Positions

Overview

  • Dr. Garvey is Professor of Medicine in the Department of Nutrition Sciences at the University of Alabama at Birmingham. He obtained his MD degree, cum laude, from St. Louis University in 1978, and completed residency training in Internal Medicine at Barnes Hospital, Washington University, in 1981. He then was a clinical fellow in Endocrinology and Metabolism at the University of Colorado Health Sciences Center and University of California, San Diego School of Medicine. He subsequently held faculty posts at the University of California, School of Medicine (Assistant Professor), Indiana University School of Medicine (Associate and full Professor), and from 1994 to 2003 was the Director of the Division of Endocrinology, Diabetes, and Medical Genetics at the Medical University of South Carolina. Dr. Garvey moved to UAB on June 1, 2004.

    Dr. Garvey has achieved international recognition for his research in the metabolic, molecular, and genetic pathogenesis of insulin resistance, Type 2 Diabetes, and obesity. His studies have involved the cellular and molecular biology of cell and animal models, metabolic investigations of human subjects on metabolic research wards, and the genetic basis of diseases in Gullah-speaking African Americans, Pima Indians, and national cohorts of diabetes patients. He has brought basic technology directly to the study of human patients, and the combined approach of human physiology, genetics, and basic cell and molecular biology has provided the laboratory with a flexible capability for hypothesis testing relevant to human disease. By studying molecular parameters and differential gene expression in muscle and fat tissue from metabolically characterized individuals, the Garvey laboratory has made important observations regarding the pathogenesis of human insulin resistance. He has been a principle contributor to our understanding of the role of the glucose transport system and glucose transporter proteins in human insulin resistance. The laboratory has also identified a polymorphisms in the uncoupling protein 3 gene as a "thrifty gene" and susceptibility gene for severe obesity in African Americans. He also served as the PI of an NIH-funded Program Project to study markers and mechanisms of diabetes vascular complications in collaboration with two national trial cohorts. Dr. Garvey has directed an independent laboratory since 1987 supported by the National Institutes of Health (NIDDK, NHLBI), the Department of Veterans Affairs, the AHA, JDFI, the ADA, and other agencies. Dr. Garvey also has a track record of community based research and outreach in the context of two initiatives, Project Sugar (a genetics study among Gullah-speaking African Americans) and MUSC/HBCU Partners in Wellness (a program in community health at 6 historically black colleges and universities in SC intended to challenge minority students towards careers in the health professions).

