Selected Publications

Academic Article

Year Title Altmetric
2022 Validation of PRKCB Immunohistochemistry as a Biomarker for the Diagnosis of Ewing SarcomaFetal and Pediatric Pathology2022
2021 Reactive oxygen species produced by altered tumor metabolism impacts cancer stem cell maintenanceRedox Biology.  44. 2021
2021 Novel dopamine receptor 3 antagonists inhibit the growth of primary and temozolomide resistant glioblastoma cellsPLoS One.  16. 2021
2021 A role for GLUT3 in glioblastoma cell invasion that is not recapitulated by GLUT1Cell Adhesion and Migration.  15:101-115. 2021
2020 A cell-penetrating MARCKS mimetic selectively triggers cytolytic death in glioblastomaOncogene.  39:6961-6974. 2020
2020 Sphingolipid metabolism in glioblastoma and metastatic brain tumors: A review of sphingomyelinases and sphingosine-1-phosphateBiomolecules.  10:1-23. 2020
2020 Glioma stem cells and their roles within the hypoxic tumor microenvironmentTheranostics.  11:665-683. 2020
2020 The role of metabolic plasticity in blood and brain stem cell pathophysiologyCancer Research.  80:5-16. 2020
2019 Deletion of the RNA regulator HuR in tumor-associated microglia and macrophages stimulates anti-tumor immunity and attenuates glioma growthGlia.  67:2424-2439. 2019
2019 SOD2 acetylation and deacetylation: Another tale of Jekyll and Hyde in cancer 2019
2019 Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cellsJournal of Ovarian Research.  12. 2019
2019 HPAanalyze: An R package that facilitates the retrieval and analysis of the Human Protein Atlas dataBMC Bioinformatics.  20. 2019
2019 Anti-cancer effects of the HuR inhibitor, MS-444, in malignant glioma cellsCancer Biology and Therapy.  20:979-988. 2019
2019 BEERE: a web server for biomedical entity expansion, ranking and explorationsNucleic Acids Research.  47:W578-W586. 2019
2019 Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastomaInternational Journal of Oncology.  54:2039-2053. 2019
2019 New quantitative approach reveals heterogeneity in mitochondrial structure–function relations in tumor-initiating cellsJournal of Cell Science.  132. 2019
2019 Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma AngiogenesisStem Cells.  37:453-462. 2019
2019 Recasting the Cancer Stem Cell Hypothesis: Unification Using a Continuum Model of Microenvironmental ForcesCurrent stem cell reports.  5:22-30. 2019
2018 UAB30, a novel RXR agonist, decreases tumorigenesis and leptomeningeal disease in group 3 medulloblastoma patient-derived xenograftsJournal of Neuro-Oncology.  140:209-224. 2018
2018 IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 11 Medical and Health Sciences 1103 Clinical SciencesCell Communication and Signaling.  16. 2018
2018 Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in VitroACS Chemical Biology.  13:2048-2057. 2018
2018 Reactive species balance via GTP cyclohydrolase i regulates glioblastoma growth and tumor initiating cell maintenanceNeuro-Oncology.  20:1055-1067. 2018
2018 Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucoseBiomarker Research.  6. 2018
2018 The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1 signalingJournal of Biological Chemistry.  293:5659-5667. 2018
2018 The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells 2018
2017 Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivoJCI Insight.  2. 2017
2017 NOS Expression and NO Function in Glioma and Implications for Patient TherapiesAntioxidants and Redox Signaling.  26:986-999. 2017
2017 Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cellsJournal of Neuro-Oncology.  132:219-229. 2017
2017 Modeling Physiologic Microenvironments in Three-Dimensional Microtumors Maintains Brain Tumor Initiating Cells.Journal of cancer stem cell research.  5. 2017
2017 The Arf activator GBF1 localizes to plasma membrane sites involved in cell adhesion and motility.Cellular Logistics.  7:e1308900. 2017
