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Kirk Habegger
Associate Professor
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E-mail
habegger@uab.edu
kirkhabegger@uabmc.edu
Phone
205-934-9836
205-934-9835
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Map of Science
Co-investigator Network
Kirk Habegger
Associate Professor
Positions
Scientist (C)
,
Comprehensive Diabetes Center
,
School of Medicine
2013 -
Associate Professor (P)
,
Medicine - Endocrinology, Diabetes, and Metabolism
,
Department of Medicine
2013 -
Associate Scientist (C)
,
Center for Exercise Medicine
,
Cell, Developmental and Integrative Biology (CDIB)
2014 -
Scientist (C)
,
Center for AIDS Research
,
School of Medicine
2015 -
Scientist (C)
,
Nutrition Obesity Res Center (NORC)
,
Nutrition Sciences Research
2018 -
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
Altmetric
2021
Glucagon-receptor signaling regulates weight loss via central KLB receptor complexes.
.
JCI insight
.
2021
2020
High-Fat and High-Sucrose Diets Impair Time-of-Day Differences in Spatial Working Memory of Male Mice
2020
2020
A small molecule, UAB126, reverses diet-induced obesity and its associated metabolic disorders
.
Diabetes
. 69:2003-2016.
2020
2020
Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization
2020
2020
In utero nutritional stress as a cause of obesity: Altered relationship between body fat, leptin levels and caloric intake in offspring into adulthood
.
Life Sciences
. 254.
2020
2020
Revisiting the pharmacological value of glucagon: An editorial for the special issue “the biology and pharmacology of Glucagon”
.
International Journal of Molecular Sciences
. 21.
2020
2020
Glucagon-receptor signaling reverses hepatic steatosis independent of leptin receptor expression
.
Endocrinology
. 161.
2020
2019
Glucagon regulation of energy expenditure
.
International Journal of Molecular Sciences
. 20.
2019
2019
The islet-expressed Lhx1 transcription factor interacts with islet-1 and contributes to glucose homeostasis
2019
2018
Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia
.
Molecular Metabolism
. 17:28-38.
2018
2018
Hepatic glucagon receptor signaling enhances insulin-stimulated glucose disposal in rodents
.
Diabetes
. 67:2157-2166.
2018
2018
Glucagon receptor signaling regulates energy metabolism via hepatic farnesoid X receptor and fibroblast growth factor 21
.
Diabetes
. 67:1773-1782.
2018
2018
Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance
.
Molecular Metabolism
. 12:48-61.
2018
2018
Dietary manipulations that induce ketosis activate the HPA axis in male rats and mice: A potential role for fibroblast growth factor-21
.
Endocrinology
. 159:400-413.
2018
2017
LDB1 regulates energy homeostasis during diet-induced obesity
.
Endocrinology
. 158:1289-1297.
2017
2017
Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats
.
International Journal of Obesity
. 41:381-389.
2017
2016
Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease
.
Cell
. 167:843-857.e14.
2016
2016
Fibroblast activation protein (FAP) as a novel metabolic target
.
Molecular Metabolism
. 5:1015-1024.
2016
2016
Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding
2016
2015
FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice
.
Diabetologia
. 58:2414-2423.
2015
2015
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
.
Nature Medicine
. 21:27-36.
2015
2015
Ghrelin
.
Molecular Metabolism
. 4:437-460.
2015
2014
GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats
.
Diabetes
. 63:505-513.
2014
2014
Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors
.
Diabetes
. 63:122-131.
2014
2014
Chromium enhances insulin responsiveness via AMPK
.
Journal of Nutritional Biochemistry
. 25:565-572.
2014
2014
Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia
.
Gut
. 63:1238-1246.
2014
2013
The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms
.
Nature Communications
. 4.
2013
2013
High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice
.
Circulation
. 128:2364-2371.
2013
2013
Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans
.
Science Translational Medicine
. 5.
2013
2013
GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats
.
Diabetes
. 62:3261-3267.
2013
2013
Fibroblast growth factor 21 mediates specific glucagon actions
.
Diabetes
. 62:1453-1463.
2013
2013
P62 Links β-adrenergic input to mitochondrial function and thermogenesis
.
Journal of Clinical Investigation
. 123:469-478.
2013
2012
Targeted estrogen delivery reverses the metabolic syndrome
.
Nature Medicine
. 18:1847-1856.
2012
2012
Caloric restriction chronically impairs metabolic programming in mice
.
Diabetes
. 61:2734-2742.
