Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Potential therapeutic targets of epithelial–mesenchymal transition in melanomaCancer Letters.  391:125-140. 2017
2017 Pomegranate for prevention and treatment of cancer: An updateMolecules.  22. 2017
2016 ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosisArchives of Biochemistry and Biophysics.  609:39-50. 2016
2016 Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel AntidotesAmerican Journal of Pathology.  186:2637-2649. 2016
2016 Phytochemicals for the management of melanomaMini-Reviews in Medicinal Chemistry.  16:953-979. 2016
2015 Topical application of delphinidin reduces psoriasiform lesions in the flaky skin mouse model by inducing epidermal differentiation and inhibiting inflammationBritish Journal of Dermatology.  172:354-364. 2015
2015 Targeting drivers of melanoma with synthetic small molecules and phytochemicalsCancer Letters.  359:20-35. 2015
2014 Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating NotchBiochemical and Biophysical Research Communications.  451:394-401. 2014
2014 Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathwayCancer Prevention Research.  7:186-198. 2014
2013 Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related proteinBiochemical and Biophysical Research Communications.  438:607-612. 2013
2013 Chlorine induces the unfolded protein response in murine lungs and skinAmerican Journal of Respiratory Cell and Molecular Biology.  49:197-203. 2013
2013 Fisetin inhibits growth, induces G2/M arrest and apoptosis of human epidermoid carcinoma A431 cells: Role of mitochondrial membrane potential disruption and consequent caspases activationExperimental Dermatology.  22:470-475. 2013
2013 Delphinidin, a dietary antioxidant, induces human epidermal keratinocyte differentiation but not apoptosis: Studies in submerged and three-dimensional epidermal equivalent modelsExperimental Dermatology.  22:342-348. 2013
2012 Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCsBiochemical and Biophysical Research Communications.  425:177-181. 2012
2012 Butein induces apoptosis and inhibits prostate tumor growth in Vitro and in VivoAntioxidants and Redox Signaling.  16:1195-1204. 2012
2012 Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetinInternational Journal of Cancer.  130:1695-1705. 2012
2011 Polyphenols: Skin photoprotection and inhibition of photocarcinogenesisMini-Reviews in Medicinal Chemistry.  11:1200-1215. 2011
2011 Natural agents: Cellular and molecular mechanisms of photoprotectionArchives of Biochemistry and Biophysics.  508:144-151. 2011
2011 Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased mitf levelsJournal of Investigative Dermatology.  131:1291-1299. 2011
2010 Lifestyle as risk factor for cancer: Evidence from human studiesCancer Letters.  293:133-143. 2010
2010 Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cellsCarcinogenesis.  31:1424-1433. 2010
2009 Aryl hydrocarbon receptor is an ozone sensor in human skinJournal of Investigative Dermatology.  129:2396-2403. 2009
2009 Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skinExperimental Dermatology.  18:553-561. 2009
2009 Delphinidin, an anthocyanidin in pigmented fruits and vegetables, induces apoptosis and cell cycle arrest in human colon cancer HCT116 cellsMolecular Carcinogenesis.  48:260-270. 2009
2009 A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-κB-signaling pathwaysCarcinogenesis.  30:300-307. 2009
2008 A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: Involvement of nuclear factor-κB signalingCancer Research.  68:8564-8572. 2008
2008 A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude miceCancer Research.  68:8555-8563. 2008
2008 Guggulsterone modulates MAPK and NF-κB pathways and inhibits skin tumorigenesis in SENCAR miceCarcinogenesis.  29:2011-2018. 2008
2008 Inhibition of epidermal growth factor receptor signaling pathway by delphinidin, an anthocyanidin in pigmented fruits and vegetablesInternational Journal of Cancer.  123:1508-1515. 2008
2008 Dietary agents for chemoprevention of prostate cancerCancer Letters.  265:167-176. 2008
2008 Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cellsCarcinogenesis.  29:1049-1056. 2008
2008 Cancer chemoprevention through dietary antioxidants: Progress and promiseAntioxidants and Redox Signaling.  10:475-510. 2008
2008 Prevention of prostate cancer through custom tailoring of chemopreventive regimenChemico-Biological Interactions.  171:122-132. 2008
2008 Cannabinoids for cancer treatment: Progress and promiseCancer Research.  68:339-342. 2008
