Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implicationsPharmacology and Therapeutics.  233. 2022
2021 Sam68 promotes hepatic gluconeogenesis via CRTC2Nature Communications.  12. 2021
2021 Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured HeartCirculation Research.  129:1006-1020. 2021
2021 Functional inhibition of valosin-containing protein induces cardiac dilation and dysfunction in a new dominant-negative transgenic mouse modelCells.  10. 2021
2021 Deletion of PRAK Mitigates the Mitochondria Function and Suppresses Insulin Signaling in C2C12 Myoblasts Exposed to High GlucoseFrontiers in Pharmacology.  12. 2021
2021 Hsp22 deficiency induces age-dependent cardiac dilation and dysfunction by impairing autophagy, metabolism, and oxidative responseAntioxidants.  10. 2021
2021 Ablation of Sam68 in adult mice increases thermogenesis and energy expenditureThe FASEB Journal.  35. 2021
2021 The essential role of prak in preserving cardiac function and insulin resistance in high-fat diet-induced diabetesInternational Journal of Molecular Sciences.  22. 2021
2021 Visualization and Identification of Bioorthogonally Labeled Exosome Proteins Following Systemic Administration in MiceFrontiers in Cell and Developmental Biology.  9. 2021
2021 Ablation of lncrna miat attenuates pathological hypertrophy and heart failureTheranostics.  11:7995-8007. 2021
2020 Novel genomic targets of valosin-containing protein in protecting pathological cardiac hypertrophyScientific Reports.  10. 2020
2020 Genomic characterization reveals novel mechanisms underlying the valosin-containing protein-mediated cardiac protection against heart failureRedox Biology.  36. 2020
2020 Irisin Improves Myocardial Performance and Attenuates Insulin Resistance in Spontaneous Mutation (Leprdb) MiceFrontiers in Pharmacology.  11. 2020
2020 Irisin counteracts high glucose and fatty acid-induced cytotoxicity by preserving the AMPK-insulin receptor signaling axis in C2C12 myoblastsAmerican Journal of Physiology: Endocrinology and Metabolism.  318:E791-E805. 2020
2020 MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failureAmerican Journal of Physiology: Heart and Circulatory Physiology.  318:H682-H695. 2020
2020 Paracetamol inhibits Ca2+ permeant ion channels and Ca2+ sensitization resulting in relaxation of precontracted airway smooth muscleJournal of Pharmacological Sciences.  142:60-68. 2020
2020 Analysis of mesenchymal stem cell proteomes in situ in the ischemic heartTheranostics.  10:11324-11338. 2020
2019 Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cellsNature Communications.  10. 2019
2019 NS8593 inhibits Ca2+ permeant channels reversing mouse airway smooth muscle contractionLife Sciences.  238. 2019
2019 Sam68 impedes the recovery of arterial injury by augmenting inflammatory responseJournal of Molecular and Cellular Cardiology.  137:82-92. 2019
2019 The Valosin-Containing Protein Protects the Heart against Pathological Ca2+ Overload by Modulating Ca2+ Uptake ProteinsToxicological Sciences.  171:473-484. 2019
2019 Danhong injection mobilizes endothelial progenitor cells to repair vascular endothelium injury via upregulating the expression of Akt, eNOS and MMP-9Phytomedicine.  61. 2019
2019 OBG-like ATPase 1 inhibition attenuates angiotensin II-induced hypertrophic response in human ventricular myocytes via GSK-3beta/beta-catenin signallingClinical and Experimental Pharmacology and Physiology.  46:743-751. 2019
2019 Azithromycin inhibits muscarinic 2 receptor-activated and voltage-activated Ca 2+ permeant ion channels and Ca 2+ sensitization, relaxing airway smooth muscle contractionClinical and Experimental Pharmacology and Physiology.  46:329-336. 2019
2019 Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heartJournal of Cellular Physiology.  234:1671-1681. 2019
2019 Convergences of Life Sciences and Engineering in Understanding and Treating Heart FailureCirculation Research.  124:161-169. 2019
