Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Redox-Sensitive Innate Immune Pathways during Macrophage Activation in Type 1 DiabetesAntioxidants and Redox Signaling.  29:1373-1398. 2018
2018 Sex differences underlying pancreatic islet biology and its dysfunctionMolecular Metabolism.  15:82-91. 2018
2018 The proinflammatory effects of macrophage-derived NADPH oxidase function in autoimmune diabetesFree Radical Biology and Medicine.  125:81-89. 2018
2018 Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intoleranceMolecular Metabolism.  12:48-61. 2018
2018 Redox-dependent inflammation in islet transplantation rejectionFrontiers in Endocrinology.  9. 2018
2018 Manganoporphyrin-Polyphenol Multilayer Capsules as Radical and Reactive Oxygen Species (ROS) ScavengersChemistry of Materials.  30:344-357. 2018
2018 Superoxide production by NADPH oxidase intensifies macrophage antiviral responses during diabetogenic coxsackievirus infectionJournal of Immunology.  200:61-70. 2018
2017 Islet encapsulation with polyphenol coatings decreases pro-inflammatory chemokine synthesis and T cell traffickingBiomaterials.  128:19-32. 2017
2016 Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β Group VIA phospholipase a2Journal of Biological Chemistry.  291:23268-23281. 2016
2016 NADPH oxidase-derived superoxide provides a third signal for CD4 T cell effector responsesJournal of Immunology.  197:1733-1742. 2016
2015 Loss of NOX-derived superoxide exacerbates diabetogenic CD4 T-cell effector responses in type 1 diabetesDiabetes.  64:4171-4183. 2015
2015 Diabetes: hydrogen-bonded multilayers of tannic Acid as mediators of T-cell immunity (adv. Healthcare mater. 5/2015).Advanced Healthcare Materials.  4:685. 2015
2015 Hydrogen-bonded multilayers of tannic acid as mediators of T-cell immunityAdvanced Healthcare Materials.  4:686-694. 2015
2015 Loss of NADPH oxidase-derived superoxide skews macrophage phenotypes to delay type 1 diabetesDiabetes.  64:937-946. 2015
2015 Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD miceDiabetes.  64:541-554. 2015
2015 Minireview: Directed differentiation and encapsulation of Islet β-cells—Recent advances and future considerationsMolecular Endocrinology -Baltimore-.  29:1388-1399. 2015
2014 Effects of metalloporphyrins on reducing inflammation and autoimmunityAntioxidants and Redox Signaling.  20:2465-2477. 2014
2014 Evidence of contribution of iPLA2β-mediated events during islet β-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2β in T1D developmentEndocrinology.  155:3352-3364. 2014
2013 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathwaysCancer Research.  73:6609-6620. 2013
2013 Diabetes-related impairment in bone strength is established early in the life course.World Journal of Diabetes.  4:145-150. 2013
2013 The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesisAnnals of the New York Academy of Sciences.  1281:16-35. 2013
2012 Ultrathin polymeric coatings based on hydrogen-bonded polyphenol for protection of pancreatic islet cellsAdvanced Materials for Optics and Electronics.  22:3389-3398. 2012
2012 Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic miceFree Radical Biology and Medicine.  52:2047-2056. 2012
2012 Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome (HIDS)Journal of Inherited Metabolic Disease.  35:159-168. 2012
2012 Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activitiesAmino Acids.  42:95-113. 2012
2012 Erratum: Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities (Amino Acids DOI: 10.1007/s00726-010-0603-6)Amino Acids.  42:115-116. 2012
2011 Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent models of ischemic stroke and subarachnoid hemorrhageJournal of Pharmacology and Experimental Therapeutics.  338:906-916. 2011
2011 A multivalent vaccine for type 1 diabetes skews T cell subsets to Th2 phenotype in NOD miceImmunologic Research.  50:213-220. 2011
2011 Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetesDiabetes.  60:2144-2151. 2011
2010 NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunityJournal of Immunology.  185:5247-5258. 2010
2010 Redox modulation protects islets from transplant-related injuryDiabetes.  59:1731-1738. 2010
2010 Macrophage and T Cell ROS Production Is Critical for T1D PathogenesisDiabetes.  59:A361-A361. 2010
2009 FoxO1 links insulin resistance to proinflammatory cytokine IL-1β production in macrophagesDiabetes.  58:2624-2633. 2009
2009 Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the ratFree Radical Biology and Medicine.  47:917-923. 2009
2009 Inhibition of Superoxide Synthesis Prevents T Cell AutoreactivityDiabetes.  58:A50-A50. 2009
2009 Redox Modulation Ablates Adaptive Immune Effector Response by Inhibiting IL-12-IL-12R SignalingDiabetes.  58:A327-A328. 2009
2008 Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-κB activation in vascular smooth muscle cellsAtherosclerosis.  201:248-257. 2008
2008 Redox modulation inhibits CD8 T cell effector functionFree Radical Biology and Medicine.  45:1477-1486. 2008
2008 Reactive oxygen species generation is necessary for diabetogenic T cell effector functionDiabetes.  57:A354-A354. 2008
2008 Redox modulation impairs allograft rejectionDiabetes.  57:A543-A544. 2008
2008 Redox modulation regulates T cell activation and effector function through a tumor necrosis factor alpha converting enzyme (TACE) dependent mechanismDiabetes.  57:A53-A53. 2008
2007 A catalytic antioxidant quells the response to alloantigenActa Diabetologica.  44:S48-S48. 2007
2007 Autoimmune diabetes is dependent on a proinflammatory third signalActa Diabetologica.  44:S52-S52. 2007
2007 Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndromeJournal of Inherited Metabolic Disease.  30:888-895. 2007
2007 Critical role of superoxide (O2-) production in the pathogenesis of autoimmune diabetes (T1D)Diabetes.  56:A59-A59. 2007
2007 Reactive oxygen species generation is necessary for autoimmune T cell effector functionDiabetes.  56:A58-A59. 2007
2007 Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsivenessJournal of Immunology.  178:908-917. 2007
2006 Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibilityDiabetes.  55:3455-3462. 2006
2006 Blockade of the inflammatory third signal in conjunction with antigenic immunization as a potentially novel immunosuppression strategyDiabetes.  55:A447-A447. 2006
2006 Redox modulation inhibits diabetogenic T cell activation and T1DDiabetes.  55:A89-A89. 2006
2006 The role of ER-stress in the antigenic response of the BDC-2.5 T cellDiabetes.  55:A88-A88. 2006
2006 Redox modulation of innate immune-derived pro-inflammatory third signals prevents diabetogenesisFree Radical Biology and Medicine.  41:S76-S76. 2006
2005 Catalytic antioxidant disruption of innate-mediated pro-inflammatory cytokine and reactive oxygen species third signal delays spontaneous autoimmune diabetes in the NOD mouseDiabetes.  54:A25-A25. 2005
2004 Disruption of pro-inflammatory cytokine and reactive oxygen species dependent third signal leads to antigen-specific hyporesponsiveness that is STAT-4 dependentDiabetes.  53:A301-A302. 2004
2004 Genetic ablation of macrophage/neutrophil NADPH oxidase activity inhibits T1D development in NOD miceDiabetes.  53:A26-A26. 2004
2004 Quelling oxidative stress during human islet isolation correlates with reduced NF-kappa B-dependent pro-inflammatory mediators: Implications for the development of footprint assays for transplant successDiabetes.  53:A454-A454. 2004
2004 Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: Implication for their use in targeting oxidation-reduction reactions in innate immunityFree Radical Biology and Medicine.  36:233-247. 2004
2004 Caspase-1 Is Not Required for Type 1 Diabetes in the NOD MouseDiabetes.  53:99-104. 2004
2002 Therapeutic induction of diabetes resistance and antigen-specific hyporesponsiveness using a superoxide dismutase mimic (AEOL 10113)Diabetes.  51:A288-A289. 2002
2002 Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophagesJournal of Immunology.  168:825-833. 2002
2001 A metalloporphyrin-based superoxide dismutase mimetic inhibits type I diabetesFree Radical Biology and Medicine.  31:S50-S50. 2001