    He has provided service as a member of national research review committees for the Juvenile Diabetes Research Foundation, the American Diabetes Association, the VA Merit Review Program, and the National Institutes of Health. He was a standing member of the Metabolism Study Section at NIH from 1998-2002, and has chaired several ad hoc NIH study sections. Dr. Garvey currently serves on the editorial boards of Diabetes, and has previously served in this capacity for the Journal of Clinical Endocrinology and Metabolism and Diabetes Reviews. He is a member of the American Society for Clinical Investigation, the Association of American Physicians, the Endocrine Society, and the American Diabetes Association, and the North American Association for the Study of Obesity.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Core Principles, Treatment Standards, and Provider Competencies for the Care of Patients with Obesity 2019
    2019 Testosterone therapy in men with hypogonadism prevents progression from prediabetes to type 2 diabetes: Eight-year data from a registry study 2019
    2019 Commentary from the American association of clinical endocrinologists on the U.S. preventive services task force recommandations regarding weight loss interventions 2019
    2019 The diagnosis and evaluation of patients with obesity 2019
    2019 Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm – 2019 executive summary 2019
    2019 Nutrition therapy for adults with diabetes or prediabetes: A consensus report 2019
    2019 Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: A hypothesis-generating prospective study of cardiovascular events in T1D 2019
    2018 Dysglycemia-based chronic disease: An American association of clinical endocrinologists position statement 2018
    2018 Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes 2018
    2018 Improved systemic metabolism and adipocyte biology in miR-150 knockout mice 2018
    2018 Leptin, An Adipokine With Central Importance in the Global Obesity Problem 2018
    2018 The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis 2018
    2018 Oxidative stress and cardiovascular risk in type 1 diabetes mellitus: Insights from the DCCT/EDIC study 2018
    2018 Relationship of Circulating miRNAs with Insulin Sensitivity and Associated Metabolic Risk Factors in Humans 2018
    2018 Effect of Lorcaserin Alone and in Combination with Phentermine on Food Cravings After 12-Week Treatment: A Randomized Substudy 2018
    2018 Apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in T1D 2018
    2018 Application of the AACE/ACE advanced framework for the diagnosis of obesity and cardiometabolic disease staging in a general population from 3 regions of Venezuela: The vemsols study results 2018
    2018 Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm - 2018 executive summary 2018
    2017 Obesity and cardiometabolic disease -more than meets the eye 2017
    2017 Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis 2017
    2017 Cardiometabolic disease staging predicts effectiveness of weight-loss therapy to prevent type 2 diabetes: Pooled results from phase III clinical trials assessing phentermine/topiramate extended release 2017
    2017 To the editor: Author response to Dr. Zhu 2017
    2017 Childhood maltreatment is an independent risk factor for prediabetic disturbances in glucose regulation 2017
    2017 Letter to the Editor 2017
    2017 Coadministration of lorcaserin and phentermine for weight management: A 12-week, randomized, pilot safety study 2017
    2017 F2-Isoprostanes Reflect Oxidative Stress Correlated With Lean Mass and Bone Density but Not Insulin Resistance. 2017
    2017 Impact on psychosocial outcomes of a nationally available weight management program tailored for individuals with type 2 diabetes: Results of a randomized controlled trial 2017
    2017 Endostatin inhibits androgen-independent prostate cancer growth by suppressing nuclear receptor-mediated oxidative stress 2017
    2017 Pharmacotherapy for Weight Management in the VHA 2017
    2017 Reply: Role of Adiponectin: Important or Null? 2017
    2017 Adiposity-based chronic disease as a new diagnostic term: The American association of clinical endocrinologists and American college of endocrinology position statement 2017
    2017 CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2017 EXECUTIVE SUMMARY 2017
    2017 Update and next steps for real-world translation of interventions for type 2 diabetes prevention: Reflections from a diabetes care editors' expert forum. Diabetes care 2016;39:1186-1201 2017
    2017 Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons 2017
    2016 Patient-centered care of the patient with obesity 2016
    2016 Effects of liraglutide 3.0 mg on weight and risk factors in hispanic versus non-hipanic populations: Subgroup analysis from scale randomized trials 2016
    2016 Randomized controlled trial of a nationally available weight control program tailored for adults with type 2 diabetes 2016
    2016 The Adipokine-Cardiovascular-Lifestyle Network: Translation to Clinical Practice 2016
    2016 Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDIC 2016
    2016 The prevalence and distribution of the amyloidogenic transthyretin (TTR) V122I allele in Africa 2016
    2016 Impact of lorcaserin on glycemic control in overweight and obese patients with type 2 diabetes: analysis of week 52 responders and nonresponders 2016
    2016 Skeletal muscle TRIB3 mediates glucose toxicity in diabetes and high-fat diet-induced insulin resistance 2016
    2016 Trends in Cardiovascular Health Metrics in Obese Adults: National Health and Nutrition Examination Survey (NHANES), 1988-2014 2016
    2016 AP2-NR4A3 transgenic mice display reduced serum epinephrine because of increased catecholamine catabolism in adipose tissue 2016
    2016 American association of clinical endocrinologists and American college of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity: Executive summary 2016
    2016 Significance of epicardial and intrathoracic adipose tissue volume among type 1 diabetes patients in the DCCT/EDIC: A pilot study 2016
    2016 Do glycemic marker levels vary by race? Differing results from a cross-sectional analysis of individuals with and without diagnosed diabetes 2016
    2016 Transculturalization recommendations for developing Latin American clinical practice algorithms in endocrinology - Proceedings of the 2015 pan-American workshop by the American association of clinical endocrinologists and American college of endocrinology 2016
    2016 Data on carotid intima-media thickness and lipoprotein subclasses in type 1 diabetes from the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) 2016
    2016 Deletion of the toll-like receptor 5 gene per se does not determine the gut microbiome profile that induces metabolic syndrome: Environment trumps genotype 2016
    2016 Cardiometabolic disease risk in metabolically healthy and unhealthy obesity: Stability of metabolic health status in adults 2016
    2016 Tribbles Homolog 3 Promotes Foam Cell Formation Associated with Decreased Proinflammatory Cytokine Production in Macrophages: Evidence for Reciprocal Regulation of Cholesterol Uptake and Inflammation 2016
    2016 Ablation of the duodenal mucosa as a strategy for glycemic control in type 2diabetes: Role of nutrient signaling or simple weight loss 2016
    2016 American association of clinical endocrinologists and American college of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity 2016
    2016 Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm - 2016 executive summary 2016
    2016 Nuclear magnetic resonance-determined lipoprotein subclasses and carotid intima-media thickness in type 1 diabetes 2016
    2016 Weight maintenance: Challenges, tools and strategies for primary care physicians 2016
    2015 Consensus statement by the American association of clinical endocrinologists and American College of endocrinology on the comprehensive type 2 diabetes management algorithm - 2015 executive summary 2015
    2015 AACE response to a candid discussion of obesity 2015
    2015 Development of a weighted cardiometabolic disease staging (CMDS) system for the prediction of future diabetes 2015
    2015 Advances in the science, treatment, and prevention of the disease of obesity: Ref lections from a diabetes care editors' expert forum 2015
    2015 American Association of Clinical Endocrinologists and American College of Endocrinology - Clinical practice guidelines for developing a diabetes mellitus comprehensive care plan - 2015 2015
    2015 Challenging obesity: Patient, provider, and expert perspectives on the roles of available and emerging nonsurgical therapies 2015
    2015 Weight Loss and the Prevention and Treatment of Type 2 Diabetes Using Lifestyle Therapy, Pharmacotherapy, and Bariatric Surgery: Mechanisms of Action 2015
    2015 AACE/ACE comprehensive diabetes management algorithm 2015 2015
    2015 AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY--CLINICAL PRACTICE GUIDELINES FOR DEVELOPING A DIABETES MELLITUS COMPREHENSIVE CARE PLAN--2015--EXECUTIVE SUMMARY 2015
    2015 AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY - CLINICAL PRACTICE GUIDELINES FOR DEVELOPING A DIABETES MELLITUS COMPREHENSIVE CARE PLAN - 2015. 2015
    2015 AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY--CLINICAL PRACTICE GUIDELINES FOR DEVELOPING A DIABETES MELLITUS COMPREHENSIVE CARE PLAN--2015--EXECUTIVE SUMMARY 2015
    2015 KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression 2015
    2015 The conundrum of whole foods versus macronutrient composition in assessing effects on insulin sensitivity 2015
    2014 Weight-loss therapy in type 2 diabetes: Effects of phentermine and topiramate extended release 2014