2019 A defined combination of four active principles from the Danhong injection is necessary and sufficient to accelerate EPC-mediated vascular repair and local angiogenesisFrontiers in Pharmacology.  10. 2019
2019 P38-Regulated/activated protein kinase plays a pivotal role in protecting heart against ischemia-reperfusion injury and preserving cardiac performanceAmerican Journal of Physiology: Cell Physiology.  317:C525-C533. 2019
2018 Semen cassiae Extract Inhibits Contraction of Airway Smooth MuscleFrontiers in Pharmacology.  9. 2018
2018 Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscleScientific Reports.  8. 2018
2018 Myocyte-specific overexpressing HDAC4 promotes myocardial ischemia/reperfusion injuryMolecular Medicine.  24. 2018
2018 Generation and Role of Oscillatory Contractions in Mouse Airway Smooth MuscleCellular Physiology and Biochemistry.  47:1546-1555. 2018
2018 Danhong Injection Protects Against Hypertension-Induced Renal Injury Via Down-Regulation of Myoglobin Expression in Spontaneously Hypertensive RatsKidney and Blood Pressure Research.  43:12-24. 2018
2018 E2F1 suppresses oxidative metabolism and endothelial differentiation of bone marrow progenitor cellsCirculation Research.  122:701-711. 2018
2018 Regenerative potential of neonatal porcine heartsCirculation.  138:2809-2816. 2018
2018 Transgenic overexpression of active HDAC4 in the heart attenuates cardiac function and exacerbates remodeling in infarcted myocardiumJournal of Applied Physiology.  125:1968-1978. 2018
2017 Danhong injection reduces vascular remodeling and up-regulates the Kallikrein-kinin system in spontaneously hypertensive ratsScientific Reports.  7. 2017
2017 Irisin plays a pivotal role to protect the heart against ischemia and reperfusion injuryJournal of Cellular Physiology.  232:3775-3785. 2017
2017 Sodium Butyrate Protects ­Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic MiceJournal of Cellular Biochemistry.  118:2395-2408. 2017
2017 Characterization and analysis of long noncoding rna (lncRNA) in In Vitro- and Ex Vivo-derived cardiac progenitor cellsPLoS One.  12. 2017
2017 Distinct effects of Ca2+ sparks on cerebral artery and airway smooth muscle cell tone in mice and humansInternational Journal of Biological Sciences.  13:1242-1253. 2017
2017 E2F-2 promotes nuclear condensation and enucleation of terminally differentiated erythroblastsMolecular and Cellular Biology.  37. 2017
2017 The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivoScientific Reports.  7. 2017
2016 Coordinated activation of VEGF/VEGFR-2 and PPARδ pathways by a multi-component Chinese medicine DHI accelerated recovery from peripheral arterial disease in type 2 diabetic micePLoS One.  11. 2016
2016 E2F1 Hinders Skin Wound Healing by Repressing Vascular Endothelial Growth Factor (VEGF) Expression, Neovascularization, and Macrophage RecruitmentPLoS One.  11. 2016
2016 Foxc1 Regulates Early Cardiomyogenesis and Functional Properties of Embryonic Stem Cell Derived CardiomyocytesStem Cells.  34:1487-1500. 2016
2016 Targeted Inhibition of Leucine-Rich Repeat and Immunoglobulin Domain-Containing Protein 1 in Transplanted Neural Stem Cells Promotes Neuronal Differentiation and Functional Recovery in Rats Subjected to Spinal Cord InjuryCritical Care Medicine.  44:e146-e157. 2016
2016 Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted heartsAmerican Journal of Physiology: Cell Physiology.  310:C270-C283. 2016
2016 Cortex phellodendri Extract Relaxes Airway Smooth MuscleEvidence-Based Complementary and Alternative Medicine.  2016. 2016
2016 IL-10 accelerates re-endothelialization and inhibits post-injury intimal hyperplasia following carotid artery denudationPLoS One.  11. 2016
2015 Inhibition of Oct 3/4 mitigates the cardiac progenitor-derived myocardial repair in infarcted myocardiumStem Cell Research and Therapy.  6. 2015
2015 Negative Regulation of miR-375 by Interleukin-10 Enhances Bone Marrow-Derived Progenitor Cell-Mediated Myocardial Repair and Function after Myocardial InfarctionStem Cells.  33:3519-3529. 2015
