osteoblast activity and increased osteocyte necrosis after closed bone fracture and hemorrhagic shock 1996
    1996 Platelet activating factor and its role in trauma, shock, and sepsis 1996
    1996 Inhibition of the Biologic Activity of Tumor Necrosis Factor Maintains Vascular Endothelial Cell Function during Hyperdynamic Sepsis 1996
    1996 Is Sepsis-Induced Apoptosis Associated with Macrophage Dysfunction? 1996
    1996 A novel nonanticoagulant heparin prevents vascular endothelial cell dysfunction during hyperdynamic sepsis 1996
    1996 Administration of a matrix metalloproteinase inhibitor after hemorrhage improves cardiovascular and hepatocellular function 1996
    1996 Pentoxifylline maintains vascular endothelial cell function during hyperdynamic and hypodynamic sepsis 1996
    1996 Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes 1996
    1995 Effect of surgical trauma on splenocyte and peritoneal macrophage immune function 1995
    1995 Dietary n-3 polyunsaturated fatty acid modulation of immune cell function before or after trauma 1995
    1995 Hepatocellular dysfunction occurs earlier than the onset of hyperdynamic circulation during sepsis 1995
    1995 Sustained elevation in circulating catecholamine levels during polymicrobial sepsis 1995
    1995 The gut: A cytokine-generating organ in systemic inflammation? 1995
    1995 The induction of accelerated thymic programmed cell death during polymicrobial sepsis: Control by corticosteroids but not tumor necrosis factor 1995
    1995 The role of bacterial translocation on Kupffer cell immune function following hemorrhage. 1995
    1995 Trauma-hemorrhage causes prolonged depression in cellular immunity 1995
    1995 Tumor necrosis factor-α administration increases kupffer cell cyclic adenosine monophosphate levels 1995
    1994 Aggressive fluid resuscitation following intestinal ischemia-reperfusion in immature rats prevents metabolic derangements and down regulates interleukin-6 release 1994
    1994 Chemically modified heparin improves hepatocellular function, cardiac output, and microcirculation after trauma-hemorrhage and resuscitation 1994
    1994 Differential alterations in cyclic nucleotide levels in kupffer cells and hepatocytes following trauma-hemorrhage and resuscitation 1994
    1994 Editorial 1994
    1994 Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock 1994
    1994 Hemorrhage induces a reduction in the capacity of macrophages to mobilize intracellular calcium secondary to formyl-methionyl-leucyl-phenylalanine stimulation: Association with alterations in cell surface Fc receptor expression and increased prostaglandin release 1994
    1994 Role of kupffer cells in interleukin-6 release following trauma-hemorrhage and resuscitation 1994
    1994 Severe depression of gut absorptive capacity in patients following trauma or sepsis 1994
    1993 Reperfusion injury following testicular torsion and detorsion in prepubertal rats 1993
    1993 Pentoxifylline restores cardiac output and tissue perfusion after trauma- hemorrhage and decreases susceptibility to sepsis 1993
    1993 Prevention of peritoneal adhesions by administration of sodium carboxymethyl cellulose and oral vitamin E 1993
    1993 Restoration of gut absorptive capacity following trauma-hemorrhagic shock by the adjuvant use of heparan sulfate 1993
    1992 Adenosine triphosphate-magnesium chloride in radiation injury 1992
    1992 Energetics of defective macrophage antigen presentation after hemorrhage as determined by ultraresolution 31P nuclear magnetic resonance spectrometry: Restoration with adenosine triphosphate-MgCl2 1992
    1992 Erratum: Energetics of defective macrophage antigen presentation after hemorrhage as determined by ultraresolution 31P nuclear magnetic resonance spectrometry: Restoration with adenosine triphosphate-MgCl2 (Surgery (1992) 112 (150-158)) 1992
    1992 Hepatocellular dysfunction persists during early sepsis despite increased volume of crystalloid resuscitation 1992
    1992 Interferon-γ attenuates hemorrhage-induced suppression of macrophage and splenocyte functions and decreases susceptibility to sepsis 1992
    1992 Mechanism of the beneficial effects of pentoxifylline on hepatocellular function after trauma hemorrhage and resuscitation 1992
    1992 Protective effects of preheparinization on the microvasculature during and after hemorrhagic shock 1992
    1991 Adequate crystalloid resuscitation restores but fails to maintain the active hepatocellular function following hemorrhagic shock 1991
    1991 Eicosanoids regulate tumor necrosis factor synthesis after hemorrhage in vitro and in vivo 1991
    1990 Passive immunization against cachectin (TNF-α) prevents hemorrhage-induced suppression of kupffer cell functions 1990
    1990 Sepsis selectively activates peritoneal but not alveolar macrophage to release inflammatory mediators (IL-1, IL-6, and TNF) 1990
    1989 ATP-MgCl2 and liver blood flow following shock and ischemia. 1989
    1988 Mechanism of calcium and magnesium translocation in acute pancreatitis: A temporal correlation between hypocalcemia and membrane-mediated excessive intracellular calcium accumulation in soft tissues 1988
    1988 Use of magnesium-ATP following liver ischemia 1988
