Positions

Overview

  • Irshad H. Chaudry was born on May 2, 1945. He received a B.S. as well as M.S. with honors from Sind University, and a Ph.D. from Monash University, Australia. After his postdoctoral training at Toronto University, Canada, he was an appointed as an Instructor and subsequently as an Assistant Professor at the Jewish Hospital and Washington University School of Medicine. He then moved to Yale University as an Associate Professor and subsequently became a Professor. He moved to Michigan State University in 1986 as Professor and Director of Research and in 1996 became the Director of the Center for Surgical Research at Brown University. In 2000, he became the Director of the Center for Surgical Research at the University of Alabama at Birmingham. His has over 600 publications to his credit and is a recipient of the NIH MERIT award.

    Current research interests include determining the mechanisms responsible for cellular and subcellular alterations following soft tissue trauma, bone fracture, hemorrhage and sepsis. Additionally, the use of novel, readily available, FDA approved inexpensive therapeutic agents to attenuate such alterations in patients following trauma is planned. Other areas include evaluation of: (1) gender dimorphism and the mechanisms responsible for producing cardiovascular and hepatocellular dysfunction and immunological alterations following trauma-hemorrhage; (2) trauma-induced changes in the hypothalamus-pituitary-adrenal axis; (3) apoptosis of immune cells; and (4) wound healing. Specific research interests include determining the mechanism of regulation of estradiol levels by hypothalamic/pituitary factors, adrenals and steroidogenic enzyme activity and how differences in estradiol levels or the estradiol: androgen ratio due to the estrus cycle, ovariectomy, and age affect immune responses after trauma. Studies of T lymphocytes, macrophages and Kupffer cell functions using molecular biological techniques are being conducted to determine why low estradiol fails to maintain immune functions in aged females after trauma. The use of estradiol, Raloxifene, prolactin, metoclopramide, or flutamide to restore immune/cardiovascular functions following trauma should yield novel information and provide an innovative approach for improving the host responses and reducing mortality from sepsis following trauma in postmenopausal and in surgically ovariectomized patients with low estrogen activity. Additional interests encompass the mechanisms by which androgen depletion/androgen antagonists improve cardiac performance and other organ functions after trauma. These studies also examine whether androgen depletion/androgen antagonists affect the adrenals and modify the response of the heart, liver and vascular smooth muscle to catecholamines. The hemodynamic parameters and organ functions being measured include blood flow, circulating blood volume, cardiac output, left ventricular performance, vascular reactivity, liver, gut, adrenal and pulmonary functions. The integration of cardiac function with other organ functions and detailed mechanistic studies at the cellular and subcellular levels using physiological, pharmacological and molecular biology techniques to identify targets for novel treatment modalities using sex steroid antagonists/agonists or hormones should provide new information for the improved treatment of trauma victims with major blood loss and for decreasing the susceptibility to sepsis following trauma.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 A systematic review of large animal models of combined traumatic brain injury and hemorrhagic shock 2019
    2019 Part III: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Fluid Resuscitation and Antimicrobial Therapy Endpoints 2019
    2019 Premise for Standardized Sepsis Models 2019
    2018 Gender differences in trauma, shock and sepsis 2018
    2018 Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (Infection, (2018), 46, 5, (687-691), 10.1007/s15010-018-1183-8) 2018
    2018 Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis 2018
    2018 Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. 2018
    2018 Minimum quality threshold in pre-clinical sepsis studies (mqtipss): An international expert consensus initiative for improvement of animal modeling in sepsis 2018
    2017 Treatment of traumatic brain injury with 17α-ethinylestradiol-3-sulfate in a rat model 2017
    2017 Hepatoprotective effects of corilagin following hemorrhagic shock are through Akt-dependent pathway 2017
    2016 The Role and Use of Estrogens Following Trauma 2016
    2015 Hepatoprotective effect of casodex after trauma hemorrhage in a rodent model 2015
    2015 Morbidity and survival probability in burn patients in modern burn care 2015
    2015 17a-ethynylestradiol-3-sulfate treatment of severe blood loss in rats 2015
    2015 Expression of Concern 2015
    2015 Inflammatory response to traumatic injury: Clinical and animal researches in inflammation 2015
    2015 Potential therapeutic targets for sepsis in women 2015
    2015 Salutary Effects of Estrogen Sulfate for Traumatic Brain Injury 2015
    2015 The ERRor of our ways: Estrogen-related receptors are about energy, not hormones, and are potential new targets for trauma and shock 2015
    2014 Abandon the mouse research ship? Not just yet! 2014
    2014 Efficacy of 17α-ethynylestradiol-3-sulfate for severe hemorrhage in minipigs in the absence of fluid resuscitation 2014
    2014 Gender differences in sepsis: Cardiovascular and immunological aspects 2014
    2014 Gender-specific effects on immune response and cardiac function after trauma hemorrhage and sepsis 2014
    2014 Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model 2014
    2014 Sex- and diagnosis-dependent differences in mortality and admission cytokine levels among patients admitted for intensive care 2014
    2014 The august krogh principle: Seeking unity in diversity: Reply 2014
    2013 17β-estradiol confers protection after traumatic brain injury in the rat and involves activation of G protein-coupled estrogen receptor 1 2013
    2013 Trauma-associated human neutrophil alterations revealed by comparative proteomics profiling 2013
    2013 Role of Akt/HO-1 pathway in estrogen-mediated attenuation of trauma-hemorrhage-induced lung injury 2013
    2013 Tranexamic acid and trauma: Current status and knowledge gaps with recommended research priorities 2013
    2013 Hepatic gene expression patterns following trauma-hemorrhage: Effect of posttreatment with estrogen 2013
    2012 The effects of estrogen on various organs: Therapeutic approach for sepsis, trauma, and reperfusion injury. Part 1: Central nervous system, lung, and heart 2012
    2012 The effects of estrogen on various organs: Therapeutic approach for sepsis, trauma, and reperfusion injury. Part 2: Liver, intestine, spleen, and kidney 2012
    2012 Does gender influence outcomes in critically ill patients? 2012
    2012 Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1 2012
    2011 Influence of aging and hemorrhage injury on Sirt1 expression: Possible role of myc-Sirt1 regulation in mitochondrial function 2011
    2011 Liver X receptor protects against liver injury in sepsis caused by rodent cecal ligation and puncture 2011
    2011 Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury 2011
    2011 Lidocaine suppresses mouse Peyer's Patch T cell functions and induces bacterial translocation 2011
    2011 Role of PPARγ in the salutary effects of 17β-estradiol on kupffer cell cytokine production following trauma-hemorrhage 2011
    2011 The mitoscriptome in aging and disease 2011
    2010 Erratum: The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage 2010
    2010 Erratum: The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage (Annals of Surgery (2007) 245:6 (971-7)) 2010
    2010 Single photon emission computed tomography demonstrated efficacy of 17β-estradiol therapy in male rats after trauma-hemorrhage and extended hypotension 2010
    2010 Salutary effects of 17β-estradiol on Peyer's patch T cell functions following trauma-hemorrhage 2010
    2010 Corrigendum to "Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage" [J. Mol. Cell. Cardiol. 42 (2007) 620-630] (DOI:10.1016/j.yjmcc.2006.12.004) 2010
    2010 Corrigendum to "Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhage" [J. Mol. Cell. Cardiol. 40 (2006) 570-579] (DOI:10.1016/j.yjmcc.2006.01.008) 2010
    2010 Lidocaine enhances apoptosis and suppresses mitochondrial functions of human neutrophil in vitro 2010
    2010 Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotension 2010
    2010 Hypoxia-induced alteration of mitochondrial genes in cardiomyocytes: Role of Bnip3 and Pdk1 2010
    2010 Mechanism of the anti-inflammatory effect of 17β-estradiol on brain following trauma-hemorrhage 2010
    2009 Gut dysfunction following alcohol exposure and trauma 2009
    2009 Trauma-hemorrhage and hypoxia differentially influence kupffer cell phagocytic capacity: Role of hypoxia-inducible-factor-1α and phosphoinositide 3-kinase/akt activation 2009
    2009 Anosmin-1 involved in neuronal cell migration is hypoxia inducible and cancer regulated 2009
    2009 Erratum: Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels (Shock (2008) 30 (372-378)) 2009
    2009 Cellular mechanisms of injury after major trauma 2009
    2009 Analysis of the relationship between longitudinal gene expressions and ordered categorical event data 2009
    2009 ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-γ in a rodent model of alcohol intoxication and burn injury 2009
    2009 The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage 2009
    2009 Inflammation and the host response to injury, a large-scale collaborative project: Patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients 2009
    2009 Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O-2 production and intestinal edema following alcohol intoxication and burn injury 2009
    2009 Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: Heme oxygenase-1-derived normalization of hepatic inflammatory responses 2009
    2009 Estrogen suppresses cardiac IL-6 after trauma-hemorrhage via a hypoxia-inducible factor 1α-mediated pathway 2009
    2009 Mechanism of the salutary effects of estrogen on Kupffer cell phagocytic capacity following trauma-hemorrhage: Pivotal role of Akt activation 2009
    2009 Therapy of hemorrhagic shock : New strategies based on experimental results 2009
    2009 The role of estrogen and receptor agonists in maintaining organ function after trauma-hemorrhage 2009
    2009 When apoptosis meets autophagy: deciding cell fate after trauma and sepsis 2009
    2009 Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-κB signaling 2009
    2009 Role of extracellular signal-regulated protein kinase (ERK) in 17β-estradiol-mediated attenuation of lung injury after trauma-hemorrhage 2009
    2009 Effect of interleukin-15 on depressed splenic dendritic cell functions following trauma-hemorrhage 2009
    2009 Large-scale multiplexed quantitative discovery proteomics enabled by the use of an M 18O-labeled universal reference sample 2009
    2009 Mechanism of salutary effects of estrogen on cardiac function following trauma-hemorrhage: Akt-dependent HO-1 up-regulation 2009
    2009 Suppression of activation and costimulatory signaling in splenic CD4 + T cells after trauma-hemorrhage reduces t-cell function: A mechanism of post-traumatic immune suppression 2009
    2008 Estrogen and multiple organ dysfunction syndrome in critical illness: From bench to bedside 2008
    2008 Activation of endoplasmic reticulum stress response following trauma-hemorrhage 2008
    2008 Estradiol's salutary effects on keratinocytes following trauma-hemorrhage are mediated by estrogen receptor (ER)-α and ER-β 2008
    2008 Estrogen prevents intestinal inflammation after trauma-hemorrhage via downregulation of angiotensin II and angiotensin II subtype I receptor 2008
    2008 Estrogen: A novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations (Molecular Medicine (2008) 14, 3-4, (213-221)) 2008
    2008 Role of estrogen receptor subtypes in estrogen-induced organ-specific vasorelaxation after trauma-hemorrhage 2008
    2008 Systematic analysis of the salutary effect of estrogen on cardiac performance after trauma-hemorrhage 2008
    2008 Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels 2008
    2008 Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation- induced hepatic injury 2008
    2008 The role of MIP-1α in the development of systemic inflammatory response and organ injury following trauma hemorrhage 2008
    2008 Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase G 2008
    2008 Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis 2008
    2008 Bench-to-bedside review: Latest results in hemorrhagic shock 2008
    2008 Alcohol, burn injury, and the intestine. 2008
    2008 The role of estrogen receptor subtypes on hepatic neutrophil accumulation following trauma-hemorrhage: Direct modulation of CINC-1 production by Kupffer cells 2008
    2008 Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage (Journal of Leukocyte Biology (2006) 79,5,(963-970) DOI: 10.1189/jlb.1005596) 2008
    2008 p38 MAPK-dependent eNOS upregulation is critical for 17β-estradiol- mediated cardioprotection following trauma-hemorrhage 2008
    2008 Inhibition of protein tyrosine phosphatases prevents mesenteric lymph node T-cell suppression following alcohol intoxication and burn injury 2008
    2008 Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients 2008
    2008 Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhage 2008
    2008 Acute alcohol intoxication potentiates neutrophil-mediated intestinal tissue damage after burn injury 2008
    2008 Effect of 17β-estradiol on signal transduction pathways and secondary damage in experimental spinal cord trauma 2008
    2008 Estrogen-mediated activation of non-genomic pathway improves macrophages cytokine production following trauma-hemorrhage 2008
    2008 Estrogen: A novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations 2008
    2008 Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process 2008
    2008 Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice 2008
    2008 17β-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-α 2008
    2008 Heme oxygenase-1 protects against neutrophil-mediated intestinal damage by down-regulation of neutrophil p47phox and p67phox activity and O2- production in a two-hit model of alcohol intoxication and burn injury 2008
    2008 Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1 2008
    2008 Sex steroids/receptor antagonist: Their use as adjuncts after trauma-hemorrhage for improving immune/cardiovascular responses and for decreasing mortality from subsequent sepsis 2008
    2007 Trauma and immune response-Effect of gender differences 2007
    2007 Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhage 2007
    2007 Mechanism of salutary effects of finasteride on post-traumatic immune/inflammatory response: Upregulation of estradiol synthesis 2007
    2007 Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation 2007
    2007 V. Guidelines for sedation and analgesia during mechanical ventilation general overview 2007
    2007 Estrogen receptor-α predominantly mediates the salutary effects of 17β-estradiol on splenic macrophages following trauma-hemorrhage 2007
    2007 Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: Up-regulation of the PI-3K/Akt pathway 2007
    2007 Metabolic modulators following trauma sepsis: Sex hormones 2007
    2007 Regulation of the postburn wound inflammatory response by γδ T-cells 2007
    2007 Surgical trauma-induced adrenal insufficiency is associated with postoperative inflammatory responses 2007
    2007 17β-Estradiol normalizes Toll receptor 4, mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhage 2007
    2007 Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage 2007
    2007 Salutary effects of 17β-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily via estrogen receptor-α 2007
    2007 The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage 2007
    2007 The role of estrogen receptor subtypes in ameliorating hepatic injury following trauma-hemorrhage 2007
    2007 Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats 2007
    2007 Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage 2007
    2007 Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage 2007
    2007 Erratum: Mitochondria play an important role in 17β-estradiol attenuation of H2O2-induced rat endothelial cell apoptosis (American Journal of Physiology Endocrinology and Metabolism (2007) 292 (E585-E593)) 2007
    2007 TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage 2007
    2007 The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels 2007
    2007 17β-Estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage 2007
    2007 Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway 2007
    2007 Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production 2007
    2007 The role of MAPK in Kupffer cell Toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage 2007
    2007 17β-Estradiol inhibits keratinocyte-derived chemokine production following trauma-hemorrhage 2007
    2007 Does estrogen contribute to the hepatic regeneration following portal branch ligation in rats? 2007
    2007 Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway 2007
    2007 Influence of sex and age on mods and cytokines after multiple injuries 2007
    2007 Mitochondria play an important role in 17β-estradiol attenuation of H2O2-induced rat endothelial cell apoptosis 2007
    2007 17β-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhage 2007
    2007 Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage 2007
    2007 G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage 2007
    2007 Impact of sex and age on bone marrow immune responses in a murine model of trauma-hemorrhage 2007
    2007 Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged mice 2007
    2007 Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage 2007
    2007 Young and middle-age associated differences in cytokeratin expression after bone fracture, tissue trauma, and hemorrhage 2007
    2006 Estrus cycle: Influence on cardiac function following trauma-hemorrhage 2006
    2006 Erratum: Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice (Journal of Immunology (2006) 177 (4514-4520)) 2006
    2006 A role for corticosterone in impaired intestinal immunity and barrier function in a rodent model of acute alcohol intoxication and burn injury 2006
    2006 Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice 2006
    2006 Effects of 17β-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage 2006
    2006 Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways 2006
    2006 Effects of 17β-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females 2006
    2006 High dynamic range characterization of the trauma patient plasma proteome 2006
    2006 Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice 2006
    2006 Maintenance of lung myeloperoxidase activity in proestrus females after trauma-hemorrhage: Upregulation of heme oxygenase-1 2006
    2006 Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia 2006
    2006 Upregulation of mitochondrial respiratory complex IV by estrogen receptor-β is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage 2006
    2006 Castration prevents suppression of MHC class II (Ia) expression on macrophages after trauma-hemorrhage 2006
    2006 17β-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-α 2006
    2006 A novel role for IL-18 in corticosterone-mediated intestinal damage in a two-hit rodent model of alcohol intoxication and injury 2006
    2006 Nitric oxide contributes to the development of a post-injury Th2 T-cell phenotype and immune dysfunction 2006
    2006 Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis 2006
    2006 A role of PPAR-γ in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage 2006
    2006 Inflammation and the Host Response to Injury: An overview of the multicenter study of the genomic and proteomic response to burn injury 2006
    2006 Sex differences in mortality after burn injury: Results of analysis of the National Burn Repository of the American Burn Association 2006
    2006 Are the protective effects of 17β-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-α or ER-β? 2006
    2006 Glucosamine administration during resuscitation improves organ function after trauma hemorrhage 2006
    2006 Inhibition of cardiac PGC-1α expression abolishes ERβ agonist-mediated cardioprotection following trauma-hemorrhage 2006
    2006 Better understanding of organ dysfunction requires proteomic involvement 2006
    2006 Salutary effects of estrogen receptor-β agonist on lung injury after trauma-hemorrhage 2006
