My lab has been at the forefront of developing and using clinically-relevant genetic models (Drosophila melanogaster) to address the pathophysiological basis of human circadian/metabolic disorders linked to cardiometabolic disease, myofibrillar-myopathies, proteinopathies neuropathies, sleep, and aging disruptions. I also integrate physiological, cell-molecular, genetics, genomics, and nutritional approaches to understand how lifestyle (including circadian rhythms, eating/sleeping patterns) and genetic factors act to maintain the structural integrity of cells, tissues, and organs that in turn dictates organismal physiology. Additionally, using strategic collaborations, I apply the findings to higher mammals and humans to develop therapies for human metabolic and myofibrillar and misfolding protein disorders.
Major Lab Projects:
1. Circadian Rhythms Disruptions, Cardiometabolic Disorders, Aging, and Their Mitigation using Time-Restricted Feeding:
2. Cell-molecular Basis of Cardiomyopathies, Neuropathies, and Aging Linked with Protein Misfolding/Aggregation
3. Delineate Pathological Pathways Linking Insomnia With Cardiovascular Diseases
4. Mutant-Lamin (LMNA) Based Cardiomyopathies, Skeletal Myopathies, and Lipodystrophies: