Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Targeting focal adhesion kinase in cancer cells and the tumor microenvironment 2020
2019 FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammationScientific Reports.  9. 2019
2019 Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells.Journal of Biological Chemistry.  294:11213-11224. 2019
2019 SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypes.Kidney International.  95:1494-1504. 2019
2019 FAK inhibition reduces metastasis of α4 integrin-expressing melanoma to lymph nodes by targeting lymphatic VCAM-1 expression.Biochemical and Biophysical Research Communications.  509:1034-1040. 2019
2019 Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.Journal of Medicinal Chemistry.  62:987-992. 2019
2019 Nuclear focal adhesion kinase controls vascular smooth muscle cell proliferation and neointimal hyperplasia through GATA4-mediated cyclin D1 transcriptionCirculation Research.  125:152-166. 2019
2018 Irradiation of pediatric glioblastoma cells promotes radioresistance and enhances glioma malignancy via genome-wide transcriptome changes.Oncotarget.  9:34122-34131. 2018
2018 DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity.Oncotarget.  9:31719-31743. 2018
2018 Identification of radiation responsive genes and transcriptome profiling via complete RNA sequencing in a stable radioresistant U87 glioblastoma model.Oncotarget.  9:23532-23542. 2018
2016 miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20.Oncotarget.  7:78667-78679. 2016
2016 De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability SyndromeAmerican Journal of Human Genetics.  99:711-719. 2016
2016 SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated GenesMolecular Cell.  61:859-873. 2016
2015 ErbB2-intronic microRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling.Cell Death and Disease.  6:e1742. 2015
2014 Transcript variants of RUNX1T1: new insight into t(8;21)-positive leukemia.Leukemia Research.  38:1018-1019. 2014
2014 New discoveries of old SON: a link between RNA splicing and cancer.Journal of Cellular Biochemistry.  115:224-231. 2014
2013 Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.Blood.  121:3714-3717. 2013
2013 Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7).Journal of Biological Chemistry.  288:9165-9176. 2013
2013 SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster.Journal of Biological Chemistry.  288:5381-5388. 2013
2012 Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.Blood.  120:1473-1484. 2012
2012 Negative effects of GM-CSF signaling in a murine model of t(8;21)–induced leukemiaBlood.  119:3155-3163. 2012
2011 SON Controls Cell-Cycle Progression by Coordinated Regulation of RNA SplicingMolecular Cell.  42:185-198. 2011
2009 Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: Role of calmodulinClinical Cancer Research.  15:1288-1296. 2009
2009 RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesisBlood.  113:883-886. 2009
2008 Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis 2008

Education And Training

  • Doctor of Philosophy in Medical Pathology, University of Alabama at Birmingham 2003
  • Master's Level Degree in Medical Basic Sciences/Other, Seoul National University 1998
  • Full Name

  • Eun Young Ahn