    2006 Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis 2006
    2006 MyD88 and Src are differentially regulated in Kupffer cells of males and proestrus females following hypoxia 2006
    2006 A role of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit rodent model of alcohol intoxication and injury 2006
    2006 Estradiol improves cardiac and hepatic function after trauma-hemorrhage: Role of enhanced heat shock protein expression 2006
    2006 Influence of gender and age on T-cell responses in a murine model of trauma-hemorrhage: Differences between circulating and tissue-fixed cells 2006
    2006 Alcohol intoxication and post-burn complications 2006
    2006 Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury 2006
    2006 Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: Up-regulation of estrogen receptor-β-dependent HO-1 2006
    2006 Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1 2006
    2006 Gender and sex hormones influence the response to trauma and sepsis - Potential therapeutic approaches 2006
    2006 Gender and susceptibility to sepsis following trauma 2006
    2006 Kupffer cells and their mediators: The culprits in producing distant organ damage after trauma-hemorrhage 2006
    2006 Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhage 2006
    2006 Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-β agonist: Up-regulation of cardiac heat shock factor-1 and heat shock proteins 2006
    2006 T cells of the γδ T-cell receptor lineage play an important role in the postburn wound healing process 2006
    2006 Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage 2006
    2005 Cecal ligation and puncture 2005
    2005 Erratum: A network-based analysis of systemic inflammation in humans (Nature (2005) 437 (1032-1037) DOI: 10.1038/nature03985) 2005
    2005 Gender differences in acute response to trauma-hemorrhage 2005
    2005 PGC-1 upregulation via estrogen receptors: A common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage 2005
    2005 Opiate analgesics contribute to the development of post-injury immunosuppression 2005
    2005 Dehydroepiandrosterone modulates toll-like receptor expression on splenic macrophages of mice after severe polymicrobial sepsis 2005
    2005 Current understanding of gender dimorphism in hepatic pathophysiology 2005
    2005 The association between sex and mortality among burn patients as modified by age 2005
    2005 Role of thromboxane in producing hepatic injury during hepatic stress 2005
    2005 Salutary effects of androstenediol on hepatic function after trauma-hemorrhage are mediated via peroxisome proliferators-activated receptor gamma 2005
    2005 Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injury 2005
    2005 L-arginine improves wound healing after trauma-hemorrhage by increasing collagen synthesis 2005
    2005 Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: Upregulation of heme oxygenase 2005
    2005 Mechanism responsible for the salutary effects of flutamide on cardiac performance after trauma-hemorrhagic shock: Upregulation of cardiomyocyte estrogen receptors 2005
    2005 Surgical trauma and immunosuppression: Pathophysiology and potential immunomodulatory approaches 2005
    2005 Mouse genetic background influences severity of immune responses following trauma-hemorrhage 2005
    2005 Gender differences in small intestinal perfusion following trauma hemorrhage: The role of endothelin-1 2005
    2005 Inhibition of IL-18 reduces myeloperoxidase activity and prevents edema in intestine following alcohol and burn injury 2005
    2005 Quantitative proteome analysis of human plasma following in vivo lypopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach 2005
    2005 Transgenic prolactin-/- mice: Effect of trauma-hemorrhage on splenocyte functions 2005
    2005 Application of genome-wide expression analysis to human health and disease 2005
    2005 Alcohol ingestion before burn injury decreases splanchnic blood flow and oxygen delivery 2005
    2005 Genetic variability in the immune-inflammatory response after major burn injury 2005
    2005 Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: Role of endothelial and inducible nitric oxide synthase 2005
    2005 Dehydroepiandrosterone restores depressed peripheral blood mononuclear cell function following major abdominal surgery via the estrogen receptors 2005
    2004 Insights into the role of interleukin-6 in the induction of hepatic injury after trauma-hemorrhagic shock 2004
    2004 Splenectomy differentially influences immune responses in various tissue compartments of the body 2004
    2004 Mechanism of cardiac depression after trauma-hemorrhage: Increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac function 2004
    2004 Mechanisms of hemorrhage-induced hepatic insulin resistance: Role of tumor necrosis factor-α 2004
    2004 The role of the mitochondrion in trauma and shock 2004
    2004 MAP kinases differentially regulate the expression of macrophage hyperactivity after thermal injury 2004
    2004 Cellular Alterations Following Shock and Trauma and Their Modulation 2004
    2004 Estradiol's effect on portal response to endothelin-1 after trauma-hemorrhage 2004
    2004 The role of γδ T cells in the regulation of neutrophil-mediated tissue damage after thermal injury 2004
    2004 Enhanced isolated pancreatic islet recovery and functionality in rats by 17β-estradiol treatment of brain death donors 2004
    2004 Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage 2004
    2004 The effect of inhibition of a major cell signaling pathway following trauma hemorrhage on hepatic injury and interleukin 6 levels 2004
    2004 Differences in the expression of LPS-receptors are not responsible for the sex-specific immune response after trauma and hemorrhagic shock 2004
    2004 Are the immune responses different in middle-aged and young mice following bone fracture, tissue trauma and hemorrhage? 2004
    2004 Alpha1-acid-glycoprotein protects against trauma-hemorrhagic shock 2004
    2004 Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage 2004
    2004 The role of interleukin-10 in the regulation of the systemic inflammatory response following trauma-hemorrhage 2004
    2004 Gender differences in small intestinal endothelial function: Inhibitory role of androgens 2004
    2004 Gender differences in small intestinal endothelial function: inhibitory role of androgens. 2004
    2004 Sex steroid-mediated regulation of macrophage/monocyte function in a two-hit model of trauma-hemorrhage and sepsis 2004
    2004 Physiological Levels of 5α-Dihydrotestosterone Depress Wound Immune Function and Impair Wound Healing Following Trauma-Hemorrhage 2004
    2004 Metabolic disturbances in shock, and the role of ATP-MgCl2 and sex steroids 2004
    2003 Brain Death Significantly Reduces Isolated Pancreatic Islet Yields and Functionality In Vitro and In Vivo after Transplantation in Rats 2003
    2003 Role of thromboxane in producing portal hypertension following trauma-hemorrhage 2003
    2003 Role of thromboxane in producing portal hypertension following trauma-hemorrhage. 2003
    2003 Sex Differences in Hepatic Heme Oxygenase Expression and Activity Following Trauma and Hemorrhagic Shock 2003
    2003 Inhibition of Fas/Fas ligand signaling improves septic survival: Differential effects on macrophage apoptotic and functional capacity 2003
    2003 Cellular, molecular and sexual dimorphic response to trauma-hemorrhage 2003
    2003 Immunomodulatory effects of dehydroepiandrosterone in proestrus female mice after trauma-hemorrhage 2003
    2003 Administration of progesterone after trauma and hemorrhagic shock prevents hepatocellular injury 2003
    2003 Androgen-mediated modulation of macrophage function after trauma-hemorrhage: Central role of 5α-dihydrotestosterone 2003
    2003 Mechanism for normal splenic T lymphocyte functions in proestrus females after trauma: Enhanced local synthesis of 17β-estradiol 2003
    2003 Mechanism for normal splenic T lymphocyte functions in proestrus females after trauma: enhanced local synthesis of 17beta-estradiol. 2003
    2003 Sex-specific p38 MAP kinase activation following trauma-hemorrhage: Involvement of testosterone and estradiol 2003
    2003 Differential alterations in intestinal permeability after trauma-hemorrhage 2003
    2003 Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: Role of vascular endothelial cell function 2003
    2003 Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: role of vascular endothelial cell function. 2003
    2003 Progesterone administration after trauma and hemorrhagic shock improves cardiovascular responses 2003
    2003 Endocrine targets in experimental shock. 2003
    2003 Effect of estradiol administration on splanchnic perfusion after trauma-hemorrhage and sepsis 2003
    2003 Mechanism of the salutary effects of 17β-estradiol following trauma-hemorrhage: Direct downregulation of Kupffer cell proinflammatory cytokine production 2003
    2003 Adrenomedullin and adrenomedullin binding protein-1: Their role in the septic response 2003
    2003 Age-related gender differential in outcome after blunt or penetrating trauma. 2003
    2003 Differential fluid regulation during and after soft tissue trauma and hemorrhagic shock in males and proestrus females. 2003
    2003 Hemorrhage induces the rapid development of hepatic insulin resistance 2003
    2003 Hemorrhage induces the rapid development of hepatic insulin resistance. 2003
    2003 Immunoprotection in proestrus females following trauma-hemorrhage: The pivotal role of estrogen receptors 2003
    2003 Regulation of macrophage IL-10 production postinjury via beta2 integrin signaling and the P38 MAP kinase pathway. 2003
    2003 The association between gender and mortality among trauma patients as modified by age 2003
    2003 Upregulation of hepatic prolactin receptor gene expression by 17β-estradiol following trauma-hemorrhage 2003
    2002 Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: Role of adrenomedullin and adrenomedullin binding protein-1 2002
    2002 Gender dimorphism in immune responses following trauma and hemorrhage 2002
    2002 Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPK/ERK mechanisms. 2002
    2002 Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-κB and MAPK/ERK mechanisms 2002
    2002 Flutamide induces relaxation in large and small blood vessels 2002
    2002 Adrenomedullin binding protein-1 modulates vascular responsiveness to adrenomedullin in late sepsis 2002