2016 Novel Retinoid UAB30 Decreases Tumorigenicity and Cancer Stem Cell Maintenance in Human Neuroblastoma Patient-Derived XenograftsJournal of the American College of Surgeons.  223:e160-e161. 2016
2016 334 A Functional Screen Identifies miRNAs that Induce Radioresistance in GlioblastomasNeurosurgery.  63:197-198. 2016
2016 Metabolic, autophagic, and mitophagic activities in cancer initiation and progressionBiomedical Journal.  39:98-106. 2016
2015 ROCK inhibition facilitates in vitro expansion of glioblastoma stem-like cellsPLoS One.  10. 2015
2015 Kinome-wide shRNA screen identifies the receptor tyrosine kinase AXL as a key regulator for mesenchymal glioblastoma stem-like cellsStem Cell Reports.  4:899-913. 2015
2015 Acquisition of meiotic DNA repair regulators maintain genome stability in glioblastomaCell Death and Disease.  6. 2015
2015 Development of a Sox2 reporter system modeling cellular heterogeneity in gliomaNeuro-Oncology.  17:361-371. 2015
2015 A new mitochondrial pool of cyclin E, regulated by Drp1, is linked to cell-density-dependent cell proliferationJournal of Cell Science.  128:4171-4182. 2015
2014 A functional screen identifies miRs that induce radioresistance in glioblastomasMolecular Cancer Research.  12:1767-1778. 2014
2014 Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cellsCell Death and Differentiation.  21:258-269. 2014
2014 Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchyGenes and Development.  28:1085-1100. 2014
2014 High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factorCell Reports.  6:117-129. 2014
2014 Method for Efficient Transduction of Cancer Stem Cells.Journal of cancer stem cell research.  2. 2014
2014 Microenvironmental Variables Must Influence Intrinsic Phenotypic Parameters of Cancer Stem Cells to Affect TumourigenicityPLoS Computational Biology.  10. 2014
2014 Phage display discovery of novel molecular targets in glioblastoma- initiating cellsCell Death and Differentiation.  21:1325-1339. 2014
2013 Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17AJournal of Experimental Medicine.  210:2851-2872. 2013
2013 Microenvironmental variables must influence intrinsic phenotypic parameters of cancer stem cells to affect tumourigenicity 2013
2013 Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptakeNature Neuroscience.  16:1373-1382. 2013
2013 Aptamer identification of brain tumor-initiating cellsCancer Research.  73:4923-4936. 2013
2013 Multiplex Flow Cytometry Barcoding and Antibody Arrays Identify Surface Antigen Profiles of Primary and Metastatic Colon Cancer Cell LinesPLoS One.  8. 2013
2013 Intrinsic cell factors that influence tumourigenicity in cancer stem cells - towards hallmarks of cancer stem cells 2013
2012 Laminin alpha 2 enables glioblastoma stem cell growthAnnals of Neurology.  72:766-778. 2012
2012 The quest for self-identity: Not all cancer stem cells are the sameClinical Cancer Research.  18:3495-3498. 2012
2012 Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneityGenes and Development.  26:1247-1262. 2012
2012 Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potentialCell Death and Differentiation.  19:428-439. 2012
2011 Twisted tango: Brain tumor neurovascular interactionsNature Neuroscience.  14:1375-1381. 2011
2011 Direct In Vivo evidence for tumor propagation by glioblastoma cancer stem cellsPLoS One.  6. 2011
2011 Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisionsCell Death and Disease.  2. 2011
2011 Glioma stem cell maintenance: The role of the microenvironmentCurrent Pharmaceutical Design.  17:2386-2401. 2011
2011 Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2Cell.  146:53-66. 2011
2011 Acidic stress promotes a glioma stem cell phenotypeCell Death and Differentiation.  18:829-840. 2011
