• In October 2015, Dr. Herbert Chen was named as the new Chairman of the Department of Surgery. A native of Wisconsin, Chen received his undergraduate degree from Stanford University and began his medical education at the Duke University School of Medicine, graduating in 1992. He completed his surgical residency in general surgery at Johns Hopkins in 1999, along with a postdoctoral research fellowship in 1997 and a surgical oncology and endocrinology fellowship in 2000. Dr. Chen came to UAB from the University of Wisconsin, where he was the Layton F. Rikkers, M.D., Chair in Surgical Leadership, chair of the Division of General Surgery, vice chair of Research for the Department of Surgery and professor in the departments of Surgery, Biomedical Engineering and Pediatrics. Dr. Chen is a specialist in endocrine surgery, a funded surgeon scientist, and a dedicated educator. Dr. Chen is an Associate/Section Editor for Annals of Surgery, Annals of Surgical Oncology, Scientific American Surgery, The Oncologist, and Journal of Surgical Research, and serves on six other editorial boards. He is also the Past-President of Association for Academic Surgery, the current Secretary-Treasurer for Surgical Biology Club II, and the current President-Elect for the Society of Clinical Surgery. Dr. Chen has mentored over 100 faculty, post-doctoral fellows, residents, medical students, and undergraduates in his lab.

    Dr. Chen’s clinical interests include endocrine and neuroendocrine disease with a focus on minimally invasive endocrine surgery. He has one of the largest experiences with radioguided parathyroidectomy (MIRP), and performs high volume thyroid and adrenal surgery. Dr. Chen’s laboratory focuses on the role of cellular signaling pathways in the differentiation and growth of neuroendocrine (NE) tumors including carcinoid, pancreatic islet cell, pheochromocytoma, and medullary thyroid cancer.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 From the Editor – in – Chief: Top papers from the association of women surgeons 2023
    2023 Hypercalcemia with a parathyroid hormone level of ≤50 pg/mL: Is this primary hyperparathyroidism?Surgery.  173:154-159. 2023
    2023 Thyroid hormone replacement following lobectomy: Long-term institutional analysis 15 years after surgerySurgery.  173:189-192. 2023
    2022 Response to: Hypercalcemia with a parathyroid hormone level of ≤50 pg/mL: Is this primary hyperparathyroidism?Surgery2022
    2022 Program characteristics of cardiothoracic surgery departments versus divisionsJournal of Cardiothoracic Surgery.  17. 2022
    2022 Protein Kinase D1 Signaling in Cancer Stem Cells with Epithelial-Mesenchymal PlasticityCells.  11. 2022
    2022 From the editor – In – Chief: Featured papers in the November 2022 issue 2022
    2022 Pearls and Pitfalls for Surgical Investigators in Basic and Translational ResearchJournal of Surgical Research.  279:A1-A7. 2022
    2022 There's no such thing as a free lunch: Outcomes of concurrent parathyroidectomy and thyroidectomy among CESQIP surgeons 2022
    2022 Gender role incongruency in general surgery applicants 2022
    2022 Is preoperative parathyroid localization necessary for tertiary hyperparathyroidism? 2022
    2022 Leadership Development Among Junior Surgery Residents: Communication and PerceptionJournal of Surgical Research.  277:A18-A24. 2022
    2022 The American Association of Endocrine Surgeons Guidelines for the Definitive Surgical Management of Secondary and Tertiary Renal HyperparathyroidismAnnals of Surgery.  276:E141-E176. 2022
    2022 Vitamin D deficiency is associated with single gland parathyroid disease 2022
    2022 Parathyroidectomy for Normocalcemic Tertiary Hyperparathyroidism: A 19-Year ExperienceJournal of Surgical Research.  276:362-368. 2022
    2022 Digital presence as a communication tool for building reputation in an academic department 2022
    2022 Resident self-assessment of common endocrine procedures 2022
    2022 Are We Undertreating Black Patients with Nonfunctional Pancreatic Neuroendocrine Tumors? Critical Analysis of Current Surveillance Guidelines by RaceJournal of the American College of Surgeons.  234:599-606. 2022
    2022 Mediastinal parathyroidectomy: Utilization of a multidisciplinary, robotic-assisted transthoracic approach in challenging cases 2022
    2022 Public Humiliation in the Surgical Clerkship: Qualitative Analysis of Responses to the Association of American Medical Colleges Graduation QuestionnaireJournal of the American College of Surgeons.  234:701-707. 2022
    2022 Using the H-index as a factor in the promotion of surgical facultyVaccine Reports.  8. 2022
    2022 Colectomy for polyps is associated with high risk for complications and low risk for malignancy: Time for endoluminal surgery? 2022
    2022 Colon cancer deadlier in the young? A shifting paradigm 2022
    2022 Emergency department disposition: Do surgical residents contribute to inefficiency? 2022
    2022 Outpatient parathyroidectomy in the pediatric population: An 18-year experienceJournal of Pediatric Surgery.  57:410-413. 2022
    2022 Trends of contralateral prophylactic mastectomy at the time of ipsilateral breast tumor recurrence 2022
    2022 United States medical licensing examination Step 1 scores are a quantifiably better predictor of American board of surgery in-training examination success compared to Step 2 scores 2022
    2022 Vascular invasion predicts advanced tumor characteristics in papillary thyroid carcinoma 2022
    2022 Closing the gap: Increasing female representation in surgical leadership 2022
    2022 Ranking NIH Funding of Surgical Departments Based Upon a Modified IndexJournal of Surgical Research.  270:335-340. 2022
    2022 “Finding a General Surgeon: Self-Referral in the Digital Era” 2022
    2022 Changes in Imaging Utilization for Primary Hyperparathyroidism 2022
    2022 Comparative utility of preoperative imaging in normocalcemic versus hypercalcemic primary hyperparathyroidism 2022
    2022 From the Editor – in – Chief: Featured Papers in the February 2023 Issue 2022
    2022 High-Throughput Analysis to Identify Activators of Notch SignalingMethods in Molecular Biology.  2472:49-56. 2022
    2022 Localizing ureteral catheters for left-sided colectomy and proctectomy: Do the risks justify the benefits? 2022
    2022 My surgical practice: Radioguided parathyroid surgery, how and why we use it 2022
    2022 Patient Satisfaction is Equivalent for Inpatient and Outpatient Minimally-Invasive AdrenalectomyJournal of Surgical Research.  269:207-211. 2022
    2022 Prevalence, Bias, and Rank List Impact of Illegal Questions in Surgical Specialty Residency InterviewsJournal of Surgical Education.  79:69-76. 2022
    2021 Ex Vivo Modeling of Human Neuroendocrine Tumors in Tissue SurrogatesFrontiers in Endocrinology.  12. 2021
    2021 Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumorsOncogenesis.  10. 2021
    2021 Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signalingCommunications Biology.  4. 2021
    2021 Surgical research journals - Under review: An assessment of diversity among editorial boards and outcomes of peer review 2021
    2021 The Other Global Pandemic: Scientific Racism and the Normality BiasAnnals of Surgery.  274:E646-E648. 2021
    2021 US Medical Licensing Exam Performance and American Board of Surgery Qualifying and Certifying ExaminationsJournal of the American College of Surgeons.  233:722-729. 2021
    2021 An evaluation of social media utilization by general surgery programs in the COVID-19 era 2021
    2021 Does Chair of Surgery Gender Influence Divisional or Residency Program Director Gender Diversity?Journal of Surgical Research.  267:224-228. 2021
    2021 From the Editor – in – Chief: Featured papers in the November Issue 2021
    2021 The Reporting of Race and Ethnicity in Surgery LiteratureJAMA Surgery.  156:1036-1041. 2021
    2021 Wide provider variation in cost for thyroidectomy: Potential benefits of standardizing practice?Journal of Surgical Research.  267:9-16. 2021
    2021 A single institution experience with papillary thyroid cancer: Are outcomes better at comprehensive cancer centers? 2021
    2021 NIH Funding of Researchers in Surgery: Decreased Career Development Awards Over TimeJournal of Surgical Research.  266:6-12. 2021
    2021 Outcomes of the First Virtual General Surgery Certifying Exam of the American Board of SurgeryAnnals of Surgery.  274:467-472. 2021
    2021 The euthyroid state: An often difficult-to-achieve (and unnecessary?) goal at the time of surgery 2021
    2021 Anti-SSTR2 antibody-drug conjugate for neuroendocrine tumor therapyCancer Gene Therapy.  28:799-812. 2021
    2021 Higher prevalence of Concomitant Hyperparathyroidism in African American Patients Undergoing Thyroid SurgeryJournal of Surgical Research.  264:124-128. 2021