    2002 Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury 2002
    2002 Decreased 5α-dihydrotestosterone catabolism suppresses T lymphocyte functions in males after trauma-hemorrhage 2002
    2002 Estrogen pretreatment protects males against hypoxia-induced immune depression 2002
    2002 Decreased 5alpha-dihydrotestosterone catabolism suppresses T lymphocyte functions in males after trauma-hemorrhage. 2002
    2002 Estrogen pretreatment protects males against hypoxia-induced immune depression. 2002
    2002 Saturation of adrenomedullin receptors plays an important role in reducing pulmonary clearance of adrenomedullin during the late stage of sepsis 2002
    2002 L-arginine: A unique amino acid for improving depressed wound immune function following hemorrhage 2002
    2002 Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury. 2002
    2002 Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis 2002
    2002 A universal distribution for component failure times 2002
    2002 Administration of human inter-α-inhibitors maintains hemodynamic stability and improves survival during sepsis 2002
    2002 Differential alterations in cardiovascular responses during the progression of polymicrobial sepsis in the mouse 2002
    2002 Differential expression and tissue compartmentalization of the inflammatory response following thermal injury 2002
    2002 Estradiol administration improves splanchnic perfusion following trauma-hemorrhage and sepsis 2002
    2002 Gender differences in mortality following burn injury 2002
    2002 Gender dimorphism in immune responses following trauma and hemorrhage. 2002
    2002 Preservation of splenic immune functions by female sex hormones after trauma-hemorrhage 2002
    2002 Relationships between burn size, immunosuppression, and macrophage hyperactivity in a murine model of thermal injury 2002
    2002 Scientific priorities and strategic planning for resuscitation research and life saving therapy following traumatic injury: Report of the PULSE Trauma Work Group 2002
    2002 Scientific priorities and strategic planning for resuscitation research and life saving therapy following traumatic injury: Report of the PULSE Trauma Work Group 2002
    2002 Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-α production by Kupffer cells 2002
    2002 The cellular basis of post-burn immunosuppression: macrophages and mediators. 2002
    2002 Trauma-haemorrhage-induced alterations in thymic prolactin receptor expression: Implications in immune dysfunction 2002
    2001 Norepinephrine-induced hepatocellular dysfunction in early sepsis is mediated by activation of α2-adrenoceptors 2001
    2001 17β-Estradiol normalizes immune responses in ovariectomized females after trauma-hemorrhage 2001
    2001 Resistance of macrophages to the suppressive effect of interleukin-10 following thermal injury 2001
    2001 Resistance of macrophages to the suppressive effect of interleukin-10 following thermal injury. 2001
    2001 The role of lipopolysaccharide in stimulating adrenomedullin production during polymicrobial sepsis 2001
    2001 The small intestine is an important source of adrenomedullin release during polymicrobial sepsis 2001
    2001 MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsis 2001
    2001 Divergent Immune Responses in Male and Female Mice after Trauma-Hemorrhage: Dimorphic Alterations in T Lymphocyte Steroidogenic Enzyme Activities. 2001
    2001 The role of Kupffer cell α2-adrenoceptors in norepinephrine-induced TNF-α production 2001
    2001 Gender differences in the inflammatory response and survival following haemorrhage and subsequent sepsis 2001
    2001 Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated 2001
    2001 IL-10 mediation of activation-induced Th1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis 2001
    2001 The small intestine plays an important role in upregulating CGRP during sepsis 2001
    2001 Adrenal insufficiency during the late stage of polymicrobial sepsis 2001
    2001 Attenuation of vascular endothelial dysfunction by testosterone receptor blockade after trauma and hemorrhagic shock 2001
    2001 Continuous resuscitation after hemorrhage and acute fluid replacement improves cardiovascular responses 2001
    2001 Cyclooxygenase-2-mediated regulation of Kupffer cell interleukin-6 production following trauma-hemorrhage and subsequent sepsis 2001
    2001 DHEA: A novel adjunct for the treatment of male trauma patients 2001
    2001 Dehydroepiandrosterone restores hepatocellular function and prevents liver damage in estrogen-deficient females following trauma and hemorrhage 2001
    2001 Divergent immune responses in male and female mice after trauma-hemorrhage: Dimorphic alterations in T lymphocyte steroidogenic enzyme activities 2001
    2001 Evolution of an immune suppressive macrophage phenotype as a product of p38 MAPK activation in polymicrobial sepsis 2001
    2001 Glycine attenuates hepatocellular depression during early sepsis and reduces sepsis-induced mortality 2001
    2001 Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis 2001
    2001 Testosterone and estrogen differently effect Th1 and Th2 cytokine release following trauma-haemorrhage 2001
    2001 The role of adrenomedullin in producing differential hemodynamic responses during sepsis 2001
    2000 Gut-derived norepinephrine plays a critical role in producing hepatocellular dysfunction during early sepsis 2000
    2000 Severe hypoxemia in the absence of blood loss causes a gender dimorphic immune response 2000
    2000 Sustained elevation of norepinephrine depresses hepatocellular function 2000
    2000 Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal function 2000
    2000 Estradiol administration after trauma-hemorrhage improves cardiovascular and hepatocellular functions in male animals 2000
    2000 The female reproductive cycle is an important variable in the response to trauma-hemorrhage 2000
    2000 Insight into the mechanism by which metoclopramide improves immune functions after trauma-hemorrhage 2000
    2000 The dissociation between upregulated endothelins and hemodynamic responses during polymicrobial sepsis 2000
    2000 Mechanism of the beneficial effects of pentoxifylline during sepsis: Maintenance of adrenomedullin responsiveness and downregulation of proinflammatory cytokines 2000
    2000 Reversal of sexual dimorphism in splenic T lymphocyte responses after trauma-hemorrhage with aging 2000
    2000 Inhibition of tyrosine kinase signaling after trauma-hemorrhage: A novel approach for improving organ function and decreasing susceptibility to subsequent sepsis 2000
    2000 Preinduction of heat shock proteins protects cardiac and hepatic functions following trauma and hemorrhage 2000
    2000 Alterations in tissue oxygen consumption and extraction after trauma and hemorrhagic shock 2000
    2000 Androgen and estrogen receptors in splenic T lymphocytes: Effects of flutamide and trauma-hemorrhage 2000
    2000 Critical role of oxygen radicals in the initiation of hepatic depression after trauma hemorrhage 2000
    2000 Does burn wound excision after thermal injury attenuate subsequent macrophage hyperactivity and immunosuppression? 2000
    2000 Does early infusion of red blood cells after trauma and hemorrhage improve organ functions? 2000
    2000 Effect of gender and sex hormones on immune responses following shock 2000
    2000 Effect of naloxone on immune responses after hemorrhagic shock 2000
    2000 IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis 2000
    2000 Immune depression in polymicrobial sepsis: The role of necrotic (injured) tissue and endotoxin 2000
    2000 Immune dysfunction following trauma-haemorrhage: Influence of gender and age 2000
    2000 Insight into the mechanism by which estradiol improves organ functions after trauma-hemorrhage 2000
    2000 Insights into the role of γδ T lymphocytes in the immunopathogenic response to thermal injury 2000
    2000 Is prostacyclin responsible for producing the hyperdynamic response during early sepsis? 2000
    2000 L-Arginine attenuates trauma-hemorrhage-induced liver injury 2000
    2000 Mechanism of hepatocellular dysfunction during sepsis: the role of gut-derived norepinephrine (review). 2000
    2000 Metoclopramide: A novel adjunct for improving cardiac and hepatocellular functions after trauma-hemorrhage 2000
    2000 Plasma α-glutathione S-transferase: A sensitive indicator of hepatocellular damage during polymicrobial sepsis 2000
    2000 Restoration of body temperature to normothermia during resuscitation following trauma-hemorrhage improves the depressed cardiovascular and hepatocellular functions 2000
    2000 The aromatase inhibitor, 4-hydroxyandrostenedione, restores immune responses following trauma-hemorrhage in males and decreases mortality from subsequent sepsis 2000
    2000 The important role of the gut in initiating the hyperdynamic response during early sepsis 2000
    2000 Upregulation of inducible nitric oxide synthase and nitric oxide occurs later than the onset of the hyperdynamic response during sepsis 2000
    1999 Reply: Letters to the editor 1999
    1999 Differential alterations in systemic and regional oxygen delivery and consumption during the early and late stages of sepsis 1999
    1999 Role of protein kinase C in cyclic AMP-mediated suppression of T-lymphocyte activation following burn injury 1999
    1999 Pentoxifylline prevents the transition from the hyperdynamic to hypodynamic response during sepsis 1999
    1999 Is gut the major source of proinflammatory cytokine release during polymicrobial sepsis? 1999
    1999 Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhage 1999
    1999 Salutary effects of ATP-MgCl2 on the depressed endothelium-dependent relaxation during hyperdynamic sepsis 1999
    1999 Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by Fas ligand and not endotoxin 1999
    1999 Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis 1999
    1999 Pulmonary clearance of adrenomedullin is reduced during the late stage of sepsis 1999
    1999 Hypoxemia in the absence of blood loss upregulates iNOS expression and activity in macrophages 1999
    1999 Adrenomedullin is upregulated in the heart and aorta during the early and late stages of sepsis 1999
    1999 L-arginine restores splenocyte functions after trauma and hemorrhage potentially by improving splenic blood flow 1999
    1999 Proteasome participates in the alteration of signal transduction in T and B lymphocytes following trauma-hemorrhage 1999
