Positions

Overview

  • Dr. Heath is an Associate Professor of Medicine at the University of Alabama at Birmingham. She is Board-certified in Internal Medicine and Infectious Diseases. She also received a Master’s Degree in Microbiology and Immunology. Her translational laboratory is focused on investigating T and B cell biology in HIV infection and vaccine development, with external funding through NIH and CDC.  Her research program has focused on understanding 1) HIV specific CD8 T cell responses and how exhaustion, senescence, and inflammation impair immunity; 2) use of cell death and survival biomarkers to elucidate the generation and maintenance of robust anti-viral immune responses in HIV infection and vaccination; 3) accelerated aging and immunosenescence in HIV infection and the extent that mitochondrial dysfunction drives this; and 4) preservation of immune function and benefit of rapid detection and treatment of acute HIV. Dr. Heath has also developed primary HIV infection laboratories with nucleic acid amplification testing and subsequently fourth generation HIV testing for the detection of acute HIV. She also serves as the PI on the CDC funded program implementing Universal HIV Screening and linkage to care at the UAB Emergency Department with expansion to community health centers serving populations disproportionately affected by HIV. Dr. Heath is a Co-Investigator of the Alabama Vaccine Research Clinic (AVRC) and serves as PI for ongoing clinical trials for early HIV treatment and therapeutic vaccination for immune preservation. She is also active in the AIDS Clinical Trials Group (ACTG) and the HIV Vaccine Trials Network (HVTN)
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Impact of first-line antiretroviral therapy regimens on the restoration of the CD4/CD8 ratio in the CNICS cohortJournal of Antimicrobial Chemotherapy.  75:1604-1610. 2020
    2019 Plasma levels of soluble membrane attack complex are elevated despite viral suppression in HIV patients with poor immune reconstitutionClinical and Experimental Immunology.  198:359-366. 2019
    2019 Loss of CXCR4 on non-classical monocytes in participants of the Women's Interagency HIV Study (WIHS) with subclinical atherosclerosisCardiovascular Research.  115:1029-1040. 2019
    2019 Enhanced facilitation and diminished inhibition characterizes the pronociceptive endogenous pain modulatory balance of persons living with HIV and chronic painJournal of NeuroVirology.  25:57-71. 2019
    2019 Increased influenza-specific antibody avidity in HIV-infected women compared with HIV-infected men on antiretroviral therapyAIDS.  33:33-44. 2019
    2018 Intersectional health-related stigma in persons living with HIV and chronic pain: implications for depressive symptoms 2018
    2018 Drug use is associated with anti-CD4 IgG-mediated CD4+ T cell death and poor CD4+ T cell recovery in viral-suppressive HIV-infected individuals under antiretroviral therapyCurrent HIV Research.  16:143-150. 2018
    2017 The effect of plasma auto-igGs on CD4+ T cell apoptosis and recovery in HIV-infected patients under antiretroviral therapyJournal of Leukocyte Biology.  102:1481-1486. 2017
    2017 Brief Report: IL-1β Levels Are Associated with Chronic Multisite Pain in People Living with HIV 2017
    2017 Pathological Role of Anti-CD4 Antibodies in HIV-Infected Immunologic Nonresponders Receiving Virus-Suppressive Antiretroviral TherapyJournal of Infectious Diseases.  216:82-91. 2017
    2017 Increased glucose transporter-1 expression on intermediate monocytes from HIV-infected women with subclinical cardiovascular diseaseAIDS.  31:199-205. 2017
    2017 Association of macrophage inflammation biomarkers with progression of subclinical carotid artery atherosclerosis in HIV-infected women and menJournal of Infectious Diseases.  215:1352-1361. 2017
    2016 HIV-1-specific CD8 T cells exhibit limited cross-reactivity during acute infectionJournal of Immunology.  196:3276-3286. 2016
    2015 Inhibition of the lymphocyte metabolic switch by the oxidative burst of human neutrophilsClinical Science.  129:489-504. 2015
    2012 Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in african americansHuman Molecular Genetics.  21:4334-4347. 2012
    2011 Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutatedJournal of Experimental Medicine.  208:2237-2249. 2011
    2011 Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppression 2011
    2011 CD8 T-cell proliferative capacity is compromised in primary HIV-1 infection 2011
    2010 CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcriptionJournal of Experimental Medicine.  207:51-59. 2010
    2007 Functionally competent antigen-specific Cd127hi memory CD8 + T cells are preserved only in HIV-infected individuals receiving early treatmentJournal of Infectious Diseases.  195:108-117. 2007
    2006 Therapeutic immunization strategies for HIV infection.Current Opinion in HIV and AIDS.  1:74-81. 2006
    1997 Follicular dendritic cells (FDC) in retroviral infection: Host/pathogen perspectivesImmunological Reviews.  156:185-197. 1997