    2021 Prophylactic Central Neck Dissection in Papillary Thyroid Carcinoma: All Risks, No RewardJournal of Surgical Research.  264:230-235. 2021
    2021 Corrigendum to: Overexpression of somatostatin receptor type 2 in neuroendocrine tumors for improved Ga68-DOTATATE imaging and treatment [Surgery. 2020 Jan;167(1):189-196. doi: 10.1016/j.surg.2019.05.092. Epub 2019 Oct 16.PMID: 31629542] (Surgery (2020) 167(1) (189–196), (S0039606019305835), (10.1016/j.surg.2019.05.092))Surgery.  170:351. 2021
    2021 Tired of Being Ignored: Fatigue as a Presenting Symptom in Primary HyperparathyroidismJournal of Surgical Research.  263:53-56. 2021
    2021 American Journal of Surgery editorial board statement 2021
    2021 Hyperthyroidism Symptoms, Management, and Outcomes in Children and Adults Seeking Definitive Surgical TreatmentAnnals of Surgery.  273:E181-E182. 2021
    2021 Do male chairs of surgery have implicit gender bias in the residency application process? 2021
    2021 From the Editor – in – Chief: Papers from the Society of Black Academic Surgeons 2021
    2021 Gamma Secretase Inhibitors in Cancer: A Current Perspective on Clinical Performance 2021
    2021 Intraoperative parathyroid hormone measurement facilitates outpatient thyroidectomy in children 2021
    2021 From Presentation to Publication: Where did Abstracts at the 2017 Academic Surgical Congress End up? A Three-Year AnalysisJournal of Surgical Research.  259:163-169. 2021
    2021 Influence of fellowship educational experience on practice patterns for adrenalectomy: A survey of recent AAES fellowship graduates 2021
    2021 Prognostic Impact of Tumor Size on Pancreatic Neuroendocrine Tumor Recurrence May Have Racial VariancePancreas.  50:347-352. 2021
    2021 Tertiary Hyperparathyroidism: Why the Delay?Annals of Surgery.  273:e120-e122. 2021
    2021 The Influence of an Acting or Subintern on Third-Year Medical School Surgery Clerkship StudentsJournal of Surgical Research.  259:8-13. 2021
    2021 Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and ProspectiveFrontiers in Cell and Developmental Biology.  9. 2021
    2021 Finding a cancer surgeon: How hospital websites make this difficult for their patients 2021
    2021 Re-operative parathyroidectomy: How many positive localization studies are required? 2021
    2021 Can patients find an Endocrine Surgeon? How hospital websites hide the expertise of these medical professionals 2021
    2021 Endocrine surgery is at the forefront of gender diversity 2021
    2021 Low-cost devices to prevent SARS-CoV-2 infection during open and laparoscopic surgery 2021
    2021 Notch signaling in thyroid cancerAdvances in Experimental Medicine and Biology.  1287:155-168. 2021
    2021 Parathyroid Imaging Practices for Primary Hyperparathyroidism Without Previous Operations Among Endocrine Surgery Program Directors 2021
    2021 Parathyroidectomy for osteoporosis: More complex than we thought?Annals of Surgery.  273:e19-e20. 2021
    2021 Race and Gender Disparities in Access to Parathyroidectomy: A Need to Change Processes for Diagnosis and Referral to SurgeonsAnnals of Surgical Oncology.  28:476-483. 2021
    2020 Can the Use of Video-Based Interventions Increase Public Knowledge About Endocrine Surgeons?Journal of Surgical Research.  256:119-123. 2020
    2020 Non-toxic fragment of botulinum neurotoxin type A and monomethyl auristatin E conjugate for targeted therapy for neuroendocrine tumorsCancer Gene Therapy.  27:898-909. 2020
    2020 Parathyroidectomy for Mild Hyperparathyroidism in the Octogenarian: Is Age Really Just a Number?Annals of Surgery.  272:e285-e286. 2020
    2020 Discordance Between the American Thyroid Association and the American College of Radiology Guideline Systems for Thyroid Nodule BiopsyJournal of Surgical Research.  255:469-474. 2020
    2020 Re-Operative Parathyroidectomy in Patients With Mild Primary HyperparathyroidismJournal of Surgical Research.  255:130-134. 2020
    2020 Repeat Attending Exposure Influences Operative Autonomy in Endocrine Surgical ProceduresJournal of Surgical Education.  77:e71-e77. 2020
    2020 Synthetic Makaluvamine Analogs Decrease c-Kit Expression and Are Cytotoxic to Neuroendocrine Tumor CellsMolecules.  25. 2020
    2020 Follicular Neoplasms of the Thyroid: Can They Be Observed?Annals of Surgery.  272:628. 2020
    2020 A Randomized Controlled Clinical Trial: No Clear Benefit to Prophylactic Central Neck Dissection in Patients With Clinically Node Negative Papillary Thyroid CancerAnnals of Surgery.  272:496-503. 2020
    2020 Cross-Sectional Analysis of Global Surgery Opportunities Among General Surgery Residency ProgramsJournal of Surgical Education.  77:1179-1185. 2020
    2020 EDITORIAL: From the Editors of AJS 2020
    2020 Preoperative parathyroid localization does not improve surgical outcomes for patients with primary hyperparathyroidism 2020
    2020 Screening for primary hyperparathyroidism in a tertiary stone clinic, a useful endeavorGeriatric Nephrology and Urology.  52:1651-1655. 2020
    2020 Phosphoprotein-based biomarkers as predictors for cancer therapy 2020
    2020 From the Editor – in – Chief: Featured papers in the August Issue 2020
    2020 What is global surgery? Identifying misconceptions among health professionals 2020
    2020 Parathyroid Disease: Often Forgotten and Undertreated 2020
    2020 From the Editor – in – Chief: Featured papers in the June Issue 2020
    2020 Outpatient thyroidectomy in the pediatric population 2020
    2020 The evolving practice patterns of academic endocrine surgeons: A cross-sectional analysis of the faculty practice solutions center database 2014 to 2017Annals of Surgery.  271:1156-1164. 2020
    2020 From the Editor-in-Chief: the top papers from the North Pacific Surgical Association 2020
    2020 Single Gland, Ectopic Location: Adenomas are Common Causes of Primary Hyperparathyroidism in Children and AdolescentsWorld Journal of Surgery.  44:1518-1525. 2020
    2020 EDITORIAL-From the Editor – in – Chief 2020
    2020 Executive Summary of the American Association of Endocrine Surgeons Guidelines for the Definitive Surgical Management of Thyroid Disease in AdultsAnnals of Surgery.  271:399-410. 2020
    2020 The American association of endocrine surgeons guidelines for the definitive surgical management of thyroid disease in adultsAnnals of Surgery.  271:E21-E93. 2020
    2020 Increasing Use of Thyroidectomy as Definitive Treatment for HyperthyroidismJournal of Surgical Research.  246:435-441. 2020
    2020 A growth model of neuroendocrine tumor surrogates and the efficacy of a novel somatostatin-receptor–guided antibody-drug conjugate: Perspectives on clinical response?Surgery.  167:197-203. 2020
    2020 Assessing American Thyroid Association Guidelines for Total Thyroidectomy in Graves' DiseaseJournal of Surgical Research.  245:64-71. 2020
    2020 Four decades of the American Association of Endocrine Surgeons (AAES): Past, present, and futureSurgery.  167:1-3. 2020
    2020 Overexpression of somatostatin receptor type 2 in neuroendocrine tumors for improved Ga68-DOTATATE imaging and treatmentSurgery.  167:189-196. 2020
    2020 Targeted Exosomes for Drug Delivery: Biomanufacturing, Surface Tagging, and ValidationBiotechnology Journal.  15. 2020
    2020 Who are you?Surgery.  167:4-9. 2020
    2019 Analysis of Open Payments Receipts Among Surgical Faculty at a Large Academic InstitutionJournal of Surgical Research.  244:599-603. 2019
    2019 What Does the Average Person Know About Endocrine and Vascular Surgeons?Journal of Surgical Research.  244:348-351. 2019
    2019 Are Tc-99m-Sestamibi Scans in Patients With Secondary Hyperparathyroidism and Renal Failure Needed?Journal of Surgical Research.  243:380-383. 2019
    2019 Factors Affecting Readmission After Pediatric Thyroid Resection: A National Surgical Quality Improvement Program-Pediatric EvaluationJournal of Surgical Research.  243:33-40. 2019
    2019 Heterogeneity of vascular endothelial cells, de novo arteriogenesis and therapeutic implications in pancreatic neuroendocrine tumorsJournal of Clinical Medicine.  8. 2019
    2019 Retraction Notice to “Factors Affecting Readmission Following Pediatric Thyroid Resection: A NSQIP-P Evaluation” [Journal of Surgical Research 243 (2019) 33-4](S0022480419302938)(10.1016/j.jss.2019.05.002)Journal of Surgical Research.  243:R1. 2019
    2019 Failure to Diagnose and Treat Hyperparathyroidism Among Patients with Hypercalcemia: Opportunities for Intervention at the Patient and Physician Level to Increase Surgical Referral 2019
    2019 Precisely Control Mitochondria with Light to Manipulate Cell Fate DecisionBiophysical Journal.  117:631-645. 2019
    2019 Prevalence of Thymic Parathyroids in Primary Hyperparathyroidism During Radioguided ParathyroidectomyClinical Medicine Insights: Endocrinology and Diabetes.  12. 2019
