Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviorsJournal of Clinical Investigation.  129:3407-3419. 2019
2019 Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3 2019
2019 A network of phosphatidylinositol (4,5)-bisphosphate (PIP2) binding sites on the dopamine transporter regulates amphetamine behavior in Drosophila MelanogasterMolecular Psychiatry2019
2017 Atypical dopamine efflux caused by 3,4-methylenedioxypyrovalerone (MDPV) via the human dopamine transporterJournal of Chemical Neuroanatomy.  83-84:69-74. 2017
2015 Sodium-dependent vitamin C transporter-2 mediates vitamin C transport at the cortical nerve terminalJournal of Neuroscience Research.  93:1881-1890. 2015
2015 Dual agonist occupancy of at 1 -R-α 2C -AR heterodimers results in atypical G s -PKA signalingNature Chemical Biology.  11:271-279. 2015
2015 Zn2+ reverses functional deficits in a de novo dopamine transporter variant associated with autism spectrum disorderMolecular Autism.  6. 2015
2015 Rare Autism-Associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and BehaviorsEBioMedicine.  2:135-146. 2015
2015 mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neurotransmission 2015
2014 Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function 2014
2014 PIP2 regulates psychostimulant behaviors through its interaction with a membrane proteinNature Chemical Biology.  10:582-589. 2014
2014 SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and traffickingTranslational Psychiatry.  4:e464. 2014
2013 De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorderMolecular Psychiatry.  18:1315-1323. 2013
2013 Drosophila melanogaster: A novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter geneMolecular Psychiatry.  18:1235. 2013
2013 Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate 2013
2013 Erratum: Yohimbine depresses excitatory transmission in BNST and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes (Neuropsychopharmacology (2013) 38 (1140) DOI: 10.1038/npp.2013.14)Neuropsychopharmacology.  38:1140. 2013
2012 Yohimbine depresses excitatory transmission in bnst and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processesNeuropsychopharmacology.  37:2253-2266. 2012
2011 Erratum: Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT (Nature Neuroscience (2011) 14 (469-477))Nature Neuroscience.  14:1617. 2011
2011 Impaired striatal akt signaling disrupts dopamine homeostasis and increases feedingPLoS ONE.  6. 2011
2011 Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase i in drosophila oocytesPLoS Genetics.  7. 2011
2011 Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DATNature Neuroscience.  14:469-477. 2011
2011 Amphetamine actions rely on the availability of phosphatidylinositol-4,5-bisphosphate.BMC Pharmacology.  11:A19-A19. 2011
2010 Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis 2010
2010 Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expressionACS Chemical Neuroscience.  1:476-481. 2010
2010 Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking 2010
2010 Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder 2010
2009 cGMP-dependent protein kinase iα associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptakeMolecular Brain.  2. 2009
2009 Subcellular localization of the antidepressant-sensitive norepinephrine transporterBMC Neuroscience.  10. 2009
2009 A closer look at amphetamine-induced reverse transport and trafficking of the dopamine and norepinephrine transportersMolecular Neurobiology.  39:73-80. 2009
2008 Stoned B mediates sorting of integral synaptic vesicle proteinsNeuroscience.  153:1048-1063. 2008
2005 Drosophila Nod protein binds preferentially to the plus ends of microtubules and promotes microtubule polymerization in vitro 2005
2004 Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransductionNature Neuroscience.  7:1070-1078. 2004
2004 Ceramidase regulates synaptic vesicle exocytosis and trafficking 2004
2004 The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesisDevelopmental Biology.  270:290-307. 2004
2003 Techniques to dissect cellular and subcellular function in the Drosophila nervous systemMethods in Cell Biology.  2003:195-265. 2003
2002 Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development 2002
2001 Drosophila fragile x-related gene regulates the MAP1B homolog Futsch to control synaptic structure and functionCell.  107:591-603. 2001
2001 Orphan kinesin NOD lacks motile properties but does possess a microtubule-stimulated ATPase activity 2001
1999 Mutations in the α-tubulin 67C gene specifically impair achiasmate segregation in Drosophila melanogaster 1999
1999 Identification of novel Drosophila meiotic genes recovered in a P- element screen 1999
1999 The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles 1999
1996 Anastral meiotic spindle morphogenesis: Role of the non-claret disjunctional kinesin-like protein 1996
1993 Calmodulin binding to and cAMP-dependent phosphorylation of kinesin light chains modulate kinesin ATPase activityJournal of Biological Chemistry.  268:11176-11187. 1993
1988 Calmodulin- and protein phosphorylation-independent release of catecholamines from PC-12 cellsFEBS Letters.  229:238-242. 1988
1988 The effect of down regulation of protein kinase C on the inhibitory modulation of dorsal root ganglion neuron Ca2+ currents by neuropeptide Y 1988
1987 Down regulation of protein kinase C in neuronal cells: Effects on neurotransmitter release 1987
1984 Transfer of cholesterol from its site of synthesis to the plasma membraneJournal of Biological Chemistry.  259:14624-14630. 1984
1984 Cholesterol oxidase susceptibility of the red cell membrane 1984
1984 The intracellular movement of cholesterol in fibroblastsThe FASEB Journal.  43. 1984

Chapter

Year Title Altmetric
2013 Neurotransmitter Transporters.  238-240. 2013
1988 Neurotransmitter Modulation of Calcium Currents in Rat Sensory Neurons.  263-273. 1988

Education And Training

  • Doctor of Philosophy, University of Chicago 1992
  • Full Name

  • Heinrich Matthies