Positions

Overview

  • Dr. Hildreth obtained his BS in Biology from East Carolina University and his DVM from the North Carolina State University. He then completed a small animal rotating internship at the University of Florida and a small animal surgical residency at the Ohio State University. During his residency he completed a concurrent MS degree evaluating the use of PTHrP as an in vitro bone-forming agent.

    After his residency, he stayed at Ohio State to complete a PhD focused on the role of PTHrP in skeletal development and the use of PTHrP as a bone-forming agent. During his PhD, he developed an intense interest in the advanced imaging of bone using microCT, particularly in response to bone-forming therapies or genetic modification. This resulted in collaborations with multiple bone biology and cancer research laboratories.

    Upon completing his PhD in 2014 he was hired as an associate faculty member within the OSU-CVM as an Instructor of Small Animal Surgical Practice. In this role, he taught bone biology, general surgery, and orthopedics in the veterinary curriculum. Starting in 2015, he also joined the laboratory of Dr. Michael C. Ostrowski in the Comprehensive Cancer Center as a Post-Doctoral Fellow. His focus was investigating 1) the role of macrophages and osteoclasts in breast cancer bone metastasis and 2) transcription factors and microRNAs regulating osteoblast and osteoclast formation. In May 2017 he continuing his work with Dr. Ostrowski at the Medical University of South Carolina's Hollings Cancer Center. In October 2018 he was promoted to Research Assistant Professor after receiving a NIH K01 Award.

    In July 2019 he started a tenure track Assistant Professor position at the University of Alabama-Birmingham (UAB) in the Department of Pathology’s Division of Molecular and Cellular Pathology and the O’Neal Comprehensive Cancer Center, where his work focuses on the role of macrophages and osteoclasts in breast cancer bone metastasis and primary bone tumors.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Eomes partners with PU.1 and MITF to Regulate Transcription Factors Critical for osteoclast differentiation 2019
    2018 Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation 2018
    2018 The FGF-23/klotho axis and its relationship with phosphorus, calcium, vitamin D, PTH, aldosterone, severity of disease, and outcome in hospitalised foals 2018
    2018 Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth 2018
    2017 What is your diagnosis? 2017
    2017 Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele 2017
    2016 p16, pRb, and p53 in feline oral squamous cell carcinoma 2016
    2016 Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-Eyed Mutant 2016
    2015 Engraftment and bone mass are enhanced by PTHrP 1–34 in ectopically transplanted vertebrae (vossicle model) and can be non-invasively monitored with bioluminescence and fluorescence imaging 2015
    2015 Deletion of the nuclear localization sequence and C-terminus of parathyroid hormone–related protein decreases osteogenesis and chondrogenesis but increases adipogenesis and myogenesis in murine bone marrow stromal cells 2015
    2015 Animal Models of Bone Metastasis 2015
    2015 Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma 2015
    2014 Canine prostate cancer cell line (Probasco) produces osteoblastic metastases in vivo 2014
    2014 Expression of DGCR8-dependent microRNAs is indispensable for osteoclastic development and bone-resorbing activity 2014
    2014 Self-doped polyaniline-based interdigitated electrodes for electrical stimulation of osteoblast cell lines 2014
    2014 Use of sedation and ropivacaine-morphine epidural for femoral head and neck ostectomy in a dog 2014
    2012 Effects of parathyroid hormone-related protein and macrophage inflammatory protein-1α in Jurkat T-cells on tumor formation in vivo and expression of apoptosis regulatory genes in vitro 2012
    2011 Effect of zoledronic acid and amputation on bone invasion and lung metastasis of canine osteosarcoma in nude mice 2011
    2010 The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice 2010
    2010 PTHrP 1-141 and 1-86 increase in vitro bone formation 2010
    2008 Comparison of arthroscopy and arthrotomy for diagnosis of medial meniscal pathology: An ex vivo study 2008
    2007 Ulnocarpal arthrodesis for the treatment of radial agenesis in a dog 2007
    2006 Biomechanical and histologic comparison of single-layer continuous Cushing and simple continuous appositional cystotomy closure by use of poliglecaprone 25 in rats with experimentally induced inflammation of the urinary bladder 2006
    2006 In vitro evaluation of five canine tibial plateau leveling methods 2006

    Research Overview

  • Bone biology
    Macrophages
    Osteoclasts
    Skeletal development
    Breast cancer
    Primary bone tumors
    Osteosarcoma
    Metastasis
    Nanoparticle drug delivery
    Advanced small animal imaging
  • Education And Training

  • Medical University of South Carolina Biochemistry and Molecular Biology and Hollings Cancer Center, Postdoctoral Fellowship 2018
  • Ohio State University Cancer Biology and Genetics and James Comprehensive Cancer Center, Postdoctoral Fellowship 2017
  • Full Name

  • Blake Hildreth