2011 Molecular targeting of neural cancer stem cells: TTAGGG, you're it!Clinical Cancer Research.  17:3-5. 2011
2011 Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3Cancer Cell.  19:498-511. 2011
2010 Erythropoietin receptor signaling through STAT3 Is required for glioma stem cell maintenanceGenes and Cancer.  1:50-61. 2010
2010 Integrin Alpha 6 regulates glioblastoma stem cellsCell Stem Cell.  6:421-432. 2010
2010 Hypoxia inducible factors in cancer stem cellsBritish Journal of Cancer.  102:789-795. 2010
2010 Targeting A20 decreases glioma stem cell survival and tumor growthPLoS Biology.  8. 2010
2010 Notch promotes radioresistance of glioma stem cellsStem Cells.  28:17-28. 2010
2009 The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotypeCell Cycle.  8:3274-3284. 2009
2009 Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growthStem Cells.  27:2393-2404. 2009
2009 NDRG4 is required for cell cycle progression and survival in glioblastoma cellsJournal of Biological Chemistry.  284:25160-25169. 2009
2009 Turning cancer stem cells inside out: An exploration of glioma stem cells signalling pathwaysJournal of Biological Chemistry.  284:16705-16709. 2009
2009 Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem CellsCancer Cell.  15:501-513. 2009
2008 Brain cancer stem cells display preferential sensitivity to Akt inhibitionStem Cells.  26:3027-3036. 2008
2008 c-Myc is required for maintenance of glioma cancer stem cellsPLoS One.  3. 2008
2008 Targeting cancer stem cells through L1CAM suppresses glioma growthCancer Research.  68:6043-6048. 2008
2007 The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasionMolecular Cancer Therapeutics.  6:2449-2457. 2007
2007 Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinasesOncogene.  26:4084-4094. 2007
2007 A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growthMolecular Carcinogenesis.  46:488-496. 2007
2006 Glioma stem cells promote radioresistance by preferential activation of the DNA damage responseNature.  444:756-760. 2006
2006 APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt pathway via the phosphoinositol phosphatase SHIP2Circulation Research.  99:829-836. 2006
2006 AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant gliomaCancer Research.  66:8722-8730. 2006
2006 Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factorCancer Research.  66:7843-7848. 2006
2006 A novel low molecular weight inhibitor of focal adhesion kinase and insulin-like growth factor-1 receptor, TAE226, inhibits glioma growth.Journal of Clinical Oncology.  24:11505. 2006
2005 Loss of phosphatase and tensin homologue increases transforming growth factor β-mediated invasion with enhanced SMAD3 transcriptional activityCancer Research.  65:11276-11281. 2005
2005 Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determinationMolecular and Cellular Biology.  25:9460-9468. 2005
2004 SB-431542, a small molecule transforming growth factor-β-receptor antagonist, inhibits human glioma cell line proliferation and motilityMolecular Cancer Therapeutics.  3:737-745. 2004
2004 Selective Deficiency of the "Bone-related" Runx2-II Unexpectedly Preserves Osteoblast-mediated SkeletogenesisJournal of Biological Chemistry.  279:20307-20313. 2004
2003 Methyl parathion: A review of health effects 2003
2001 An Essential Role for Mad Homology Domain 1 in the Association of Smad3 with Histone Deacetylase ActivityJournal of Biological Chemistry.  276:22595-22603. 2001
2001 Transforming growth factor-β signaling in cancerMicroscopy Research and Technique.  52:363-373. 2001
2001 The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosisJournal of Bone and Mineral Research.  16:1754-1764. 2001
1999 Targeted disruption of Smad3 reveals an essential role in transforming growth factor β-mediated signal transductionMolecular and Cellular Biology.  19:2495-2504. 1999


