Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Focal Adhesion Kinase Activity and Localization is Critical for TNF-α-Induced Nuclear Factor-κB ActivationInflammation2021
2020 Targeting focal adhesion kinase in cancer cells and the tumor microenvironment 2020
2020 SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemiaCancer Gene Therapy2020
2019 FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammationScientific Reports.  9. 2019
2019 Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells.Journal of Biological Chemistry.  294:11213-11224. 2019
2019 SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypes.Kidney International.  95:1494-1504. 2019
2019 FAK inhibition reduces metastasis of α4 integrin-expressing melanoma to lymph nodes by targeting lymphatic VCAM-1 expression.Biochemical and Biophysical Research Communications.  509:1034-1040. 2019
2019 Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.Journal of Medicinal Chemistry.  62:987-992. 2019
2019 Nuclear focal adhesion kinase controls vascular smooth muscle cell proliferation and neointimal hyperplasia through GATA4-mediated cyclin D1 transcriptionCirculation Research.  125:152-166. 2019
2018 Irradiation of pediatric glioblastoma cells promotes radioresistance and enhances glioma malignancy via genome-wide transcriptome changes.Oncotarget.  9:34122-34131. 2018
2018 DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity.Oncotarget.  9:31719-31743. 2018
2018 Identification of radiation responsive genes and transcriptome profiling via complete RNA sequencing in a stable radioresistant U87 glioblastoma model.Oncotarget.  9:23532-23542. 2018
2016 miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20.Oncotarget.  7:78667-78679. 2016
2016 De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability SyndromeAmerican Journal of Human Genetics.  99:711-719. 2016
2016 SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated GenesMolecular Cell.  61:859-873. 2016
2015 ErbB2-intronic microRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling.Cell Death and Disease.  6:e1742. 2015
2014 Transcript variants of RUNX1T1: new insight into t(8;21)-positive leukemia.Leukemia Research.  38:1018-1019. 2014
2014 New discoveries of old SON: a link between RNA splicing and cancer.Journal of Cellular Biochemistry.  115:224-231. 2014
2013 Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.Blood.  121:3714-3717. 2013
2013 Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7).Journal of Biological Chemistry.  288:9165-9176. 2013
2013 SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster.Journal of Biological Chemistry.  288:5381-5388. 2013
2012 Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.Blood.  120:1473-1484. 2012
2012 Negative effects of GM-CSF signaling in a murine model of t(8;21)–induced leukemiaBlood.  119:3155-3163. 2012
2011 SON Controls Cell-Cycle Progression by Coordinated Regulation of RNA SplicingMolecular Cell.  42:185-198. 2011
2009 Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: Role of calmodulinClinical Cancer Research.  15:1288-1296. 2009
2009 RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesisBlood.  113:883-886. 2009
2008 Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis 2008

Education And Training

  • Doctor of Philosophy in Medical Pathology, University of Alabama at Birmingham 2003
  • Master's Level Degree in Medical Basic Sciences/Other, Seoul National University 1998
  • Full Name

  • Erin Eun-Young Ahn