2015 Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic miceCardiovascular Diabetology.  14. 2015
2015 Therapeutic manipulation of angiogenesis with miR-27bVascular Cell.  7. 2015
2015 Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial InfarctionCirculation Research.  117:52-64. 2015
2015 Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardiumInternational Journal of Cardiology.  192:61-69. 2015
2015 HDAC4 Degradation Mediates HDAC Inhibition-Induced Protective Effects Against Hypoxia/Reoxygenation InjuryJournal of Cellular Physiology.  230:1321-1331. 2015
2015 Chloroquine inhibits Ca signaling in murine CD4 + thymocytesCellular Physiology and Biochemistry.  36:133-140. 2015
2015 A critical role of Src family kinase in SDF-1/CXCR4-mediated bone-marrow progenitor cell recruitment to the ischemic heartJournal of Molecular and Cellular Cardiology.  81:49-53. 2015
2015 Genetic deletion of TNFR2 augments inflammatory response and blunts satellite-cell-mediated recovery response in a hind limb ischemia modelThe FASEB Journal.  29:1208-1219. 2015
2015 Involvement of large-conductance Ca2+-activated K+ channels in chloroquine-induced force alterations in pre-contracted airway smooth musclePLoS One.  10. 2015
2015 Renalase is a novel target gene of hypoxia-inducible factor-1 in protection against cardiac ischaemia-reperfusion injuryCardiovascular Research.  105:182-191. 2015
2015 Inhibition of Sam68 triggers adipose tissue browningJournal of Endocrinology.  225:181-189. 2015
2015 Relaxant action of Plumula Nelumbinis extract on mouse airway smooth muscleEvidence-Based Complementary and Alternative Medicine.  2015. 2015
2015 Trans-system mechanisms against ischemic myocardial injuryComprehensive Physiology.  5:167-192. 2015
2014 E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expressionCardiovascular Research.  104:412-422. 2014
2014 Infrared fluorescent protein 1.4 genetic labeling tracks engrafted cardiac progenitor cells in mouse ischemic heartsPLoS One.  9. 2014
2014 Stimulation of glucagon-like peptide-1 receptor through exendin-4 preserves myocardial performance and prevents cardiac remodeling in infarcted myocardiumAmerican Journal of Physiology: Endocrinology and Metabolism.  307:E630-E643. 2014
2014 Assessing in vitro stem-cell function and tracking engraftment of stem cells in ischaemic hearts by using novel iRFP gene labellingJournal of Cellular and Molecular Medicine.  18:1889-1894. 2014
2014 Specific inhibition of HDAC4 in cardiac progenitor cells enhances myocardial repairsAmerican Journal of Physiology: Cell Physiology.  307. 2014
2014 Non-selective cation channels mediate chloroquine-induced relaxation in precontracted mouse airway smooth musclePLoS One.  9. 2014
2014 MiR-92a regulates viability and angiogenesis of endothelial cells under oxidative stressBiochemical and Biophysical Research Communications.  446:952-958. 2014
2014 Bitter tastants induce relaxation of rat thoracic aorta precontracted with high K+Clinical and Experimental Pharmacology and Physiology.  41:301-308. 2014
2014 Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: Improving the safety of iPS cell transplantation to myocardiumCell Cycle.  13:762-771. 2014
2014 Enhanced potency of cell-based therapy for ischemic tissue repair using an injectable bioactive epitope presenting nanofiber support matrixJournal of Molecular and Cellular Cardiology.  74:231-239. 2014
2014 HDAC4: Mechanism of regulation and biological functionsEpigenomics.  6:139-150. 2014
2014 MiR-92a inhibits vascular smooth muscle cell apoptosis: Role of the MKK4-JNK pathwayApoptosis: an international journal on programmed cell death.  19:975-983. 2014
2013 Gli3 regulation of myogenesis is necessary for ischemia-induced angiogenesisCirculation Research.  113:1148-1158. 2013
2013 Endothelial dysfunction and systemic hypertension by selective cGMP-dependent protein kinase i inhibition using novel cell-penetrating peptide delivered in vivoInternational Journal of Cardiology.  167:2114-2119. 2013
