Positions

Selected Publications

Academic Article

Year Title Altmetric
2016 The Notch pathway in colorectal cancer 2016
2015 Notch-1 Promotes Stemness and Epithelial to Mesenchymal Transition in Colorectal Cancer 2015
2014 GSK-3 as potential target for therapeutic irvention in cancer 2014
2014 Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: Opportunities for therapeutic intervention 2014
2014 NOTCH and PTEN in prostate cancer 2014
2012 Developmental pathways in colon cancer: Crosstalk between WNT, BMP, Hedgehog and Notch 2012
2011 Label-free classification of cultured cells through diffraction imaging 2011
2009 Notch-1 signaling is lost in prostate adenocarcinoma and promotes PTEN gene expression 2009
2009 Targeting the leukemic stem cell: The Holy Grail of leukemia therapy 2009
2008 Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia 2008
2008 HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia 2008
2008 Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy 2008
2007 Chromosomal analysis and identification based on optical tweezers and Raman spectroscopy: Reply 2007
2007 CBF-1 (RBP-Jκ) binds to the PTEN promoter and regulates PTEN gene expression 2007
2006 The MLL partial tandem duplication in acute myeloid leukaemia 2006
2006 Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance 2006
2006 Chromosomal analysis and identification based on optical tweezers and Raman spectroscopy 2006
2006 Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells 2006
2005 The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: What's genetics got to do with it? 2005
2005 Acquired immunodeficiency syndrome associated lymphoma 2005
2005 Activated EGFR promotes the survival of B-lineage acute leukemia in the absence of stromal cells 2005
2005 Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines 2005
2005 Effects of endogenous epidermal growth factor receptor signaling on DNA synthesis and ERK activation in a cytokine-dependent hematopoietic cell line 2005
2005 Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active notch-1 2005
2005 Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support 2005
2005 Upping the bid on engineered inducible cell death 2005
2004 The complexity of PTEN: Mutation, marker and potential target for therapeutic intervention 2004
2004 JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis 2004
2003 B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression 2003
2003 Treatment by design in leukemia, a meeting report, Philadelphia, Pennsylvania, December 2002 2003
2002 Microarray analysis of a t(4;11)q(21;23) cell line with B-lineage developmental potential reveals a distinct pattern of Hox gene 2002
2001 Pro-B-cell to pre-B-cell development in B-lineage acute lymphoblastic leukemia expressing the MLL/AF4 fusion protein 2001
2001 VH gene replacement in thymocytes 2001
2000 De novo IgH gene segment rearrangement leads to functional pre-BCR expression in a novel B-lineage all cell like expressing MLL/AF4. 2000
2000 Endogenous Notch-1 cleavage in human B-lineage cells. 2000
2000 Microenvironmental influences on human B-cell development 2000
2000 Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells 2000
1999 Notch expression and signaling in normal and leukemic human B-lineage cells. 1999
1999 IgM heavy chain complementarity-determining region 3 diversity is constrained by genetic and somatic mechanisms until two months after birth 1999
1999 Analysis of notch during human B-lineage development. 1999
1999 The expression of long HCDR3 intervals is constrained by both genetic and somatic mechanisms during human B-cell ontogeny 1999
1998 V(H) gene replacement occurs in the spleen and bone marrow of non-autoimmune quasi-monoclonal mice 1998
1998 Sequence analysis of the mouse RAG locus intergenic region 1998
1998 Sequence of the Rag1 and Rag2 intergenic region in zebrafish (Danio rerio) 1998
1998 Molecular mechanisms involved in receptor editing at the Ig heavy chain locus 1998
1997 Ig D(H) gene segment transcription and rearrangement before surface expression of the pan-B-cell marker CD19 in normal human bone marrow 1997
1996 Transcriptional regulation of the recombinase activating genes in murine pre-b cells 1996
1996 The J chain gene is transcribed during B and T lymphopoiesis in humans 1996
1995 Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors 1995
1995 ACTIVATION AND REGULATION OF HUMAN DJC-MU-GENE SEGMENT REARRANGEMENT PRIOR TO SURFACE EXPRESSION OF THE B-CELL MARKER-CD19 1995
1995 DJC-MU REARRANGEMENTS ARE PRESENT BUT NOT TRANSCRIBED IN HUMAN THYMOCYTES 1995
1995 J-CHAIN EXPRESSION DURING NORMAL HUMAN B-LINEAGE DEVELOPMENT 1995
1995 Analysis of DHQ52 Gene Segment Transcription and Rearrangement During B‐Cell Development in Human Fetal Bone Marrow 1995
1995 Developmental Regulation of the Human Antibody Repertoire 1995
1994 REGULATION OF EARLY HUMAN B-LYMPHOCYTE DIFFERENTIATION BY INTERLEUKIN-7 1994
1994 EARLY ACTIVATION OF THE DHQ52 PROMOTER DURING HUMAN B-CELL ONTOGENY 1994
1993 DEVELOPMENTAL REGULATION OF IMMUNOGLOBULIN DH AND JH GENE SEGMENT EXPRESSION IN MAN 1993
1993 TRANSGENIC EXPRESSION OF HUMAN TERMINAL DEOXYNUCLEOTIDYL-TRANSFERASE IN MOUSE THYMUS 1993
1993 DEVELOPMENTAL REGULATION OF DH AND JH GENE SEGMENT REARRANGEMENT IN MAN 1993
1992 ANALYSIS OF IMMUNOGLOBULIN DJ TRANSCRIPTS FROM BONE-MARROW AND FETAL LIVER INDICATES DEVELOPMENTAL REGULATION OF DH AND J(H) GENE SEGMENT REARRANGEMENT 1992

