Selected Publications

Academic Article

Year Title Altmetric
2023 Syntaxin 1 Ser14 phosphorylation is required for nonvesicular dopamine release.Science Advances.  9:eadd8417. 2023
2021 Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric diseaseJCI Insight.  6. 2021
2021 A network of phosphatidylinositol (4,5)-bisphosphate (PIP2) binding sites on the dopamine transporter regulates amphetamine behavior in Drosophila MelanogasterMolecular Psychiatry.  26:4417-4430. 2021
2021 Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-DystoniaeLife.  10. 2021
2021 Autism-Associated Variant in the SLC6A3 Gene Alters the Oral Microbiome and Metabolism in a Murine ModelFrontiers in Psychiatry.  12. 2021
2019 Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviorsJournal of Clinical Investigation.  129:3407-3419. 2019
2019 Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3 2019
2017 Atypical dopamine efflux caused by 3,4-methylenedioxypyrovalerone (MDPV) via the human dopamine transporterJournal of Chemical Neuroanatomy.  83-84:69-74. 2017
2015 Sodium-dependent vitamin C transporter-2 mediates vitamin C transport at the cortical nerve terminalJournal of Neuroscience Research.  93:1881-1890. 2015
2015 Dual agonist occupancy of at 1 -R-α 2C -AR heterodimers results in atypical G s -PKA signalingNature Chemical Biology.  11:271-279. 2015
2015 Zn2+ reverses functional deficits in a de novo dopamine transporter variant associated with autism spectrum disorderMolecular Autism.  6. 2015
2015 Rare Autism-Associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and BehaviorsEBioMedicine.  2:135-146. 2015
2015 mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neurotransmission 2015
2014 Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function 2014
2014 PIP2 regulates psychostimulant behaviors through its interaction with a membrane proteinNature Chemical Biology.  10:582-589. 2014
2014 SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and traffickingTranslational Psychiatry.  4:e464. 2014
2013 De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorderMolecular Psychiatry.  18:1315-1323. 2013
2013 Drosophila melanogaster: A novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter geneMolecular Psychiatry.  18:1235. 2013
2013 Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate 2013
2013 Erratum: Yohimbine depresses excitatory transmission in BNST and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes (Neuropsychopharmacology (2013) 38 (1140) DOI: 10.1038/npp.2013.14)Neuropsychopharmacology.  38:1140. 2013
2012 Yohimbine depresses excitatory transmission in bnst and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processesNeuropsychopharmacology.  37:2253-2266. 2012
2011 Amphetamine actions rely on the availability of phosphatidylinositol-4,5-bisphosphateBMC Pharmacology.  11:a19. 2011
2011 Erratum: Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT (Nature Neuroscience (2011) 14 (469-477))Nature Neuroscience.  14:1617. 2011
2011 Impaired striatal akt signaling disrupts dopamine homeostasis and increases feedingPLoS One.  6. 2011
2011 Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase i in drosophila oocytesPLoS Genetics.  7. 2011
2011 Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DATNature Neuroscience.  14:469-477. 2011
2010 Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis 2010
2010 Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expressionACS Chemical Neuroscience.  1:476-481. 2010
2010 Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking 2010
2010 Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder 2010
2009 cGMP-dependent protein kinase iα associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptakeMolecular Brain.  2. 2009
2009 Subcellular localization of the antidepressant-sensitive norepinephrine transporterBMC Neuroscience.  10. 2009
2009 A closer look at amphetamine-induced reverse transport and trafficking of the dopamine and norepinephrine transportersMolecular Neurobiology.  39:73-80. 2009
2008 Stoned B mediates sorting of integral synaptic vesicle proteinsNeuroscience.  153:1048-1063. 2008
2005 Drosophila Nod protein binds preferentially to the plus ends of microtubules and promotes microtubule polymerization in vitroMolecular Biology of the Cell.  16:5400-5409. 2005
2004 Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransductionNature Neuroscience.  7:1070-1078. 2004
2004 Ceramidase regulates synaptic vesicle exocytosis and trafficking 2004
2004 The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesisDevelopmental Biology.  270:290-307. 2004
2003 Techniques to dissect cellular and subcellular function in the Drosophila nervous systemMethods in Cell Biology.  2003:195-265. 2003
2002 Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development 2002
2001 Drosophila fragile x-related gene regulates the MAP1B homolog Futsch to control synaptic structure and functionCell.  107:591-603. 2001
2001 Orphan kinesin NOD lacks motile properties but does possess a microtubule-stimulated ATPase activityMolecular Biology of the Cell.  12:4000-4012. 2001
1999 Mutations in the α-tubulin 67C gene specifically impair achiasmate segregation in Drosophila melanogaster 1999
1999 Identification of novel Drosophila meiotic genes recovered in a P- element screen 1999
1999 The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles 1999
1996 Anastral meiotic spindle morphogenesis: Role of the non-claret disjunctional kinesin-like protein 1996
1993 Calmodulin binding to and cAMP-dependent phosphorylation of kinesin light chains modulate kinesin ATPase activityJournal of Biological Chemistry.  268:11176-11187. 1993
1988 Calmodulin- and protein phosphorylation-independent release of catecholamines from PC-12 cellsFEBS Letters.  229:238-242. 1988
1988 The effect of down regulation of protein kinase C on the inhibitory modulation of dorsal root ganglion neuron Ca2+ currents by neuropeptide Y 1988
1987 Down regulation of protein kinase C in neuronal cells: Effects on neurotransmitter release 1987
1984 Transfer of cholesterol from its site of synthesis to the plasma membraneJournal of Biological Chemistry.  259:14624-14630. 1984
1984 Cholesterol oxidase susceptibility of the red cell membrane 1984
1984 The intracellular movement of cholesterol in fibroblasts 1984


Year Title Altmetric
2021 Membrane transport.  1073-1075. 2021
2013 Neurotransmitter Transporters.  238-240. 2013
1988 Neurotransmitter Modulation of Calcium Currents in Rat Sensory Neurons.  263-273. 1988

Education And Training

  • Doctor of Philosophy, University of Chicago 1992
  • Full Name

  • Heinrich Matthies