2013 Contrasting roles of E2F2 and E2F3 in endothelial cell growth and ischemic angiogenesisJournal of Molecular and Cellular Cardiology.  60:68-71. 2013
2013 Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and functionJournal of Biological Chemistry.  288:18022-18034. 2013
2013 Contrasting Roles of E2F2 and E2F3 in Cardiac NeovascularizationPLoS One.  8. 2013
2013 Rosuvastatin Enhances Angiogenesis via eNOS-Dependent Mobilization of Endothelial Progenitor CellsPLoS One.  8. 2013
2013 Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injuryBiochemical and Biophysical Research Communications.  431:566-571. 2013
2013 CXC-chemokine receptor 4 antagonist AMD3100 promotes cardiac functional recovery after ischemia/reperfusion injury via endothelial nitric oxide synthase-dependent mechanismCirculation.  127:63-73. 2013
2012 Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted heartsJournal of Biological Chemistry.  287:39338-39348. 2012
2012 Angiogenic Factor AGGF1 Promotes Therapeutic Angiogenesis in a Mouse Limb Ischemia ModelPLoS One.  7. 2012
2012 Breaking the harmony of TNF-α signaling for cancer treatmentOncogene.  31:4117-4127. 2012
2012 The role of notch 1 activation in cardiosphere derived cell differentiationStem Cells and Development.  21:2122-2129. 2012
2012 Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κBCirculation.  126:418-429. 2012
2012 Enhanced angiogenic and cardiomyocyte differentiation capacity of epigenetically reprogrammed mouse and human endothelial progenitor cells augments their efficacy for ischemic myocardial repairCirculation Research.  111:180-190. 2012
2012 CXCR4 antagonist AMD3100 accelerates impaired wound healing in diabetic miceJournal of Investigative Dermatology.  132:711-720. 2012
2012 Progenitor cell mobilization and recruitment: SDF-1, CXCR4, α4-integrin, and c-kitProgress in Molecular Biology and Translational Science.  111:243-264. 2012
2011 Interleukin-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardiumCirculation Research.  109:1280-1289. 2011
2011 Exosomes from human CD34+ stem cells mediate their proangiogenic paracrine activityCirculation Research.  109:724-728. 2011
2010 CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activityCirculation Research.  107:1083-1093. 2010
2010 Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cellsJournal of Molecular and Cellular Cardiology.  49:490-498. 2010
2010 Inhibition of melanoma angiogenesis by telomere homolog oligonucleotidesJournal of Oncology2010
2010 Myocardial knockdown of mRNA-stabilizing protein HuR attenuates post-MI inflammatory response and left ventricular dysfunction in IL-10-null miceThe FASEB Journal.  24:2484-2494. 2010
2010 Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome functionJournal of Neuroscience Research.  88:167-178. 2010
2009 Regulation of vascular contractility and blood pressure by the E2F2 transcription factorCirculation.  120:1213-1221. 2009
2009 Small interfering RNA-directed targeting of Toll-like receptor 4 inhibits human prostate cancer cell invasion, survival, and tumorigenicityMolecular Immunology.  46:2876-2884. 2009
2009 Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expressionCirculation Research.  104:1209-1216. 2009
2009 IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuRCirculation Research.  104. 2009
2008 Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repairCirculation Research.  102. 2008
2008 Anti-vascular permeability of the cleaved reactive center loop within the carboxyl-terminal domain of C1 inhibitorMolecular Immunology.  45:1743-1751. 2008
2007 Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heartJournal of Experimental Medicine.  204:3257-3269. 2007
2007 STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: Analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarctionCirculation Research.  101:910-918. 2007
