Positions

Overview

  • Edward Taub is a University Professor in the Department of Psychology and is the director of the CI Therapy Research Group and Taub Training Clinic. He received his PhD in psychology from New York University in 1970 under the supervision of Dr. Edgar E. Coons and later worked with Dr. Neil E. Miller.

    Dr. Taub is a behavioral neuroscientist who developed a family of techniques — Constraint-Induced Movement therapy (or CI therapy) — that have been shown to be effective in improving the rehabilitation of movement after stroke, traumatic brain injury, cerebral palsy in young children, multiple sclerosis, and other neurological injuries. He also has developed a form that is efficacious in the treatment of post-stroke aphasia. This work is associated with his study of the nature of the plastic brain reorganization induced by CI therapy and the ways it can be harnessed to produce new treatments in neurorehabilitation. An important part of his laboratory’s work is devoted to identifying these processes in the patients receiving CI therapy, using such structural imaging methods as voxel-based morphometry (VBM) and Diffusion Tensor Imaging (DTI), and most recently magnetic resonance spectroscopy (MRS).

    Research with pediatric patients with cerebral palsy and adults with MS is ongoing. Pilot work has begun using a progression of training techniques to enable motor complete tetraplegic patients paralyzed from the neck down to operate their wheelchair by hand movements applied to an armrest-based toggle switch and to feed themselves by raising hand to mouth.

    Over 700 papers have been published on the effects of CI therapy in its various forms, and the treatment was the subject of the first successful multi-center randomized clinical trial for upper extremity stroke rehabilitation funded by NIH. Dr. Taub is the recipient of nine national society awards for his research. His body of CI therapy research was named by the Society of Neuroscience as one of the top 10 Translational Neuroscience Accomplishments of the 20th century and one of the 10 “most exciting lines of neuroscience” being carried out. He is past president of the Biofeedback Society of America, has been on the Board of Directors of four scientific societies and is a Past President, Section J (Psychology) of AAAS.

    The research training in Dr. Taub’s laboratory is based on the Method of Strong Inference: experiments are designed on the basis of “logic trees” and consider multiple alternate hypotheses. Graduate students are strongly encouraged to publish their results. In the past, students have averaged two senior-authored papers, three co-authorships, and multiple society presentations.

    • Research Overview

  • Based on research Dr. Taub conducted with deafferented monkeys, his laboratory developed the neurorehabilitation technique termed Constraint-Induced therapy or CI therapy. Over the past 20 years, Dr. Taub and collaborators have used a CI Therapy approach to develop successful treatments for the motor deficit resulting from damage to the central nervous system in a number of conditions that had previously proved refractory to treatment: stroke in the chronic phase, traumatic brain injury in the chronic phase, cerebral palsy of varied etiologies, multiple sclerosis, and focal hand dystonia in musicians. The CI Therapy approach has also been used to improve speech expression and comprehension in patients with post-stroke aphasia.

    In addition to his work on translating the deafferented monkey research into clinical interventions with rigorous evidence of efficacy, Dr. Taub has also conducted considerable research applying functional and structural neuroimaging techniques to study neuroplasticity in humans after brain injury, which has resulted in publications in Science and Nature, among other prominent outlets. Among the more striking results to emerge recently from his laboratory is a voxel-based morphometry (VBM) analysis of structural magnetic resonance images (MRIs) before and after upper-extremity CI therapy in chronic stroke survivors, showing a profuse increase in amount of grey matter in brain areas related to arm control and learning. Work is now ongoing to identify the microstructural and cellular basis of this grey matter change using magnetic resonance spectroscopy (MRS).

    In October 2014 the CI Therapy Research Group was honored to host a visit by the Dalai Lama; Dr. Taub participated in a symposium/dialog with him on “Neuroplasticity and Healing.”

    Behavioral neuroscience, behavioral medicine, neurorehabilitation, neural plasticity

    • Principal Investigator On

    Investigator On

    Education And Training

  • Doctor of Philosophy in Psychology, New York University 1970

    • Full Name

  • Edward Taub