    Research Overview

  • HIV
    Acute HIV
    Immunology
  • Principal Investigator On

  • Private Grant  awarded by GENECURE BIOTECHNOLOGIES, LLC 2015 - 2021
  • DETECT-HIV – Discovering Emerging Trends through Enhanced Community Testing for HIV Infection  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2020
  • Integrated HIV Surveillance and Prevention Programs for Health Departments  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2020
  • (CSSC-001) Convalescent Plasma to Stem Coronavirus: A Randomized Controlled Double Blinded Phase 2 Study Comparing the Efficacy and Safety of Human Coronavirus Immune Plasma (HCIP) vs. control( SARS-CoV-2 non-immune plasma) among Adults Exposed to COVID-19 and (CSSC-004) Convalescent Plasma to Stem Coronavirus: A Randomized Controlled Double Blinded Phase 2 Study Comparing the Efficacy and Safety of Human Coronavirus Immune Plasma (HCIP) vs. Control (SARS-CoV-2 non-immune plasma)  awarded by Johns Hopkins University 2020
  • Private Grant  awarded by ICHOR MEDICAL SYSTEMS INC 2019 - 2020
  • On the Pathogenic Role of Anti-CD4+ Tcell Recovery After Antiretroviral Therapy in HIV Disease  awarded by Medical University of South Carolina 2018 - 2020
  • DETECT-HIV - Discovering Emerging Trends through Enhanced Community Testing for HIV Infection  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2019
  • National Center for HIV-AIDS, Viral Hepatitis, STD, and TB Prevention Integrated HIV Surveillance and Prevention Programs for Health Departments  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2019
  • DETECT-HIV - Discovering Emerging Trends Through Enhanced Community Testing For HIV Infection  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2018 - 2019
  • National Center for HIV-AIDS, Viral Hepatitis, STD, and TB Prevention Integrated HIV Surveillance and Prevention Programs for Health Departments  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2018 - 2019
  • UAB Center for AIDS Research - The Role of HIV-Infection and Antiretroviral Therapy Related Mitochondrial Toxicity in Accelerated Aging  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • Expanded Human Immunodeficiency (HIV) Testing for Disproportionately Affected Populations  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2017
  • Expanded Human Immunodeficiency (HIV) Testing for Disproportionately Affected Populations  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2016
  • Expanded Human Immunodeficiency (HIV) Testing for Disproportionately Affected Populations  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2015
  • Regional AIDS Education and Training Centers-Base  awarded by Emory University 2014 - 2015
  • Regional AIDS Education and Training Centers-MAI  awarded by Emory University 2014 - 2015
  • Expanded Human Immunodeficiency (HIV) Testing for Disproportionately Affected Populations  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2014
  • Private Grant  awarded by GEO VAX, INC. 2011 - 2014
  • Expanded Human Immunodeficiency Virus (HIV) Testing for Disproportionately Affected Populations  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2013
  • Apoptosis of HIV Vaccine Elicited B Responses as a Marker of Vaccine Durability  awarded by Hutchinson (Fred) Cancer Research Center 2012 - 2013
  • Private Grant  awarded by MERCK & COMPANY, INC. 2008 - 2013
  • Private Grant  awarded by Gilead Sciences 2009 - 2013
  • Survival Factors Regulating the HIV-Specific Cytotoxic T Lymphocyte Response  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2007 - 2013
  • Expanded Human Immunodeficiency Virus (HIV) Testing for Disproportionately Affected Populations  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2012
  • UAB Center for AIDS Research - Diversity Supplement (HEATH)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2012
  • Expanded Human Immunodeficiency Virus (HIV) Testing for Disproportionately Affected Populations  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2011
  • Expanded Human Immunodeficiency Virus (HIV) Testing for Disproportionately Affected Populations  awarded by ALABAMA DEPARTMENT OF PUBLIC HEALTH 2010 - 2011
  • Investigator On

