Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Author Correction: Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruptionNature Communications.  11. 2020
2019 Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruptionNature Communications.  10. 2019
2019 Time-Restricted Eating to Prevent and Manage Chronic Metabolic DiseasesAnnual Review of Nutrition.  39:291-315. 2019
2019 Suppression of myopathic lamin mutations by muscle-specific activation ofAMPKand modulation of downstream signalingHuman Molecular Genetics.  28:351-371. 2019
2018 Increasing autophagy and blocking Nrf2 suppress laminopathy-induced age-dependent cardiac dysfunction and shortened lifespanAging Cell.  17:e12747-e12747. 2018
2018 Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathyeLife.  7. 2018
2017 TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespanFEBS Letters.  591:3447-3458. 2017
2017 Time-restricted feeding for prevention and treatment of cardiometabolic disorders 2017
2017 ADrosophilamodel of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects 2017
2016 A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in DrosophilaJournal of Molecular Biology.  428:2446-2461. 2016
2016 Using Drosophila as an integrated model to study mild repetitive traumatic brain injuryScientific Reports.  6. 2016
2016 Huntington’s Disease-Induced Cardiac Disorders Affect Multiple Cellular Pathways 2016
2016 The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin IIJournal of Biological Chemistry.  291:1763-1773. 2016
2015 A Failure to CommunicateJournal of Biological Chemistry.  290:29270-29280. 2015
2015 Time-restricted feeding attenuates age-related cardiac decline in DrosophilaScience.  347:1265-1269. 2015
2014 Mapping Interactions between Myosin Relay and Converter Domains That Power Muscle FunctionJournal of Biological Chemistry.  289:12779-12790. 2014
2014 Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosisRare Diseases.  2:e968003-e968003. 2014
2014 The UNC-45 Myosin ChaperoneInternational Review of Cell and Molecular Biology.  103-144. 2014
2013 Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila HeartPLoS Genetics.  9:e1004024-e1004024. 2013
2012 Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness 2012
2012 Interaction of oxidized chaperonin GroEL with an unfolded protein at low temperatures 2012
2012 Alternative Relay and Converter Domains Tune Native Muscle Myosin Isoform Function in DrosophilaJournal of Molecular Biology.  416:543-557. 2012
2012 Transgenic expression and purification of myosin isoforms using the Drosophila melanogaster indirect flight muscle systemMethods.  56:25-32. 2012
2011 Two Drosophila Myosin Transducer Mutants with Distinct Cardiomyopathies Have Divergent ADP and Actin AffinitiesJournal of Biological Chemistry.  286:28435-28443. 2011
2011 Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stabilityJournal of Cell Science.  124:699-705. 2011
2011 The UNC-45 Chaperone Is Critical for Establishing Myosin-Based Myofibrillar Organization and Cardiac Contractility in the Drosophila Heart ModelPLoS ONE.  6:e22579-e22579. 2011
2010 Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthaseBiochemical and Biophysical Research Communications.  396:317-322. 2010
2010 Mutating the Converter–Relay Interface of Drosophila Myosin Perturbs ATPase Activity, Actin Motility, Myofibril Stability and Flight AbilityJournal of Molecular Biology.  398:625-632. 2010
2009 Alternative Exon 9-Encoded Relay Domains Affect More than One Communication Pathway in the Drosophila Myosin HeadJournal of Molecular Biology.  389:707-721. 2009
2008 Divalent cations stabilize GroEL under conditions of oxidative stressBiochemical and Biophysical Research Communications.  368:625-630. 2008
2006 Protection of GroEL by its methionine residues against oxidation by hydrogen peroxideBiochemical and Biophysical Research Communications.  347:534-539. 2006
2006 αB-Crystallin Maintains Skeletal Muscle Myosin Enzymatic Activity and Prevents its Aggregation under Heat-shock StressJournal of Molecular Biology.  358:635-645. 2006
2005 On the chaperonin activity of GroEL at heat-shock temperature 2005
2004 Hydrogen peroxide induces the dissociation of GroEL into monomers that can facilitate the reactivation of oxidatively inactivated rhodanese 2004
2004 Oxidized GroEL can function as a chaperoninFrontiers in Bioscience.  9:724-724. 2004
2002 GroEL interacts transiently with oxidatively inactivated rhodanese facilitating its reactivationBiochemical and Biophysical Research Communications.  294:893-899. 2002
2002 Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B 2002
2001 Recurrent strokes--an interesting pedigreeJournal of the Association of Physicians of India.  49:765-766. 2001
1999 Lipoprotein(a) and coronary heart disease in Indian populationJournal of the Association of Physicians of India.  47:1157-1160. 1999
1997 Oxidative stress and metabolic control in non-insulin dependent diabetes mellitus 1997

Research Overview

  • My lab has been at the forefront of developing and using clinically-relevant genetic models (Drosophila melanogaster) to address the pathophysiological basis of human circadian/metabolic disorders linked to cardiometabolic disease, myofibrillar-myopathies, proteinopathies neuropathies, sleep, and aging disruptions. I also integrate physiological, cell-molecular, genetics, genomics, and nutritional approaches to understand how lifestyle (including circadian rhythms, eating/sleeping patterns) and genetic factors act to maintain the structural integrity of cells, tissues, and organs that in turn dictates organismal physiology. Additionally, using strategic collaborations, I apply the findings to higher mammals and humans to develop therapies for human metabolic and myofibrillar and misfolding protein disorders.
    Major Lab Projects:
    1. Circadian Rhythms Disruptions, Cardiometabolic Disorders, Aging, and Their Mitigation using Time-Restricted Feeding:
    2. Cell-molecular Basis of Cardiomyopathies, Neuropathies, and Aging Linked with Protein Misfolding/Aggregation
    3. Delineate Pathological Pathways Linking Insomnia With Cardiovascular Diseases
    4. Mutant-Lamin (LMNA) Based Cardiomyopathies, Skeletal Myopathies, and Lipodystrophies:
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Kumaun University 2001
  • Master of Science in Organic Chemistry, Kumaun University 1995
  • Bachelor of Science or Mathematics in Chemistry, Kumaun University 1993
  • Full Name

  • Girish Melkani