    2019 Pulmonary carcinoid surface receptor modulation using histone deacetylase inhibitorsCancers.  11. 2019
    2019 Growing Human Parathyroids in a Microphysiological System: A Novel Approach to Understanding and Developing New Treatments for Hyperparathyroidism 2019
    2019 Considerations for Thyroidectomy as Treatment for Graves DiseaseClinical Medicine Insights: Endocrinology and Diabetes.  12. 2019
    2019 Is Frozen-Section Analysis During Thyroid Operation Useful in the Era of Molecular Testing?Journal of the American College of Surgeons.  228:474-479. 2019
    2019 National Cancer Institute Centers and Society of Surgical Oncology Cancer Research SynergyJournal of Surgical Research.  236:92-100. 2019
    2019 Characterization of somatostatin receptors (SSTRs) expression and antiproliferative effect of somatostatin analogues in aggressive thyroid cancersSurgery.  165:64-68. 2019
    2019 Gender and Racial Disparities in Survival After Surgery Among Papillary and Patients With Follicular Thyroid Cancer: A 45-Year ExperienceClinical Medicine Insights: Endocrinology and Diabetes.  12. 2019
    2019 Management of Gastrointestinal Neuroendocrine TumorsClinical Medicine Insights: Endocrinology and Diabetes.  12. 2019
    2018 Why Is Hyperparathyroidism Underdiagnosed and Undertreated in Older Adults?Clinical Medicine Insights: Endocrinology and Diabetes.  11. 2018
    2018 Can imaging studies be omitted in patients with sporadic primary hyperparathyroidism?Journal of Surgical Research.  231:257-262. 2018
    2018 To admit or not to admit? Experience with outpatient thyroidectomy for Graves’ disease in a high-volume tertiary care center 2018
    2018 A Structured Compensation Plan Improves But Does Not Erase the Sex Pay Gap in SurgeryAnnals of Surgery.  268:442-448. 2018
    2018 Ensuring Equity, Diversity, and Inclusion in Academic Surgery: An American Surgical Association White PaperAnnals of Surgery.  268:403-407. 2018
    2018 How academically productive are endocrine surgeons in the United States?Journal of Surgical Research.  229:122-126. 2018
    2018 Hyperthyroidism is Underdiagnosed and Undertreated in 3336 Patients: An Opportunity for Improvement and InterventionAnnals of Surgery.  268:506-512. 2018
    2018 Reducing cost and improving operating room efficiency: examination of surgical instrument processingJournal of Surgical Research.  229:15-19. 2018
    2018 Selecting post-acute care settings after abdominal surgery: Are we getting it right? 2018
    2018 The Role of Notch3 in Cancer 2018
    2018 The effects of tenure and promotion on surgeon productivityJournal of Surgical Research.  227:67-71. 2018
    2018 Wide variation in cost of surgical care for parathyroidectomy: is there a need for standardization of practice?Surgery.  163:638-642. 2018
    2018 Editorial: The phantom menace: implications of polyclonality for surgical treatment of primary hyperparathyroidismSurgery.  163:15-16. 2018
    2018 Notch3 as a novel therapeutic target in metastatic medullary thyroid cancerSurgery.  163:104-111. 2018
    2018 Racial disparities in the cost of surgical care for parathyroidectomyJournal of Surgical Research.  221:216-221. 2018
    2017 Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomasNature Communications.  8. 2017
    2017 Failure to Diagnose Hyperparathyroidism in 10,432 Patients with HypercalcemiaAnnals of Surgery.  266:632-640. 2017
    2017 MicroRNA-21 and long non-coding RNA MALAT1 are overexpressed markers in medullary thyroid carcinomaExperimental and Molecular Pathology.  103:229-236. 2017
    2017 Reduced disparities and improved surgical outcomes for Asian Americans with colorectal cancerJournal of Surgical Research.  218:23-28. 2017
    2017 Antineoplastic effects of histone deacetylase inhibitors in neuroendocrine cancer cells are mediated through transcriptional regulation of Notch1 by activator protein 1Cancer Medicine.  6:2142-2152. 2017
    2017 The Association for Academic Surgeons 2001-2010: a decade of inclusivenessJournal of Surgical Research.  217:16-19. 2017
    2017 Encapsulated follicular variant of papillary thyroid cancer: are these tumors really benign?Journal of Surgical Research.  216:138-142. 2017
    2017 Optimizing Outpatient Pain Management After Thyroid and Parathyroid Surgery: A Two-Institution ExperienceAnnals of Surgical Oncology.  24:1951-1957. 2017
    2017 Neuroendocrine Tumors of the StomachSurgical Clinics of North America.  97:333-343. 2017
    2017 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease during Pregnancy and the PostpartumThyroid.  27:315-389. 2017
    2017 Intraoperative Parathyroid Hormone Levels at 5 min Can Identify Multigland DiseaseAnnals of Surgical Oncology.  24:733-738. 2017
    2017 Notch3 expression correlates with thyroid cancer differentiation, induces apoptosis, and predicts disease prognosisCancer.  123:769-782. 2017
    2017 Neuroendocrine Tumor-Targeted Upconversion Nanoparticle-Based Micelles for Simultaneous NIR-Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence ImagingAdvanced Functional Materials.  27. 2017
    2017 Extracellular Superoxide Dismutase Expression in Papillary Thyroid Cancer Mesenchymal Stem/Stromal Cells Modulates Cancer Cell Growth and MigrationScientific Reports.  7. 2017
    2017 AB3-loaded and tumor-targeted unimolecular micelles for medullary thyroid cancer treatmentJournal of Materials Chemistry B.  5:151-159. 2017
    2017 Dysadherin specific drug conjugates for the treatment of thyroid cancers with aggressive phenotypesOncotarget.  8:24457-24468. 2017
    2017 Histone deacetylase inhibitor thailandepsin-A activates Notch signaling and suppresses neuroendocrine cancer cell growth in vivoOncotarget.  8:70828-70840. 2017
    2017 How long should we follow patients after apparently curative parathyroidectomy?Surgery.  161:54-61. 2017
    2017 Minimally invasive follicular thyroid cancer: treat as a benign or malignant lesion?Journal of Surgical Research.  207:235-240. 2017
    2017 The Epstein-Barr virus EBNA2 protein induces a subset of NOTCH target genes in thyroid cancer cell lines but fails to suppress proliferationSurgery.  161:195-201. 2017
    2017 The changing pattern of diagnosing primary hyperparathyroidism in young patients 2017
    2016 The PARP inhibitor ABT-888 potentiates dacarbazine-induced cell death in carcinoidsCancer Gene Therapy.  23:348-354. 2016
    2016 Thyroidectomy for Graves’ disease in children: Indications and complicationsJournal of Pediatric Surgery.  51:1680-1683. 2016
    2016 Antiplatelet and Anticoagulant Medications Significantly Increase the Risk of Postoperative Hematoma: Review of over 4500 Thyroid and Parathyroid ProceduresAnnals of Surgical Oncology.  23:2874-2882. 2016
    2016 Hands-on training in the operating room as a method of continuing education for surgeons in practiceJAMA Surgery.  151:869-870. 2016
    2016 KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapyClinical materials.  97:22-33. 2016
    2016 Postacute care after major abdominal surgery in elderly patients intersection of age, functional status, and postoperative complicationsJAMA Surgery.  151:759-766. 2016
    2016 Notch1 signaling regulates the aggressiveness of differentiated thyroid cancer and inhibits SERPINE1 expressionClinical Cancer Research.  22:3582-3592. 2016
    2016 A phase II trial of a histone deacetylase inhibitor panobinostat in patients with low-grade neuroendocrine tumors 2016
    2016 Should Vitamin D deficiency be corrected before parathyroidectomy?Journal of Surgical Research.  204:94-100. 2016
    2016 Generation of Novel Thyroid Cancer Stem-Like Cell Clones Effects of Resveratrol and Valproic AcidAmerican Journal of Pathology.  186:1662-1673. 2016
    2016 Thailandepsin A-loaded and octreotide-functionalized unimolecular micelles for targeted neuroendocrine cancer therapyClinical materials.  91:1-10. 2016
    2016 When patients call their surgeon's office: An opportunity to improve the quality of surgical care and prevent readmissions 2016
    2016 Compromised Outcome of Papillary Thyroid Cancer at Low-Volume Treatment Centers: Practice Makes Perfect?Annals of Surgical Oncology.  23:355-357. 2016
    2016 Parathyroidectomy is underused in patients with tertiary hyperparathyroidism after renal transplantationSurgery.  159:172-180. 2016
    2016 Primary hyperparathyroidismUlusal cerrahi dergisi.  32:58-66. 2016
    2016 Prospective Intervention of a Novel Levothyroxine Dosing Protocol Based on Body Mass Index after Thyroidectomy Presented at the American College of Surgeons 100th Annual Clinical Congress, San Francisco, CA, October 2014.Journal of the American College of Surgeons.  222:83-88. 2016
    2015 Adenomas of cervical maldescended parathyroid glands: Pearls and pitfallsANZ Journal of Surgery.  85:957-961. 2015
