Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Combined mTORC1/mTORC2 inhibition blocks growth and induces catastrophic macropinocytosis in cancer cells 2019
2019 Targeting dna damage response as a strategy to treat hpv infectionsInternational Journal of Molecular Sciences.  20. 2019
2019 NVN1000, a novel nitric oxide-releasing compound, inhibits HPV-18 virus production by interfering with E6 and E7 oncoprotein functionsAntiviral Research.  170. 2019
2019 Genome-wide profiling of cervical rna-binding proteins identifies human papillomavirus regulation of rnaseh2a expression by viral e7 and e2f1mBio.  10. 2019
2018 Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification 2018
2017 Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing 2017
2017 Efficient, ultra-high-Affinity chromatography in a one-step purification of complex proteins 2017
2016 The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function 2016
2015 Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicingeLife.  4. 2015
2015 In vitro and in vivo assays for studying histone ubiquitination and deubiquitination 2015
2015 Snail2/slug cooperates with polycomb repressive complex 2 (Prc2) to regulate neural crest development 2015
2014 The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damageJournal of Biological Chemistry.  289:32883-32894. 2014
2014 HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSαMolecular Cell.  55:31-46. 2014
2014 The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitmentNature Communications.  5. 2014
2014 Sp7 and Runx2 molecular complex synergistically regulate expression of target genesConnective Tissue Research.  55:83-87. 2014
2013 USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicingGenes and Development.  27:1581-1595. 2013
2013 Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progressionCell Cycle.  12:3408-3416. 2013
2011 Purification of histone ubiquitin ligases from HeLa cellsMethods.  54:315-325. 2011
2011 Regulation of histone H2A and H2B deubiquitination and xenopus development by USP12 and USP46Journal of Biological Chemistry.  286:7190-7201. 2011
2011 PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramingSTEM CELLS.  29:229-240. 2011
2010 Polycomb repressive complex 2 in embryonic stem cells: An overviewProtein and Cell.  1:1056-1062. 2010
2009 Regulation of Set9-Mediated H4K20 Methylation by a PWWP Domain ProteinMolecular Cell.  33:428-437. 2009
2009 In vitro and in vivo assays for studying histone ubiquitination and deubiquitination.Methods in Molecular Biology.  523:295-309. 2009
2008 Role of hPHF1 in H3K27 methylation and Hox gene silencingMolecular and Cellular Biology.  28:1862-1872. 2008
2008 PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiationJournal of Molecular and Cellular Cardiology.  44:47-58. 2008
2007 Regulation of cell cycle progression and gene expression by H2A deubiquitinationNature.  449:1068-1072. 2007
2006 Role of Bmi1 in H2A ubiquitylation and Hox gene silencingJournal of Biological Chemistry.  281:22537-22544. 2006
2006 "Cullin 4 makes its mark on chromatin".Cell Division.  1:14. 2006
2006 Histone H3 and H4 Ubiquitylation by the CUL4-DDB-ROC1 Ubiquitin Ligase Facilitates Cellular Response to DNA DamageMolecular Cell.  22:383-394. 2006
2004 Role of histone H2A ubiquitination in Polycomb silencingNature.  431:873-878. 2004
2003 mAM Facilitates Conversion by ESET of Dimethyl to Trimethyl Lysine 9 of Histone H3 to Cause Transcriptional RepressionMolecular Cell.  12:475-487. 2003
2003 Role of Histone H3 Lysine 27 Methylation in X InactivationScience.  300:131-135. 2003
2002 Role of Histone H3 Lysine 27 Methylation in Polycomb-Group SilencingScience.  298:1039-1043. 2002
2002 Purification and Functional Characterization of SET8, a Nucleosomal Histone H4-Lysine 20-Specific MethyltransferaseCurrent Biology.  12:1086-1099. 2002
2002 Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factorOncogene.  21:148-152. 2002
2001 Purification and Functional Characterization of a Histone H3-Lysine 4-Specific MethyltransferaseMolecular Cell.  8:1207-1217. 2001
2001 Methylation of Histone H4 at Arginine 3 Facilitating Transcriptional Activation by Nuclear Hormone ReceptorScience.  293:853-857. 2001
2001 Mi2, an auto-antigen for dermatomyositis, is an ATP-dependent nucleosome remodeling factorNucleic Acids Research.  29:2517-2521. 2001
1997 In vitro experimental systems for HPV: Epithelial raft cultures for investigations of viral reproduction and pathogenesis and for genetic analyses of viral proteins and regulatory sequencesClinics in Dermatology.  15:217-227. 1997
1996 Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: Activation of telomerase and allele losses at 3p, 10p, 11q and/or 18qOncogene.  13:1249-1257. 1996
1994 Structure and expression of the human gene for the α subunit of prolyl 4- hydroxylase. The two alternatively spliced types of mRNA correspond to two homologous exons the sequences of which are expressed in a variety of tissuesJournal of Biological Chemistry.  269:27847-27854. 1994
1992 Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins 1992
1992 Control of human papillomavirus type 11 origin of replication by the E2 family of transcription regulatory proteinsJournal of Virology.  66:5224-5231. 1992
1992 Epithelial-specific gene expression during differentiation of stratified primary human keratinocyte cultures. 1992
1992 Intermolecular triplex formation distorts the DNA duplex in the regulatory region of human papillomavirus type-11Journal of Biological Chemistry.  267:5488-5494. 1992
1992 Structure of the human 70 K type IV collagenase gene and assignment of the gene to the q21 region of chromosome 16.Matrix (Stuttgart, Germany). Supplement.  1:84. 1992
