Positions

Overview

  • Frances (Fran) Lund completed her undergraduate studies in Microbiology at the University of Notre Dame (B.S., cum laude, 1987). She performed her graduate work with Dr. Ronald B. Corley in the Department of Microbiology at Duke University. She obtained her Ph.D. in Immunology in 1992 and went on to a post-doctoral immunology fellowship in Dr. Maureen Howard’s group at DNAX Research Institute in Palo Alto, CA. In 1997 she moved to the Trudeau Institute, a basic biomedical infectious disease research institute, and started her own research lab. Over the next 11 years, Dr. Lund and her scientific partner, Dr. Troy Randall, developed research programs studying humoral and cellular immune responses to pulmonary and intestinal pathogens. In 2008, they joined the University of Rochester as Professors within the Division of Allergy, Immunology and Rheumatology (Department of Medicine). Over the next four years, Dr. Lund developed additional research programs in autoimmunity and allergy and began her work in human translational immunology. In 2012, Drs. Lund and Randall and their joint labs were recruited to UAB. Dr. Lund is currently serving as the Charles H. McCauley Professor and Chair of the Department of Microbiology. She holds a secondary appointment in the Division of Clinical Immunology and Rheumatology and is a senior scientist in the Comprehensive Cancer Center and the Comprehensive Arthritis, Musculoskeletal and Autoimmunity Center.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Erratum: Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus (Immunity (2018) 49(4) (725–739.e6), (S1074761318303789), (10.1016/j.immuni.2018.08.015)) 2020
    2019 Erratum to: Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion (Nature Communications, (2018), 9, 1, (3698), 10.1038/s41467-018-05853-7) 2019
    2019 T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells 2019
    2019 Compartmentalization of dendritic cell and T-cell interactions in the lymph node: Anatomy of T-cell fate decisions 2019
    2019 Ifnγ induces epigenetic programming of human t-bethi b cells and promotes tlr7/8 and il-21 induced differentiation 2019
    2019 The establishment of resident memory B cells in the lung requires local antigen encounter 2019
    2018 CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism 2018
    2018 Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion 2018
    2018 Human leukocyte antigen class I and II knockout human induced pluripotent stem cell–derived cells: Universal donor for cell therapy 2018
    2018 Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus 2018
    2018 CD38 knockout suppresses tumorigenesis in mice and clonogenic growth of human lung cancer cells 2018
    2017 Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection 2017
    2017 Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal 2017
    2017 CD38 in the pathogenesis of allergic airway disease: Potential therapeutic targets 2017
    2017 Blimp-1-dependent and -independent natural antibody production by B-1 and B-1-derived plasma cells 2017
    2016 T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite 2016
    2016 IgM Memory Cells: First Responders in Malaria 2016
    2015 B lymphocytes are required during the early priming of CD4+ T cells for clearance of pneumocystis infection in mice 2015
    2015 Discovery of potent inhibitors of Schistosoma mansoni NAD+ catabolizing enzyme 2015
    2015 Airway responsiveness in CD38-deficient mice in allergic airway disease: Studies with bone marrow chimeras 2015
    2015 Alzheimer's disease pathology is attenuated in a CD38-deficient mouse model 2015
    2014 Dendritic cells and B cells: Unexpected partners in Th2 development 2014
    2014 Epitope-Specific Regulation of Memory Programming by Differential Duration of Antigen Presentation to Influenza-Specific CD8+ T Cells 2014
    2014 FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability 2014
    2014 B cells mediate chronic allograft rejection independently of antibody production 2014
    2014 Innate IFNγ-producing B cells 2014
    2014 Prolonged antigen presentation by immune complex-binding dendritic cells programs the proliferative capacity of memory CD8 T cells 2014
    2014 The deficiency of Gαq leads to enhanced T-cell survival 2014
    2013 CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell- mediated suppression of CD8+ T cell responses to influenza 2013
    2013 Cluster of differentiation 38 (CD38) mediates bile acid-induced acinar cell injury and pancreatitis through cyclic ADP-ribose and intracellular calcium release 2013
    2013 IL-17-producing B cells combat parasites 2013
    2013 Protein kinase Cβ is required for lupus development in sle mice 2013