2007 Chemoprevention of prostate cancer through dietary agents: Progress and promiseCancer Epidemiology, Biomarkers and Prevention.  16:2193-2203. 2007
2007 Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in miceCancer Research.  67:3475-3482. 2007
2007 Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivoClinical Cancer Research.  13:1611-1619. 2007
2007 Apoptosis by dietary factors: The suicide solution for delaying cancer growthCarcinogenesis.  28:233-239. 2007
2007 Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosisJournal of Investigative Dermatology.  127:222-232. 2007
2007 Fishing for allergens hiding as prohaptensJournal of Investigative Dermatology.  127:992-993. 2007
2007 Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude miceCarcinogenesis.  28:163-173. 2007
2006 Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G 1 cell cycle arrestJournal of Biological Chemistry.  281:39480-39491. 2006
2006 Insulin-like growth factor-I axis as a pathway for cancer chemopreventionClinical Cancer Research.  12:5611-5614. 2006
2006 Botanical antioxidants in the prevention of photocarcinogenesis and photoagingExperimental Dermatology.  15:678-684. 2006
2006 Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallateCancer Research.  66:2500-2505. 2006
2005 Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathwayCarcinogenesis.  26:1956-1964. 2005
2005 Photochemoprevention of ultraviolet B signaling and photocarcinogenesisMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  571:153-173. 2005
2005 Cannabinoid receptor as a novel target for the treatment of prostate cancerCancer Research.  65:1635-1641. 2005
2005 Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-κB pathways and inhibits skin tumorigenesis in CD-1 miceInternational Journal of Cancer.  113:423-433. 2005
2004 Modulation of phosphatidylinositol-3-kinase/protein kinase B- and mitogen-activated protein kinase-pathways by tea polyphenols in human prostate cancer cellsJournal of Cellular Biochemistry.  91:232-242. 2004
2004 Antioxidants of the Beverage Tea in Promotion of Human HealthAntioxidants and Redox Signaling.  6:571-582. 2004
2003 Suppression of ultraviolet B exposure-mediated activation of NF-κB in normal human keratinocytes by resveratrolNeoplasia : An International Journal for Oncology Research.  5:74-82. 2003
2002 Botanical antioxidants for chemoprevention of photocarcinogenesis.Frontiers in Bioscience.  7. 2002
2001 Involvement of the retinoblastoma (pRb) - E2F/DP pathway during antiproliferative effects of resveratrol in human epidermoid carcinoma (A431) cellsBiochemical and Biophysical Research Communications.  288:579-585. 2001
2001 Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cellsBiochemical and Biophysical Research Communications.  287:914-920. 2001
2001 Effects of solar radiation on cutaneous detoxification pathwaysJournal of Photochemistry and Photobiology B: Biology.  63:61-69. 2001
2001 Resveratrol causes WAF-1/p21-mediated G1-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cellsClinical Cancer Research.  7:1466-1473. 2001
2001 Chapter 22 Effects of solar radiation on detoxification mechanisms in the skinComprehensive Series in Photosciences.  3:419-436. 2001
2001 Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stressCarcinogenesis.  22:287-294. 2001
1999 Glutathione redox system in oxidative lung injuryCritical Reviews in Toxicology.  29:543-568. 1999
1998 Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxideJournal of Applied Toxicology.  18:307-312. 1998
1998 Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxide.Journal of Applied Toxicology.  18:307-312. 1998

Chapter

Year Title Altmetric
2016 Fisetin and its role in chronic diseases.  213-244. 2016
2012 Dietary phytochemicals and chemoprevention of solar ultraviolet radiation-induced skin cancer.  295-321. 2012
2011 Botanical antioxidants for skin protection: An overview.  51-63. 2011
2009 Botanical Antioxidants for Protection Against Damage from Sunlight.  161-183. 2009
2008 Dietary phytochemicals in the chemoprevention of prostate cancer.  221-244. 2008
2006 Vitamins and polyphenols in systemic photoprotection.  113-121. 2006
2006 Molecular mechanisms of chemoprevention of cancer by pomegranate.  117-131. 2006

Education And Training

  • Doctorate in Biochemistry, 1998
  • Master of Science in Biochemistry, Aligarh Muslim University 1991
  • Bachelor of Science or Mathematics in Biology, Aligarh Muslim University 1989
  • Full Name

  • Farrukh Afaq
  • Blazerid

  • fafaq