    2015 Kidney Disease Improving Global Outcomes guidelines and parathyroidectomy for renal hyperparathyroidismJournal of Surgical Research.  199:115-120. 2015
    2015 Substernal goiter: When is a sternotomy required?Journal of Surgical Research.  199:121-125. 2015
    2015 Chrysin suppresses achaete-scute complex-like 1 and alters the neuroendocrine phenotype of carcinoidsCancer Gene Therapy.  22:496-505. 2015
    2015 Do additional imaging studies change operative management in patients undergoing adrenalectomy? Presented at Central Surgical Association, Chicago, IL March 2015.Surgery.  158:1003-1011. 2015
    2015 Does levothyroxine administration impact parathyroid localization?Journal of Surgical Research.  198:360-365. 2015
    2015 How well does renal transplantation cure hyperparathyroidism?Annals of Surgery.  262:653-659. 2015
    2015 Thyroglobulin antibody resolution after total thyroidectomy for cancerJournal of Surgical Research.  198:366-370. 2015
    2015 Novel analogs targeting histone deacetylase suppress aggressive thyroid cancer cell growth and induce re-differentiationCancer Gene Therapy.  22:410-416. 2015
    2015 Hypoparathyroidism after total thyroidectomy: Incidence and resolutionJournal of Surgical Research.  197:348-353. 2015
    2015 Radioguided parathyroidectomy for tertiary hyperparathyroidismJournal of Surgical Research.  195:406-411. 2015
    2015 Surgery: Papillary thyroid cancer-how aggressive should surgery be?Nature Reviews Endocrinology.  11:195-196. 2015
    2015 Clinical and Socioeconomic Factors Influence Treatment Decisions in Graves’ DiseaseAnnals of Surgical Oncology.  22:1196-1199. 2015
    2015 Is intraoperative parathyroid hormone testing in patients with renal insufficiency undergoing parathyroidectomy for primary hyperparathyroidism accurate? 2015
    2015 Outcomes After Subtotal Parathyroidectomy for Primary Hyperparathyroidism due to Hyperplasia: Significance of Whole vs. Partial Gland RemnantAnnals of Surgical Oncology.  22:966-971. 2015
    2015 Tumor-suppressor role of notch3 in medullary thyroid carcinoma revealed by genetic and pharmacological inductionMolecular Cancer Therapeutics.  14:499-512. 2015
    2015 All Thyroid Ultrasound Evaluations are Not Equal: Sonographers Specialized in Thyroid Cancer Correctly Label Clinical N0 Disease in Well Differentiated Thyroid CancerAnnals of Surgical Oncology.  22:422-428. 2015
    2015 CaPTHUS Scoring Model in Primary Hyperparathyroidism: Can It Eliminate the Need for ioPTH Testing?Annals of Surgical Oncology.  22:1191-1195. 2015
    2015 Chasing Calcitonin: Reoperations for Medullary Thyroid CarcinomaAnnals of Surgical Oncology.  22:7-8. 2015
    2015 Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesisOncotarget.  6:12080-12093. 2015
    2015 Evaluation and management of the pediatric thyroid nodule 2015
    2015 Justified Follow-Up: A Final Intraoperative Parathyroid Hormone (ioPTH) Over 40 pg/mL is Associated with an Increased Risk of Persistence and Recurrence in Primary HyperparathyroidismAnnals of Surgical Oncology.  22:454-459. 2015
    2015 Lymph Node Metastases do not Impact Survival in Follicular Variant Papillary Thyroid CancerAnnals of Surgical Oncology.  22:158-163. 2015
    2015 Preventing Postoperative Hypocalcemia in Patients with Graves Disease: A Prospective StudyAnnals of Surgical Oncology.  22:952-958. 2015
    2014 Failure of Radioactive Iodine in the Treatment of HyperthyroidismAnnals of Surgical Oncology.  21:4174-4180. 2014
    2014 Surgeon and Staff Radiation Exposure During Radioguided Parathyroidectomy at a High-Volume InstitutionAnnals of Surgical Oncology.  21:3853-3858. 2014
    2014 Is intraoperative parathyroid hormone monitoring necessary with ipsilateral parathyroid gland visualization during anticipated unilateral exploration for primary hyperparathyroidism: A two-institution analysis of more than 2,000 patientsSurgery.  156:760-768. 2014
    2014 A survey of preferences regarding surgical approach to thyroid surgeryWorld Journal of Surgery.  38:696-703. 2014
    2014 Improvement of sleep disturbance and insomnia following parathyroidectomy for primary hyperparathyroidismWorld Journal of Surgery.  38:542-548. 2014
    2014 Markedly elevated thyroglobulin levels in the preoperative thyroidectomy patient correlates with metastatic burdenJournal of Surgical Research.  187:1-5. 2014
    2014 Predictors of recurrence in primary hyperparathyroidism: An analysis of 1386 casesAnnals of Surgery.  259:563-568. 2014
    2014 Hypothyroidism after a cancer diagnosis: Etiology, diagnosis, complications, and management 2014
    2014 An intact parathyroid hormone-based protocol for the prevention and treatment of symptomatic hypocalcemia after thyroidectomyJournal of Surgical Research.  186:23-28. 2014
    2014 Disease outcomes and nodal recurrence in patients with papillary thyroid cancer and lateral neck nodal metastasesANZ Journal of Surgery.  84:240-244. 2014
    2014 Distinguishing classical papillary thyroid microcancers from follicular-variant microcancersJournal of Surgical Research.  190:151-156. 2014
    2014 Elevated parathyroid hormone after parathyroidectomy delays symptom improvementJournal of Surgical Research.  190:119-125. 2014
    2014 Hesperetin Activates the Notch1 Signaling Cascade, Causes Apoptosis, and Induces Cellular Differentiation in Anaplastic Thyroid CancerAnnals of Surgical Oncology.  21:497-504. 2014
    2014 Identifying predictors of a difficult thyroidectomyJournal of Surgical Research.  190:157-163. 2014
    2014 Is central lymph node dissection necessary for parathyroid carcinoma?Surgery.  156:1336-1341. 2014
    2014 Novel approaches in anaplastic thyroid cancer therapy 2014
    2014 Novel thyroidectomy difficulty scale correlates with operative timesWorld Journal of Surgery.  38:1984-1989. 2014
    2014 Parathyroid conditions in childhoodSeminars in Pediatric Surgery.  23:66-70. 2014
    2014 Postoperative surveillance of small appendiceal carcinoid tumors 2014
    2014 Primary hyperparathyroidism across the ages: Presentation and outcomesJournal of Surgical Research.  190:185-190. 2014
    2014 Radioactive iodine remnant uptake after completion thyroidectomy: Not such a complete cancer operationAnnals of Surgical Oncology.  21:1379-1383. 2014
    2014 Recurrent and persistence primary hyperparathyroidism occurs more frequently in patients with double adenomasJournal of Surgical Research.  190:198-202. 2014
    2014 Role of cervical ultrasound in detecting thyroid pathology in primary hyperparathyroidismJournal of Surgical Research.  190:575-578. 2014
    2014 Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growthCancer Biology and Therapy.  15:510-515. 2014
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    2014 The novel histone deacetylase inhibitor thailandepsin A inhibits anaplastic thyroid cancer growthJournal of Surgical Research.  190:191-197. 2014
    2014 The roles of the epithelial-mesenchymal transition marker PRRX1 and miR-146b-5p in papillary thyroid carcinoma progressionAmerican Journal of Pathology.  184:2342-2354. 2014
    2014 Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivoCancer Gene Therapy.  21:518-525. 2014
    2014 Thyroidectomy as primary treatment optimizes body mass index in patients with hyperthyroidismAnnals of Surgical Oncology.  21:2303-2309. 2014
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    2013 The role of epithelial mesenchymal transition markers in thyroid carcinoma progressionEndocrine Pathology.  24:206-212. 2013
    2013 Timing of symptom improvement after parathyroidectomy for primary hyperparathyroidismSurgery.  154:1463-1469. 2013
    2013 Leflunomide suppresses growth in human medullary thyroid cancer cellsJournal of Surgical Research.  185:212-216. 2013
    2013 MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through akt inhibitionAnnals of Surgical Oncology.  20:3862-3868. 2013
    2013 Octreotide-functionalized and resveratrol-loaded unimolecular micelles for targeted neuroendocrine cancer therapyNanoscale.  5:9924-9933. 2013
    2013 The Role of Cdk5 in Neuroendocrine Thyroid CancerCancer Cell.  24:499-511. 2013
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    2013 Nondiagnostic fine-needle aspirations of the thyroid: Is the risk of malignancy higher?Journal of Surgical Research.  184:746-750. 2013
    2013 Remnant uptake as a postoperative oncologic quality indicatorThyroid.  23:1269-1276. 2013
    2013 The incidence of thyroid cancer by f ine needle aspiration varies by age and genderJournal of Surgical Research.  184:761-765. 2013
    2013 Minimal benefit to subsequent intraoperative parathyroid hormone testing after all four glands have been identifiedAnnals of Surgical Oncology.  20:4200-4204. 2013
    2013 Multigland disease and slower decline in intraoperative PTH characterize mild primary hyperparathyroidismAnnals of Surgical Oncology.  20:4205-4211. 2013