    2014 American association of clinical endocrinologists and american college of endocrinology consensus conference on obesity: building an evidence base for comprehensive action. 2014
    2014 American association of clinical endocrinologists and american college of endocrinology position statement on the 2014 advanced framework for a new diagnosis of obesity as a chronic disease. 2014
    2014 Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes 2014
    2014 Use of HbA1c for diagnoses of diabetes and prediabetes: Comparison with diagnoses based on fasting and 2-Hr glucose values and effects of gender, race, and age 2014
    2014 BMI, RQ, diabetes, and sex affect the relationships between amino acids and clamp measures of insulin action in humans 2014
    2014 Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin 2014
    2014 Carboxylated and uncarboxylated forms of osteocalcin directly modulate the glucose transport system and inflammation in adipocytes 2014
    2014 Cardiovascular risk in Gullah African Americans with high familial risk of type 2 diabetes mellitus: Project SuGAR 2014
    2014 Influence of acute hyperlipidemia to adipocyte-derived hormones in lean normotensive and subjects with metabolic syndrome 2014
    2014 KSRP ablation enhances brown fat gene program in white adipose tissue through reduced miR-150 expression 2014
    2014 Lipoprotein insulin resistance index: A lipoprotein particle-derived measure of insulin resistance 2014
    2014 Novel effects of Brefeldin A (BFA) in signaling through the insulin receptor (IR) pathway and regulating FoxO1-mediated transcription. 2014
    2014 Plasma total homocysteine and carotid intima-media thickness in type 1 diabetes: A prospective study 2014
    2014 Prevention of type 2 diabetes in subjects with prediabetes and metabolic syndrome treated with phentermine and topiramate extended release 2014
    2014 The progression of cardiometabolic disease: Validation of a new cardiometabolic disease staging system applicable to obesity 2014
    2013 TRIB3 mediates glucose-induced insulin resistance via a mechanism that requires the hexosamine biosynthetic pathway 2013
    2013 6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3 2013
    2013 Erratum: AACE Obesity Position Statement (Endocrine Practice (2012) 18 (642-648)) 2013
    2013 Type 2 diabetes with partial lipodystrophy of the limbs: A new lipodystrophy phenotype 2013
    2013 A complications-based clinical staging of obesity to guide treatment modality and intensity 2013
    2013 Apolipoprotein-defined lipoproteins and apolipoproteins: Associations with abnormal albuminuria in type 1 diabetes in the diabetes control and complications trial/epidemiology of diabetes interventions and complications cohort 2013
    2013 Clinical practice guidelines for healthy eating for the prevention and treatment of metabolic and endocrine diseases in adults: Cosponsored by the American association of clinical endocrinologists/the american college of endocrinology and the obesity society: Executive summary 2013
    2013 New options for the treatment of obesity and type 2 diabetes mellitus (narrative review) 2013
    2013 New tools for weight-loss therapy enable a more robust medical model for obesity treatment: Rationale for a complications-centric approach 2013
    2013 Phentermine and topiramate extended-release: A new treatment for obesity and its role in a complications-centric approach to obesity medical management 2013
    2013 Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci 2013
    2013 A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry 2013
    2013 American association of clinical endocrinologists' comprehensive diabetes management algorithm 2013 consensus statement 2013
    2013 Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages 2013
    2013 AdR1-TG/TALLYHO mice have improved lipid accumulation and insulin sensitivity 2013
    2013 Limitations in the use of indices using glucose and insulin levels to predict insulin sensitivity: Impact of race and gender and superiority of the indices derived from oral glucose tolerance test in African Americans 2013
    2013 Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient - 2013 update: Cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery 2013
    2013 Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient-2013 update: Cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery 2013
    2013 Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient-2013 update: Cosponsored by American association of clinical endocrinologists, the obesity society, and American society for metabolic & bariatric surgery 2013
    2013 VPO1 Mediates ApoE Oxidation and Impairs the Clearance of Plasma Lipids 2013
    2013 AACE comprehensive diabetes management algorithm 2013. 2013
    2013 American Association of Clinical Endocrinologists' comprehensive diabetes management algorithm 2013 consensus statement--executive summary. 2013
    2013 In response 2013
    2013 Prostaglandin A2 enhances cellular insulin sensitivity via a mechanism that involves the orphan nuclear receptor NR4A3 2013
    2013 The clinical approach to the detection of lipodystrophy - An AACE consensus statement 2013
    2013 The impact of weight loss among seniors on medicare spending 2013
    2013 Use of available glucose-lowering agents in patients with different levels of renal impairment 2013
    2012 Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations 2012
    2012 Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids 2012
    2012 Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess 2012
    2012 American association of clinical endocrinologists' position statement on obesity and obesity medicine 2012
    2012 Opportunities for using lipoprotein subclass profile by nuclear magnetic resonance spectroscopy in assessing insulin resistance and diabetes prediction 2012
    2012 Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression 2012
    2012 Skeletal muscle lipid peroxidation and insulin resistance in humans 2012
    2012 Noggin is novel inducer of mesenchymal stem cell adipogenesis: Implications for bone health and obesity 2012
    2012 Adiponectin-AdipoR1/2-APPL1 signaling axis suppresses human foam cell formation: Differential ability of AdipoR1 and AdipoR2 to regulate inflammatory cytokine responses 2012
    2012 Controlled-release phentermine/topiramate in severely obese adults: A randomized controlled trial (EQUIP) 2012
    2012 Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): A randomized, placebo-controlled, phase 3 extension study 2012
    2012 Effects of colesevelam on glucose absorption and hepatic/peripheral insulin sensitivity in patients with type 2 diabetes mellitus 2012
    2011 A clustering analysis of lipoprotein diameters in the metabolic syndrome 2011
    2011 Significant Weight Loss With Controlled-Release Phentermine/Topiramate (PHEN/TPM CR) Is Associated With Significant Reductions in Use of Concomitant Medications For Cardiometabolic Diseases Over 108 Weeks 2011
    2011 Decreased progression to diabetes in subjects with prediabetes after 2 years of treatment with controlled-release phentermine/topiramate 2011
    2011 Long-term weight loss with controlled-release phentermine/topiramate reverses metabolic syndrome and improves associated traits 2011
    2011 Lipoprotein Lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS 2011
    2011 Effects of macrophage-specific adiponectin expression on lipid metabolism in vivo 2011
    2011 Intramyocellular lipid and insulin resistance: Differential relationships in European and African Americans 2011
    2011 Dietary adherence during weight loss predicts weight regain 2011
    2011 Genes and biochemical pathways in human skeletal muscle affecting resting energy expenditure and fuel partitioning 2011
    2010 Colesevelam in Combination with Metformin Significantly Reduces Low-Density Lipoprotein Particle Concentration in Patients with Early Type 2 Diabetes 2010
    2010 Deletion of insulin receptor in chondrocytes sensitizes IGF-1 signaling and action 2010
    2010 Low-Dose Controlled-Release Phentermine/Topiramate (PHEN/TPM CR) For Weight Loss and Management of Type 2 Diabetes Mellitus (T2DM) 2010
    2010 Colesevelam for Hispanic patients with hypercholesterolaemia and prediabetes 2010
    2010 Initial treatment with metformin plus colesevelam provides greater glycaemic control than metformin alone in Hispanic patients with type 2 diabetes mellitus 2010
    2010 Once-daily, low-dose, controlled-release phentermine/topiramate results in significant clinical improvements in overweight/obese patients with type 2 diabetes 2010
    2010 Phentermine/topiramate combination therapy significantly improves glucose impairment in overweight/obese patients 2010
    2010 Admixture Mapping of Type 2 Diabetes and Lipoprotein Subclasses in Gullah-Speaking African Americans in Project SuGAR 2010
    2010 Changes in Insulin Sensitivity in Overweight/Obese Patients Treated with Low-Dose, Controlled-Release Phentermine/Topiramate(PHEN/TPM) 2010
    2010 Effects of Resistance Exercise and Aging on NR4A Protein Levels in Skeletal Muscle 2010
    2010 Improvements in Dyslipidemia and Other Cardiometabolic Disease Risk Factors with Low-Dose, Controlled-Release Phentermine/Topiramate (PHEN/TPM) 2010
    2010 Initial Combination Therapy with Metformin plus Colesevelam Safely Achieves Glycemic and Lipid Goals with Less Diarrhea in Early Type 2 Diabetes Mellitus 2010
    2010 Lipid Metabolism Modulated by Macrophage Adiponectin Expression In Vivo 2010
    2010 Metabolic Effects of Adipocyte-Specific NR4A3 Over-Expression in Mice 2010