2007 C1 inhibitor-mediated protection from sepsisJournal of Immunology.  179:3966-3972. 2007
2007 Enhanced voluntary alcohol consumption after estrogen supplementation negates estrogen-mediated vascular repair in ovariectomized miceEndocrinology.  148:3618-3624. 2007
2007 An anti-endotoxin peptide that generates from the amino-terminal domain of complement regulatory protein C1 inhibitorBiochemical and Biophysical Research Communications.  359:285-291. 2007
2007 Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 actionBiochemical and Biophysical Research Communications.  358:1120-1127. 2007
2007 C5aR-mediated myocardial ischemia/reperfusion injuryBiochemical and Biophysical Research Communications.  357:446-452. 2007
2007 Tumor necrosis factor-α receptor p75 is required in ischemia-induced neovascularizationCirculation.  115:752-762. 2007
2006 Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activityBiochemical and Biophysical Research Communications.  350:162-168. 2006
2006 Estrogen receptors α and β mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarctionCirculation.  114:2261-2270. 2006
2006 Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injuryBiochemical and Biophysical Research Communications.  349:504-512. 2006
2006 IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expressionThe FASEB Journal.  20. 2006
2006 Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGFProceedings of the National Academy of Sciences of USA.  103:11015-11020. 2006
2006 Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9Circulation.  113:1605-1614. 2006
2006 Functional disruption of α4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularizationJournal of Experimental Medicine.  203:153-163. 2006
2005 Erratum: The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-α-induced transcriptional repression of cyclin A (Journal of Clinical Investigation (2005) 115 (1785-1796) DOI: 10.1172/JCI22849)Journal of Clinical Investigation.  115:2955. 2005
2005 Erratum: The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-α-induced transcriptional repression of cyclin A (Journal of Clinical Investigation (2005) 115 (1785-1796) DOI: 10.1172/JCI22849)Journal of Clinical Investigation.  115:2297. 2005
2005 Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathyCirculation.  112:93-102. 2005
2005 Ethanol modulation of TNF-alpha biosynthesis and signaling in endothelial cells: Synergistic augmentation of TNF-alpha mediated endothelial cell dysfunctions by chronic ethanolAlcoholism: Clinical and Experimental Research.  29:930-938. 2005
2005 Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarctionJournal of Clinical Investigation.  115:326-338. 2005
2005 The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-α-induced transcriptional repression of cyclin AJournal of Clinical Investigation.  115:1785-1796. 2005
2005 Use of recombinant adeno-associated viral vectors as a tool for labeling bone marrow cellsJournal of Molecular and Cellular Cardiology.  38:799-802. 2005
2001 Preselective gene therapy for fabry diseaseProceedings of the National Academy of Sciences of USA.  98:3428-3433. 2001
2000 Long-term enzyme correction and lipid reduction in multiple organs of primary and secondary transplanted Fabry mice receiving transduced bone marrow cellsProceedings of the National Academy of Sciences of USA.  97:7515-7520. 2000
2000 Variegation of retroviral vector gene expression in myeloid cellsGene Therapy (Basingstoke).  7:153-166. 2000
1999 Circulating α-galactosidase a derived from transduced bone marrow cells: Relevance for corrective gene transfer for fabry diseaseHuman Gene Therapy.  10:1931-1939. 1999

Chapter

Year Title Altmetric
2015 Diagnostic and Prognostic Applications of microRNA-Abundant Circulating Exosomes.  1-34. 2015
2013 Hypoxic preconditioning of cardiac progenitor cells for ischemic heart.  427-435. 2013

Education And Training

  • Doctor of Medicine, Tongji University 1989
  • Full Name

  • Gangjian Qin