Selected Publications

Academic Article

Year Title Altmetric
2022 Developing 3D Organoid Raft Cultures from Patient-Derived Xenografts as Rapid Models to Screen Efficacy of Experimental TherapeuticsInternational Journal of Molecular Sciences.  23. 2022
2022 A signature of Prevotella copri and Faecalibacterium prausnitzii depletion, and a link with bacterial glutamate degradation in the Kenyan colorectal cancer patientsJournal of Gastrointestinal Oncology.  13:2282-2292. 2022
2022 DCZ0415, a small-molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β-catenin pathway in colorectal cancerMolecular Oncology.  16:1728-1745. 2022
2020 Autocrine/paracrine actions of growth hormone in human melanoma cell linesBiochemistry and Biophysics Reports.  21. 2020
2018 Editorial 2018
2018 Tea polyphenols for the prevention of UVB-induced skin cancer 2018
2017 Phytochemicals for the Prevention of PhotocarcinogenesisPhotochemistry and Photobiology.  93:956-974. 2017
2017 Potential therapeutic targets of epithelial–mesenchymal transition in melanomaCancer Letters.  391:125-140. 2017
2017 Pomegranate for prevention and treatment of cancer: An updateMolecules.  22. 2017
2016 ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosisMolecular cell biology research communications : MCBRC.  609:39-50. 2016
2016 Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototypeScientific Reports.  6. 2016
2016 Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel AntidotesAmerican Journal of Pathology.  186:2637-2649. 2016
2016 Phytochemicals for the management of melanomaMini-Reviews in Medicinal Chemistry.  16:953-979. 2016
2016 Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanomaOncotarget.  7:1227-1241. 2016
2015 Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasisSkin Pharmacology and Physiology.  28:177-188. 2015
2015 Targeting drivers of melanoma with synthetic small molecules and phytochemicalsCancer Letters.  359:20-35. 2015
2015 Topical application of delphinidin reduces psoriasiform lesions in the flaky skin mouse model by inducing epidermal differentiation and inhibiting inflammationBritish Journal of Dermatology.  172:354-364. 2015
2015 Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFκB signaling pathways in SKH-1 hairless micePhotochemistry and Photobiology.  91:225-234. 2015
2015 Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cellsOncotarget.  6:28296-28311. 2015
2014 Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating NotchBiochemical and Biophysical Research Communications.  451:394-401. 2014
2014 Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathwayCancer Prevention Research.  7:186-198. 2014
2014 Fisetin inhibits human melanoma cell invasion through promotion of mesenchymal to epithelial transition and by targeting MAPK and NFκB signaling pathwaysPLoS One.  9. 2014
2013 Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by Targeting Akt-ERK axisPLoS One.  8. 2013
2013 Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruptionToxicology and Applied Pharmacology.  272:879-887. 2013
2013 Delphinidin Reduces Cell Proliferation and Induces Apoptosis of Non-Small-Cell Lung Cancer Cells by Targeting EGFR/VEGFR2 Signaling PathwaysPLoS One.  8. 2013
2013 Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related proteinBiochemical and Biophysical Research Communications.  438:607-612. 2013
2013 Chlorine induces the unfolded protein response in murine lungs and skinAmerican Journal of Respiratory Cell and Molecular Biology.  49:197-203. 2013
2013 Fisetin inhibits growth, induces G2/M arrest and apoptosis of human epidermoid carcinoma A431 cells: Role of mitochondrial membrane potential disruption and consequent caspases activationExperimental Dermatology.  22:470-475. 2013
2013 Delphinidin, a dietary antioxidant, induces human epidermal keratinocyte differentiation but not apoptosis: Studies in submerged and three-dimensional epidermal equivalent modelsExperimental Dermatology.  22:342-348. 2013
2012 Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytesPhotochemistry and Photobiology.  88:1184-1190. 2012
2012 Pomegranate fruit extract inhibits UVB-induced inflammation and proliferation by modulating NF-κB and MAPK signaling pathways in mouse skinPhotochemistry and Photobiology.  88:1126-1134. 2012
2012 Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCsBiochemical and Biophysical Research Communications.  425:177-181. 2012
2012 Butein induces apoptosis and inhibits prostate tumor growth in Vitro and in VivoAntioxidants and Redox Signaling.  16:1195-1204. 2012
2012 Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetinInternational Journal of Cancer.  130:1695-1705. 2012
2011 Natural agents: Cellular and molecular mechanisms of photoprotectionMolecular cell biology research communications : MCBRC.  508:144-151. 2011
2011 Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased mitf levelsJournal of Investigative Dermatology.  131:1291-1299. 2011
