• Dr. Liu graduated from China Medical University with a D.M.D. degree in 1994 and from Wuhan University with a Ph.D. degree in 1999. He received postdoctoral training in the Medical College of Georgia and the University of Alabama at Birmingham through 2003. Dr. Liu worked as a Research Associate from 2003-2006 in the Department of Cell Biology at University of Alabama at Birmingham. He was appointed as Assistant Professor in the Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine in 2006 and was promoted to Associate Professor in 2012.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Cell senescence and fibrotic lung diseases 2020
    2020 Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution 2020
    2020 PAI-1 regulation of TGF-β1-induced alveolar Type II cell senescence, SASP secretion, and SASP-mediated activation of alveolar macrophages 2020
    2019 Inhibition of glutaminase 1 attenuates experimental pulmonary fibrosis 2019
    2019 Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury 2019
    2019 Cellular Metabolism in Lung Health and Disease 2019
    2019 Impairment of fatty acid oxidation in alveolar epithelial cells mediates acute lung injury 2019
    2018 IFN regulatory factor 2 inhibits expression of glycolytic genes and lipopolysaccharide-Induced proinflammatory responses in macrophages 2018
    2018 Glutaminolysis promotes collagen translation and stability via a-ketoglutarate-mediated mTOR activation and proline hydroxylation 2018
    2018 MicroRNA-145 antagonism reverses TGF-b inhibition of F508del CFTR correction in airway Epithelia 2018
    2017 The lung likes the little fella miR-29 2017
    2017 Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosis 2017
    2017 Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease 2017
    2017 Autoimmunity to vimentin is associated with outcomes of patients with idiopathic pulmonary fibrosis 2017
    2017 Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2 2017
    2017 miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions 2017
    2017 MIR-34a inhibits lung fibrosis by inducing lung fibroblast senescence 2017
    2017 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs. 2017
    2017 Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentin 2017
    2016 Mechanosensing by the α 6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis 2016
    2016 MicroRNA-27a-3p is a negative regulator of lung fibrosis by targeting myofibroblast differentiation 2016
    2016 Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma 2016
    2016 MicroRNAs for osteosarcoma in the mouse: A meta-analysis 2016
    2015 Glycolytic reprogramming in myofibroblast differentiation and lung fibrosis 2015
    2015 Metabolic reprogramming is required for myofibroblast contractility and differentiation 2015
    2015 The code of non-coding RNAs in lung fibrosis 2015
    2015 Monocyte chemotactic protein-induced protein 1 and 4 form a complex but act independently in regulation of interleukin-6 mRNA degradation 2015
    2015 Noninvasive imaging of experimental lung fibrosis 2015
    2015 IL-13 induces YY1 through the AKT pathway in lung fibroblasts 2015
    2015 The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages 2015
    2015 Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence 2015
    2015 Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism 2015
    2015 ncRNA-regulated immune response and its role in inflammatory lung diseases 2015
    2014 Therapeutic targeting of Src kinase in myofibroblast differentiation and pulmonary fibrosis 2014
    2014 MiR-27a regulates inflammatory response of macrophages by targeting IL-10 2014
    2014 The human long noncoding RNA lnc-IL7R regulates the inflammatory response 2014
    2013 MiR-125a-5p regulates differential activation of macrophages and inflammation 2013
    2013 MicroRNA let-7c regulates macrophage polarization 2013
    2013 Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality 2013
    2013 MiR-145 regulates myofibroblast differentiation and lung fibrosis 2013
    2013 MCPIP1 negatively regulates toll-like receptor 4 signaling and protects mice from LPS-induced septic shock 2013
    2013 Targeted disruption of MCPIP1/Zc3h12a results in fatal inflammatory disease 2013
    2013 MiR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling 2013
    2013 MicroRNAs in immune response and macrophage polarization 2013
    2013 Histone modifications in senescence-associated resistance to apoptosis by oxidative stress 2013
    2012 p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells 2012
    2012 Identification of TLT2 as a receptor for efferocytosis 2012
    2012 Identification of TLT2 as an engulfment receptor for apoptotic cells 2012