1991 Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cellsJournal of Biological Chemistry.  266:16485-16490. 1991
1991 Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain geneJournal of Biological Chemistry.  266:221-228. 1991
1991 Characterization of the 3′ half of the human type IV collagen α5 gene that is affected in the Alport syndromeGenomics.  9:1-9. 1991
1990 Structure and expression of type IV collagenase genesCell differentiation and development : the official journal of the International Society of Developmental Biologists.  32:307-312. 1990
1990 Structure of the human laminin B1 chain geneJournal of Biological Chemistry.  265:15611-15616. 1990
1990 Structure of the human type IV collagenase geneJournal of Biological Chemistry.  265:11077-11082. 1990
1990 Characterization of cDNA and Genomic Clones for the α Subunit of Human Prolyl 4‐HydroxylaseAnnals of the New York Academy of Sciences.  580:473-476. 1990
1990 Identification of mutations in the COL4A5 collagen gene in Alport syndromeScience.  248:1224-1227. 1990
1989 Mapping the genetic organization of RNA by electron microscopyMethods in Enzymology.  180:239-261. 1989
1988 Characterization of the human gene for a polypeptide that acts both as the β subunit of prolyl 4-hydroxylase and as protein disulfide isomeraseJournal of Biological Chemistry.  263:16218-16224. 1988
1987 Genetic relationship among human papillomaviruses associated with benign and malignant tumours of patients with epidermodysplasia verruciformisJournal of General Virology.  68:3091-3103. 1987
1986 Large introns in the 3' end of the gene for the proα1(IV) chain of human basement membrane collagen 1986
1986 The gene for the alpha 1(IV) chain of human type IV procollagen: the exon structures do not coincide with the two structural subdomains in the globular carboxy-terminus of the protein. 1986
1985 Characterization of 64-, 123- and 182-base-pair exons in the mouse α2(IV) collagen geneNature.  317:177-179. 1985
1983 Four unique genes required for β tubulin expression in vertebratesCell.  32:713-724. 1983
1982 Structure of two human α-tubulin genes 1982
1981 Identification of the gene and mRNA for the adenovirus terminal protein precursorCell.  23:497-508. 1981
1981 Sequences of human adenovirus Ad3 and Ad7 DNAs encoding the promoter and first leader segment of late RNAsGene.  13:133-143. 1981
1981 Structural variation among human β-tubulin genes 1981
1980 Incomplete splicing and deficient accumulation of the fiber messenger RNA in monkey cells infected by human adenovirus type 2Journal of Molecular Biology.  139:221-242. 1980
1980 Patterns and consequences of adenoviral RNA splicing Ex pluribus unum - Ex uno pluraTrends in Biochemical Sciences.  5:174-178. 1980
1979 RNA transcription and splicing at early and intermediate times after adenovirus-2 infectionSymposia on Quantitative Biology.  44:401-414. 1979
1979 Complex splicing patterns of RNAs from the early regions of adenovirus-2Journal of Molecular Biology.  134:265-303. 1979
1979 Adenovirus DNA replication in soluble extracts of infected cell nuclei 1979
1979 Comparison of late mRNA splicing among class B and class C adenovirusesJournal of Virology.  30:899-912. 1979
1979 Identification and mapping of the transcriptional and translational products of the yeast plasmid, 2μ circleCell.  16:827-839. 1979
1979 Site-specific recombination in phage Mu 1979
1978 Inversion of the G DNA segment of phage Mu controls phage infectivityNature.  271:577-580. 1978
1978 The structure of late adenovirus type 2 messenger RNAsBrookhaven Symposia in Biology.  No. 29:345-347. 1978
1978 A supplementary adenoviral leader sequence and its role in messenger translationCell.  15:511-526. 1978
1978 Adjacent insertion sequences IS2 and IS5 in bacteriophage mu mutants and an IS5 in a lambda darg bacteriophageJournal of Bacteriology.  133:1427-1436. 1978
1978 Heteroduplex electron microscopy of phage Mu Mutants containing IS1 insertions and chloramphenicol resistance transposonsGene.  3:333-346. 1978
1978 The spliced structures of adenovirus 2 fiber message and the other late mRNAsCell.  15:497-510. 1978
1977 Electron microscopic characterization of DNAs of non-defective deletion mutants of bacteriophage MuJournal of Molecular Biology.  113:591-609. 1977
1977 Sequence arrangements of the Escherichia coli chromosome and of putative insertion sequences, as revealed by electron microscopic heteroduplex studiesJournal of Molecular Biology.  113:611-621. 1977
1977 Underwound loops in self-renatured DNA can be diagnostic of inverted duplications and translocated sequencesJournal of Molecular Biology.  113:579-589. 1977
1977 A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybridsCell.  11:819-836. 1977
1977 Adenovirus-2 messengers. An example of baroque molecular architecture 1977
1977 An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNACell.  12:1-8. 1977
1976 The invertible DNA segments of coliphages Mu and P1 are identicalVirology.  74:242-248. 1976
1974 Electron microscope study of the structures of λdv DNAsJournal of Molecular Biology.  86. 1974
1973 Electron microscope mapping of the distribution of ribosomal genes of the Bacillus subtilis chromosomeJournal of Molecular Biology.  75. 1973
1973 Electron microscope study of the structures of the Bacillus subtilis prophages, SPO2 and φ105Journal of Molecular Biology.  75. 1973
1972 Map of the partial sequence homology between DNA molecules of Bacillus subtilis bacteriophages SPO2 and φ105Journal of Molecular Biology.  68. 1972

Chapter

Year Title Altmetric
2013 Ubiquitin Specific Peptidase 16.  2090-2094. 2013

Teaching Activities

Education And Training

  • Doctorate Level Degree in Plant Sciences, China Agricultural University 1997
  • Full Name

  • Hengbin Wang