Chapter

Year Title Altmetric
2007 Critical roles of the Raf/MEK/ERK pathway in apoptosis and drug resistance.  101-134. 2007

Teaching Activities

  • HRP200 - Responsible Conduct Research (Fall Term 2019) 2019
  • HRP401 - Honors Seminar I (Fall Term 2019) 2019
  • HRP405 - Team-Based Prob Solving in HP (Fall Term 2019) 2019
  • HRP411 - Honors Community Service Proj (Fall Term 2019) 2019
  • HRP411 - Honors Community Service Proj (Fall Term 2019) 2019
  • HRP415 - Mentored Res in the Hlth Profs (Fall Term 2019) 2019
  • HRP200 - Responsible Conduct Research (Summer Term 2019) 2019
  • HRP411 - Honors Community Service Proj (Summer Term 2019) 2019
  • HRP415 - Mentored Res in the Hlth Profs (Summer Term 2019) 2019
  • HRP475 - Special Tops in HS or Clin Res (Summer Term 2019) 2019
  • HRP200 - Responsible Conduct Research (Spring Term 2019) 2019
  • HRP402 - Honors Seminar II (Spring Term 2019) 2019
  • HRP411 - Honors Community Service Proj (Spring Term 2019) 2019
  • HRP415 - Mentored Res in the Hlth Profs (Spring Term 2019) 2019
  • BMD430 - Clin Immunology for HP (Fall Term 2018) 2018
  • BMD430 - Clin Immunology for HP (Fall Term 2018) 2018
  • HRP200 - Responsible Conduct Research (Fall Term 2018) 2018
  • HRP401 - Honors Seminar I (Fall Term 2018) 2018
  • HRP405 - Team-Based Prob Solving in HP (Fall Term 2018) 2018
  • HRP411 - Honors Community Service Proj (Fall Term 2018) 2018
  • HRP415 - Mentored Res in the Hlth Profs (Fall Term 2018) 2018
  • HRP475 - Special Tops in HS or Clin Res (Fall Term 2018) 2018
  • HRP415 - Mentored Res in the Hlth Profs (Summer Term 2018) 2018
  • HRP200 - Responsible Conduct Research (Summer Term 2018) 2018
  • HRP411 - Honors Community Service Proj (Summer Term 2018) 2018
  • HRP475 - Special Tops in HS or Clin Res (Summer Term 2018) 2018
  • BMD330 - Clin Microbiology for HP (Spring Term 2018) 2018
  • BMD330 - Clin Microbiology for HP (Spring Term 2018) 2018
  • HRP200 - Responsible Conduct Research (Spring Term 2018) 2018
  • HRP402 - Honors Seminar II (Spring Term 2018) 2018
  • HRP410 - Honors Research Project (Spring Term 2018) 2018
  • HRP411 - Honors Community Service Proj (Spring Term 2018) 2018
  • HRP415 - Mentored Res in the Hlth Profs (Spring Term 2018) 2018
  • HRP475 - Special Tops in HS or Clin Res (Spring Term 2018) 2018
  • BMD320 - Surv of Cell Biology for HP (Fall Term 2017) 2017
  • BMD320 - Surv of Cell Biology for HP (Fall Term 2017) 2017
  • HRP200 - Responsible Conduct Research (Fall Term 2017) 2017
  • HRP401 - Honors Seminar I (Fall Term 2017) 2017
  • HRP405 - Team-Based Prob Solving in HP (Fall Term 2017) 2017
  • HRP411 - Honors Community Service Proj (Fall Term 2017) 2017
  • HRP415 - Mentored Res in the Hlth Profs (Fall Term 2017) 2017
  • BMD497 - Dir BMD Research Studies (Summer Term 2017) 2017
  • BMD330 - Clin Microbiology for HP (Spring Term 2017) 2017
  • BMD330 - Clin Microbiology for HP (Spring Term 2017) 2017
  • BMD497 - Dir BMD Research Studies (Spring Term 2017) 2017
  • BMD320 - Surv of Cell Biology for HP (Fall Term 2016) 2016
  • BMD320 - Surv of Cell Biology for HP (Fall Term 2016) 2016
  • BMD497 - Dir BMD Research Studies (Fall Term 2016) 2016
  • BMD497 - Dir BMD Research Studies (Fall Term 2016) 2016
  • BMD497 - Dir BMD Research Studies (Summer Term 2016) 2016
  • BMD202 - Surv of BioMed Sciences Lit (Spring Term 2016) 2016
  • BMD202 - Surv of BioMed Sciences Lit (Spring Term 2016) 2016
  • BMD330 - Clin Microbiology for HP (Spring Term 2016) 2016
  • HRP410 - Honors Project (Spring Term 2016) 2016
  • BMD320 - Surv of Cell Biology for HP (Fall Term 2015) 2015
  • BMD430 - Clin Immunology for HP (Fall Term 2015) 2015
  • CLS518 - Immunology (Fall Term 2015) 2015
  • MT418 - Immunology (Fall Term 2015) 2015
  • BMD497 - Dir BMD Research Studies (Summer Term 2015) 2015
  • BMD330 - Clin Microbiology for HP (Spring Term 2015) 2015
  • BMD320 - Surv of Cell Biology for HP (Fall Term 2014) 2014
  • CLS518 - Immunology (Fall Term 2014) 2014
  • MT418 - Immunology (Fall Term 2014) 2014
  • Full Name

  • Fred Bertrand