Chapter

Year Title Altmetric
2012 Reactive oxygen species - Key immune mediators in type 1 diabetes.  3493-3520. 2012

Principal Investigator On

  • Oxidative Post-Translational Modification of Type 1 Diabetes Autoantigens  awarded by Juvenile Diabetes Research Foundation International 2018 - 2021
  • Optimizing Encapsulation to Treat Type 1 Diabetes Mellitus: The Role of Oxygenation, Antigen Shedding and Innate Immune Response in Graft Success  awarded by University of Miami 2019
  • Islet Encapsulation with lmmunomodulatory Nanothin Coatings  awarded by Juvenile Diabetes Research Foundation International 2019
  • Redox Regulation of Anti-Viral Responses in Type 1 Diabetes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • Encapsulation of Neonatal Porcine Islets with Novel Nano Thin lmmunomodulatory Coating of Polyphenolic Antioxidant  awarded by University of Alberta at Edmonton 2016 - 2018
  • Islet Encapsulation with Immunomodulatory Nanothin Coatings  awarded by Juvenile Diabetes Research Foundation International 2016 - 2018
  • CD4 T cell Metabolism as a Therapeutic Target in Type 1 Diabetes  awarded by Juvenile Diabetes Research Foundation International 2017
  • Synergism of Innate Immune-Derived Reactive Oxygen Species and T Cell Effector Responses in Type 1 Diabetes  awarded by American Diabetes Association, Inc. 2012 - 2017
  • Islet Encapsulation with Immunomodulatory Nanothin Coatings  awarded by Juvenile Diabetes Research Foundation International 2015 - 2016
  • HSF/GEF Scholar Award for Hubert Tse  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2009 - 2014
  • Rheumatic Diseases Core Center: Pilot Project - P & F 4  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • The Role of Reactive Oxygen Species in Innate and Adaptive Immune Function in Type 1 Diabetes  awarded by American Diabetes Association, Inc. 2009 - 2012
  • Investigator On