    2013 PECAM1+/Sca1+/CD38+ Vascular Cells Transform into Myofibroblast-Like Cells in Skin Wound Repair 2013
    2012 Decreased krev interaction-trapped 1 expression leads to increased vascular permeability and modifies inflammatory responses in vivo 2012
    2012 CD38 deficiency in the tumor microenvironment attenuates glioma progression and modulates features of tumor-associated microglia/macrophages 2012
    2012 Regulation of T H2 development by CXCR5 + dendritic cells and lymphotoxin-expressing B cells 2012
    2012 Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation 2012
    2012 Unraveling effector functions of B cells during infection: The hidden world beyond antibody production 2012
    2011 CD62Lneg CD38+ expression on circulating CD4 + T cells identifies mucosally differentiated cells in protein fed mice and in human celiac disease patients and controls 2011
    2011 Editorial overview 2011
    2011 Regulation of antinucleoprotein IgG by systemic vaccination and its effect on influenza virus clearance 2011
    2011 Contributions of antinucleoprotein IgG to heterosubtypic immunity against influenza virus 2011
    2010 The ecto-enzyme CD38 is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells 2010
    2010 Mouse embryonic fibroblasts from CD38 knockout mice are resistant to oxidative stresses through inhibition of reactive oxygen species production and Ca2+ overload 2010
    2010 Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity 2010
    2010 Erratum: Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenza (Nature Immunology (2010) 11 (216-224)) 2010
    2010 Effector and regulatory B cells: Modulators of CD4+ T cell immunity 2010
    2010 Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+T cell responses to influenza 2010
    2009 Insights into the heterogeneity of human B cells: Diverse functions, roles in autoimmunity, and use as therapeutic targets 2009
    2009 Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides 2009
    2009 CD38 facilitates recovery from traumatic brain injury 2009
    2009 Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide 2009
    2009 Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus 2009
    2008 Cytokine-producing B lymphocytes - key regulators of immunity 2008
    2008 Role of CD38 in TNF-α-induced airway hyperresponsiveness 2008
    2008 B cells promote resistance to heterosubtypic strains of influenza via multiple mechanisms 2008
    2008 Dual role of CD38 in microglial activation and activation-induced cell death 2008
    2007 Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by ADP-ribose, the major product generated by the CD38 enzyme reaction 2007
    2007 Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9 2007
    2007 Identification of an alternative Gαq-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes 2007
    2007 Like niacin deficient rats, CD38-/- mice show improved performance in the water maze 2007
    2007 CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses. 2007
    2007 CD38: An ecto-enzyme at the crossroads of innate and adaptive immune responses 2007
    2007 NAADP as a second messenger: Neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells 2007
    2006 CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge 2006
    2006 Signaling properties of CD38 in the mouse immune system: enzyme-dependent and -independent roles in immunity. 2006
    2006 Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives 2006
    2006 Redesign of Schistosoma mansoni NAD+ catabolizing enzyme: Active site H103W mutation restores ADP-ribosyl cyclase activity 2006
    2006 Persistence and Responsiveness of Immunologic Memory in the Absence of Secondary Lymphoid Organs 2006
    2006 Suppressed insulin signaling and increased apoptosis in Cd38-null islets 2006
    2006 Decreased cADPR and increased NAD+ in the Cd38-/- mouse 2006
    2006 Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection 2006
    2006 CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism 2006
    2006 B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection 2006
    2006 Role of CD38 in airway function 2006
    2006 Uneven distribution of MHC class II epitopes within the influenza virus 2006
    2005 CD8 T cell-mediated lung damage in response to the extracellular pathogen Pneumocystis is dependent on MHC class I expression by radiation-resistant lung cells 2005
    2005 Cutting Edge: The development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor α, and Th2 cells 2005
    2005 ADP-ribosyl cyclase and GDP-ribosyl cyclase activities are not always equivalent: Impact on the study of the physiological role of cyclic ADP-ribose 2005
    2005 CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection 2005