    2013 Presentation, management, and outcomes of hyperparathyroidism in octogenarians and nonagenariansAnnals of Surgical Oncology.  20:4195-4199. 2013
    2013 Parathyroid cryopreservation after parathyroidectomy: A worthwhile practice?Annals of Surgical Oncology.  20:2256-2260. 2013
    2013 Resveratrol induces differentiation markers expression in anaplastic thyroid carcinoma via activation of Notch1 signaling and suppresses cell growthMolecular Cancer Therapeutics.  12:1276-1287. 2013
    2013 Erratum: Neuroendocrine phenotype alteration and growth suppression through apoptosis by MK-2206, an allosteric inhibitor of AKT, in carcinoid cell lines in vitro (Anti-Cancer Drugs (2013) 24 (66-72)) 2013
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    2013 Synchronous and antecedent nonthyroidal malignancies in patients with papillary thyroid carcinomaJournal of the American College of Surgeons.  216:1174-1180. 2013
    2013 Consensus guidelines for the management and treatment of neuroendocrine tumorsPancreas.  42:557-577. 2013
    2013 Doing away with the rule of 10 %Annals of Surgical Oncology.  20:1403-1404. 2013
    2013 Hereditary medullary thyroid cancer: Age-appropriate thyroidectomy improves disease-free survivalAnnals of Surgical Oncology.  20:1451-1455. 2013
    2013 Role of postoperative vitamindand/or calcium routine supplementation in preventing hypocalcemia after thyroidectomy:Asystematic review and meta-analysis 2013
    2013 Lymph node ratio predicts recurrence in papillary thyroid cancer 2013
    2013 Early-phase technetium-99m sestamibi scintigraphy can improve preoperative localization in primary hyperparathyroidism 2013
    2013 Synergistic effect of pasireotide and teriflunomide in carcinoids in vitro 2013
    2013 Using body mass index to predict optimal thyroid dosing after thyroidectomyJournal of the American College of Surgeons.  216:454-460. 2013
    2013 Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic thyroid carcinoma in vitro and in vivoCancer.  119:774-781. 2013
    2013 Utility of 111indium-pentetreotide scintigraphy in patients with neuroendocrine tumorsAnnals of Surgical Oncology.  20:640-645. 2013
    2013 A short-stay unit for thyroidectomy patients increases discharge efficiencyJournal of Surgical Research.  184:204-208. 2013
    2013 Cancer after thyroidectomy: A multi-institutional experience with 1,523 patientsJournal of the American College of Surgeons.  216:571-577. 2013
    2013 Clinicopathologic characteristics of colonic carcinoid tumorsJournal of Surgical Research.  184:183-188. 2013
    2013 Creation of a "wisconsin Index" nomogram to predict the likelihood of additional hyperfunctioning parathyroid glands during parathyroidectomyAnnals of Surgery.  257:138-141. 2013
    2013 Current understanding and management of medullary thyroid cancer 2013
    2013 Expression of epithelial-mesenchymal transition regulators SNAI2 and TWIST1 in thyroid carcinomasModern Pathology.  26:54-61. 2013
    2013 Incidence and localization of ectopic parathyroid adenomas in previously unexplored patientsWorld Journal of Surgery.  37:102-106. 2013
    2013 Increased efficiency of endocrine procedures performed in an ambulatory operating roomJournal of Surgical Research.  184:200-203. 2013
    2013 Neuroendocrine phenotype alteration and growth suppression through apoptosis by MK-2206, an allosteric inhibitor of AKT, in carcinoid cell lines in vitro 2013
    2013 New developments in the diagnosis and treatment of thyroid cancerCA: A Cancer Journal for Clinicians.  63:373-394. 2013
    2013 Radioactive iodine scanning is not beneficial but its use persists for euthyroid patientsJournal of Surgical Research.  184:269-273. 2013
    2013 Radioguided parathyroidectomy effective in pediatric patientsJournal of Surgical Research.  184:312-317. 2013
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    2013 Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell lineCancer Medicine.  2:734-743. 2013
    2013 Unilateral thyroidectomy for the treatment of benign multinodular goiterJournal of Surgical Research.  184:514-518. 2013
    2012 Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapyNanoscale.  4:7185-7193. 2012
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    2012 Is minimally invasive parathyroidectomy associated with greater recurrence compared to bilateral exploration? Analysis of more than 1,000 casesSurgery.  152:1008-1015. 2012
    2012 Is previous same quadrant surgery a contraindication to laparoscopic adrenalectomy?Surgery.  152:1211-1217. 2012
    2012 Is thyroidectomy in patients with Hashimoto thyroiditis more risky?Journal of Surgical Research.  178:529-532. 2012
    2012 Same-day thyroidectomy program: Eligibility and safety evaluationSurgery.  152:1133-1141. 2012
    2012 Symptoms of gastroesophageal reflux disease improve after parathyroidectomySurgery.  152:1232-1237. 2012
    2012 Changes in swallowing-related quality of life after parathyroidectomy for hyperparathyroidism: A prospective cohort study 2012
    2012 Incidence of concomitant hyperparathyroidism in patients with thyroid disease requiring surgeryJournal of Surgical Research.  178:264-267. 2012
    2012 Routine chest X-ray prior to thyroid surgery: Is it always necessary?World Journal of Surgery.  36:2584-2589. 2012
    2012 Sestamibi imaging for primary hyperparathyroidism: The impact of surgeon interpretation and radiologist volumeAnnals of Surgical Oncology.  19:3827-3831. 2012
    2012 Thyroidectomy decreases snoring and sleep apnea symptomsThyroid.  22:1160-1164. 2012
    2012 Persistent hypertension after adrenalectomy for an aldosterone-producing adenoma: Weight as a critical prognostic factor for aldosterone's lasting effect on the cardiac and vascular systemsJournal of Surgical Research.  177:241-247. 2012
    2012 Surveillance of small rectal carcinoid tumors in the absence of metastatic diseaseAnnals of Surgical Oncology.  19:3486-3490. 2012
    2012 Current Treatment of Papillary Thyroid MicrocarcinomaAdvances in Surgery.  46:191-203. 2012
    2012 Safety and feasibility of laparoscopic resection for large (≥6 cm) pheochromocytomas without suspected malignancy 2012
    2012 The role of gender in primary hyperparathyroidism: Same disease, different presentationAnnals of Surgical Oncology.  19:2958-2962. 2012
    2012 No need to abandon unilateral parathyroid surgeryJournal of the American College of Surgeons.  215:297. 2012
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    2012 Sestamibi-negative patients: To operate or image?Annals of Surgical Oncology.  19:2086-2087. 2012
    2012 Does the final intraoperative PTH level really have to fall into the normal range to signify cure?Annals of Surgical Oncology.  19:1862-1867. 2012
    2012 Are there predictors of malignancy in patients with multinodular goiter?Journal of Surgical Research.  174:207-210. 2012
    2012 Preoperative ultrasonography findings predict the need for repeated surgery in papillary thyroid cancer 2012
    2012 What is the Utility of distal forearm DXA in primary Hyperparathyroidism? 2012
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    2012 Breast radiation correlates with side of parathyroid adenomaWorld Journal of Surgery.  36:607-611. 2012
    2012 False-negative fine-needle aspiration of thyroid nodules cannot be attributed to sampling error alone 2012
    2012 Hürthle cell metaplasia on fine-needle aspiration biopsy is not by itself an indication for thyroid surgery 2012
    2012 Presurgical localization of parathyroid adenomas with magnetic resonance imaging at 3.0 T: An adjunct method to supplement traditional imagingAnnals of Surgical Oncology.  19:981-989. 2012
    2012 The necessity and reliability of intraoperative parathyroid hormone (PTH) Testing in patients with mild hyperparathyroidism and PTH levels in the normal range: ReplyWorld Journal of Surgery.  36:484-485. 2012
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    2011 Limitations of the ACS NSQIP in thyroid surgeryAnnals of Surgical Oncology.  18:3529-3530. 2011
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    2011 Should all papillary thyroid microcarcinomas be aggressively treated?: An analysis of 18,445 casesAnnals of Surgery.  254:653-660. 2011
    2011 Antiproliferative effect of chrysin on anaplastic thyroid cancerJournal of Surgical Research.  170:84-88. 2011
    2011 Can biochemical abnormalities predict symptomatology in patients with primary hyperparathyroidism?Journal of the American College of Surgeons.  213:410-414. 2011
    2011 Fine needle aspiration of the thyroid: A contemporary experience of 3981 casesJournal of Surgical Research.  170:48-51. 2011
    2011 Influence of Surgical Volume on Operative Failures for HyperparathyroidismAdvances in Surgery.  45:237-248. 2011