2011 Polyphenols: Skin photoprotection and inhibition of photocarcinogenesisMini-Reviews in Medicinal Chemistry.  11:1200-1215. 2011
2010 Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermisPhotochemistry and Photobiology.  86:1318-1326. 2010
2010 Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cellsCarcinogenesis.  31:1424-1433. 2010
2010 In vitro and in vivo effects of water extract of white cocoa tea (Camellia ptilophylla) against human prostate cancerPharmaceutical Research.  27:1128-1137. 2010
2010 Lifestyle as risk factor for cancer: Evidence from human studiesCancer Letters.  293:133-143. 2010
2009 Aryl hydrocarbon receptor is an ozone sensor in human skinJournal of Investigative Dermatology.  129:2396-2403. 2009
2009 Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skinExperimental Dermatology.  18:553-561. 2009
2009 Delphinidin, an anthocyanidin in pigmented fruits and vegetables, induces apoptosis and cell cycle arrest in human colon cancer HCT116 cellsMolecular Carcinogenesis.  48:260-270. 2009
2009 A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-κB-signaling pathwaysCarcinogenesis.  30:300-307. 2009
2008 A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: Involvement of nuclear factor-κB signalingCancer Research.  68:8564-8572. 2008
2008 A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude miceCancer Research.  68:8555-8563. 2008
2008 Guggulsterone modulates MAPK and NF-κB pathways and inhibits skin tumorigenesis in SENCAR miceCarcinogenesis.  29:2011-2018. 2008
2008 Inhibition of epidermal growth factor receptor signaling pathway by delphinidin, an anthocyanidin in pigmented fruits and vegetablesInternational Journal of Cancer.  123:1508-1515. 2008
2008 Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylationToxicology and Applied Pharmacology.  231:52-60. 2008
2008 Dietary agents for chemoprevention of prostate cancerCancer Letters.  265:167-176. 2008
2008 Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cellsCarcinogenesis.  29:1049-1056. 2008
2008 Cancer chemoprevention through dietary antioxidants: Progress and promiseAntioxidants and Redox Signaling.  10:475-510. 2008
2008 Phytochemicals for prevention of solar ultraviolet radiation-induced damagesPhotochemistry and Photobiology.  84:489-500. 2008
2008 Prevention of prostate cancer through custom tailoring of chemopreventive regimenChemico-Biological Interactions.  171:122-132. 2008
2008 Cannabinoids for cancer treatment: Progress and promiseCancer Research.  68:339-342. 2008
2007 Chemoprevention of prostate cancer through dietary agents: Progress and promiseCancer Epidemiology, Biomarkers and Prevention.  16:2193-2203. 2007
2007 Pomegranate derived products for cancer chemopreventionSeminars in Cancer Biology.  17:377-385. 2007
2007 Inhibition of UVB-mediated oxidative stress and markers of photoaging in immortalized HaCaT keratinocytes by pomegranate polyphenol extract POMxPhotochemistry and Photobiology.  83:882-888. 2007
2007 Protective effect of sanguinarine on ultraviolet B-mediated damages in SKH-1 hairless mouse skin: Implications for prevention of skin cancerPhotochemistry and Photobiology.  83:986-993. 2007
2007 A novel antioxidant 3-O-Caffeoyl-1-methylquinic acid enhances ultraviolet A-mediated apoptosis in immortalized HaCaT keratinocytes via Sp1-dependent transcriptional activation of p21WAF1/Cip1Oncogene.  26:3559-3571. 2007
2007 Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in miceCancer Research.  67:3475-3482. 2007
2007 Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivoClinical Cancer Research.  13:1611-1619. 2007
2007 Apoptosis by dietary factors: The suicide solution for delaying cancer growthCarcinogenesis.  28:233-239. 2007
2007 Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-κB activation in normal human bronchial epithelial cellsOncogene.  26:673-682. 2007
2007 Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosisJournal of Investigative Dermatology.  127:222-232. 2007
2007 Fishing for allergens hiding as prohaptensJournal of Investigative Dermatology.  127:992-993. 2007
2007 Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude miceCarcinogenesis.  28:163-173. 2007
2006 Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G 1 cell cycle arrestJournal of Biological Chemistry.  281:39480-39491. 2006
2006 Insulin-like growth factor-I axis as a pathway for cancer chemopreventionClinical Cancer Research.  12:5611-5614. 2006
2006 Botanical antioxidants in the prevention of photocarcinogenesis and photoagingExperimental Dermatology.  15:678-684. 2006
2006 Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytesPhotochemistry and Photobiology.  82:398-405. 2006
2006 Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallateCancer Research.  66:2500-2505. 2006
2005 Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathwayCarcinogenesis.  26:1956-1964. 2005
2005 Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer 2005