    2012 Extracellular histones inhibit efferocytosis 2012
    2012 MiR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling 2012
    2012 Regulation of alveolar epithelial Na + channels by ERK1/2 in chlorine-breathing mice 2012
    2012 Participation of miR-200 in pulmonary fibrosis 2012
    2011 Intracellular HMGB1 Negatively regulates efferocytosis 2011
    2011 The receptor for urokinase regulates TLR2 mediated inflammatory responses in neutrophils 2011
    2011 Identification of a microRNA signature in renal fibrosis: Role of miR-21 2011
    2011 Postexposure administration of a β2-agonist decreases chlorine-induced airway hyperreactivity in mice 2011
    2011 New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis 2011
    2011 Participation of the receptor for advanced glycation end products in efferocytosis 2011
    2010 Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils 2010
    2010 HMGB1 inhibits macrophage activity in efferocytosis through binding to the αvβ3-integrin 2010
    2010 The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosis 2010
    2010 miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis 2010
    2010 Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines 2010
    2010 Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation 2010
    2010 Modulation of SCFβ-TrCP-dependent IκBα ubiquitination by hydrogen peroxide 2010
    2009 Participation of the urokinase receptor in neutrophil efferocytosis 2009
    2009 Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species 2009
    2009 miR-147, a microRNA that is induced upon toll-like receptor stimulation, regulates murine macrophage inflammatory responses 2009
    2009 Participation of mammalian target of rapamycin complex 1 in toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury 2009
    2009 Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury 2009
    2009 p53 attenuates lipopolysaccharide-induced NF-κB activation and acute lung injury 2009
    2009 Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase 2009
    2008 Potential role of high-mobility group box 1 in cystic fibrosis airway disease 2008
    2008 High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine 2008
    2008 Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury 2008
    2008 PAI-1 inhibits neutrophil efferocytosis 2008
    2008 Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations 2008
    2008 Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury 2008
    2008 Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-κB activation requires cytosolic and nuclear activity 2008
    2008 Role of extracellular superoxide in neutrophil activation: Interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production 2008
    2007 Involvement of vitronectin in lipopolysaccaride-induced acute lung injury 2007
    2007 Variant IL-1 receptor-associated kinase-1 mediates increased NF-κB activity 2007
    2007 Semi-quantitative RT-PCR analysis of LIM mineralization protein 1 and its associated molecules in cultured human dental pulp cells 2007
    2006 Myosin VI is a mediator of the p53-dependent cell survival pathway 2006
    2006 Regulation of the p53 transcriptional activity 2006
    2006 DNA polymerase η, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation 2006
    2005 The C-terminal sterile α motif and the extreme C terminus regulate the transcriptional activity of the α isoform of p73 2005
    2004 DeltaNp73beta is active in transactivation and growth suppression. 2004
    2004 ΔNp73β Is Active in Transactivation and Growth Suppression 2004
    2003 Characterization of p73 functional domains necessary for transactivation and growth suppression 2003
    2003 The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein 2003
    2003 Isolation and characterization of fourteen novel putative and nine known target genes of the p53 family 2003
    2002 The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis 2002


    Year Title Altmetric
    2015 How noncoding RNAs contribute to macrophage polarization.  59-84. 2015

    Research Overview

  • Dr. Liu's research focuses on the role of non-coding RNAs in regulation of lung inflammation, injury and repair. Dr. Liu's research recently developed a new direction to study the role of cellular metabolism in the pathogenesis of lung injury and fibrosis.
  • Education And Training

  • Medical College of Georgia, Postdoctoral Research
  • University of Alabama at Birmingham Hospital, Postdoctoral Research
  • Doctor of Science in Biology / Biological Sciences, Wuhan University 1999
  • Doctor of Medicine, China Medical University 1994
  • Full Name

  • Gang Liu