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Kirk Habegger
Associate Professor
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E-mail
habegger@uab.edu
kirkhabegger@uabmc.edu
Phone
205-934-9836
205-934-9835
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Map of Science
Kirk Habegger
Associate Professor
Positions
Scientist (C)
,
Comprehensive Diabetes Center
,
School of Medicine
Scientist (C)
,
Center for AIDS Research
,
School of Medicine
Associate Professor (P)
,
Medicine - Endocrinology, Diabetes, and Metabolism
,
Department of Medicine
Scientist (C)
,
Nutrition Obesity Res Center (NORC)
,
Nutrition Sciences Research
Associate Scientist (C)
,
Center for Exercise Medicine
,
Cell, Developmental and Integrative Biology (CDIB)
Publications
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2022
Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice
.
Diabetes
. 71:2123-2135.
2022
2022
Mother-child cardiometabolic health 4–10 years after pregnancy complicated by obesity with and without gestational diabetes
2022
2022
Cross Talk Between Insulin and Glucagon Receptor Signaling in the Hepatocyte
.
Diabetes
. 71:1842-1851.
2022
2021
Sam68 promotes hepatic gluconeogenesis via CRTC2
.
Nature Communications
. 12.
2021
2021
The transcriptional co-regulator LDB1 is required for brown adipose function
.
Molecular Metabolism
. 53.
2021
2021
Mito: Mendelian interactions alter in vivo glucose metabolism and insulin sensitivity in healthy mice
2021
2021
Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure
2021
2021
Glucagon’s Metabolic Action in Health and Disease
.
Comprehensive Physiology
. 11:1759-1783.
2021
2021
Glucagon receptor signaling regulates weight loss via central KLB receptor complexes
.
JCI Insight
. 6.
2021
2020
High-Fat and High-Sucrose Diets Impair Time-of-Day Differences in Spatial Working Memory of Male Mice
.
Obesity
. 28:2347-2356.
2020
2020
A small molecule, UAB126, reverses diet-induced obesity and its associated metabolic disorders
.
Diabetes
. 69:2003-2016.
2020
2020
In utero nutritional stress as a cause of obesity: Altered relationship between body fat, leptin levels and caloric intake in offspring into adulthood
.
Life Sciences
. 254.
2020
2020
Revisiting the pharmacological value of glucagon: An editorial for the special issue “the biology and pharmacology of Glucagon”
.
International Journal of Molecular Sciences
. 21.
2020
2020
Glucagon-receptor signaling reverses hepatic steatosis independent of leptin receptor expression
2020
2020
Increased glucose availability attenuates myocardial ketone body utilization
.
Journal of the American Heart Association
. 9.
2020
2019
Glucagon regulation of energy expenditure
.
International Journal of Molecular Sciences
. 20.
2019
2019
The islet-expressed Lhx1 transcription factor interacts with islet-1 and contributes to glucose homeostasis
2019
2018
Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia
.
Molecular Metabolism
. 17:28-38.
2018
2018
Hepatic glucagon receptor signaling enhances insulin-stimulated glucose disposal in rodents
.
Diabetes
. 67:2157-2166.
2018
2018
Glucagon receptor signaling regulates energy metabolism via hepatic farnesoid X receptor and fibroblast growth factor 21
.
Diabetes
. 67:1773-1782.
2018
2018
Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance
.
Molecular Metabolism
. 12:48-61.
2018
2018
Dietary manipulations that induce ketosis activate the HPA axis in male rats and mice: A potential role for fibroblast growth factor-21
2018
2017
LDB1 regulates energy homeostasis during diet-induced obesity
2017
2017
Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats
.
International Journal of Obesity
. 41:381-389.
2017
2016
Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease
.
Cell
. 167:843-857.e14.
2016
2016
Fibroblast activation protein (FAP) as a novel metabolic target
.
Molecular Metabolism
. 5:1015-1024.
2016
2016
Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding
.
Journal of Applied Physiology
. 121:687-698.
2016
2015
FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice
.
Diabetologia
. 58:2414-2423.
2015
2015
Ghrelin
.
Molecular Metabolism
. 4:437-460.
2015
2015
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
.
Nature Medicine
. 21:27-36.
2015
2014
GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats
.
Diabetes
. 63:505-513.
2014
2014
Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors
.
Diabetes
. 63:122-131.
2014
2014
Chromium enhances insulin responsiveness via AMPK
.
Journal of Nutritional Biochemistry
. 25:565-572.
2014
2014
Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia
.
Gut
. 63:1238-1246.
2014
2013
The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms
.
Nature Communications
. 4.
2013
2013
High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice
.
Circulation
. 128:2364-2371.
2013
2013
Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans
.
Science Translational Medicine
. 5.
2013
2013
GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats
.
Diabetes
. 62:3261-3267.
2013
2013
Fibroblast growth factor 21 mediates specific glucagon actions
.
Diabetes
. 62:1453-1463.
2013
2013
P62 Links β-adrenergic input to mitochondrial function and thermogenesis
.
Journal of Clinical Investigation
. 123:469-478.
2013
2012
Targeted estrogen delivery reverses the metabolic syndrome
.
Nature Medicine
. 18:1847-1856.
2012
2012
Caloric restriction chronically impairs metabolic programming in mice
.
Diabetes
. 61:2734-2742.
2012
2012
Acylation type determines Ghrelin's effects on energy homeostasis in rodents
2012
2012
Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism
.
Physiological Reviews
. 92:1479-1514.
2012
2012
MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: Is there relevance for body weight regulation?
2012
2012
AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol
2012
2012
The goat-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction
.
PLoS One
. 7.
2012
2012
Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle
.
Diabetologia
. 55:457-467.
2012
2012
Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats
.
Obesity Surgery
. 22:140-151.
2012
2012
Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21
.
Journal of Peptide Science
. 18:383-393.
2012
2011
Ghrelin receptor deficiency does not affect diet-induced atherosclerosis in low-density lipoprotein receptor-null mice
.
Frontiers in Endocrinology
. 2.
2011
2011
Evidence coupling increased hexosamine biosynthesis pathway activity to membrane cholesterol toxicity and cortical filamentous actin derangement contributing to cellular insulin resistance
2011
2011
Neural regulation of cholesterol metabolism.
.
Current Opinion in Lipidology
. 22:283-287.
2011
2011
A role for astrocytes in the central control of metabolism
2011
2010
The metabolic actions of glucagon revisited
.
Nature Reviews Endocrinology
. 6:689-697.
2010
2010
Glucagon regulation of energy metabolism
.
Physiology and Behavior
. 100:545-548.
2010
2010
CNS leptin action modulates immune response and survival in sepsis
2010
2010
Erratum: Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin (Endocrinology (2009) 150, (1636-1645) DOI: 10.1210/en.2008-1102)
2010
2009
Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin
2009
2006
Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring rats
2006
2005
Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats
.
Neuroscience
. 131:871-876.
2005
2004
Glutathione S-transferase 8-8 expression is lower in alcohol-preferring than in alcohol-nonpreferring rats
.
Alcoholism: Clinical and Experimental Research
. 28:1622-1628.
2004
2003
Analyses of Quantitative Trait Loci Contributing to Alcohol Preference in HAD1/LAD1 and HAD2/LAD2 Rats
.
Alcoholism: Clinical and Experimental Research
. 27:1710-1717.
2003
Background
Education And Training
Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology,
Indiana University System : Indiana University/Purdue University at Indianapolis
2009
Awards And Honors
The American Society for Nutrition’s Bio-Serv Award in Experimental Animal Nutrition
,
2018
Pittman Scholar in the UAB School of Medicine
,
2017
President’s Oral Session
,
2016
Nominee - Helmholtz Young Investigator Diabetes Award
,
2016
UAB-CFAR Early Career Investigator Award
,
2016
Paper of the Year
,
2014
Early Investigator Award
,
2013
Jack Davis Award
,
2007
Contact
Full Name
Kirk
Habegger