2005 Photochemoprevention of ultraviolet B signaling and photocarcinogenesisMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  571:153-173. 2005
2005 Cannabinoid receptor as a novel target for the treatment of prostate cancerCancer Research.  65:1635-1641. 2005
2005 Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-κB pathways and inhibits skin tumorigenesis in CD-1 miceInternational Journal of Cancer.  113:423-433. 2005
2005 Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytesPhotochemistry and Photobiology.  81:38-45. 2005
2005 Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivinPhotochemistry and Photobiology.  81:25-31. 2005
2004 Modulation of phosphatidylinositol-3-kinase/protein kinase B- and mitogen-activated protein kinase-pathways by tea polyphenols in human prostate cancer cellsJournal of Cellular Biochemistry.  91:232-242. 2004
2004 Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 miceOncogene.  23:5203-5214. 2004
2004 Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skinOncogene.  23:5151-5160. 2004
2004 Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappaB and induction of apoptosisOncogene.  23:2507-2522. 2004
2004 Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrinToxicology and Applied Pharmacology.  195:361-369. 2004
2004 Antioxidants of the Beverage Tea in Promotion of Human HealthAntioxidants and Redox Signaling.  6:571-582. 2004
2003 Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kappa B by green tea polyphenol in SKH-1 hairless miceOncogene.  22:9254-9264. 2003
2003 Inhibition of ultraviolet B-mediated activation of nuclear factor κB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallateOncogene.  22:1035-1044. 2003
2003 Photochemoprevention of skin cancer by botanical agents 2003
2003 Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless miceToxicology and Applied Pharmacology.  186:28-37. 2003
2003 Suppression of ultraviolet B exposure-mediated activation of NF-κB in normal human keratinocytes by resveratrolNeoplasia.  5:74-82. 2003
2002 Photochemoprevention by botanical antioxidantsSkin Pharmacology and Physiology.  15:297-306. 2002
2002 Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cellsOncogene.  21:3727-3738. 2002
2002 Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells.Oncogene.  21:3727-3738. 2002
2002 Botanical antioxidants for chemoprevention of photocarcinogenesis.Frontiers in Bioscience-Landmark.  7. 2002
2001 Involvement of the retinoblastoma (pRb) - E2F/DP pathway during antiproliferative effects of resveratrol in human epidermoid carcinoma (A431) cellsBiochemical and Biophysical Research Communications.  288:579-585. 2001
2001 Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol ( - )-epigallocatechin-3-gallateToxicology and Applied Pharmacology.  176:110-117. 2001
2001 Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cellsBiochemical and Biophysical Research Communications.  287:914-920. 2001
2001 Effects of solar radiation on cutaneous detoxification pathways 2001
2001 Resveratrol causes WAF-1/p21-mediated G1-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cellsClinical Cancer Research.  7:1466-1473. 2001
2001 Chapter 22 Effects of solar radiation on detoxification mechanisms in the skinComprehensive Series in Photosciences.  3:419-436. 2001
2001 Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stressCarcinogenesis.  22:287-294. 2001
2000 N-acetyl L-cysteine attenuates oxidant-mediated toxicity induced by chrysotile fibersToxicology Letters.  117:53-60. 2000
1999 Chrysotile-mediated imbalance in the glutathione redox system in the development of pulmonary injuryToxicology Letters.  106:31-39. 1999
1999 Glutathione redox system in oxidative lung injuryCritical Reviews in Toxicology.  29:543-568. 1999
1998 Activation of alveolar macrophages and peripheral red blood cells in rats exposed to fibers/particlesToxicology Letters.  99:175-182. 1998
1998 Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxideJournal of Applied Toxicology.  18:307-312. 1998
1998 Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxide.Journal of Applied Toxicology.  18:307-312. 1998
1995 Influence of hexachlorocyclohexane on phosphoinositides in rat erythrocyte membranes and brainToxicology.  95:135-140. 1995


Year Title Altmetric
2016 Fisetin and its role in chronic diseases.  213-244. 2016
2012 Dietary phytochemicals and chemoprevention of solar ultraviolet radiation-induced skin cancer.  295-321. 2012
2011 Botanical antioxidants for skin protection: An overview.  51-63. 2011
2009 Botanical Antioxidants for Protection Against Damage from Sunlight.  161-183. 2009
2009 Botanical Antioxidants for Protection Against Damage from Sunlight.  161-183. 2009
2008 Dietary phytochemicals in the chemoprevention of prostate cancer.  221-244. 2008
2006 Vitamins and polyphenols in systemic photoprotection.  113-121. 2006
2006 Molecular mechanisms of chemoprevention of cancer by pomegranate.  117-131. 2006

Full Name

  • Farrukh Afaq