    2010 Once-Daily, Low-Dose, Controlled-Release Phentermine/Topiramate Demonstrates Significant Improvement in Weight, Related Risk in Overweight/Obese Patients with Comorbidities. 2010
    2010 Osteocalcin Effects on Cytokine Secretion by Adipose Tissue and Glucose Uptake in L6 Muscle Cells: Linking the Skeleton with Insulin Resistance and Inflammation 2010
    2010 The Safety and Tolerability of Metformin plus Colesevelam in Drug-Naive Patients with Early Type 2 Diabetes Mellitus 2010
    2010 Macrophage adiponectin expression improves insulin sensitivity and protects against inflammation and atherosclerosis 2010
    2010 Skeletal muscle HNE is related to insulin resistance in sedentary individuals 2010
    2010 Type 2 Diabetes-associated changes in the plasma lipidome in obese women 2010
    2010 Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: Role in glucose-induced insulin resistance 2010
    2010 The genetic architecture of lipoprotein subclasses in Gullah-speaking African American families enriched for type 2 diabetes: The Sea Islands Genetic African American Registry (Project SuGAR) 2010
    2010 A diabetes-specific enteral formula improves glycemic variability in patients with type 2 diabetes. 2010
    2010 Colesevelam hydrochloride to treat hypercholesterolemia and improve glycemia in prediabetes: a randomized, prospective study. 2010
    2010 Initial combination therapy with metformin and colesevelam for achievement of glycemic and lipid goals in early type 2 diabetes. 2010
    2010 Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women 2010
    2010 Relationship between Insulin Sensitivity and Muscle Lipids may Differ with Muscle Group and Ethnicity. 2010
    2009 Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance 2009
    2009 One-Year Treatment with Low Dose VI-0521 in Type 2 Diabetes Demonstrates Sustained Weight Loss and Continuous Glycemic Benefit 2009
    2009 The Plasma Metabolome in Overweight Type 2 Diabetes Mellitus (T2DM) vs. Non-Diabetic Subjects with or without an Uncoupling Protein 3 (UCP3) Missense Mutation Reveals Novel Metabolite Signatures Reflective of Genotype and Diabetic Status 2009
    2009 A qualitative assessment of educational opportunities for primary care providers in type 2 diabetes care 2009
    2009 Treatment with VI-0521 (phentermine and topiramate) leads to one year durable glycaemic benefit and weight loss in subjects with type 2 diabetes 2009
    2009 Helicobacter pylori Infection and Inflammation: Implication for the Pathophysiology of Diabetes and Coronary Heart Disease in Asian Indians. 2009
    2009 Apolipoprotein-Defined Lipoproteins in the DCCT/EDIC Cohort: Associations with Diabetic Nephropathy in Type 1 Diabetes 2009
    2009 Genes and Biochemical Pathways in Human Skeletal Muscle Affecting Resting Energy Expenditure and Fuel Partitioning 2009
    2009 One-Year Treatment with VI-0521 in Type 2 Diabetes Demonstrates Continued Glycemic Improvement and Weight Loss 2009
    2009 Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid β-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women 2009
    2009 H. pylori-induced higher C-reactive protein in obese African Americans 2009
    2009 Adiponectin reduces lipid accumulation in macrophage foam cells 2009
    2009 Genome-wide linkage scan in gullah-speaking african american families with type 2 diabetes: The sea islands genetic African American Registry (Project SuGAR) 2009
    2009 NUTRITION AND CONTROL OF DIABETES IN HOSPITALIZED PATIENTS 2009
    2008 Adiponectin multimers and metabolic syndrome traits: Relative adiponectin resistance in African Americans 2008
    2008 Intracellular Lipid Accumulation in Liver and Muscle and the Insulin Resistance Syndrome 2008
    2008 Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the diabetes control and complications trial 2008
    2008 Entero-insular axis and postprandial insulin differences in African American and European American children 2008
    2008 Effect of two carbohydrate-modified tube-feeding formulas on metabolic responses in patients with type 2 diabetes 2008
    2008 PIOGLITAZONE PREVENTS OBESITY-INDUCED MITOCHONDRIAL DYSFUNCTION IN LIVER OF THE DIABETIC ZUCKER FATTY RAT 2008
    2008 Risk factors related to inflammation and endothelial dysfunction in the dcct/edic cohort and their relationship with nephropathy and macrovascular complications 2008
    2008 The Weight Effects of VI-0521 in Type 2 Diabetes 2008
    2008 Effect of VI-0521 (phentermine and topiramate) in type 2 diabetes 2008
    2008 Genome-wide linkage scan in Gullah-speaking African American families with Type 2 diabetes: The Sea Islands Genetic African American Registry (Project SuGAR) 2008
    2008 Metabolic syndrome traits and endothelial dysfunction: Role of ethnicity 2008
    2008 Osteocalcin is not just for bones: Effects on adipocytes and role in human metabolism 2008
    2008 Overexpression of adiponectin reduces lipid accumulation in human THP-1 macrophage foam cells 2008
    2008 The HOMA index estimation of insulin resistance is affected by ethnicity 2008
    2008 Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort 2008
    2008 Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort 2008
    2008 Comprehensive plasma acylcarnitine profiles of type 2 diabetic and non-diabetic subjects with or without an uncoupling protein 3 (UCP3) missense polymorphism 2008
    2008 Diagnosis and management of prediabetes in the continuum of hyperglycemia - When do the risks of diabetes begin? A consensus statement from the American College of Endocrinology and the American Association of Clinical Endocrinologists 2008
    2008 Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects 2008
    2008 Ethnic heterogeneity in glucoregulatory function during treatment with atypical antipsychotics in patients with schizophrenia 2008
    2007 The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle (Endocrine (2007) 31, 1 (5-17) DOI: 10.1007/s12020-007- 0007-x) 2007
    2007 Insulin's actions on plasma free fatty acids are normal in patients with stage 2 to 3 chronic kidney disease 2007
    2007 Reply: 'Second generation antipsychotic drugs: Is there a common mechanism in the development of obesity?' [2] 2007
    2007 NR4A orphan nuclear receptors modulate insulin action and the glucose transport system: Potential role in insulin resistance 2007
    2007 Adiponectin and the metabolic syndrome: Mechanisms mediating risk for metabolic and cardiovascular disease 2007
    2007 Ethnic differences in adiponectin multimer distribution and relationships with metabolic syndrome traits 2007
    2007 Fat depots and adipokines in morbidly obese individuals 2007
    2007 Functional study of Trb 3 related to diabetic skeletal muscle 2007
    2007 Pioglitazone therapy restores the coupling of electron transport to ATP synthesis in skeletal muscle of obese zucker rats 2007
    2007 Long-Term Effect of Diabetes and Its Treatment on Cognitive Function 2007
    2007 Atypical antipsychotic drugs directly impair insulin action in adipocytes: Effects on glucose transport, lipogenesis, and antilipolysis 2007
    2007 The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle 2007
    2007 Geographical patterns of end-stage renal disease incidence and risk factors in rural and urban areas of South Carolina 2007
    2006 Polymorphism in the transcription factor 7-Like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women 2006
    2006 Administration of pioglitazone in low-density lipoprotein receptor-deficient mice inhibits lesion progression and matrix metalloproteinase expression in advanced atherosclerotic plaques 2006
    2006 Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages 2006
    2006 Nuclear magnetic resonance-determined lipoprotein subclass profile in the DCCT/EDIC cohort: Associations with carotid intima-media thickness 2006
    2006 Proinflammatory cytokine production and insulin sensitivity regulated by overexpression of resistin in 3T3-L1 adipocytes 2006
    2006 A diabetes management program using diabetes-specific meal replacements and snack bars improves weight loss, metabolic parameters, and quality of life (QOL) 2006
    2006 A role for C/EBP-delta in mitochondrial dysfunction and insulin resistance in skeletal muscle 2006
    2006 CETP gene variation has pronounced independent effect on HDL levels and HDL particle size in type 1 diabetes 2006
    2006 Effects of short-term very low calorie diet (VLCD) on secretion of adipocytokines in human adipose tissue 2006
    2006 Resistin autoregulates inflammatory cytokine production and induces insulin resistance in adipocytes 2006
    2006 Editorial: Uncoupling protein 3 and human metabolism 2006
    2006 Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction 2006
    2006 Adiponectin multimeric complexes and the metabolic syndrome trait cluster 2006
    2005 Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation 2005
    2005 Modified lipoprotein-immune complexes and progression of internal carotid intima-media thickness in type 1 diabetes 2005
    2005 Mitochondrial DNA genetic diversity among four ethnic groups in Sierra Leone 2005
    2005 Mitochondrial DNA (mtDNA) haplotypes reveal maternal population genetic affinities of Sea Island Gullah-speaking African Americans 2005
    2005 Adiponectin multimeric complexes and the metabolic syndrome trait cluster 2005
    2005 Administration of pioglitazone to LDL receptor-deficient mice inhibits progression of intimal lesions and expression of matrix metalloproteinases and adhesion molecules 2005
    2005 Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes: Associations with microvascular disease complications in the DCCT/EDIC cohort 2005
