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Erin Eun-Young Ahn
Associate Professor
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E-mail
eyahn@uab.edu
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Erin Eun-Young Ahn
Associate Professor
Positions
Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
2020 -
Associate Professor (P)
,
Molecular & Cellular Pathology
,
Joint Pathology
2020 -
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2021
Focal Adhesion Kinase Activity and Localization is Critical for TNF-α-Induced Nuclear Factor-κB Activation
.
Inflammation
.
2021
2020
Targeting focal adhesion kinase in cancer cells and the tumor microenvironment
2020
2020
SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia
.
Cancer Gene Therapy
.
2020
2019
FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation
.
Scientific Reports
. 9.
2019
2019
Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells.
.
Journal of Biological Chemistry
. 294:11213-11224.
2019
2019
SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypes.
.
Kidney International
. 95:1494-1504.
2019
2019
FAK inhibition reduces metastasis of α4 integrin-expressing melanoma to lymph nodes by targeting lymphatic VCAM-1 expression.
.
Biochemical and Biophysical Research Communications
. 509:1034-1040.
2019
2019
Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.
.
Journal of Medicinal Chemistry
. 62:987-992.
2019
2019
Nuclear focal adhesion kinase controls vascular smooth muscle cell proliferation and neointimal hyperplasia through GATA4-mediated cyclin D1 transcription
.
Circulation Research
. 125:152-166.
2019
2018
Irradiation of pediatric glioblastoma cells promotes radioresistance and enhances glioma malignancy via genome-wide transcriptome changes.
.
Oncotarget
. 9:34122-34131.
2018
2018
DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity.
.
Oncotarget
. 9:31719-31743.
2018
2018
Identification of radiation responsive genes and transcriptome profiling via complete RNA sequencing in a stable radioresistant U87 glioblastoma model.
.
Oncotarget
. 9:23532-23542.
2018
2016
miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20.
.
Oncotarget
. 7:78667-78679.
2016
2016
De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome
.
American Journal of Human Genetics
. 99:711-719.
2016
2016
SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes
.
Molecular Cell
. 61:859-873.
2016
2015
ErbB2-intronic microRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling.
.
Cell Death and Disease
. 6:e1742.
2015
2014
Transcript variants of RUNX1T1: new insight into t(8;21)-positive leukemia.
.
Leukemia Research
. 38:1018-1019.
2014
2014
New discoveries of old SON: a link between RNA splicing and cancer.
.
Journal of Cellular Biochemistry
. 115:224-231.
2014
2013
Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.
.
Blood
. 121:3714-3717.
2013
2013
Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7).
.
Journal of Biological Chemistry
. 288:9165-9176.
2013
2013
SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster.
.
Journal of Biological Chemistry
. 288:5381-5388.
2013
2012
Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.
.
Blood
. 120:1473-1484.
2012
2012
Negative effects of GM-CSF signaling in a murine model of t(8;21)–induced leukemia
.
Blood
. 119:3155-3163.
2012
2011
SON Controls Cell-Cycle Progression by Coordinated Regulation of RNA Splicing
.
Molecular Cell
. 42:185-198.
2011
2009
Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: Role of calmodulin
.
Clinical Cancer Research
. 15:1288-1296.
2009
2009
RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis
.
Blood
. 113:883-886.
2009
2008
Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis
2008
Research
Principal Investigator On
SON-Mediated RNA Splicing in Glioblastoma
awarded by
National Cancer Institute/NIH/DHHS
2020 - 2025
SON-Mediated Gene Expression and Leukemia
awarded by
National Cancer Institute/NIH/DHHS
2020 - 2022
Background
Education And Training
Doctor of Philosophy in Medical Pathology,
University of Alabama at Birmingham
2003
Master's Level Degree in Medical Basic Sciences/Other,
Seoul National University
1998
Contact
Full Name
Erin Eun-Young
Ahn