Year Title Altmetric
2008 TGF-b: A Multipotential Cytokine. The TGF-b Family 2008
2008 The Rationale for and Effects of Targeting TGF- for Glioma Therapy.  Ed. 2.  2008


Year Title Altmetric
2011 The Cancer Stem Cell Paradigm.  225-248. 2011
2008 The Rationale for and Effects of Targeting TGF-β for Glioma Therapy.  335-351. 2008

Research Overview

  • In many cancers including glioblastoma, tumor microenvironments contribute to disease progression including through the promotion of tumor initiating (cancer stem cell) phenotypes. The overall goal of my laboratory is to understand how we can target tumor microenvironmental effects for novel therapies against glioma.
  • Principal Investigator On

  • A20 Promotes Glioma Stem Cell Mediated Tumorigenesis  awarded by National Cancer Institute/NIH/DHHS
  • Aberrant Signaling from Brain Tumors Regulates Distant and Local Environments  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Biosynthetic Metabolic Pathway Regulation of Glioma Growth  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Carbonic Anhydrase Inhibition to Improve Glioblastoma Standard of Care  awarded by SOUTHEASTERN BRAIN TUMOR FOUNDATION
  • Consequences of Metabolic Reprogramming by GLUT3 in GBM  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Defining a Role for the GCH1/BH4 Pathway in Brain Tumor Therapeutic Resistance  awarded by American Brain Tumor Association
  • Identification of Glucose Transporter 3 Inhibitors for Glioblastoma Treatment  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Microenvironmental Regulation of Glioblastoma Angiogenesis via CHD7  awarded by National Cancer Institute/NIH/DHHS
  • Novel Mouse Models to Understand ST6Gal1-Mediated Sialylation Effects in the Developing and Pathologic Brain  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Private Grant  awarded by VIVO BIOSCIENCES, INC. ^
  • Private Grant  awarded by IN8BIO INC.
  • Private Grant  awarded by IN8BIO INC.
  • Restoring the Sphingolipid Balance in Glioblastoma  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Sialylation in the Maintenance and Metabolic Plasticity of Neural Stem Cell-Like Brain Tumor Cells  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Targeting Acid Ceramidase to Improve the Efficacy of Herpes Oncolytic Virus  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Investigator On

  • A Phase 1 Study of M032, a Genetically Engineered HSV-1 Expressing IL-12, in Patients with Recurrent/Progressive Glioblastoma Multiforme, Anaplastic Astrocytoma, or Gliosarcoma  awarded by National Cancer Institute/NIH/DHHS
  • Biological Comparisons Among Three Derivative Models of Glioma Patient Cancers Under Microenvironmental Stress  awarded by National Cancer Institute/NIH/DHHS
  • Boosting the Systemic and in Situ CD4+ T-Cell Responses to Malignant Glioma by Oncolytic HSV Virotherapy  awarded by DOD - Department of Defense
  • Comprehensive Cancer Center Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Support Grant - Neuro-Oncology  awarded by National Cancer Institute/NIH/DHHS
  • Credentialing Next-generation Human Glioma Models for Precision Therapeutics  awarded by National Cancer Institute/NIH/DHHS
  • Exploring Novo-TTF in Advanced Patient Derived GBM Models with Multi-Omics  awarded by American Association for Cancer Research
  • Novel Fluorinated Amino Ester Prodrugs For PET Imaging Of Gliomas  awarded by National Cancer Institute/NIH/DHHS
  • Private Grant  awarded by NOVOCURE, INC.
  • Private Grant  awarded by VARIAN MEDICAL SYSTEMS, INC.
  • RT-SQuARED-M Method to Study the Precise Role of Mitochondria in the Oxidative Damage Caused by Environmental Toxins  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • RT-SQuARED-M Method to Study the Precise Role of Mitochondria in the Oxidative Damage Caused by Environmental Toxins  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Role of PIM Kinase in Maintaining Hepatoblastoma Tumor Initiating Cell Population  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE
  • The Role of CK2 in Glioblastoma Development  awarded by National Cancer Institute/NIH/DHHS
  • Using Common Fund Data to Inform Rare Disease Preclinical Models and Prioritize Drug Repurposing  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS
  • Full Name

  • Anita Hjelmeland