    1999 Dehydroepiandrosterone restores immune function following trauma-haemorrhage by a direct effect on T lymphocytes 1999
    1999 Does fas ligand or endotoxin contribute to thymic apoptosis during polymicrobial sepsis? 1999
    1999 Gender dimorphism in trauma-hemorrhage-induced thymocyte apoptosis 1999
    1999 Immunological consequences of trauma and shock 1999
    1999 Organ dysfunction following hemorrhage and sepsis: mechanisms and therapeutic approaches (Review). 1999
    1999 Reduction in vascular responsiveness to adrenomedullin during sepsis 1999
    1999 Trauma-hemorrhage delays wound healing potentially by increasing pro- inflammatory cytokines at the wound site 1999
    1999 What is the role of interleukin 10 in polymicrobial sepsis: Anti- inflammatory agent or immunosuppressant? 1999
    1998 Dehydroepiandrosterone: An inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage 1998
    1998 The pivotal role of adrenomedullin in producing hyperdynamic circulation during the early stage of sepsis 1998
    1998 Upregulation of Kupffer cell β-adrenoceptors and cAMP levels during the late stage of sepsis 1998
    1998 Testosterone: The crucial hormone responsible for depressing myocardial function in males after trauma-hemorrhage 1998
    1998 Testosterone: The culprit for producing splenocyte immune depression after trauma hemorrhage 1998
    1998 Trauma-hemorrhage activates signal transduction pathways in mouse splenic T cells 1998
    1998 The organs responsible for increased nitric oxide production after trauma-hemorrhage and resuscitation 1998
    1998 Sepsis induces increased apoptosis in lamina propria mononuclear cells which is associated with altered cytokene gene expression 1998
    1998 Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin-mediated process 1998
    1998 Left ventricular thrombus 1998
    1998 Is gut the 'motor' for producing hepatocellular dysfunction after trauma and hemorrhagic shock? 1998
    1998 Pentoxifylline increases gut ketogenesis following trauma and hemorrhagic shock 1998
    1998 Cardiac contractility and structure are not significantly compromised even during the late, hypodynamic stage of sepsis 1998
    1998 Chronic resuscitation after trauma-hemorrhage and acute fluid replacement improves hepatocellular function and cardiac output 1998
    1998 Does neutrophil-mediated oxidative stress play any significant role in producing hepatocellular dysfunction during early sepsis? 1998
    1998 Hepatocellular dysfunction after severe hypotension in the absence of blood loss is associated with the increased IL-6 and PGE2 1998
    1998 Increased gut permeability after hemorrhage is associated with upregulation of local and systemic IL-6 1998
    1998 Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis? 1998
    1998 L-arginine restores the depressed cardiac output and regional perfusion after trauma-hemorrhage 1998
    1998 Lymphocyte Apoptosis in Sepsis 1998
    1998 Sepsis induces increased apoptosis in lamina propria mononuclear cells which is associated with altered cytokine gene expression 1998
    1998 Severe depression of host immune functions following closed-bone fracture, soft-tissue trauma, and hemorrhagic shock 1998
    1998 The contribution of soft-tissue trauma and/or bone fracture to depressed immunity following hemorrhagic shock in an experimental setting 1998
    1998 Thermal injury alters macrophage responses to prostaglandin E2: Contribution to the enhancement of inducible nitric oxide synthase activity 1998
    1998 Up-regulation of a novel potent vasodilatory peptide adrenomedullin during polymicrobial sepsis 1998
    1997 Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males 1997
    1997 Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males 1997
    1997 Male sex steroids are responsible for depressing macrophage immune function after trauma-hemorrhage 1997
    1997 Administration of ATP-MgCl2 following hemorrhage and resuscitation increases hepatic phosphoenolpyruvate carboxykinase and decreases pyruvate kinase activities 1997
    1997 Severe hypoxemia in the absence of blood loss depresses hepatocellular function and up-regulates IL-6 and PGE2 1997
    1997 Impaired enterocyte triglyceride synthesis after trauma-hemorrhage and resuscitation. 1997
    1997 Inducible macrophage apoptosis following sepsis is mediated by cysteine protease activation and nitric oxide release 1997
    1997 Intestinal alkaline phosphatase: role in the depressed gut lipid transport after trauma-hemorrhagic shock. 1997
    1997 Salutary effects of ATP-MgCl2 on altered hepatocyte signal transduction after hemorrhagic shock 1997
    1997 Endothelial nitric oxide synthase is downregulated during hyperdynamic sepsis 1997
    1997 Liver endothelial cell function is depressed only during hypodynamic sepsis 1997
    1997 Trauma-hemorrhage induces increased thymic apoptosis while decreasing IL-3 release and increasing GM-CSF 1997
    1997 Effects of prolactin and metoclopramide on macrophage cytokine gene expression in late sepsis 1997
    1997 Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males 1997
    1997 Flutamide: A novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock 1997
    1997 Mechanism of intestinal mucosal immune dysfunction following trauma- hemorrhage: Increased apoptosis associated with elevated Fas expression in Peyer's patches 1997
    1997 The role of neutrophils in producing hepatocellular dysfunction during the hyperdynamic stage of sepsis in rats 1997
    1996 Prolactin Administration Following Hemorrhagic Shock Improves Macrophage Cytokine Release Capacity and Decreases Mortality from Subsequent Sepsis 1996
    1996 Depressed osteoblast activity after trauma-hemorrhage 1996
    1996 Immune dysfunction in murine polymicrobial sepsis: Mediators, macrophages, lymphocytes and apoptosis 1996
    1996 Impaired enterocyte triglyceride synthesis after trauma-hemorrhage and resuscitation 1996
    1996 Intestinal alkaline phosphatase: Role in the depressed gut lipid transport after trauma-hemorrhagic shock 1996
    1996 Mechanism of hepatocellular dysfunction during hyperdynamic sepsis 1996
    1996 Mechanism of hepatocellular dysfunction following trauma and hemorrhagic shock: Key role of hypoxemia 1996
    1996 Metoclopramide improves splenocyte immune function and restores plasma corticosteroid levels after hemorrhagic shock 1996
    1996 Prolactin improves depressed macrophage indugible cytokine gene expression in peritoneal macrophages (PMφ), splenic macrophages (SMφ) and kupffer cells (KC) following sepsis 1996
    1996 Trauma-hemorrhage induces increased thymic apoptosis while decreasing il-3 release 1996
    1996 Depressed osteoblast activity and increased osteocyte necrosis after closed bone fracture and hemorrhagic shock 1996
    1996 Increased melatonin levels after hemorrhagic shock in male and female C3H/HeN mice 1996
    1996 Platelet activating factor and its role in trauma, shock, and sepsis 1996
    1996 Differential induction of apoptosis in lymphoid tissues during sepsis: Variation in onset, frequency, and the nature of the mediators 1996
    1996 Effects of nonanticoagulant heparin on cardiovascular and hepatocellular function after hemorrhagic shock 1996
    1996 Inhibition of the Biologic Activity of Tumor Necrosis Factor Maintains Vascular Endothelial Cell Function during Hyperdynamic Sepsis 1996
    1996 Is Sepsis-Induced Apoptosis Associated with Macrophage Dysfunction? 1996
    1996 A novel nonanticoagulant heparin prevents vascular endothelial cell dysfunction during hyperdynamic sepsis 1996
    1996 Administration of a matrix metalloproteinase inhibitor after hemorrhage improves cardiovascular and hepatocellular function 1996
    1996 Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation 1996
    1996 Immune function is more compromised after closed bone fracture and hemorrhagic shock than hemorrhage alone 1996
    1996 Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge 1996
    1996 Pentoxifylline maintains vascular endothelial cell function during hyperdynamic and hypodynamic sepsis 1996
    1996 Pentoxifylline restores the depressed cardiac performance after trauma- hemorrhage and resuscitation 1996
    1996 Prolactin inhibits the increased cytokine gene expression in Kupffer cells following haemorrhage 1996
    1996 Relationship of pelvic radiation to intestinal blood flow 1996
    1996 Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes 1996
    1995 Effect of surgical trauma on splenocyte and peritoneal macrophage immune function 1995
    1995 ATP-MgCl2restores depressed endothelial cell function after hemorrhagic shock and resuscitation 1995
    1995 Cytokine gene expression in splenic macrophages and kupffer cells following haemorrhage 1995
    1995 Dietary n-3 polyunsaturated fatty acid modulation of immune cell function before or after trauma 1995
    1995 Does Endotoxin Play a Major Role in Inducing the Depression of Macrophage Function During Polymicrobial Sepsis? 1995
    1995 Downregulation of hepatic β-adrenergic receptors after trauma and hemorrhagic shock 1995
    1995 Effects of hydroxyethyl starch after trauma-hemorrhagic shock: Restoration of macrophage integrity and prevention of increased circulating interleukin- 6 levels 1995
    1995 Endothelium-dependent relaxation is depressed at the macro- and microcirculatory levels during sepsis 1995
    1995 Hemorrhage affects the ability of murine peritoneal macrophages to alkanize intracellular ph in acidic environments 1995
    1995 Hepatocellular dysfunction occurs earlier than the onset of hyperdynamic circulation during sepsis 1995
    1995 Hypoxemia in the absence of blood loss or significant hypotension causes inflammatory cytokine release 1995
    1995 Impaired gut lipid absorptive capacity after trauma-hemorrhage and resuscitation 1995
    1995 Intraperitoneal sodium carboxymethylcellulose administration prevents reformation of peritoneal adhesions following surgical lysis 1995
    1995 PAF-antagonist administration after hemorrhage-resuscitation prevents splenocyte immunodepression 1995
    1995 Sustained elevation in circulating catecholamine levels during polymicrobial sepsis 1995
    1995 The gut: A cytokine-generating organ in systemic inflammation? 1995
    1995 The induction of accelerated thymic programmed cell death during polymicrobial sepsis: Control by corticosteroids but not tumor necrosis factor 1995