  • UAB-MISS MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS)  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2026
  • Matrikines and COPD-PH COVID-19  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2024
  • UAB Center for AIDS Research (CFAR)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • UAB Center for AIDS Research (CFAR) - Mobile Testing to Increase HIV-testing Uptake in Rural Alabama: A Pilot Implementation Project (MOBILISE)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • UAB Center for AIDS Research - Core C - Clinical Core  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • UAB Center for AIDS Research - Using Big Data to Estimate Undiagnosed HIV Infection and Inform Testing Interventions in Alabama  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • VVTEU Protocol Development and Implementation for Task Areas B-C Phase II Vaccine Trial for Influenza (“Flu Pandemic” or “H7”)  awarded by VANDERBILT UNIVERSITY MEDICAL CENTER 2014 - 2023
  • Vaccine and Treatment Evaluation Units  awarded by VANDERBILT UNIVERSITY MEDICAL CENTER 2014 - 2023
  • Vaccine and Treatment Evaluation Units - Admin Task  awarded by VANDERBILT UNIVERSITY 2014 - 2023
  • Private Grant  awarded by Gilead Sciences 2020 - 2023
  • Private Grant  awarded by MERCK SHARP & DOHME CORP 2020 - 2023
  • Private Grant  awarded by Gilead Sciences 2018 - 2022
  • Private Grant  awarded by Janssen 2020 - 2022
  • Private Grant  awarded by GlaxoSmithKline 2018 - 2022
  • Private Grant  awarded by BAVARIAN NORDIC A/S 2019 - 2021
  • Private Grant  awarded by VIIV HEALTHCARE COMPANY 2016 - 2021
  • Private Grant  awarded by VIIV HEALTHCARE COMPANY 2016 - 2021
  • Unsolicited R24 CFAR Network of Clinical Systems (CNICS)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2021
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Comprehensive Cancer Center Core Support Grant - Administrative Supplement to Stimulate Research in HIV/AIDS Cancer Research  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Comprehensive Cancer Center Core Support Grant - Administrative Supplement to Stimulate Research in HIV/AIDS Cancer Research  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Private Grant  awarded by Gilead Sciences 2016 - 2021
  • Alabama Clinical Trials Unit (CTU)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2017 - 2020
  • HPTN 083-A Phase 2b/3 Double Blind Safety and Efficacy Study of Injectable Cabotegravir Compared to Daily Oral Tenofovir Disoproxil Fumarate/Emtricitabine (TDF/FTC), For Pre-Exposure Prophylaxis in HIV-Uninfected Cisgender Men and Transgender Women who have Sex with Men  awarded by FAMILY HEALTH INTERNATIONAL 2017 - 2020
  • HVTN 703/HPTN 081 Protocol Funding (PF)  awarded by Hutchinson (Fred) Cancer Research Center 2015 - 2020
  • Private Grant  awarded by GlaxoSmithKline 2019 - 2020
  • Private Grant  awarded by BIODTECH, INC 2017 - 2020
  • Private Grant  awarded by Gilead Sciences 2019
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2019
  • HPTN 078: Enhancing Recruitment, Linkage to Care and Treatment for HIV-Infected Men Who Have Sex with Men (MSM) in the United States  awarded by FAMILY HEALTH INTERNATIONAL 2015 - 2019
  • Private Grant  awarded by PROTEUS DIGITAL HEALTH, INC. 2017 - 2019
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • UAB Center for AIDS Research - Clinical Core C  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • Private Grant  awarded by JANSSEN R&D IRELAND 2016 - 2019
  • Private Grant  awarded by Gilead Sciences 2016 - 2019
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Comprehensive Cancer Center Core Support Grant - Administrative Supplement to Stimulate Research in HIV/AIDS Cancer Research  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Private Grant  awarded by VIIV HEALTHCARE COMPANY 2016 - 2018
  • HVTN Protocol Funding (PF)  awarded by Hutchinson (Fred) Cancer Research Center 2015 - 2018
  • NIAID-Fred Hutch-Janssen Collaboration CTU/Clinical Trial Site Activities for HVTN 117/118  awarded by Hutchinson (Fred) Cancer Research Center 2015 - 2018
  • AIDS Clinical Trials Group: Protocol Funds FTE Funding  awarded by Brigham and Women's Hospital 2014 - 2018
  • AIDS Clinical Trials Group: Protocol Funds  awarded by Brigham and Women's Hospital 2014 - 2018
  • Private Grant  awarded by ROCHE DIAGNOSTICS OPERATIONS INC 2018
  • Private Grant  awarded by VICAL, INC. 2017 - 2018
  • Private Grant  awarded by MERCK & COMPANY, INC. 2015 - 2018
  • Private Grant  awarded by Gilead Sciences 2015 - 2018
  • Private Grant  awarded by Gilead Sciences 2015 - 2017
  • Private Grant  awarded by GENOCEA BIOSCIENCES, INC. 2015 - 2017
  • Private Grant  awarded by BAVARIAN NORDIC A/S 2014 - 2017
  • Private Grant  awarded by GENOCEA BIOSCIENCES, INC. 2015 - 2016
  • Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICS  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2016
  • Private Grant  awarded by GENOCEA BIOSCIENCES, INC. 2014 - 2016
  • Neutrophil-Mediated Immune Suppression as a Mechanism of HIV-1 Pathogenesis  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2016
  • Private Grant  awarded by VICAL, INC. 2014 - 2016
  • Private Grant  awarded by GlaxoSmithKline 2015
  • HVTN Protocol Funding (PF)  awarded by Hutchinson (Fred) Cancer Research Center 2014 - 2015
  • Training in Primary Care Medicine and Dentistry: Physician Assistant Training in Primary Care  awarded by Health Resources and Services Administration/DHHS 2013 - 2015
  • Private Grant  awarded by BAVARIAN NORDIC A/S 2013 - 2015
  • Private Grant  awarded by GENOCEA BIOSCIENCES, INC. 2012 - 2014
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • UAB Center for AIDS Research - The Detrimental Nexus of HCV and HIV Infection on Bioenergetics and Immune Function  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • Private Grant  awarded by Gilead Sciences 2010 - 2014
  • Alabama - Clinical Trials Unit  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2007 - 2013
  • Education And Training

  • Doctor of Medicine, Virginia Commonwealth University 2000
  • UAB Hospital, Internship 2001
  • UAB Hospital, Residency 2003
  • UAB Hospital, Postdoctoral Fellowship 2006
  • Full Name

  • Sonya Heath