    2005 Systemic dissemination and persistence of Th2 and type 2 cells in response to infection with a strictly enteric nematode parasite 2005
    2005 Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in schistosoma mansoni 2005
    2005 Erratum: Localization of CD38 in murine B lymphocytes to plasma but not intracellular membranes (Molecular Immunology (2005) 42 (703-711)) PII: S0161589004003529 and DOI: 10.1016/j.molimm.2004.09.019 2005
    2005 Regulation of IFN-γ production by B effector 1 cells: Essential roles for T-bet and the IFN-γ receptor 2005
    2005 CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins 2005
    2005 Altered airway responsiveness in CD38-deficient mice 2005
    2005 Localization of CD38 in murine B lymphocytes to plasma but not intracellular membranes 2005
    2005 Regulatory roles for cytokine-producing B cells in infection and autoimmune disease. 2005
    2004 Role of CD38 in myometrial Ca2+ transients: Modulation by progesterone 2004
    2004 Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13 2004
    2004 Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity 2004
    2004 Methodologic advancements in the study of airway smooth muscle 2004
    2004 Structure and enzymology of ADP-ribosyl cyclases: Conserved enzymes that produce multiple calcium mobilizing metabolites 2004
    2004 CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes 2004
    2004 Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: Impact on the development of humoral immunity 2004
    2004 Chemotaxis and Calcium Responses of Phagocytes to Formyl Peptide Receptor Ligands Is Differentially Regulated by Cyclic ADP Ribose 2004
    2003 CD40, but Not CD154, Expression on B Cells is Necessary for Optimal Primary B Cell Responses 2003
    2003 Fluorometric studies of ligand-induced conformational changes of CD38 2003
    2003 Evidence for an Intracellular ADP-ribosyl Cyclase/NAD +-glycohydrolase in Brain from CD38-deficient Mice 2003
    2003 Clearance of Pneumocystis carinii in mice is dependent on B cells but not on P. carinii-specific antibody 2003
    2003 Maintenance of long term γ-herpesvirus B cell latency is dependent on CD40-mediated development of memory B cells 2003
    2003 Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption 2003
    2003 CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain 2003
    2003 Innate immunity is regulated by CD38, an ecto-enzyme with ADP-ribosyl cyclase activity 2003
    2002 Lymphotoxin-α-deficient mice make delayed, but effective, T and B cell responses to influenza 2002
    2002 Does neutrophil CD38 have a role in Ca++ signaling triggered by β2 integrin? [1] (multiple letters) 2002
    2001 Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo 2001
    2000 Reciprocal regulation of polarized cytokine production by effector B and T cells 2000
    1999 CD38 signaling in B lymphocytes is controlled by its ectodomain but occurs independently of enzymatically generated ADP-ribose or cyclic ADP- ribose 1999
    1998 Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses 1998
    1998 CD38: A new paradigm in lymphocyte activation and signal transduction 1998
    1998 Arrest of B lymphocyte terminal differentiation by CD40 signaling: Mechanism for lack of antibody-secreting cells in germinal centers 1998
    1996 Signaling Through CD38 Augments B Cell Antigen Receptor (BCR) Responses and Is Dependent on BCR Expression 1996
    1996 Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells 1996
    1995 CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regulator of CD38 induced signal transduction 1995
    1995 Murine CD38: an immunoregulatory ectoenzyme 1995
    1995 Signaling through murine CD38 is impaired in antigen receptor‐unresponsive B cells 1995
    1993 Murine CD38: An immunoregulatory ectoenzyme 1993
    1993 Expression cloning of a cDNA encoding a novel murine B cell activation marker: Homology to human CD38 1993
    1993 Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38 1993
    1993 Interleukin-5 (IL-5) and IL-6 define two molecularly distinct pathways of B-cell differentiation 1993
    1993 MHC class II limits the functional expression of endogenous superantigens in B cells 1993
    1992 Mouse mammary tumor proviral gene expression in cells of the B lineage 1992
    1992 Major histocompatibility complex-restricted recognition of retroviral superantigens by Vβ17+ T cells 1992
    1991 Regulated expression of mouse mammary tumor proviral genes in cells of the b lineage 1991
    1991 Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci 1991
    1991 Who's zooming who? 1991
    1990 Molecular events in B lymphocyte differentiation. Inducible expression of the endogenous mouse mammary tumor proviral gene, Mtv-9 1990