    2005 Dysregulation of mitochondria-related genes in skeletal muscle from insulin resistant humans is associated with suppression of transcription factors involved in mitochondrial biogenesis 2005
    2005 Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages 2005
    2005 Proteomics analysis of skeletal muscle mitochondria in type 2 diabetes reveals altered concentrations and oxidation of respiratory chain proteins 2005
    2004 Apolipoprotein C-III protein concentrations and gene polymorphisms in type 1 diabetes: Associations with lipoprotein subclasses 2004
    2004 Chronic alcohol consumption induces the metabolic stress chaperone prohibitin in liver mitochondria. 2004
    2004 Diet, insulin resistance, and obesity: Zoning in on data for Atkins dieters living in South Beach 2004
    2004 Associations of adiponectin with retinopathy in the DCCT/EDIC cohort: Influence of insulin resistance 2004
    2004 Effects of atypical antipsychotic drugs on insulin action in adipocytes 2004
    2004 Estimation of resting energy expenditure considering effects of race and diabetes status 2004
    2004 Overexpression of adiponectin but not resistin enhances adipocyte differentiation and insulin sensitivity 2004
    2004 Critical Evaluation of Adult Treatment Panel III Criteria in Identifying Insulin Resistance with Dyslipidemia 2004
    2004 Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohort 2004
    2004 Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: A role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation 2004
    2004 Foreword from the editors 2004
    2004 Individual differences in the response to ingested nutrients. 2004
    2004 Proteomic analysis of skeletal muscle mitochondria reveal decreases in complex I and IV of the electron transport chain 2004
    2004 Role of UCP2 and UCP3 in nutrition and obesity 2004
    2003 Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy - The Epidemiology of Diabetes Interventions and Complications (EDIC) study 2003
    2003 Lipoproteins in the DCCT/EDIC cohort: Associations with diabetic nephropathy 2003
    2003 Lipoprotein abnormalities in type 1 diabetes 2003
    2003 Intensive Diabetes Therapy and Carotid Intima–Media Thickness in Type 1 Diabetes Mellitus 2003
    2003 Alterations in skeletal muscle caveolins 1 and 3 in human insulin resistance and obesity 2003
    2003 Relationship between insulin senstivity and intramyocellular lipid during short term very low calorie diet in obese type 2 diabetics 2003
    2003 Fibrinogen is a marker for nephropathy and peripheral vascular disease in type 1 diabetes: Studies of plasma fibrinogen and fibrinogen gene polymorphism in the DCCT/EDIC cohort 2003
    2003 Plasma prekallikrein: A risk marker for hypertension and nephropathy in type 1 diabetes 2003
    2003 Three novel mtDNA restriction site polymorphisms allow exploration of population affinities of African Americans 2003
    2003 Serum lipoproteins in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications cohort: Associations with gender and glycemia 2003
    2003 The role of uncoupling protein 3 in human physiology 2003
    2003 Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance 2003
    2003 The role of uncoupling protein 3 in human physiology. 2003
    2003 The role of uncoupling protein 3 in human physiology 2003
    2002 The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages 2002
    2002 Effective use of thiazolidinediones for the treatment of glucocorticoid-induced diabetes 2002
    2002 Troglitazone antagonizes metabolic effects of glucocorticoids in humans: Effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin 2002
    2002 Connective tissue growth factor (CTGF) N fragment: A marker for progressive diabetic nephropathy. 2002
    2002 Flotillin-1 expression in skeletal muscle is altered in insulin resistant humans 2002
    2002 Hepatic lipase gene polymorphism is a major determinant of HDL level and HDL size in men with type 1 diabetes in the DCCT/EDIC 2002
    2001 Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: implications regarding defects in vesicle trafficking. 2001
    2001 Microarray analysis of changes in skeletal muscle gene expression in response to insulin. 2001
    2001 Mitochondrial DNA and Y-chromosome haplotypes of Gullah-speaking African Americans show closer genetic distance to Sierra Leoneans and lower Caucasian admixture than other new world African populations. 2001
    2001 A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes 2001
    2001 Effects of Insulin Resistance and type 2 diabetes on the nuclear magnetic resonance lipoprotein subclass profile 2001
    2001 Effects of race on the NMR lipoprotein profile and insulin resistance syndrome: Lipids and blood pressure are not influenced by insulin resistance in African Americans 2001
    2001 Postprandial glucose and insulin responses to dextrin-containing medical nutritional bars in persons with type 2 diabetes mellitus 2001
    2001 SNARE proteins (Syntaxin4, VAMP2, munc18) and skeletal muscle insulin resistance in rats and humans 2001
    2001 Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina 2001
    2001 Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: Implications regarding defects in vesicle trafficking 2001
    2001 Beneficial effects of intensive therapy of diabetes during adolescence: Outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT) 2001
    2000 Short-term impact of a church-based approach to lifestyle change on cardiovascular risk in African Americans 2000
    2000 Reduced plasma leptin concentrations in bulimia nervosa 2000
    2000 Nuclear magnetic resonance (NMR)-determined lipoprotein subclass profile in the DCCT/EDIC cohort: Associations with retinopathy and nephropathy 2000
    2000 Nuclear magnetic resonance (NMR)-determined lipoprotein subclass profile in the DCCT/EDIC cohort: Effects of gender, HbAlc, and DCCT randomization group. 2000
    2000 Nuclear magnetic resonance (NMR)-determined lipoprotein subclass profile: Effects of hyperglycemia, lipoprotein glycation, and comparison with standard lipid profile 2000
    2000 Paraoxonase genotype (192 Gln-Arg) and serum paraoxonase-arylesterase activity: Relationship with Type 1 diabetes and nephropathy 2000
    2000 Troglitazone is an effective therapeutic agent in patients with steroid-induced diabetes 2000
    2000 High-resolution admixture map of African Americans living in South Carolina. 2000
    1999 Endogenous mutations in human uncoupling protein 3 alter its functional properties 1999
    1999 Role of human mitochondrial translocators in the import of nuclear encoded proteins. 1999
    1999 Dual energy X-ray absorptiometry assessment of fat mass distribution and its association with the insulin resistance syndrome 1999
    1999 Aberrant DNA sequence pattern caused by a heterozygosity 1999
    1999 Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6-phosphate amidotransferase: decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione. 1999
    1999 Hyperfibrinogenemia is associated with nephropathy in type 1 diabetes 1999
    1999 Low birth weight is associated with reduced expression of GLUT4 and carnitine palmitoyltransferase-1 in adult skeletal muscle 1999
    1999 Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6-phosphate amidotransferase: Decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione 1999
    1999 Plasminogen activator inhibitor-1 is increased in type 1 diabetes patients with hypertension 1999
    1999 Sickle cell haplotypes of the African American "Gullah" of the South Carolina Sea Islands. 1999
    1999 Toward rational diagnostic criteria for the insulin resistance syndrome 1999
    1999 Troglitazone prevents glucocorticoid-induced insulin resistance in humans 1999
    1998 Clinical implications of the insulin resistance syndrome 1998
    1998 Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes 1998
    1998 Insulin action and insulin resistance: Diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system 1998
    1998 Transmission of two novel mutations in a pedigree with familial lecithin:cholesterol acyltransferase deficiency: Structure-function relationships and studies in a compound heterozygous proband 1998
    1998 Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance 1998
    1998 Apolipoprotein CIII polymorphism confers altered chemical composition of triglyceride-rich lipoprotein in type 1 diabetes 1998
    1998 Insulin resistance and defective glucose-insulin coupling in ketosis-prone type 2 diabetes of African-American youth 1998
    1998 The role of uncoupling proteins in metabolic fuel partitioning and human obesity 1998
    1998 Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African- American subjects 1998
    1998 An autosomal genomic scan for loci linked to prediabetic phenotypes in pima indians 1998
    1998 An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians 1998
    1998 Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians 1998
    1998 Cloning of Rab GTPases expressed in human skeletal muscle: Studies in insulin-resistant subjects 1998
    1998 Diabetes research in South Carolina: past, present, and future. 1998
    1998 Expression of mRNAs encoding uncoupling proteins in human skeletal muscle. Effects of obesity and diabetes 1998
    1997 Identification of Rad's effector-binding domain, intracellular localization, and analysis of expression in Pima Indians 1997
    1997 Genome scan for linkage to pre-diabetic traits in Pima Indians 1997
    1997 Gestational diabetes mellitus and gene mutations which affect insulin secretion 1997
    1997 Decreased insulin-stimulated Z-deoxyglucose uptake and impaired GLUT4 translocation in skeletal muscle of transgenic mice overexpressing glutamine: Fructose-6-phosphate amidotransferase. 1997
    1997 Ketosis-prone NIDDM in African-American children. 1997