    2011 Infrared thermographic profiles of vessel sealing devices on thyroid parenchymaJournal of Surgical Research.  170:64-68. 2011
    2011 Should patients with symptomatic Hashimoto's thyroiditis pursue surgery?Journal of Surgical Research.  170:52-55. 2011
    2011 The necessity and reliability of intraoperative parathyroid hormone (PTH) testing in patients with mild hyperparathyroidism and PTH levels in the normal rangeWorld Journal of Surgery.  35:2006-2009. 2011
    2011 Does previous head and neck irradiation increase the chance of multigland disease in patients with hyperparathyroidism?Annals of Surgical Oncology.  18:2240-2244. 2011
    2011 A pilot phase II study of valproic acid for treatment of low-grade neuroendocrine carcinoma 2011
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    2011 Total thyroidectomy: A safe and effective treatment for Graves' diseaseJournal of Surgical Research.  168:1-4. 2011
    2011 A preclinical and clinical study of lithium in low-grade neuroendocrine tumors 2011
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    2011 Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancerAnnals of Surgical Oncology.  18:1506-1511. 2011
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    2011 Is there still a glass ceiling for women in academic surgery?Annals of Surgery.  253:637-643. 2011
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    2011 What is the added benefit of cervical ultrasound to 99mTc- sestamibi scanning in primary hyperparathyroidism?Annals of Surgical Oncology.  18:2907-2911. 2011
    2010 In BriefCurrent Problems in Surgery.  47:954-956. 2010
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    2010 Signaling mechanisms in neuroendocrine tumors as targets for therapyEndocrinology and Metabolism Clinics of North America.  39:801-810. 2010
    2010 25-Hydroxyvitamin D status does not affect intraoperative parathyroid hormone dynamics in patients with primary hyperparathyroidismAnnals of Surgical Oncology.  17:2958-2962. 2010
    2010 Response to "response to: Tertiary hyperparathyroidism: Is less than a subtotal resection ever appropriate? A study on long-term outcomes"Surgery.  148:1045. 2010
    2010 DiscussionsAnnals of Surgery.  252:651. 2010
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    2010 Operative failures after parathyroidectomy for hyperparathyroidism: The influence of surgical volumeAnnals of Surgery.  252:691-694. 2010
    2010 Postoperative parathyroid hormone testing decreases symptomatic hypocalcemia and associated emergency room visits after total thyroidectomySurgery.  148:841-846. 2010
    2010 MicroRNA profiling of benign and malignant pheochromocytomas identifies novel diagnostic and therapeutic targetsEndocrine-Related Cancer.  17:835-846. 2010
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    2010 Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoidsInternational Journal of Clinical and Experimental Medicine.  3:95-102. 2010
    2010 The north american neuroendocrine tumor society consensus guideline for the diagnosis and management of neuroendocrine tumors: Pheochromocytoma, paraganglioma, and medullary thyroid cancerPancreas.  39:775-783. 2010
    2010 Lithium inhibits carcinoid cell growth in vitroAmerican Journal of Translational Research.  2:248-253. 2010
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    2010 A rising IoPTH level immediately after parathyroid resection: Are additional hyperfunctioning glands always present? an application of the wisconsin criteriaAnnals of Surgery.  251:1127-1130. 2010
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    2010 Secondary and tertiary hyperparathyroidism: The utility of ioPTH monitoringWorld Journal of Surgery.  34:1343-1349. 2010
    2010 Thyroid hormone replacement in women of reproductive age: Is surgeon knowledge related to operative volume?Thyroid.  20:627-631. 2010
    2010 ZM336372 Induces Apoptosis Associated with Phosphorylation of GSK-3β in Pancreatic Adenocarcinoma Cell LinesJournal of Surgical Research.  161:28-32. 2010
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    2010 Xanthohumol inhibits the neuroendocrine transcription factor achaete-scute complex-like 1, suppresses proliferation, and induces phosphorylated ERK1/2 in medullary thyroid cancer 2010
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    2010 Is DVT prophylaxis necessary for thyroidectomy and parathyroidectomy?Surgery.  148:1163-1169. 2010
    2010 MG-132 Inhibits Carcinoid Growth and Alters the Neuroendocrine PhenotypeJournal of Surgical Research.  158:15-19. 2010
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    2010 What is the optimal treatment for children with primary hyperparathyroidism?Journal of Pediatric Surgery.  45:1142-1146. 2010
    2009 Controversies in the surgical management of newly diagnosed and recurrent/residual thyroid cancerThyroid.  19:1373-1380. 2009
    2009 Medullary thyroid carcinoma: Targeted therapies and future directionsJournal of Oncology2009
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    2009 Tertiary hyperparathyroidism: Is less than a subtotal resection ever appropriate? A study of long-term outcomesSurgery.  146:1130-1137. 2009
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    2009 Inhibition of the PI3K pathway suppresses hormonal secretion and limits growth in pheochromocytoma cellsWorld Journal of Surgery.  33:2452-2457. 2009
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    2009 Association for Academic Surgery Presidential Address Episode VI: The Return of the Surgeon1Journal of Surgical Research.  156:333-339. 2009
    2009 Inhibition of phosphatidylinositol 3-kinase/akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumorsAnnals of Surgical Oncology.  16:2936-2942. 2009
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    2009 Secondary and Tertiary Hyperparathyroidism, State of the Art Surgical ManagementSurgical Clinics of North America.  89:1227-1239. 2009
    2009 Thyroid hormone replacement after thyroid lobectomySurgery.  146:554-560. 2009
    2009 AKT and PTEN expression in human gastrointestinal carcinoid tumorsAmerican Journal of Translational Research.  1:291-299. 2009
    2009 Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinomaAmerican Journal of Translational Research.  1:358-366. 2009
    2009 Follicular Thyroid Cancer Cell Growth Inhibition By Proteosome Inhibitor MG1321Journal of Surgical Research.  156:39-44. 2009
    2009 Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extensionClinical Endocrinology.  71:434-439. 2009
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    2009 Revisiting Adrenal Mass Size as an Indication for AdrenalectomyJournal of Surgical Research.  156:16-20. 2009
    2009 Sodium butyrate activates Notch1 signaling, reduces tumor markers, and induces cell cycle arrest and apoptosis in pheochromocytomaAmerican Journal of Translational Research.  1:178-183. 2009
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    2009 Phosphatidylinositol 3-Kinase-Akt Signaling in Pulmonary Carcinoid CellsJournal of the American College of Surgeons.  209:82-88. 2009
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    2009 ACTH-producing carcinoma of the pituitary with refractory Cushing's Disease and hepatic metastases: A case report and review of the literatureWorld Journal of Surgical Oncology.  7. 2009
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    2009 Combination therapy with histone deacetylase inhibitors and lithium chloride: A novel treatment for carcinoid tumorsAnnals of Surgical Oncology.  16:481-486. 2009
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    2008 Is Hashimoto's Thyroiditis a Risk Factor for Papillary Thyroid Cancer?Journal of Surgical Research.  150:49-52. 2008
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    2007 Motivation to Pursue Surgical Subspecialty Training: Is There a Gender Difference?Journal of the American College of Surgeons.  205:698-703. 2007
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    2006 Mitogen-Activated Protein Kinases and Chemoresistance in Pancreatic Cancer CellsJournal of Surgical Research.  136:325-335. 2006
    2006 Is tumor size the best predictor of outcome for papillary thyroid cancer?Annals of Surgical Oncology.  13:1524-1528. 2006
    2006 Metastatic neuroendocrine hepatic tumors: Resection improves survivalJAMA Surgery.  141:1000-1004. 2006
    2006 In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer 2006
    2006 What is the Biology and Optimal Treatment for Papillary Microcarcinoma of the Thyroid?Journal of Surgical Research.  134:160-162. 2006
    2006 Carcinoid TumorsSurgical Oncology Clinics of North America.  15:463-478. 2006
    2006 PrefaceSurgical Oncology Clinics of North America.  15. 2006