    1995 The role of bacterial translocation on Kupffer cell immune function following hemorrhage. 1995
    1995 Trauma-hemorrhage causes prolonged depression in cellular immunity 1995
    1995 Tumor necrosis factor-α administration increases kupffer cell cyclic adenosine monophosphate levels 1995
    1994 Methods to prevent colonic injury in pelvic radiation 1994
    1994 ATP-MgCl2 administration normalizes macrophage cAMP and gamma-adrenergic receptors after hemorrhage and resuscitation 1994
    1994 Downregulation of hepatocyte P2-purinoceptor binding capacity after trauma-hemorrhage/resuscitation 1994
    1994 ATP-MgCl2 administration normalizes macrophage cAMP and β-adrenergic receptors after hemorrhage and resuscitation 1994
    1994 ATP-MgCl2 treatment after trauma-hemorrhage/resuscitation increases hepatocyte P2-purinoceptor binding capacity 1994
    1994 ATP-MgCl2treatment after trauma-hemorrhage/resuscitation increases hepatocyte P2-purinoceptor binding capacity 1994
    1994 Administration of tumor necrosis factor-α in vivo depresses endothelium- dependent relaxation 1994
    1994 Aggressive fluid resuscitation following intestinal ischemia-reperfusion in immature rats prevents metabolic derangements and down regulates interleukin-6 release 1994
    1994 Biological significance of elevated TNF levels: In vivo administration of monoclonal antibody against TNF following haemorrhage shock increases the capacity of macrophages to release TNF while restoring immuno-responsiveness 1994
    1994 Chemically modified heparin improves hepatocellular function, cardiac output, and microcirculation after trauma-hemorrhage and resuscitation 1994
    1994 Dextran 70 administration after trauma-hemorrhagic shock does not impair cellular immune functions 1994
    1994 Differential alterations in cyclic nucleotide levels in kupffer cells and hepatocytes following trauma-hemorrhage and resuscitation 1994
    1994 Does laser-Doppler flowmetry provide a quantitative measure of hepatic perfusion 1994
    1994 Downregulation of hepatocyte P 2 -purinoceptor binding capacity after trauma-hemorrhage/resuscitation 1994
    1994 Editorial 1994
    1994 Effects of trauma, duration of hypotension, and resuscitation regimen on cellular immunity after hemorrhagic shock 1994
    1994 Energetics of lymphocyte “Burnout” in late sepsis: Adjuvant treatment with ATP-MgCl2 improves energetics and decreases lethality 1994
    1994 Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock 1994
    1994 Hemorrhage induces a reduction in the capacity of macrophages to mobilize intracellular calcium secondary to formyl-methionyl-leucyl-phenylalanine stimulation: Association with alterations in cell surface Fc receptor expression and increased prostaglandin release 1994
    1994 Measurement of circulating blood volume in vivo after trauma-hemorrhage and hemodilution 1994
    1994 Measurement of circulating blood volume in vivo after trauma-hemorrhage and hemodilution 1994
    1994 Mechanism of Enhanced Susceptibility to Sepsis Following Hemorrhage: Interleukin-10 Suppression of T-Cell Response Is Mediated by Eicosanoid-Induced Interleukin-4 Release 1994
    1994 Nitric Oxide: To Block or Enhance Its Production During Sepsis? 1994
    1994 Pentoxifylline attenuates oxygen-induced lung injury 1994
    1994 Peritoneal macrophages show increased cytokine gene expression following haemorrhagic shock 1994
    1994 Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-γ release while increasing IL-4/IL-10 production 1994
    1994 Role of kupffer cells in interleukin-6 release following trauma-hemorrhage and resuscitation 1994
    1994 Severe depression of gut absorptive capacity in patients following trauma or sepsis 1994
    1994 Vascular smooth muscle contractile function is impaired during early and late stages of sepsis 1994
    1993 Reperfusion injury following testicular torsion and detorsion in prepubertal rats 1993
    1993 Tauromustine is more effective than conventional chemotherapy in the treatment of colonic tumors 1993
    1993 A model of pulmonary atelectasis in rats: Activation of alveolar macrophage and cytokine release 1993
    1993 ATP-MgCl2 restores gut absorptive capacity early after trauma- hemorrhagic shock 1993
    1993 Alterations in circulating blood volume during polymicrobial sepsis 1993
    1993 Chemically induced hypotension increases PGE2 release and depresses macrophage antigen presentation 1993
    1993 Chloroquine inhibits macrophage tumour necrosis factor-α mRNA transcription 1993
    1993 Diltiazem reduces whole blood viscosity following trauma-hemorrhagic shock and resuscitation 1993
    1993 Endothelial cell dysfunction occurs after hemorrhage in nonheparinized but not in preheparinized models 1993
    1993 Endothelial cell dysfunction occurs very early following trauma- hemorrhage and persists despite fluid resuscitation 1993
    1993 Insights into the mechanism by which interferon-γ improves macrophage function following hemorrhage and resuscitation 1993
    1993 Mechanism of diltiazem's immunomodulatory effects after hemorrhage and resuscitation 1993
    1993 Mechanism of increased susceptibility to infection following hemorrhage 1993
    1993 Modulation of Macrophage Membrane Phospholipids by n-3 Polyunsaturated Fatty Acids Increases Interleukin 1 Release and Prevents Suppression of Cellular Immunity Following Hemorrhagic Shock 1993
    1993 Pentoxifylline restores cardiac output and tissue perfusion after trauma- hemorrhage and decreases susceptibility to sepsis 1993
    1993 Prevention of peritoneal adhesions by administration of sodium carboxymethyl cellulose and oral vitamin E 1993
    1993 Prevention of secondary cardiovascular instability after intestinal ischemia and reperfusion improves survival 1993
    1993 Restoration of gut absorptive capacity following trauma-hemorrhagic shock by the adjuvant use of heparan sulfate 1993
    1993 Role of Interleukin 6 and Transforming Growth Factor–β in the Induction of Depressed Splenocyte Responses Following Sepsis 1993
    1993 The release of transforming growth factor-β following haemorrhage: Its role as a mediator of host immunosuppression 1993
    1993 Trauma-hemorrhage and resuscitation in the mouse: Effects on cardiac output and organ blood flow 1993
    1993 Tumor necrosis factor depresses gut absorptive function 1993
    1993 Tumor necrosis factor-α produces hepatocellular dysfunction despite normal cardiac output and hepatic microcirculation 1993
    1992 Differential effects of ATP-MgCl2on portal and hepatic arterial blood flow after hemorrhage and resuscitation 1992
    1992 Direct comparison between Czerny-Lembert and circular-stapled anastomotic techniques in colorectal anastomosis: A similar pattern of healing for both 1992
    1992 Differential alterations in microvascular perfusion in various organs during early and late sepsis. 1992
    1992 Omeprazole-induced hypergastrinemia does not influence growth of colon carcinoma 1992
    1992 Does a proximal colostomy affect colorectal anastomotic healing? 1992
    1992 ATP-MgCl2 restores renal microcirculation following trauma and severe hemorrhage 1992
    1992 ATP-MgCl2restores the depressed cardiac output following trauma and severe hemorrhage even in the absence of blood resuscitation 1992
    1992 Adenosine triphosphate-magnesium chloride in radiation injury 1992
    1992 Chloroquine Attenuates Hemorrhagic Shock—Induced Immunosuppression and Decreases Susceptibility to Sepsis 1992
    1992 Crystalloid is as effective as blood in the resuscitation of hemorrhagic shock 1992
    1992 Differential alterations in microvascular perfusion in various organs during early and late sepsis 1992
    1992 Differential effects of hemorrhage on kupffer cells: decreased antigen presentation despite increased inflammatory cytokine (IL-1, IL-6 and TNF) release 1992
    1992 Diltiazem restores cardiac output and improves renal function after hemorrhagic shock and crystalloid resuscitation 1992
    1992 Does Endotoxin Tolerance Prevent the Release of Inflammatory Monokines (Interleukin 1, Interleukin 6, or Tumor Necrosis Factor) During Sepsis? 1992
    1992 Energetics of defective macrophage antigen presentation after hemorrhage as determined by ultraresolution 31P nuclear magnetic resonance spectrometry: Restoration with adenosine triphosphate-MgCl2 1992
    1992 Erratum: Energetics of defective macrophage antigen presentation after hemorrhage as determined by ultraresolution 31P nuclear magnetic resonance spectrometry: Restoration with adenosine triphosphate-MgCl2 (Surgery (1992) 112 (150-158)) 1992
    1992 Hepatocellular dysfunction persists during early sepsis despite increased volume of crystalloid resuscitation 1992
    1992 Ibuprofen restores cellular immunity and decreases susceptibility to sepsis following hemorrhage 1992
    1992 Interferon-γ attenuates hemorrhage-induced suppression of macrophage and splenocyte functions and decreases susceptibility to sepsis 1992
    1992 Measurement of hepatic blood flow after severe hemorrhage: Lack of restoration despite adequate resuscitation 1992
    1992 Mechanism of the beneficial effects of ATP-MgCl 2 following trauma-hemorrhage and resuscitation: Downregulation of inflammatory cytokine (TNF, IL-6) release 1992
    1992 Mechanism of the beneficial effects of pentoxifylline on hepatocellular function after trauma hemorrhage and resuscitation 1992
    1992 Pharmacologic agents in the treatment of ischemia, hemorrhagic shock, and sepsis 1992
    1992 Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (interleukins-1 and -6 and tumor necrosis factor) 1992
    1992 Preoperative radiation therapy produces an early and persistent reduction in colorectal anastomotic blood flow 1992
    1992 Protective effects of preheparinization on the microvasculature during and after hemorrhagic shock 1992
    1992 Sepsis induces an early increased spontaneous release of hepatocellular stimulatory factor (interleukin-6) by Kupffer cells in both endotoxin tolerant and intolerant mice 1992
    1992 Sepsis produces early depression of gut absorptive capacity: Restoration with diltiazem treatment 1992
    1991 Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity: Involvement of cell-associated tumor necrosis factor and reactive nitrogen 1991
    1991 Increase in hepatic blood flow during early sepsis is due to increased portal blood flow 1991
    1991 Measurement of D-xylose gut absorptive capacity in conscious rats 1991
