Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Genetic deletion of syndecan-4 alters body composition, metabolic phenotypes, and the function of metabolic tissues in female mice fed a high-fat diet (Running title: Sdc4 deficiency affects metabolic phenotypes)Nutrients.  11. 2019
2019 ΔFosB Requires Galanin, but not Leptin, to Increase Bone Mass via the Hypothalamus, but both are needed to increase Energy expenditureJournal of Bone and Mineral Research.  34:1707-1720. 2019
2019 HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injuryJournal of Molecular and Cellular Cardiology.  130:36-48. 2019
2019 Adult skeletal muscle deletion of Mitofusin 1 and 2 impedes exercise performance and training capacityJournal of applied physiology: respiratory, environmental and exercise physiology.  126:341-353. 2019
2018 Age- and Genotype-Specific Effects of the Angiotensin-Converting Enzyme Inhibitor Lisinopril on Mitochondrial and Metabolic Parameters in Drosophila melanogasterInternational Journal of Molecular Sciences.  19. 2018
2018 Neuronal hypothalamic regulation of body metabolism and bone density is galanin dependentJournal of Clinical Investigation.  128:2626-2641. 2018
2018 Cell-specific deletion of PGC-1α from medium spiny neurons causes transcriptional alterations and age-related motor impairmentJournal of Neuroscience.  38:3273-3286. 2018
2017 PDK4 Inhibits Cardiac Pyruvate Oxidation in Late PregnancyCirculation Research.  121:1370-1378. 2017
2017 Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heartJournal of Molecular and Cellular Cardiology.  110:80-95. 2017
2017 MiR-29b contributes to multiple types of muscle atrophyNature Communications.  8. 2017
2017 LDB1 regulates energy homeostasis during diet-induced obesityEndocrinology.  158:1289-1297. 2017
2017 Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac functionPLoS ONE.  12. 2017
2017 Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRβAJP - Heart and Circulatory Physiology.  312:H662-H671. 2017
2017 Hypothalamic ΔFosB prevents age-related metabolic decline and functions via SNSAging.  9:353-369. 2017
2017 VEGF-B: Friend or foe to the heart in times of nutrient excess?AJP - Heart and Circulatory Physiology.  313:H244-H247. 2017
2016 Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and FibrosisCell Reports.  17:3292-3304. 2016
2016 Heme oxygenase and carbon monoxide protect from muscle dystrophySkeletal Muscle.  6. 2016
2016 The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissueGenes and Development.  30:2551-2564. 2016
2016 The TreadWheel: A novel apparatus to measure genetic variation in response to gently induced exercise for DrosophilaPLoS ONE.  11. 2016
2016 Biotinylation: A novel posttranslational modification linking cell autonomous circadian clocks with metabolismAJP - Heart and Circulatory Physiology.  310:H1520-H1532. 2016
2016 A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistanceNature Medicine.  22:421-426. 2016
2016 PGC-1α induces human RPE oxidative metabolism and antioxidant capacityInvestigative Ophthalmology & Visual Science.  57:1038-1051. 2016
2016 Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator miceSkeletal Muscle.  6. 2016
2016 Adult expression of PGC-1α and -1β in skeletal muscle is not required for endurance exercise-induced enhancement of exercise capacityAJP - Endocrinology and Metabolism.  311:E928-E938. 2016
2014 PGC-1α induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscleCirculation Research.  115:504-517. 2014
2014 Hypoxic induction of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by truncated peroxisome proliferator-activated receptor γ coactivator (PGC)-1αJournal of Biological Chemistry.  289:8810-8817. 2014
2014 Running forward new frontiers in endurance exercise biologyCirculation.  129:798-810. 2014
2014 Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophinSkeletal Muscle.  4. 2014
2014 Genetic models of PGC-1 and glucose metabolism and homeostasisReviews in Endocrine and Metabolic Disorders.  15:21-29. 2014
2013 Disconnecting Mitochondrial Content from Respiratory Chain Capacity in PGC-1-Deficient Skeletal MuscleCell Reports.  3:1449-1456. 2013
2013 Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITFCancer Cell.  23:302-315. 2013
2013 PGC-1 Coactivators Regulate MITF and the Tanning ResponseMolecular Cell.  49:145-157. 2013
2012 Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamusJournal of Bone and Mineral Research.  27:1649-1658. 2012
2012 PGC-1α is dispensable for exercise-induced mitochondrial biogenesis in skeletal musclePLoS ONE.  7. 2012
2012 Cardiac angiogenic imbalance leads to peripartum cardiomyopathyNature.  485:333-338. 2012
2012 Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restrictionProceedings of the National Academy of Sciences.  109:2931-2936. 2012
2011 Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial functionNature.  478:114-118. 2011
2011 PGC-1α promotes recovery after acute kidney injury during systemic inflammation in miceJournal of Clinical Investigation.  121:4003-4014. 2011
2011 Pgc-1β regulates angiogenesis in skeletal muscleAJP - Endocrinology and Metabolism.  301. 2011
2010 PGC-1 coactivators in cardiac development and diseaseCirculation Research.  107:825-838. 2010
2010 Metabolic signatures of exercise in human plasmaScience Translational Medicine.  2. 2010
2009 The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscleProceedings of the National Academy of Sciences.  106:21401-21406. 2009
2009 Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivoBONE.  44:528-536. 2009
2009 Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice.Endocrinology.  150:135-143. 2009
2008 Doubly truncated FosB isoform (Δ2ΔFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activityJournal of Bone and Mineral Research.  23:584-595. 2008
2001 Novel antineoplastic isochalcones inhibit the expression of cyclooxygenase 1,2 and EGF in human prostate cancer cell line LNCaP.Cellular and Molecular Biology.  47:1039-1045. 2001

Education And Training

  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, Yale University 2007
  • Full Name

  • Glenn Rowe