    2006 The Surgical Management of Graves' DiseaseJournal of Surgical Research.  133:207-214. 2006
    2006 A Prospective Evaluation of Novel Methods to Intraoperatively Distinguish Parathyroid Tissue Utilizing a Parathyroid Hormone AssayJournal of Surgical Research.  133:38-41. 2006
    2006 Fine-needle aspiration optimizes surgical management in patients with thyroid cancerAnnals of Surgical Oncology.  13:859-863. 2006
    2006 ZM336372, A Raf-1 Activator, Inhibits Growth of Pheochromocytoma CellsJournal of Surgical Research.  133:42-45. 2006
    2006 Novel parathyroid hormone (1-84) assay as basis for parathyroid hormone monitoring in renal hyperparathyroidism - Invited critiqueJAMA Surgery.  141:134. 2006
    2006 The Raf-1 pathway: A molecular target for treatment of select neuroendocrine tumors? 2006
    2006 Calciphylaxis in the absence of end-stage renal disease 2006
    2006 Long-term outcomes in patients with calciphylaxis from hyperparathyroidismAnnals of Surgical Oncology.  13:96-102. 2006
    2006 The need for intraoperative parathyroid hormone monitoring during radioguided parathyroidectomy by Video-Assisted Thoracoscopy (VATS)Clinical Nuclear Medicine.  31:9-12. 2006
    2006 Treatment of advanced carcinoid tumorsApplied Catalysis A: General.  18:9-15. 2006
    2006 Treatment of advanced carcinoid tumors.Current Opinion in Oncology.  18:9-15. 2006
    2005 Hairy Enhancer of Split-1 (HES-1), a Notch1 effector, inhibits the growth of carcinoid tumor cellsSurgery.  138:1137-1142. 2005
    2005 Hyperthyroidism after parathyroid explorationSurgery.  138:1058-1065. 2005
    2005 Intraoperative neurophysiology testing of the recurrent laryngeal nerve: Plaudits and pitfallsSurgery.  138:1183-1192. 2005
    2005 Laparoscopic resection of adrenal cortical carcinoma: A cautionary noteSurgery.  138:1078-1086. 2005
    2005 The role of intraoperative parathyroid hormone testing in patients with tertiary hyperparathyroidism after renal transplantationSurgery.  138:1066-1071. 2005
    2005 Valproic acid inhibits growth, induces apoptosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cellsSurgery.  138:979-985. 2005
    2005 Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells 2005
    2005 Intraoperative parathyroid hormone testing improves cure rates in patients undergoing minimally invasive parathyroidectomySurgery.  138:583-590. 2005
    2005 Radioguided thoracoscopic mediastinal parathyroidectomy with intraoperative parathyroid hormone testingAnnals of Thoracic Surgery.  80:1262-1265. 2005
    2005 A comprehensive evaluation of perioperative adjuncts during minimally invasive parathyroidectomy: Which is most reliable?Annals of Surgery.  242:375-383. 2005
    2005 Changing trends for surgery in elderly patients with hyperparathyroidism at a single institutionJournal of Surgical Research.  127:58-62. 2005
    2005 Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signalingJournal of Clinical Endocrinology and Metabolism.  90:4350-4356. 2005
    2005 How should medical student surgical rotations be structured to optimize education?Journal of Surgical Research.  126:145-148. 2005
    2005 A mouse model of carcinoid syndrome and heart diseaseJournal of Surgical Research.  126:102-105. 2005
    2005 Medullary thyroid cancer: The functions of raf-1 and human achaete-scute homologue-1Thyroid.  15:511-521. 2005
    2005 ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cellsMolecular Cancer Therapeutics.  4:910-917. 2005
    2005 Radioguided techniques for parathyroid surgeryAsian Journal of Surgery.  28:77-81. 2005
    2004 Does propofol anesthesia affect intraoperative parathyroid hormone levels? A randomized, prospective trialSurgery.  136:1138-1142. 2004
    2004 Insulin-like growth factor 1 signaling in human gastrointestinal carcinoid tumor cellsSurgery.  136:1297-1302. 2004
    2004 Radioguided parathyroid surgeryAdvances in Surgery.  38:377-392. 2004
    2004 Thallium-pertechnetate subtraction scanning in the preoperative localization of an ectopic undescended parthyroid glandClinical Nuclear Medicine.  29:542-544. 2004
    2004 Does academic advancement impact teaching performance of surgical faculty?Surgery.  136:277-281. 2004
    2004 Chronic abdominal pain and upper gastrointestinal bleeding due to duodenal perforation caused by migrated inferior vena cava filter: A case reportVascular and Endovascular Surgery.  38:381-384. 2004
    2004 Pancreatic endocrine tumorsJournal of Surgical Research.  120:139-161. 2004
    2004 Why do students choose careers in surgery?Journal of Surgical Research.  119:124-129. 2004
    2004 Subclinical Cushing's syndrome in adrenal incidentalomasSurgical Clinics of North America.  84:875-885. 2004
    2004 Gastrointestinal Carcinoid Tumors: Factors that Predict OutcomeWorld Journal of Surgery.  28:387-392. 2004
    2004 Can Thallium-Pertechnetate Subtraction Scanning Play a Role in the Preoperative Imaging for Minimally Invasive Parathyroidectomy?Clinical Nuclear Medicine.  29:21-26. 2004
    2004 Catecholamine excess in pheochromocytoma inducing insulin resistance 2004
    2004 The utility of frozen section evaluation for follicular thyroid lesionsAnnals of Surgical Oncology.  11:94-98. 2004
    2003 An update on carcinoid tumorsProblems in General Surgery.  20:125-133. 2003
    2003 Radioguided parathyroidectomy is equally effective for both adenomatous and hyperplastic glands.Annals of Surgery.  238:332-337. 2003
    2003 Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells 2003
    2003 Radioguided Parathyroidectomy for Recurrent Hyperparathyroidism Caused by Forearm Graft HyperplasiaJournal of Bone and Mineral Research.  18:939-942. 2003
    2003 Do the best students go into general surgery?Journal of Surgical Research.  115:69-73. 2003
    2003 Health-related quality of life in hyperparathyroidism measurably improves after parathyroidectomySurgery.  134:675-681. 2003
    2003 Medical student operative experience correlates with a match to a categorical surgical program 2003
    2003 Radioguided parathyroidectomy in patients with secondary and tertiary hyperparathyroidismSurgery.  134:713-717. 2003
    2003 The role of human achaete-scute homolog-1 in medullary thyroid cancer cellsSurgery.  134:866-871. 2003
    2003 Utilization of fine-needle aspiration in patients undergoing thyroidectomy at two academic centers across the AtlanticWorld Journal of Surgery.  27:208-211. 2003
    2002 Activation of the ras/raf-1 signal transduction pathway in carcinoid tumor cells results in morphologic transdifferentiationSurgery.  132:1035-1039. 2002
    2002 Do the national institutes of health consensus guidelines for parathyroidectomy predict symptom severity and surgical outcome in patients with primary hyperparathyroidism?Surgery.  132:1013-1020. 2002
    2002 Technique of thymectomy by anterior-superior cervicomediastinal exenterationJournal of the American College of Surgeons.  195:895-900. 2002
    2002 Surgery for primary hyperparathyroidism: What is the best approach?Annals of Surgery.  236:552-553. 2002
    2002 Long-term follow-up of patients with tertiary hyperparathyroidism treated by resection of a single or double adenomaAnnals of Surgery.  235:673-680. 2002
    2002 Do future general surgery residents have adequate exposure to endocrine surgery during medical school?World Journal of Surgery.  26:17-21. 2002
    2002 Palliative thyroidectomy for malignant lymphoma of the thyroidAnnals of Surgical Oncology.  9:907-911. 2002
    2002 Primary thyroid lymphoma: Can the diagnosis be made solely by fine-needle aspiration?Annals of Surgical Oncology.  9:298-302. 2002
    2002 Radioguided parathyroidectomy via VATS combined with intraoperative parathyroid hormone testing: The surgical approach of choice for patients with mediastinal parathyroid adenomas?Journal of Bone and Mineral Research.  17:1368-1371. 2002
    2001 Do medical school surgical rotations influence subspecialty choice?Journal of Surgical Research.  97:172-178. 2001
    2001 Endoscopie Transanal Resection Provides Palliation Equivalent to Transabdominal Resection in Patients with Metastatic Rectal CancerJournal of Gastrointestinal Surgery.  5:282-286. 2001
    2001 Parathyroidectomy promotes wound healing and prolongs survival in patients with calciphylaxis from secondary hyperparathyroidismSurgery.  130:645-651. 2001
    2001 Perforated Amyand's HerniaSouthern Medical Journal.  94:496-498. 2001
    2000 General surgery and fellowship training: Opinions of surgical intern applicants and fellowship directorsSurgery.  127:14-18. 2000
    2000 Hepatic Resection Using Intermittent Vascular Inflow Occlusion and Low Central Venous Pressure Anesthesia Improves Morbidity and MortalityJournal of Gastrointestinal Surgery.  4:162-167. 2000
    2000 Use of technetium Tc 99m sestamibi scintigraphy for recurrent tertiary hyperparathyroidism from a parathyroid forearm graftSouthern Medical Journal.  93:215-217. 2000