  • UAB Center for AIDS Research (CFAR)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • UAB Diabetes Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB Diabetes Research Center - Enrichment Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Monocyte Mitochondrial Dysfunction and Kidney Stone Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2021
  • Dampening Autoimmunity with Encapsulated Autoantigens in Polyphenolic Capsules  awarded by NSF - National Science Foundation 2016 - 2020
  • Treatment of Neuropathic Pain after SCI with a Catalytic Oxidoreductant  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2013 - 2017
  • Immunomodulatory Ultrathin Coatings for Pancreatic Islet Transplantation  awarded by NSF - National Science Foundation 2013 - 2017
  • Analysis of Human and Mouse Antibodies to Beta Cell Antigens Bearing N-Acetyl Glucosamine Post-Translation Modifications and their Potential to Prevent Human Type 1 Diabetes  awarded by Juvenile Diabetes Research Foundation International 2014 - 2016
  • Glucose Regulation of Bacterial Virulence in Diabetes and Hyperglycemia  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2016
  • Private Grant  awarded by DIAMYD MEDICAL AB 2014 - 2015
  • Antibodies to Beta Cell GlcNAc - Modified Autoantigens Blocks T1D in NOD Mice  awarded by Juvenile Diabetes Research Foundation International 2012 - 2014
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Education And Training

  • Doctor of Philosophy in Microbiological Sciences and Immunology, University of Colorado System : Denver 1999
  • Bachelor of Science or Mathematics in Biochemistry, Virginia Polytechnic Institute and State University 1992
  • Awards And Honors

  • P30 Award UAB Comprehensive Diabetes Center, 2017
  • JDRF Post-doctoral fellowship (Ruth McDowell, Ph.D.) - declined, 2017
  • T32 Translational and Molecular Sciences (TMS) (T32.GM109780) pre-doctoral trainee slot – Jessie Barra (Rakesh Patel, PI), 2017
  • Associate Professor with tenure, 2016
  • UAB School of Medicine AMC21 R01 Award, 2016
  • AAI Early Career Faculty Travel Grant, 2015
  • T32 Immunologic Diseases and Basic Immunology (T32.AI007051-35) pre-doctoral trainee slot – Ashley Burg (Harry Schroeder, PI), 2015
  • T32 Dental Academic Research Training (DART) (T32.DE17607) post-doctoral trainee slot – Ruth McDowell (Mary MacDougall, PI), 2015
  • UAB Immunology, Autoimmunity, and Transplantation (IAT) Research Acceleration Project, 2014
  • UAB institutional nominee for the ADA Pathway to Stop Diabetes Award, 2014
  • AAI Early Career Faculty Travel Grant, 2014
  • American Association of Immunologists Travel for Techniques Award, 2014
  • NIH/NIDDK R01 Award DK099550, 2014
  • Featured on the cover of Diabetes Forecast (May 2013 issue), 2013
  • Pilot & Feasibility Award, 2012
  • American Diabetes Association Career Development Award, 2012
  • P30 Award UAB Comprehensive Diabetes Center, 2011
  • P30 Award UAB Comprehensive Diabetes Center, 2010
  • T32 Immunologic Diseases and Basic Immunology (T32.AI007051-35) pre-doctoral trainee slot – Lindsey Padgett (Harry Schroeder, PI), 2010
  • American Diabetes Association Junior Faculty Award, 2009
  • P30 Award UAB Rheumatic Diseases Core Center, 2009
  • 9th International Congress of the Immunology of Diabetes Society and American Diabetes Association Symposium Scholarship, 2007
  • Society for Free Radical Biology and Medicine Travel Award, 2006
  • NIH Loan Repayment Program Awardee, Pediatric Loan Repayment Program, 2004
  • Society for Free Radical Biology and Medicine Travel Award, 2004
  • Immunology of Diabetes Society Travel Award, 2002
  • Full Name

  • Hubert Tse