2012
2012
Acylation type determines Ghrelin's effects on energy homeostasis in rodents
.
Endocrinology
. 153:4687-4695.
2012
2012
Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism
.
Physiological Reviews
. 92:1479-1514.
2012
2012
MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: Is there relevance for body weight regulation?
2012
2012
AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol
.
Endocrinology
. 153:2130-2141.
2012
2012
The goat-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction
.
PLoS ONE
. 7.
2012
2012
Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle
.
Diabetologia
. 55:457-467.
2012
2012
Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats
.
Obesity Surgery
. 22:140-151.
2012
2012
Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21
.
Journal of Peptide Science
. 18:383-393.
2012
2011
Ghrelin receptor deficiency does not affect diet-induced atherosclerosis in low-density lipoprotein receptor-null mice
.
Frontiers in Endocrinology
. 2.
2011
2011
Evidence coupling increased hexosamine biosynthesis pathway activity to membrane cholesterol toxicity and cortical filamentous actin derangement contributing to cellular insulin resistance
.
Endocrinology
. 152:3373-3384.
2011
2011
Neural regulation of cholesterol metabolism
.
Current Opinion in Lipidology
. 22:283-287.
2011
2011
A role for astrocytes in the central control of metabolism
2011
2010
The metabolic actions of glucagon revisited
.
Nature Reviews Endocrinology
. 6:689-697.
2010
2010
Glucagon regulation of energy metabolism
.
Physiology and Behavior
. 100:545-548.
2010
2010
CNS leptin action modulates immune response and survival in sepsis
2010
2010
Erratum: Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin (Endocrinology (2009) 150, (1636-1645) DOI: 10.1210/en.2008-1102)
.
Endocrinology
. 151:2967.
2010
2009
Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin
.
Endocrinology
. 150:1636-1645.
2009
2006
Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring rats
2006
2005
Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats
.
Neuroscience
. 131:871-876.
2005
2004
Glutathione S-transferase 8-8 expression is lower in alcohol-preferring than in alcohol-nonpreferring rats
.
Alcoholism: Clinical and Experimental Research
. 28:1622-1628.
2004
2003
Analyses of Quantitative Trait Loci Contributing to Alcohol Preference in HAD1/LAD1 and HAD2/LAD2 Rats
.
Alcoholism: Clinical and Experimental Research
. 27:1710-1717.
2003
Research
Principal Investigator On
Private Grant
awarded by
ELI LILLY AND COMPANY
2020 - 2022
Glucagon Mediated Potentiation of Insulin Sensitivity in Glucose Metabolism
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2017 - 2022
Private Grant
awarded by
DAIICHI SANKYO, INC.
2019 - 2020
Cholesterol Toxicity as a Promising Target for Diabetes Prevention
awarded by
Indiana University
2020
Private Grant
awarded by
GLYSCEND, INC
2018 - 2019
Duodenal Nutrient Exclusion Enhances Glucose Metabolism via CNS Regulation
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2014 - 2017
FGF21 as Mediator of the Metabolic Actions of Glucagon
awarded by
American Diabetes Association, Inc.
2013 - 2014
Investigator On
Pregnancy-Specific Mechanisms Regulating Beta-Cell Proliferation and Mass
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2020 - 2025
UAB Center for AIDS Research (CFAR)
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
2019 - 2024
UAB Diabetes Research Center
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2018 - 2023
UAB Diabetes Research Center - Animal Physiology Core
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2018 - 2023
Revealing LIM Domain Transcriptional Complexes that Establish and Maintain Beta Cell Mass
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2017 - 2022
Intergenerational Transmission of Obesity
awarded by
American Heart Association
2017 - 2021
Intergenerational Transmission of Obesity - Intergenerational Transmission of Obesity in Mouse Models of in Utero Stress
awarded by
American Heart Association
2017 - 2021
Intergenerational Transmission of Obesity - UAB Strategically Focused Obesity Center (SFOC)
awarded by
American Heart Association
2017 - 2021
Background
Education And Training
Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology,
Indiana University System : Indiana University/Purdue University at Indianapolis
2009
Awards And Honors
The American Society for Nutrition’s Bio-Serv Award in Experimental Animal Nutrition
,
2018
Pittman Scholar in the UAB School of Medicine
,
2017
President’s Oral Session
,
2016
Nominee - Helmholtz Young Investigator Diabetes Award
,
2016
UAB-CFAR Early Career Investigator Award
,
2016
Paper of the Year
,
2014
Early Investigator Award
,
2013
Jack Davis Award
,
2007
Contact
Full Name
Kirk
Habegger