    1997 NIDDM and obesity are associated with Protein Kinase C abnormalities in human skeletal muscle 1997
    1997 The metabolic significance of leptin in humans: Gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure 1997
    1997 Multiple endocrinopathies in an infant with fatal neurodegenerative disease 1997
    1997 The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. 1997
    1997 Exercise in transgenic mice overexpressing GLUT4 glucose transporters: Effects on substrate metabolism and glycogen regulation 1997
    1997 Genomewide search for genes influencing percent body fat in Pima Indians: Suggestive linkage at chromosome 11q21-q22 1997
    1997 Muscle rad expression and human metabolism: Potential role of the novel ras-related GTPase in energy expenditure and body composition 1997
    1996 Identification of Rad's effector-binding domain, intracellular localization and analysis of expression in Pima Indians. 1996
    1996 Isolation by preparative free-flow electrophoresis and aqueous two-phase partition from rat adipocytes of an insulin-responsive small vesicle fraction with glucose transport activity 1996
    1996 Correlation of leptin and body fat in obese, lean, and lipodystrophic humans. 1996
    1996 Dual energy X-ray absorptiometry (DXA) assessment of fat mass and distribution and its association with the insulin resistance syndrome (IRS). 1996
    1996 Fat and muscle tissue express a common abnormality in translocation/trafficking of GLUT4/vp165 containing vesicles in NIDDM. 1996
    1996 The metabolic significance of leptin in humans. 1996
    1996 The expression of TNFα by human muscle: Relationship to insulin resistance 1996
    1995 The effects of brefeldin A on the glucose transport system in rat adipocytes: Implications regarding the intracellular locus of insulin-sensitive Glut4 1995
    1995 CHARACTERIZATION OF RAD ANTIBODY EPITOPES, GTP-BINDING PROPERTIES, AND EXPRESSION IN SKELETAL-MUSCLE OF TYPE-II DIABETICS AND THE ZUCKER DIABETIC FATTY RAT 1995
    1995 Mechanisms of enhanced insulin sensitivity in endurance-trained athletes: effects on blood flow and differential expression of GLUT 4 in skeletal muscles. 1995
    1995 ABNORMALITIES IN GLUT-4 TRANSLOCATION AND TRAFFICKING IN SKELETAL-MUSCLE CAUSE INSULIN-RESISTANCE IN HUMANS 1995
    1995 GLUCOSAMINE (GLMN) INDUCES INSULIN-RESISTANCE (IR) IN-VIVO BY AFFECTING GLUT 4 TRANSLOCATION IN SKELETAL-MUSCLE - IMPLICATIONS FOR GLUCOSE TOXICITY 1995
    1995 RAD EXPRESSION IN SKELETAL-MUSCLE OF TYPE-II DIABETICS 1995
    1995 Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle: Implications for glucose toxicity 1995
    1995 Mechanisms of enhanced insulin sensitivity in endurance-trained athletes: Effects on blood flow and differential expression of GLUT 4 in skeletal muscles 1995
    1994 GENE-EXPRESSION OF EPITHELIAL GLUCOSE TRANSPORTERS - THE ROLE OF DIABETES-MELLITUS 1994
    1994 Gene expression of epithelial glucose transporters: The role of diabetes mellitus 1994
    1994 Gene expression of epithelial glucose transporters: the role of diabetes mellitus. 1994
    1994 MUSCLE GLUT 4 EXPRESSION IS A FAMILIAL TRAIT AND DETERMINES INSULIN SENSITIVITY IN HUMANS INDEPENDENT OF OBESITY 1994
    1994 THE GOLGI-APPARATUS IS NOT REQUIRED FOR INSULIN STIMULATION OF GLUCOSE-TRANSPORT AND GLUT-4 TRANSLOCATION IN RAT ADIPOCYTES 1994
    1994 MOLECULAR ADAPTATIONS OF GLUT1 AND GLUT2 IN RENAL PROXIMAL TUBULES OF DIABETIC RATS 1994
    1994 Molecular adaptations of GLUT1 and GLUT2 in renal proximal tubules of diabetic rats. 1994
    1994 Biological actions of insulin are differentially regulated by glucose and insulin in primary cultured adipocytes: Chronic ability to increase glycogen synthase activity 1994
    1994 Glucose transporter proteins and insulin sensitivity in humans. 1994
    1994 Molecular adaptations of GLUT1 and GLUT2 in renal proximal tubules of diabetic rats 1994
    1993 Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes. Heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transporters 1993
    1993 Potential role for insulin and cycloheximide in regulating the intrinsic activity of glucose transporters in isolated rat adipocytes. 1993
    1993 Insulin-responsive human adipocytes express two glucose transporter isoforms and target them to different vesicles. 1993
    1993 MECHANISMS UNDERLYING PERIPHERAL-NERVE GLUCOSE-UPTAKE SUPPRESSION IN DIABETES 1993
    1993 EFFECTS OF DIABETES ON MYOCARDIAL GLUCOSE-TRANSPORT SYSTEM IN RATS - IMPLICATIONS FOR DIABETIC CARDIOMYOPATHY 1993
    1993 Effects of diabetes on myocardial glucose transport system in rats: implications for diabetic cardiomyopathy. 1993
    1993 1 Cellular insulin action and insulin resistance 1993
    1993 Effects of diabetes on myocardial glucose transport system in rats: Implications for diabetic cardiomyopathy 1993
    1993 Insulin-responsive human adipocytes express two glucose transporter isoforms and target them to different vesicles 1993
    1993 Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes: Heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transporters 1993
    1993 Muscle group-specific regulation of GLUT 4 glucose transporters in control, diabetic, and insulin-treated diabetic rats 1993
    1993 Potential role for insulin and cycloheximide in regulating the intrinsic activity of glucose transporters in isolated rat adipocytes 1993
    1992 MECHANISMS OF ENHANCED INSULIN ACTION IN ENDURANCE-TRAINED ATHLETES 1992
    1992 GLUCOSE TRANSPORTERS OF RAT PROXIMAL TUBULE - DIFFERENTIAL EXPRESSION AND SUBCELLULAR-DISTRIBUTION 1992
    1992 Glucose transporters of rat proximal tubule: differential expression and subcellular distribution. 1992
    1992 DIABETES DEPRESSES THE RAT CARDIAC NA+/CA2+ EXCHANGER 1992
    1992 Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM 1992
    1992 Glucose and insulin chronically regulate insulin action via different mechanisms in BC3H1 myocytes: Effects on glucose transporter gene expression 1992
    1992 Glucose transport and NIDDM 1992
    1992 Glucose transporters of rat proximal tubule: Differential expression and subcellular distribution 1992
    1991 New insights into the metabolic regulation of insulin action and insulin resistance: Role of glucose and amino acids 1991
    1991 Demonstration of a 1,25-dihydroxyvitamin D3-responsive protein in human lymphocytes: Immunologic crossreactivity and inverse regulation with the vitamin D receptor 1991
    1991 Glucose and insulin regulate insulin sensitivity in primary cultured adipocytes without affecting insulin receptor kinase activity 1991
    1991 ADAPTATIONS OF THE RAT RENAL PROXIMAL TUBULE TO UNCONTROLLED DIABETES 1991
    1991 EXPRESSION OF GLUT4 VARIES AS A FUNCTION OF SKELETAL-MUSCLE GROUP IN CONTROL, DIABETIC, AND INSULIN-TREATED DIABETIC RATS 1991
    1991 REGULATION OF TISSUE GLUT4 CONTENT VARIES AS A FUNCTION OF SKELETAL-MUSCLE GROUP AND CANNOT TOTALLY EXPLAIN INSULIN RESISTANCE IN DIABETIC RATS 1991
    1991 Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity 1991
    1989 Dexamethasone regulates the glucose transport system in primary cultured adipocytes: Different mechanisms of insulin resistance after acute and chronic exposure 1989
    1989 Expression of a glucose transporter gene cloned from brain in cellular models of insulin resistance: Dexamethasone decreases transporter mRNA in primary cultured adipocytes 1989
    1989 Glucose transport in primary cultured neurons 1989
    1989 Insulin resistance and noninsulin‐dependent diabetes mellitus: Which horse is pulling the cart? 1989
    1989 Pretranslational suppression of an insulin-responsive glucose transporter in rats with diabetes mellitus 1989
    1989 Y-1 adrenocortical tumor cells contain atrial natriuretic peptide receptors which regulate cyclic nucleotide metabolism and steroidogenesis 1989
    1988 Cellular mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes 1988
    1988 Cellular mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes. 1988
    1988 Correlation of in vivo and in vitro actions of insulin in obesity and noninsulin-dependent diabetes mellitus: Role of the glucose transport system 1988
    1988 Day-long integrated serum insulin and C-peptide profiles in patients with NIDDM. Correlation with urinary C-peptide excretion 1988
    1988 Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus 1988
    1987 Case report 417 1987
    1987 Case report 417 1987
    1987 Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes. A new mechanism of insulin resistance 1987
    1987 Human adipocyte glucose transport system. Biochemical and functional heterogeneity of hexose carriers 1987
    1987 Shunting of insulin from a retroendocytotic pathway to a degradative pathway by sodium vanadate 1987
    1987 Xanthogranulomatosis in an adult: Lipid analysis of xanthomas and plasma 1987
    1987 Xanthogranulomatosis in an adult: lipid analysis of xanthomas and plasma. 1987
    1986 Insulin induces progressive insulin resistance in cultured rat adipocytes: Sequential effects at receptor and multiple postreceptor sites 1986
    1985 Insulin receptor down-regulation is linked to an insulin-induced postreceptor defect in the glucose transport system in rat adipocytes 1985
    1985 Insulin resistance in non-insulin dependent (type II) and insulin dependent (type I) diabetes mellitus. 1985
    1985 Modulation of insulin secretion by insulin and glucose in type II diabetes mellitus 1985
    1985 The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus 1985
    1984 Primary culture of isolated adipocytes. A new model to study insulin receptor regulation and insulin action 1984
    1978 In vitro vitamin K-dependent conversion of precursor to prothrombin in chick liver 1978