    1999 Anal ultrasound predicts the response to nonoperative treatment of fecal incontinence in menAnnals of Surgery.  229:739-744. 1999
    1999 Clinically significant, isolated metastatic disease to the thyroid glandWorld Journal of Surgery.  23:177-181. 1999
    1999 Outpatient minimally invasive parathyroidectomy: A combination of sestamibi-SPECT localization, cervical block anesthesia, and intraoperative parathyroid hormone assaySurgery.  126:1016-1022. 1999
    1999 The current management of thyroid cancer.Advances in Surgery.  33:1-27. 1999
    1998 Effective long-term palliation of symptomatic, incurable metastatic medullary thyroid cancer by operative resectionAnnals of Surgery.  227:887-895. 1998
    1998 Parathyroidectomy in the elderly: Do the benefits outweigh the risks?World Journal of Surgery.  22:531-536. 1998
    1998 Hurthle cell neoplasms of the thyroid: Are there factors predictive of malignancy?Annals of Surgery.  227:542-546. 1998
    1998 Complete Hepatic Resection of Metastases from Leiomyosarcoma Prolongs SurvivalJournal of Gastrointestinal Surgery.  2:151-155. 1998
    1998 Isolated liver metastases from neuroendocrine tumors: Does resection prolong survival?Journal of the American College of Surgeons.  187:88-92. 1998
    1998 Papillary thyroid carcinoma: Justification for total thyroidectomy and management of lymph node metastasesSurgical Oncology Clinics of North America.  7:645-663. 1998
    1997 The role of fine-needle aspiration in the evaluation of thyroid nodulesProblems in General Surgery.  14:1-13. 1997
    1997 Papillary carcinoma of the thyroid: Can operative management be based solely on fine-needle aspiration?Journal of the American College of Surgeons.  184:605-610. 1997
    1997 Tissue-specific expression of human acahaete-scute homologue-1 in neuroendocrine tumors: Transcriptional regulation by dual inhibitory regionsMolecular Cancer Research.  8:677-686. 1997
    1997 Conservation of the Drosophila lateral inhibition pathway in human lung cancer: A hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression 1997
    1997 An achaete-scute homologue essential for neuroendocrine differentiation in the lungNature.  386:852-855. 1997
    1997 Acute Isovolemic Hemodilution during Major Hepatic Resection - An Initial Report: Does It Safely Reduce the Blood Transfusion Requirement?Journal of Gastrointestinal Surgery.  1:461-466. 1997
    1997 Human achaete-scute homolog-1 is highly expressed in a subset of neuroendocrine tumors 1997
    1997 Implanted programmable insulin pumps: One hundred fifty-three patient years of surgical experienceSurgery.  122:1005-1011. 1997
    1997 Telomerase activity in the differential diagnosis of papillary carcinoma of the thyroidSurgery.  122:1137-1140. 1997
    1996 Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1Surgery.  120:168-173. 1996
    1996 Parathyroidectomy in Maryland: Effects of an endocrine centerSurgery.  120:948-953. 1996
    1995 Follicular lesions of the thyroid: Does frozen section evaluation alter operative management?Annals of Surgery.  222:101-106. 1995
    1995 Adrenocorticotropic hormone-secreting pheochromocytomas: The exception to the ruleSurgery.  118:988-995. 1995
    1992 Derivation of a biologically contained replication system for human immunodeficiency virus type 1 1992


    Year Title Altmetric
    2018 Diagnosis and Management of Hyperparathyroidism.  Ed. 52.  2018
    2016 Illustrative handbook of general surgery: Second edition 2016
    2012 Success in academic surgery: Part 1 2012
    2011 Preface 2011
    2011 The handbook of endocrine surgery 2011
    2010 Preface 2010
    2010 Preface 2010
    2010 Primary hyperparathyroidism.  Ed. 153.  2010


    Year Title Altmetric
    2019 Cancer of the Endocrine System.  1074-1107.e11. 2019
    2018 Parathyroid surgery.  151-159. 2018
    2017 Parathyroid surgery in children.  61-73. 2017
    2015 Thyroid cancer.  539-561. 2015
    2014 Radioguided parathyroidectomy.  151-156. 2014
    2013 Cancer of the Endocrine System.  1112-1142. 2013
    2012 Medullary thyroid cancer.  293-296. 2012
    2012 Thyroid lymphoma and other metastatic lesions.  259-267. 2012
    2012 Fine needle aspiration biopsy of the thyroid: Thyroid lobectomy and subtotal and total thyroidectomy 2012
    2011 Clinical management of primary hyperparathyroidism.  171-178. 2011
    2008 Reoperative Endocrine Surgery.  135-149. 2008
    2007 Thyroid lymphoma and other metastatic lesions.  171-177. 2007
    2005 Hürthle cell adenoma and carcinoma.  123-128. 2005

    Research Overview

  • thyroid and parathyroid surgery, minimally invasive radioguided parathyroidectomy, adrenal surgery, endocrine surgery, neuroendocrine cancer biology
  • Principal Investigator On

  • 2020 Robert E. Reed Gastrointestinal Oncology Research Foundation and UAB Department of Surgery International Scholars Program  awarded by ROBERT E. REED GASTROINTESTINAL ONCOLOGY RESEARCH FOUNDATION
  • 2021 Robert E. Reed Foundation and UAB Department of Surgery International Research Fellows Program  awarded by ROBERT E. REED GASTROINTESTINAL ONCOLOGY RESEARCH FOUNDATION
  • 2022 Robert E. Reed Foundation and UAB Department of Surgery International Research Fellows Program  awarded by ROBERT E. REED GASTROINTESTINAL ONCOLOGY RESEARCH FOUNDATION
  • Antibody-Drug Conjugate (ADC) for Medullary Thyroid Cancer (MTC) Targeted Therapy  awarded by Howard Hughes Medical Institute
  • Characterizing the Role of NOTCH2 in Neuroendocrine Tumors  awarded by National Cancer Institute/NIH/DHHS
  • Development of Novel Therapeutic Strategies to Improve Aggressive Thyroid Cancer Outcome  awarded by Howard Hughes Medical Institute
  • Establishment of a MEN2 Thyroid Cancer Research and Training Program  awarded by American Cancer Society, Inc.
  • Multifunctional Nanomedicine for Targeted Carcinoid Cancer Therapy  awarded by American Association for Cancer Research
  • Notch Signaling in Medullary Thyroid Cancer  awarded by American Cancer Society, Inc.
  • Parathyroid Tumor Clonal Status as a Biomarker in Primary Hyperparathyroidism  awarded by University of Maryland
  • Pharmacological Upregulation of SSTR2 For Imaging and Therapy of Medullary Thyroid Cancer  awarded by INTERNATIONAL THYROID ONCOLOGY GROUP (ITOG)
  • Short-Term Research Experiences Advancing Medical Students (STREAMS)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Skin Grafting from 9-Gene Genetically Engineered Pigs in the Treatment of Burns: An Experimental Study in Monkeys  awarded by DOD - Department of Defense
  • Surgical Oncology Research Training Program  awarded by National Cancer Institute/NIH/DHHS
  • Teaching Activities

  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2016)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2017)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2017)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2017)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2017)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2017)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Fall Term 2017)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Spring Term 2016)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Spring Term 2017)
  • 80-509 - DEAN'S ACUTE CARE SURGERY ELECTIVE (Spring Term 2018)
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2017)
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2018)
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2018)
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2018)
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2018)
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2018)
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2018)
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Fall Term 2019)
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Spring Term 2018)
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Spring Term 2018)
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Spring Term 2019)
  • 80-509 - DEAN'S ENDOCRINE SURGERY ELECTIVE (Spring Term 2019)
  • 80-509 - ENDOCRINE SURGERY ELECTIVE (Fall Term 2019)
  • 80-509 - ENDOCRINE SURGERY ELECTIVE (Fall Term 2019)
  • 80-509 - ENDOCRINE SURGERY ELECTIVE (Fall Term 2019)
  • 80-509 - ENDOCRINE SURGERY ELECTIVE (Fall Term 2019)
  • 80-509 - ENDOCRINE SURGERY ELECTIVE (Fall Term 2019)
  • 80-509 - ENDOCRINE SURGERY ELECTIVE (Fall Term 2019)
  • 80-509 - ENDOCRINE SURGERY ELECTIVE (Fall Term 2019)
  • 80-509 - ENDOCRINE SURGERY ELECTIVE (Spring Term 2020)
  • STP299DI - ENDOCRINE SURGERY (Fall Term 2018)
  • Education And Training

  • Johns hopkins medical institutions, Residency
  • Johns Hopkins Medical Institutions, Postdoctoral Fellowship
  • Doctor of Medicine, Duke University 1992
  • Full Name

  • Herbert Chen