    1987 Depressed antigen presentation function and membrane interleukin-1 activity of peritoneal macrophages after laparotomy 1987
    1987 Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity 1987
    1986 Improved myocardial performance after prolonged ischemia with ATP-MgCl2cardioplegia 1986
    1986 The role of ATP-magnesium in ischemia and shock. 1986
    1986 Verapamil and ATP-MgCl2prevents cyclosporin-induced nephrotoxocity by improving mitochondrial and tissue Ca2+/Mg2+ratios 1986
    1985 Effects of regenerating liver cytosol on drug-induced hepatic failure 1985
    1985 Alleviation of cyclosporine nephrotoxicity with verapamil and adenosine triphosphate-magnesium chloride treatment 1985
    1985 Cellular alterations in shock and ischemia and their correction 1985
    1985 Increased coronary flow and myocardial efficiency with systemic infusion of adenosine triphosphate-magnesium chloride 1985
    1984 A cyclophosphamide-sensitive suppressor T cell circuit induced by thermal injury 1984
    1984 ATP-MgCl2infusion in man: Increased cardiac output without adverse systemic hemodynamic effects 1984
    1984 Improved skin flap survival with adenosine triphosphate-magnesium chloride 1984
    1984 Insulin resistance and depressed gluconeogenic capability during early hyperglycemic sepsis 1984
    1984 Nuclear magnetic resonance studies showing the reperfusion injury following ischemia and its improvement with ATP-MgCl2treatment 1984
    1983 Adenosine triphosphate uptake by liver - leaky cells or specific transport? 1983
    1983 Alterations in electron transport and cellular metabolism with shock and trauma. 1983
    1983 Beneficial effects of implanted muscle tissue on pulmonary particulate retention and survival following splenectomy 1983
    1983 Effect of immunopotentiators on Kupffer cell function and DNA synthesis after ischemia and partial hepatectomy 1983
    1983 Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model 1983
    1982 Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2 1982
    1982 Does ATP cross the cell plasma membrane? 1982
    1982 Hepatic gluconeogenic capability in sepsis is depressed before changes in oxidative capability 1982
    1981 Effect of prolonged starvation on reticuloendothelial function and survival following trauma 1981
    1981 Effects of ATP-MgCl2on hepatic metabolism and oxygen consumption 1981
    1981 Improved renal function using adenosine triphosphate-magnesium chloride in preservation of canine kidneys subjected to warm ischemia 1981
    1981 Restoration of the depressed immune response after burn injury with low-dose cyclophosphamide 1981
    1980 Amelioration of toxic acute renal failure by infusion of ATP-MgCl2 1980
    1980 Effect of splenectomy on reticuloendothelial function and survival following sepsis 1980
    1980 Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats 1980
    1980 Improved myocardial performance with infusion of adenosine triphosphate-MgCl2 1980
    1980 Is there a positive muscarinic feedback mechanism for acetylcholine release at the neuromuscular junction? 1980
    1980 Prevention of multiple systems failure 1980
    1979 Effect of sepsis on tissue adenine nucleotide levels 1979
    1979 Prostaglandin metabolism, synthesis, and blockade in hemorrhage and sepsis 1979
    1978 Improved hepatic function and survival with adenosine triphosphate magnesium chloride after hepatic ischemia 1978
    1978 The use of adenosine triphosphate with magnesium chloride in the treatment of post ischemic renal injury. 1978
    1978 Beneficial effect of ATP-MgCl2-glucose administration on survival following sepsis 1978
    1978 Enhanced recovery from severe ischemic renal injury with adenosine triphosphate-magnesium chloride: Administration after the insult 1978
    1977 Depletion and replenishment of cellular cyclic adenosine monophosphate in hemorrhagic shock 1977
    1977 Accelerated recovery of acute renal failure by infusion of adenine nucleotides - MgCl2 1977
    1977 Amelioration of acute renal failure with ATP MgCl2 infusion 1977
    1976 Alterations in adenosine 3',5' monophosphate levels in hemorrhagic shock 1976
    1976 Alterations in high-energy phosphates in hemorrhagic shock as related to tissue and organ function 1976
    1975 Degradation of adenine nucleotides by the soleus muscle in hemorrhagic shock 1975
    1975 Evidence for enhanced uptake of adenosme triphosphate by muscle of animals in shock 1975
    1975 Na+-K+ transport and adenosine nucleotides in the lung in hemorrhagic shock 1975
    1975 Relationship between nicotinamide adenine dinucleotide and survival in hemorrhagic shock 1975
    1975 Reversal of insulin resistance by in vivo infusion of ATP in experimental shock 1975
    1974 Active sodium potassium transport and ATP levels in lung and liver during shock 1974
    1974 Distribution of High-Energy Phosphates in the Heart 1974
    1974 Effect of adenosine triphosphate-magnesium chloride administration in shock 1974
    1973 ATP depletion and replenishment in hemorrhagic shock. 1973
    1973 The Effect of Low ATP on Glucose Uptake in Soleus Muscle During Hemorrhagic Shock 1973
    1972 Alterations in adenosine nucleotides in hemorrhagic shock 1972
    1972 Insulin: an allosteric modifier of the sugar carrier mechanism 1972

    Chapter

    Year Title Altmetric
    2016 The Use of Estrogen for the Treatment of Traumatic Brain Injury.  161-177. 2016
    2015 Sex differences in sepsis following trauma and injury.  255-271. 2015
    2012 Metabolic and inflammatory responses to trauma and infection 2012
    2009 Experimental Models of Sepsis and Non-Infectious SIRS.  373-389. 2009
    2007 Insight into the mechanism of gender-specific response to trauma-hemorrhage.  869-879. 2007
    2007 Trauma-hemorrhage and its effects on the endothelium.  1513-1522. 2007
    2006 Gender dimorphism and the use of sex steroid/receptor antagonist after trauma.  101-121. 2006
    2004 Ischemia and Reperfusion Injury.  73-84. 2004
    2003 The immune/inflammatory system.  377-390. 2003

    Research Overview

  • trauma, hemorrhage, sepsis, gender dimorphism, immune functions, cardiovascular functions
  • Principal Investigator On

  • Increasing Survival Rate Following Hemorrhagic Shock and Traumatic Brain Injury in Austere Environments  awarded by THE MIND RESEARCH NETWORK 2018 - 2020
  • Part B - Surviving Blood Loss: First in Human Studies to Assess Safety and Physiological Effects of Synthetic Ethinyl Estradiol-3-Sulfate (EE·3·SO4) in Healthy Subjects, Both Euvolemic and Following 10-20% Iatrogenic Blood Loss  awarded by DOD - Department of Defense 2015 - 2018
  • Treatment of Traumatic Brain Injury (TBI) with Hormonal and Pharmacological Support--Preclinical Validation Using Diffuse and Mechanical TBI Animal Models  awarded by DOD - ARMY MEDICAL RESEARCH AND MATERIAL COMMAND 2008 - 2016
  • Maintenance of Organ Function Following Injury  awarded by National Institute of General Medical Sciences/NIH/DHHS 2009 - 2014
  • Development of a Controlled Hemorrhage Model in Mature, Miniature Pigs for Multi-Center Applications and Trial of Novel Field Expedient Treatment  awarded by Texas A&M University 2012 - 2013
  • Immunological Aspects of Hemorrhage  awarded by National Institute of General Medical Sciences/NIH/DHHS 2007 - 2013
  • Evaluation of Premarin in a Rat Model of Mild and Severe Hemorrhage  awarded by Defense Advanced Research Projects Agency 2010 - 2012
  • Trauma and Inflammation Research Training  awarded by National Institute of General Medical Sciences/NIH/DHHS 2006 - 2012
  • Role of Zinc in Estrogen-Mediated Salutary Effects on Cardiovascular Functions Following Trauma-Hemorrhage  awarded by American Heart Association (Southeast Affiliate) 2009 - 2011
  • Private Grant  awarded by AKEBIA THERAPEUTICS, INC. 2010 - 2011
  • Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, 1969
  • Full Name

  • Irshad Chaudry