    Book

    Year Title Altmetric
    2018 Preface 2018

    Chapter

    Year Title Altmetric
    2018 Clinical definition of overweight and obesity.  121-143. 2018
    2010 Insulin Action.  104-125. 2010
    2006 16 - Metabolic Syndrome.  357-370. 2006

    Research Overview

  • The Garvey laboratory is interested in the molecular, metabolic, and genetic basis of type 2 diabetes mellitus, insulin resistance, and obesity. Studies involve cellular and molecular biology of cell and animal models, metabolic investigations of human subjects on a clinical research ward, and genetic epidemiology. The combined approach of human physiology, genetics, and basic cell and molecular biology provides the laboratory with a flexible and powerful capability for hypothesis testing relevant to human disease. Principal research activities include:

    Role of GLUT 4 glucose transporters and the glucose transport system in insulin resistance. This work utilizes cultured cell, animal models, and humans (in vivo metabolic studies and ex vivo studies of tissues) as model systems, and tests hypotheses relating to abnormalities in GLUT gene expression and cellular trafficking of GLUT4-containing vesicles.

    Molecular Mechanisms of Human Insulin Resistance. The laboratory systematically identifies differential gene expression in muscle and fat from insulin sensitive, insulin resistant, and Type 2 Diabetic patients using cDNA microarrays and proteomics. The contribution of selected novel genes/proteins in cell biology and metabolism is investigated using a variety of methodologies including gene hyperexpression/knock-out in cultured cells and mice.

    Molecular and Metabolic Defects Impairing Lipid Oxidation in Insulin Resistance. These studies feature application of NMR and metabolomic approaches, with a special focus on mitochondrial function, to explain defective lipid oxidation and lipid accumulation in skeletal muscle.

    Interaction between Environment and Genes in the Pathogenesis of Diabetes and Obesity and Related Metabolic Subphenotypes. These studies examine the contribution of specific gene polymorphisms (for example UCP3) to clinical and metabolic traits in relationship to environmental parameters such as diet and physical activity. Study groups include Gullah speaking African Americans and families with adolescent sib pairs discordant for obesity and/or Type 2 Diabetes.

    Pathophysiology and Clinical Diagnoses of the Insulin Resistance (or Metabolic) Syndrome. These studies include the impact of race and racial genetic admixture of the Insulin Resistance Syndrome trait cluster.

    Markers and Mechanisms of Vascular Disease in Diabetes. These studies involve secreted factors from adipocytes and gene polymorphisms, and collaborations with the DCCT/EDIC Study Group (i.e., the national cohort of DCCT/EDIC patients with Type 1 Diabetes) and the VA Diabetes Study (i.e., a VA cooperative study in Type 2 Diabetic patients).
  • Principal Investigator On

  • Private Grant  awarded by Sanofi US Services Inc 2018 - 2025
  • Private Grant  awarded by NOVO NORDISK PHARMACEUTICALS, INC. 2018 - 2023
  • UAB Diabetes Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB Diabetes Research Center - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Private Grant  awarded by NOVO NORDISK PHARMACEUTICALS, INC. 2018 - 2022
  • Obesity Health Disparities Research Center (OHDRC) - Administrative Core  awarded by NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES/NIH/DHHS 2017 - 2022
  • Private Grant  awarded by NOVO NORDISK PHARMACEUTICALS, INC. 2019 - 2021
  • Intergenerational Transmission of Obesity  awarded by American Heart Association 2017 - 2021
  • Intergenerational Transmission of Obesity - Intergenerational Transmission of Obesity in Mouse Models of in Utero Stress  awarded by American Heart Association 2017 - 2021
  • Intergenerational Transmission of Obesity - UAB Strategically Focused Obesity Center (SFOC)  awarded by American Heart Association 2017 - 2021
  • Private Grant  awarded by NOVO NORDISK PHARMACEUTICALS, INC. 2017 - 2021
  • Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study  awarded by George Washington University 2013 - 2020
  • Private Grant  awarded by NOVO NORDISK PHARMACEUTICALS, INC. 2018 - 2020
  • UAB Obesity Training Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2020
  • Emotional Distress in a Comparative Effectiveness Trial of Diabetes Treatments  awarded by George Washington University 2015 - 2020
  • Private Grant  awarded by MERCK SHARP & DOHME CORP 2015 - 2020
  • Continuation of Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)  awarded by George Washington University 2017 - 2019
  • Private Grant  awarded by NOVO NORDISK PHARMACEUTICALS, INC. 2017 - 2019
  • UAB Diabetes Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • UAB Diabetes Research Center - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • Private Grant  awarded by NOVO NORDISK PHARMACEUTICALS, INC. 2017 - 2018
  • Private Grant  awarded by NOVO NORDISK PHARMACEUTICALS, INC. 2016 - 2018
  • Private Grant  awarded by NOVO NORDISK PHARMACEUTICALS, INC. 2015 - 2017
  • Obesity Training Program (T32 DK 062710) - DiaComp Coordinating and Bioinformatics Unit  awarded by AUGUSTA UNIVERSITY - NEW 2017
  • A Randomized, Placebo Controlled Clinical Trial to Evaluate Cardiovascular Outcomes After Treatment with Exenatide Once Weekly in Patients with Type 2 Diabetes Mellitus  awarded by Duke University 2010 - 2017
  • Private Grant  awarded by LEXICON PHARMACEUTICALS, INC. 2015 - 2017
  • Private Grant  awarded by ELCELYX THERAPEUTICS, INC. 2015 - 2016
  • Private Grant  awarded by Sanofi US Services Inc 2014 - 2015
  • Private Grant  awarded by VIVUS, INC. 2013 - 2015
  • TECOS: A Randomized, Placebo Controlled Clinical Trial to Evaluate Cardiovascular Outcomes After Treatment with Sitagliptin in Patients with Type 2 Diabetes Mellitus and Inadequate Glycemic Control on Mono- or Dual Combination Oral Antihyperglycemic Therapy  awarded by Duke University 2009 - 2015
  • Private Grant  awarded by EISAI, INC. 2014
  • Private Grant  awarded by WEIGHT WATCHERS INTERNATIONAL, INC. 2012 - 2014
  • Private Grant  awarded by ABBOTT NUTRITION 2008 - 2013
  • Identification of Muscle-Specific Biomarkers of Fatty Acid Beta-Oxidation  awarded by Agricultural Research Service/Department of Agriculture 2009 - 2013
  • NR4A Orphan Receptors and Insulin Resistance  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2009 - 2013
  • UAB Diabetes Research and Training Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2013
  • UAB Diabetes Research and Training Center - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2013
  • Mechanisms of Human Insulin Resistance  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2006 - 2012
  • UAB Clinical Nutrition Research Unit - Core B (Genetics)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2007 - 2012
  • Private Grant  awarded by Nestle 2010 - 2011
  • Genetic Contributors to Diabetes and Dyslipidemia in African Americans  awarded by University of Virginia 2009 - 2011
  • Private Grant  awarded by Genzyme Corporation 2009 - 2011
  • Private Grant  awarded by GlaxoSmithKline 2006 - 2010
  • Private Grant  awarded by MERCK & COMPANY, INC. 2009 - 2010
  • Investigator On