    1991 Chloroquine attenuates hemorrhagic shock-induced suppression of Kupffer cell antigen presentation and major histocompatibility complex class II antigen expression through blockade of tumor necrosis factor and prostaglandin release 1991
    1991 ATP-MgCl2 restores the depressed hepatocellular function and hepatic blood flow following hemorrhage and resuscitation 1991
    1991 Adequate crystalloid resuscitation restores but fails to maintain the active hepatocellular function following hemorrhagic shock 1991
    1991 Anti-TNF monoclonal antibodies prevent haemorrhage-induced suppression of Kupffer cell antigen presentation and MHC class II antigen expression 1991
    1991 Association between decreased splenic ATP levels and immunodepression: Amelioration with ATP-MgCl2 1991
    1991 Blockade of prostaglandin production increases cachectin synthesis and prevents depression of macrophage functions after hemorrhagic shock 1991
    1991 Crystalloid resuscitation restores but does not maintain cardiac output following severe hemorrhage 1991
    1991 Depressed gut absorptive capacity early after trauma-hemorrhagic shock: Restoration with diltiazem treatment 1991
    1991 Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage 1991
    1991 Diltiazem restores IL-2, IL-3, IL-6, and IFN-γ synthesis and decreases host susceptibility to sepsis following hemorrhage 1991
    1991 Eicosanoids regulate tumor necrosis factor synthesis after hemorrhage in vitro and in vivo 1991
    1991 Hepatic Extraction of Indocyanine Green Is Depressed Early in Sepsis Despite Increased Hepatic Blood Flow and Cardiac Output 1991
    1991 Improved methodology for the evaluation of the velocity of clearance of indocyanine green in the rat 1991
    1991 The complex pattern of cytokines in sepsis: Association between prostaglandins, cachectin, and interleukins 1991
    1990 Hemorrhage produces depression in microvascular blood flow which persists despite fluid resuscitation 1990
    1990 Passive immunization against cachectin (TNF-α) prevents hemorrhage-induced suppression of kupffer cell functions 1990
    1990 Sepsis selectively activates peritoneal but not alveolar macrophage to release inflammatory mediators (IL-1, IL-6, and TNF) 1990
    1990 Intramural pH: A quantitative measurement for predicting colorectal anastomotic healing 1990
    1990 Cellular dysfunction in sepsis 1990
    1990 Decreased Fc receptor expression on macrophages following simple hemorrhage as observed by scanning immunoelectron microscopy 1990
    1990 Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigens 1990
    1990 Enhanced Susceptibility to Sepsis After Simple Hemorrhage: Depression of Fc and C3b Receptor-Mediated Phagocytosis 1990
    1990 Hemorrhage and resuscitation: Immunological aspects 1990
    1990 Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin 1990
    1990 Hepatocellular dysfunction occurs early after hemorrhage and persists despite fluid resuscitation 1990
    1990 Preheparinization improves organ function after hemorrhage and resuscitation 1990
    1990 Use of ATP following Shock and Ischemia 1990
    1989 ATP-MgCl2 and liver blood flow following shock and ischemia. 1989
    1989 Measurement of hepatocellular function, cardiac output, effective blood volume, and oxygen saturation in rats 1989
    1989 Mechanism of immunosuppression following hemorrhage: Defective antigen presentation by macrophages 1989
    1988 Effect of Blood Transfusion on Antigen Presentation Function and on Interleukin 2 Generation 1988
    1988 Mechanism of calcium and magnesium translocation in acute pancreatitis: A temporal correlation between hypocalcemia and membrane-mediated excessive intracellular calcium accumulation in soft tissues 1988
    1988 Metabolic Interaction Between Skeletal Muscle and Liver During Bacteremia 1988
    1988 Prostaglandin E2 depresses antigen-presenting cell function of peritoneal macrophages 1988
    1988 Use of magnesium-ATP following liver ischemia 1988
    1987 Alleviation of cyclosporine nephrotoxicity with verapamil and ATP-MgCl2: Mitochondrial respiratory and calcium studies 1987
    1987 Aterations in hepatic membrane potentials in vivo during early and late sepsis 1987
    1987 Comparison effects of ATP-MgCl2and adenosine-MgCl2on renal function following ischemia 1987
    1987 Depressed antigen presentation function and membrane interleukin-1 activity of peritoneal macrophages after laparotomy 1987
    1987 Hemorrhage Without Tissue Trauma Produces Immunosuppression and Enhances Susceptibility to Sepsis 1987
    1987 Reperfusion with ATP-MgCl2 following prolonged ischemia improves myocardial performance 1987
    1987 Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity 1987
    1986 Reoxygenation injury in isolated hepatocytes: Effect of extracellular ATP on cation homeostasis 1986
    1986 Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney 1986
    1986 Depression of Cellular Immunity After Major Injury: Its Association With Posttraumatic Complications and Its Reversal With Immunomodulation 1986
    1986 Hepatic ischemia models for determining the effects of ATP-MgCl2 treatment 1986
    1986 Improved myocardial performance after prolonged ischemia with ATP-MgCl2cardioplegia 1986
    1986 Salutary effects of ATP-MgCl2 are not dependent on the presence of vanadium or the source of ATP. 1986
    1986 The role of ATP-magnesium in ischemia and shock. 1986
    1986 Verapamil and ATP-MgCl2prevents cyclosporin-induced nephrotoxocity by improving mitochondrial and tissue Ca2+/Mg2+ratios 1986
    1985 Effects of regenerating liver cytosol on drug-induced hepatic failure 1985
    1985 Hepatic microcirculatory failure after ischemia and reperfusion: improvement with ATP-MgCl2 treatment. 1985
    1985 Adenine nucleotides and reversal of post-ischemic mitochondrial dysfunction 1985
    1985 Adenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance 1985
    1985 Alleviation of cyclosporine nephrotoxicity with verapamil and adenosine triphosphate-magnesium chloride treatment 1985
    1985 Cellular alterations in shock and ischemia and their correction 1985
    1985 Effect of pyridoxalated stabilized stroma-free hemoglobin solution on the clearance of intravascular lipid by the reticuloendothelial system 1985
    1985 Effects of heart rate and extracellular calcium on the inotropic effects of ATP and adenosine in isolated rat heart 1985
    1985 Hepatic microcirculatory failure after ischemia and reperfusion: Improvement with ATP-MgCl2 treatment 1985
    1985 Increased coronary flow and myocardial efficiency with systemic infusion of adenosine triphosphate-magnesium chloride 1985
    1985 Phospholipid and adenine nucleotide metabolism in muscle after burn injury 1985
    1985 Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneys 1985
    1985 Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys 1985
    1985 Renal handling of exogenous ATP-MgCl2 (ATP) 1985
    1985 Restoration of post-ischemic tissue ATP+ADP and tissue and mitochondrial (Mt) magnesium (Mg) by ATP-MgCl2 1985
    1984 Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia 1984
    1984 A cyclophosphamide-sensitive suppressor T cell circuit induced by thermal injury 1984
    1984 Improved mitochondrial function following ischemia and reflow by ATP-MgCl2. 1984
    1984 ATP-MgCl2 produces sustained improvement in hepatic mitochondrial function and blood flow after hepatic ischemia 1984
    1984 ATP-MgCl2infusion in man: Increased cardiac output without adverse systemic hemodynamic effects 1984
    1984 Accelerated functional recovery of isolated rat kidney with ATP-MgCl2after warm ischemia 1984
    1984 Alterations in Hepatic Water and Electrolyte Balance in Sepsis 1984
    1984 Cellular energetics and ATP-MgCl2 therapy in sepsis 1984
    1984 Dissociation between the early and late effects of ATP- and adenosine-MgCl2 on hepatocellular function following ischemia 1984
    1984 Effect of exogenous ATP-MgCl2on contractility in the isolated rat heart 1984
    1984 Hydroxyethylstarch administration does not depress reticuloendothelial function or increase mortality from sepsis 1984
    1984 Hypothyroidism abolishes the hyperdynamic phase and increases susceptibility to sepsis 1984
    1984 Improved Myocardial Recovery From Ischemia: Treatment With Low-Dose Adenosine Triphosphate-Magnesium Chloride 1984
    1984 Improved mitochondrial function following ischemia and reflow by ATP-MgCl2 1984
    1984 Improved skin flap survival with adenosine triphosphate-magnesium chloride 1984
    1984 Insulin resistance and depressed gluconeogenic capability during early hyperglycemic sepsis 1984
    1984 Nuclear magnetic resonance studies showing the reperfusion injury following ischemia and its improvement with ATP-MgCl2treatment 1984
    1983 Cellular mechanisms in shock and ischemia and their correction. 1983
    1983 Studies on the mechanism of beneficial effects of ATP-MgCl2 following hepatic ischemia. 1983
    1983 Adenosine triphosphate uptake by liver - leaky cells or specific transport? 1983
    1983 Alterations in electron transport and cellular metabolism with shock and trauma. 1983
    1983 Beneficial effects of implanted muscle tissue on pulmonary particulate retention and survival following splenectomy 1983
    1983 Cellular mechanisms in shock and ischemia and their correction 1983
    1983 Effect of immunopotentiators on Kupffer cell function and DNA synthesis after ischemia and partial hepatectomy 1983
    1983 Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model 1983
    1983 Regulation of glucose production from lactate in experimental sepsis 1983
    1983 Regulation of glucose production from lactate in experimental sepsis 1983
    1983 Studies on the mechanism of beneficial effects of ATP-MgCl2following hepatic ischemia 1983
    1982 Impairment of reticuloendothelial function following thermal injury and its restoration with ATP-MgCl2 administration 1982
    1982 Preparation of ATP-MgCl2 and precautions for its use in the study and treatment of shock and ischemia. 1982
    1982 Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2 1982
    1982 Altered Hepatocellular Active Transport: An Early Change in Peritonitis 1982
    1982 Comparison of the neuromuscular and central effects of 4-amino- and 3,4-diaminopyridine 1982
    1982 Does ATP cross the cell plasma membrane? 1982
    1982 Editorial Commentary: 'The effect of ATP on survival in intestinal ischemia shock, hemorrhagic shock, and endotoxin shock in rats' 1982