    Research Overview

  • The overarching research objective of the Lund laboratory is to identify the key players that suppress or exacerbate mucosal inflammatory responses with the long-term goal of developing therapeutics to treat immunopathology associated with chronic infectious, allergic and autoimmune disease. One of the lab’s major projects is to characterize the roles that cytokine-producing “effector” B cells play in modulating inflammation and T cell-mediated immune responses to pathogens, autoantigens and allergens. In a second project, the lab evaluates how inflammatory signals regulate the balance between the development of the antibody-producing long-lived plasma cells and the memory B cell compartment within lymphoid tissues. The lab also studies how these cells are maintained long-term at inflammatory sites. Finally, the lab examines how oxidative stress induced by reactive oxygen species impacts inflammation, immune responses and cellular metabolism. In particular, the lab is experimentally modulating the NAD metabolome of immune cell in order to alter the responsiveness of these cells to oxidative stress.

    • Principal Investigator On

  • Control of B Cell Differentiation by IFNg Induced Transcription Factors  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • Mechanisms of Tissue and Organ Specific Human B Cell Immunity - IOFM Core: Infrastructure and Opportunity Fund Management Core  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • Tissue and Organ Specific Human B Cell Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • Tissue and Organ Specific Human B Cell Immunity - Project 2: Characterization of Virus-Specific Human B Cell Subsets in Lymphoid and Non-Lymphoid Tissues  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • Tissue and Organ Specific Human B Cell Immunity - Core A: Administrative Core  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • Plasma Cells in Health and Disease-Project 2  awarded by Emory University 2016 - 2021
  • Private Grant  awarded by ALTIMMUNE INC 2020 - 2021
  • Characterization of Chemokine Producing Effector B Cells in SLE  awarded by LUPUS RESEARCH ALLIANCE 2018 - 2021
  • Understanding Long-lived Plasma Cell and Memory B cell Programs  awarded by Emory University 2019 - 2020
  • Virus-Induced Cell Fate Decisions in Anti-Viral Immunity - Core B - Viral Stocks and Reagents  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2020
  • Virus-Induced Cell Fate Decisions in Anti-Viral Immunity - Project 3 - Control of Anti-Viral B Cell Responses by IFNy T-bet and Eomes  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2020
  • Private Grant  awarded by Sanofi US Services Inc 2019 - 2020
  • Control of Anti-Viral B Cell Responses by IFNg, T-bet and Eomes  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • Discovery of New Innate Immune Pathways in Viral Recognition  awarded by University of North Carolina at Chapel Hill 2017 - 2019
  • Controlling Th2 Immunity by Tuning CXCL13 Dependent DC Migration in Lymph Nodes  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2019
  • Acquisition of an X-RAD 320 Biological Irradiator for Research in BBRB  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2016 - 2018
  • Arcturus Laser Capture Microdissection for Single Cell Isolation from Tissues  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2015 - 2017
  • The Mechanism Whereby CD38 Deficiency Inhibits Alzheimer's Disease Pathology in a Mouse Model  awarded by United States - Israel Binational Science Foundation 2012 - 2016
  • B Cells in Health and Disease  awarded by Emory University 2012 - 2016
  • Generation and Characterization of Human Cytokine-Producing B Cell Effectors  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2013
  • Private Grant  awarded by F.Hoffmann-La Roche Ltd. 2012 - 2013
  • The Role of CD38 in Neuroinflammation  awarded by United States - Israel Binational Science Foundation 2011 - 2012
  • B Cells in Health and Disease  awarded by University of Rochester 2012

    • Investigator On

    Education And Training

  • Doctor of Philosophy in Microbiological Sciences and Immunology, Duke University 1992
  • Bachelor of Science or Mathematics in Microbiology, University of Notre Dame 1987
  • DNAX Research Institute Immunology, Postdoctoral Fellowship 1997

    • Full Name

  • Frances Lund

    • Fax

  • 205-996-4008