  • Adapting MultiPLe Behavior Interventions that eFfectively Improve (AMPLIFI) Cancer Survivor Health  awarded by National Cancer Institute/NIH/DHHS 2018 - 2023
  • Adapting MultiPLe Behavior Interventions that eFfectively Improve (AMPLIFI) Cancer Survivor Health - Administrative Core  awarded by National Cancer Institute/NIH/DHHS 2018 - 2023
  • UAB Diabetes Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Effect Of Time-Restricted Feeding On 24-Hour Glycemic Control, Blood Pressure, And Cardiovascular Disease Risk Factors In Adults With Prediabetes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Obesity Risk in African American Women is Determined by a Diet-by-Phenotype Interaction  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Thrombocytopoiesis in Diabetes: Role of Damage Associated Molecular Patterns  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2023
  • Depletion of Pancreatic Lipid Improves Beta-Cell Function in Early Type 2 Diabetes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Obesity Health Disparities Research Center (OHDRC)  awarded by NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES/NIH/DHHS 2017 - 2022
  • UAB STEP-UP: Promoting Diversity Through Mentored Research Experiences (UAB STEP-UP)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • A Sleep and Media Intervention to Improve Adolescents Weight and Risk of Type 2 Diabetes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2021
  • Intergenerational Transmission of Obesity  awarded by American Heart Association 2017 - 2021
  • Comparing High and Normal Protein Diets for the Dietary Remission of Type 2 Diabetes  awarded by National Cattlemen's Beef Association 2019 - 2020
  • Trace Mineral Levels, Metabolomics, and Diabetes Risk  awarded by Indiana University 2018 - 2020
  • Identification for Predictors of Future Diabetes - Impacts of Stress and Depression  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2019
  • Race - Adiposity Interactions Regulate Mechanisms Determining Insulin Sensitivity  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2019
  • Novel Actions of Metformin to Augment Resistance Training Adaptations in Older Adults  awarded by UNIVERSITY OF KENTUCKY (RESEARCH FOUNDATION) 2014 - 2019
  • Integrative -omics Study of Postprandial Lipoprotein Phenotypes  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2019
  • UAB Diabetes Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • UAB Obesity Training Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2017
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017
  • UAB Nutrition Obesity Research Center (NORC) - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2017
  • UAB Nutrition Obesity Research Center - Core A - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2017
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2015
  • Evaluating Community Health Advisors on Diabetes Outcomes in Rural Alabama (ENCOURAGE)  awarded by American Academy of Family Physicians Foundation 2009 - 2012
  • Teaching Activities

  • NTR798 - Doc Level Non-Dissertation Res (Fall Term 2019) 2019
  • NTR798 - Doc Level Non-Dissertation Res (Spring Term 2019) 2019
  • NTR699 - Master's Level Thesis Research (Fall Term 2018) 2018
  • NTR799 - Doc Lev Dissertation Research (Summer Term 2018) 2018
  • NTR798 - Doc Level Non-Dissertation Res (Spring Term 2018) 2018
  • NTR799 - Doc Lev Dissertation Research (Spring Term 2018) 2018
  • NTR798 - Doc Level Non-Dissertation Res (Fall Term 2017) 2017
  • NTR798 - Doc Level Non-Dissertation Res (Summer Term 2017) 2017
  • NTR798 - Doc Level Non-Dissertation Res (Spring Term 2017) 2017
  • NTR798 - Doc Level Non-Dissertation Res (Fall Term 2016) 2016
  • NTR798 - Doc Level Non-Dissertation Res (Summer Term 2016) 2016
  • NTR799 - Doc Lev Dissertation Research (Summer Term 2016) 2016
  • NTR798 - Doc Level Non-Dissertation Res (Spring Term 2016) 2016
  • NTR799 - Doc Lev Dissertation Research (Spring Term 2016) 2016
  • NTR798 - Doc Level Non-Dissertation Res (Fall Term 2015) 2015
  • NTR798 - Doc Level Non-Dissertation Res (Summer Term 2015) 2015
  • NTR799 - Doc Lev Dissertation Research (Summer Term 2015) 2015
  • NTR798 - Doc Level Non-Dissertation Res (Spring Term 2015) 2015
  • NTR799 - Doc Lev Dissertation Research (Spring Term 2015) 2015
  • NTR798 - Doc Level Non-Dissertation Res (Fall Term 2014) 2014
  • NTR799 - Doc Lev Dissertation Research (Fall Term 2014) 2014
  • NTR799 - Doc Lev Dissertation Research (Summer Term 2014) 2014
  • NTR699 - Master's Level Thesis Research (Spring Term 2014) 2014
  • NTR799 - Doc Lev Dissertation Research (Spring Term 2014) 2014
  • NTR798 - Doc Level Non-Dissertation Res (Fall Term 2013) 2013
  • NTR799 - Doc Lev Dissertation Research (Fall Term 2013) 2013
  • NTR699 - Master's Level Thesis Research (Summer Term 2013) 2013
  • NTR798 - Doc Level Non-Dissertation Res (Summer Term 2013) 2013
  • NTR699 - Master's Level Thesis Research (Spring Term 2013) 2013
  • NTR798 - Doc Level Non-Dissertation Res (Spring Term 2013) 2013
  • NTR799 - Doc Lev Dissertation Research (Spring Term 2013) 2013
  • NTR798 - Doc Level Non-Dissertation Res (Fall Term 2012) 2012
  • NTR799 - Doc Lev Dissertation Research (Fall Term 2012) 2012
  • NTR798 - Doc Level Non-Dissertation Res (Summer Term 2012) 2012
  • NTR798 - Doc Level Non-Dissertation Res (Spring Term 2012) 2012
  • NTR798 - Doc Level Non-Dissertation Res (Fall Term 2011) 2011
  • NTR799 - Doc Lev Dissertation Research (Fall Term 2011) 2011
  • NTR798 - Doc Level Non-Dissertation Res (Summer Term 2011) 2011
  • NTR799 - Doc Lev Dissertation Research (Summer Term 2011) 2011
  • NTR798 - Doc Level Non-Dissertation Res (Spring Term 2011) 2011
  • NTR799 - Doc Lev Dissertation Research (Spring Term 2011) 2011
  • NTR798 - Doc Level Non-Dissertation Res (Fall Term 2010) 2010
  • NTR799 - Doc Lev Dissertation Research (Fall Term 2010) 2010
  • NTR798 - Doc Level Non-Dissertation Res (Summer Term 2010) 2010
  • NTR799 - Doc Lev Dissertation Research (Summer Term 2010) 2010
  • NTR798 - Doc Level Non-Dissertation Res (Spring Term 2010) 2010
  • NTR799 - Doc Lev Dissertation Research (Spring Term 2010) 2010
  • NTR799 - Doc Lev Dissertation Research (Fall Term 2009) 2009
  • NTR798 - Doc Level Non-Dissertation Res (Summer Term 2009) 2009
  • NTR798 - Doc Level Non-Dissertation Res (Spring Term 2009) 2009
  • NTR699 - Master's Level Thesis Research (Fall Term 2008) 2008
  • NTR798 - Doc Level Non-Dissertation Res (Fall Term 2008) 2008
  • NTR798 - Doc Level Non-Dissertation Res (Summer Term 2008) 2008
  • NTR798 - Doc Level Non-Dissertation Res (Spring Term 2008) 2008
  • NTR798 - Doc Level Non-Dissertation Res (Fall Term 2007) 2007
  • Education And Training

  • Barnes Hospital, Internship 1979
  • Barnes Hospital, Residency 1981
  • University of California San Diego Medical Center, Postdoctoral Fellowship 1984
  • University of Colorado Health Sciences Center, Postdoctoral Fellowship 1983
  • Full Name

  • W. Timothy Garvey