    1982 Hemodynamic effects of ATP-MgCl2infusion in conscious normovolemic (NV) and hypovolemic (HV) dogs 1982
    1982 Hemodynamic effects of ATP-MgCl2infusion in conscious normovolemic and hypovolemic primates 1982
    1982 Hepatic gluconeogenic capability in sepsis is depressed before changes in oxidative capability 1982
    1982 Lysine restores gluconeogenic capability but not α-adrenergic sensitivity in livers from late septic rats 1982
    1982 Preparation of ATP-MgCl2and precautions for its use in the study and treatment of shock and ischemia 1982
    1982 Restoration of hepatic mitochondrial function following global ischemia by ATP-MgCl2 1982
    1982 Restoration of hepatocellular function and blood flow following hepatic ischemia with ATP-MgCl2. 1982
    1981 Hepatocellular dysfunction in early sepsis despite increased hepatic blood flow. 1981
    1981 Oxidative capability of hepatic tissue in late sepsis. 1981
    1981 Alterations in Cell Function With Ischemia and Shock and Their Correction 1981
    1981 Effect of hemorrhagic shock on hepatic transmembrane potentials and intracellular electrolytes, in vivo 1981
    1981 Effect of prolonged starvation on reticuloendothelial function and survival following trauma 1981
    1981 Effects of ATP-MgCl2on hepatic metabolism and oxygen consumption 1981
    1981 Improved renal function using adenosine triphosphate-magnesium chloride in preservation of canine kidneys subjected to warm ischemia 1981
    1981 Local effect of thermal injury on skeletal muscle blood flow and nucleotide levels 1981
    1981 Red blood cell sodium, potassium, and ATP levels during hemorrhagic shock 1981
    1981 Restoration of the depressed immune response after burn injury with low-dose cyclophosphamide 1981
    1980 Some clinical adventures and misadventures. 1980
    1980 The use of substrates and energy in the treatment of shock. 1980
    1980 Amelioration of toxic acute renal failure by infusion of ATP-MgCl2 1980
    1980 Effect of adenosine tri phosphate-glucose administration following sepsis 1980
    1980 Effect of splenectomy on reticuloendothelial function and survival following sepsis 1980
    1980 Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats 1980
    1980 Further evidence for ATP uptake by rat tissues 1980
    1980 Improved myocardial performance with infusion of adenosine triphosphate-MgCl2 1980
    1980 Inhalation anesthetic-relaxant interactions in vitro 1980
    1980 Is there a positive muscarinic feedback mechanism for acetylcholine release at the neuromuscular junction? 1980
    1980 Prevention of multiple systems failure 1980
    1980 Sepsis and septic shock—A review of laboratory models and a proposal 1980
    1979 Impairment of reticuloendothelial system function with sepsis and its improvement with ATP-MgCl2 plus glucose administration. 1979
    1979 Dose response and cardiovascular effects of ATP-MgCl2administration in intact dogs 1979
    1979 Effect of sepsis on tissue adenine nucleotide levels 1979
    1979 Prostaglandin metabolism, synthesis, and blockade in hemorrhage and sepsis 1979
    1979 Studies of Peripheral Glucose Uptake During Sepsis 1979
    1978 Improved hepatic function and survival with adenosine triphosphate magnesium chloride after hepatic ischemia 1978
    1978 The use of adenosine triphosphate with magnesium chloride in the treatment of post ischemic renal injury. 1978
    1978 Beneficial effect of ATP-MgCl2-glucose administration on survival following sepsis 1978
    1978 Effect of insulin on glucose uptake in muscle during sepsis 1978
    1978 Enhanced recovery from severe ischemic renal injury with adenosine triphosphate-magnesium chloride: Administration after the insult 1978
    1978 Glucocorticoid effects on gluconeogenesis during hemorrhagic shock 1978
    1978 Impairment of reticuloendothelial system (RES) function with sepsis and its improvement with ATP-MgCl2and glucose administration 1978
    1978 Interaction of muscle relaxants and local anesthetics at the neuromuscular junction 1978
    1977 Depletion and replenishment of cellular cyclic adenosine monophosphate in hemorrhagic shock 1977
    1977 Accelerated recovery of acute renal failure by infusion of adenine nucleotides - MgCl2 1977
    1977 Amelioration of acute renal failure with ATP MgCl2 infusion 1977
    1977 Evidence for enhanced uptake of ATP by liver and kidney in hemorrhagic shock 1977
    1977 Evidence for enhanced uptake of ATP by liver and kidney in hemorrhagic shock 1977
    1977 Postischemic Renal Failure: Accelerated Recovery With Adenosine Triphosphate-Magnesium Chloride Infusion 1977
    1977 Restoration of cellular adenosine 3'-5'-monophosphate levels by ATP-MgCl2in hemorrhagic shock 1977
    1976 Alterations in adenosine 3',5' monophosphate levels in hemorrhagic shock 1976
    1976 Alterations in high-energy phosphates in hemorrhagic shock as related to tissue and organ function 1976
    1976 Differences in the altered energy metabolism of hemorrhagic shock and hypoxemia 1976
    1976 Effect of glucocorticoids on gluconeogenesis during hemorhagic shock 1976
    1976 Failure of nicotinamide in the treatment of hemorrhagic shock 1976
    1976 Insulin resistance and its reversal by in vivo infusion of ATP in hemorrhagic shock 1976
    1976 The effects of atherosclerosis on the hypertrophied rabbit heart 1976
    1976 Uptake of ATP by liver and kidney in vitro 1976
    1975 Characteristics of sodium and potassium transport in the lung 1975
    1975 Effect of hydrocortisone and dexamethasone on xylose uptake by isolated rat soleus muscle 1975
    1975 Degradation of adenine nucleotides by the soleus muscle in hemorrhagic shock 1975
    1975 Enhanced uptake of14C ATP by liver and kidney of animals in shock 1975
    1975 Evidence for enhanced uptake of adenosme triphosphate by muscle of animals in shock 1975
    1975 Na+-K+ transport and adenosine nucleotides in the lung in hemorrhagic shock 1975
    1975 Relationship between nicotinamide adenine dinucleotide and survival in hemorrhagic shock 1975
    1975 Reversal of insulin resistance by ATP in hemorrhagic shock 1975
    1975 Reversal of insulin resistance by in vivo infusion of ATP in experimental shock 1975
    1975 The effect of insulin on glucose uptake in soleus muscle during hemorrhagic shock 1975
    1974 Active sodium potassium transport and ATP levels in lung and liver during shock 1974
    1974 Cation transport in the liver in hemorrhagic shock 1974
    1974 Cellular alterations with shock and ischemia 1974
    1974 Depletion and Restoration of Tissue ATP in Hemorrhagic Shock 1974
    1974 Distribution of High-Energy Phosphates in the Heart 1974
    1974 Effect of adenosine triphosphate-magnesium chloride administration in shock 1974
    1974 Effect of hemorrhagic shock on tissue adenine nucleotides in conscious rats 1974
    1974 Insulin Resistance in Experimental Shock 1974
    1974 Protein synthesis by rat liver slices in hemorrhagic shock 1974
    1973 ATP depletion and replenishment in hemorrhagic shock. 1973
    1973 Impairment of cell membrane transport during shock and after treatment 1973
    1973 The Effect of Low ATP on Glucose Uptake in Soleus Muscle During Hemorrhagic Shock 1973
    1973 The effect of insulin and low ATP on glucose uptake in muscle during shock 1973
    1972 Alterations in adenosine nucleotides in hemorrhagic shock 1972
    1972 Insulin: an allosteric modifier of the sugar carrier mechanism 1972
    1970 The action of insulin on glucose uptake by isolated rat soleus muscle I. Effects of cations 1970
    1970 The action of insulin on glucose uptake by isolated rat soleus muscle II. Dissociation of a priming effect of insulin from its stimulatory effect 1970
    1970 Effect of externally added ATP on glucose uptake by isolated rat soleus muscle 1970
    1970 Evidence for the uptake of ATP by rat soleus muscle in vitro 1970
    1969 Kinetics of glucose uptake in isolated soleus muscle 1969

    Chapter

    Year Title Altmetric
    2016 The Use of Estrogen for the Treatment of Traumatic Brain Injury.  161-177. 2016
    2015 Sex differences in sepsis following trauma and injury.  255-271. 2015
    2012 Metabolic and inflammatory responses to trauma and infection 2012
    2009 Experimental Models of Sepsis and Non-Infectious SIRS.  373-389. 2009
    2007 Insight into the mechanism of gender-specific response to trauma-hemorrhage.  869-879. 2007
    2007 Trauma-hemorrhage and its effects on the endothelium.  1513-1522. 2007
    2006 Gender dimorphism and the use of sex steroid/receptor antagonist after trauma.  101-121. 2006
    2004 Ischemia and Reperfusion Injury.  73-84. 2004
    2003 The immune/inflammatory system.  377-390. 2003

    Research Overview

  • trauma, hemorrhage, sepsis, gender dimorphism, immune functions, cardiovascular functions
  • Principal Investigator On

  • Increasing Survival Rate Following Hemorrhagic Shock and Traumatic Brain Injury in Austere Environments  awarded by THE MIND RESEARCH NETWORK 2018 - 2020
  • Part B - Surviving Blood Loss: First in Human Studies to Assess Safety and Physiological Effects of Synthetic Ethinyl Estradiol-3-Sulfate (EE·3·SO4) in Healthy Subjects, Both Euvolemic and Following 10-20% Iatrogenic Blood Loss  awarded by DOD - Department of Defense 2015 - 2018
  • Treatment of Traumatic Brain Injury (TBI) with Hormonal and Pharmacological Support--Preclinical Validation Using Diffuse and Mechanical TBI Animal Models  awarded by DOD - ARMY MEDICAL RESEARCH AND MATERIAL COMMAND 2008 - 2016
  • Maintenance of Organ Function Following Injury  awarded by National Institute of General Medical Sciences/NIH/DHHS 2009 - 2014
  • Development of a Controlled Hemorrhage Model in Mature, Miniature Pigs for Multi-Center Applications and Trial of Novel Field Expedient Treatment  awarded by Texas A&M University 2012 - 2013
  • Immunological Aspects of Hemorrhage  awarded by National Institute of General Medical Sciences/NIH/DHHS 2007 - 2013
  • Evaluation of Premarin in a Rat Model of Mild and Severe Hemorrhage  awarded by Defense Advanced Research Projects Agency 2010 - 2012
  • Trauma and Inflammation Research Training  awarded by National Institute of General Medical Sciences/NIH/DHHS 2006 - 2012
  • Role of Zinc in Estrogen-Mediated Salutary Effects on Cardiovascular Functions Following Trauma-Hemorrhage  awarded by American Heart Association (Southeast Affiliate) 2009 - 2011
  • Private Grant  awarded by AKEBIA THERAPEUTICS, INC. 2010 - 2011
  • Full Name

  • Irshad Chaudry