• Edward Taub is a University Professor in the Department of Psychology and is the director of the CI Therapy Research Group and Taub Training Clinic. He received his PhD in psychology from New York University in 1970 under the supervision of Dr. Edgar E. Coons and later worked with Dr. Neil E. Miller.

    Dr. Taub is a behavioral neuroscientist who developed a family of techniques — Constraint-Induced Movement therapy (or CI therapy) — that have been shown to be effective in improving the rehabilitation of movement after stroke, traumatic brain injury, cerebral palsy in young children, multiple sclerosis, and other neurological injuries. He also has developed a form that is efficacious in the treatment of post-stroke aphasia. This work is associated with his study of the nature of the plastic brain reorganization induced by CI therapy and the ways it can be harnessed to produce new treatments in neurorehabilitation. An important part of his laboratory’s work is devoted to identifying these processes in the patients receiving CI therapy, using such structural imaging methods as voxel-based morphometry (VBM) and Diffusion Tensor Imaging (DTI), and most recently magnetic resonance spectroscopy (MRS).

    Research with pediatric patients with cerebral palsy and adults with MS is ongoing. Pilot work has begun using a progression of training techniques to enable motor complete tetraplegic patients paralyzed from the neck down to operate their wheelchair by hand movements applied to an armrest-based toggle switch and to feed themselves by raising hand to mouth.

    Over 700 papers have been published on the effects of CI therapy in its various forms, and the treatment was the subject of the first successful multi-center randomized clinical trial for upper extremity stroke rehabilitation funded by NIH. Dr. Taub is the recipient of nine national society awards for his research. His body of CI therapy research was named by the Society of Neuroscience as one of the top 10 Translational Neuroscience Accomplishments of the 20th century and one of the 10 “most exciting lines of neuroscience” being carried out. He is past president of the Biofeedback Society of America, has been on the Board of Directors of four scientific societies and is a Past President, Section J (Psychology) of AAAS.

    The research training in Dr. Taub’s laboratory is based on the Method of Strong Inference: experiments are designed on the basis of “logic trees” and consider multiple alternate hypotheses. Graduate students are strongly encouraged to publish their results. In the past, students have averaged two senior-authored papers, three co-authorships, and multiple society presentations.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Reproducibility of whole-brain temperature mapping and metabolite quantification using proton magnetic resonance spectroscopy 2020
    2019 Protocol for a Randomized Controlled Trial of CI Therapy for Rehabilitation of Upper Extremity Motor Deficit: The Bringing Rehabilitation to American Veterans Everywhere Project 2019
    2018 Comparison of reproducibility of single voxel spectroscopy and whole-brain magnetic resonance spectroscopy imaging at 3T 2018
    2018 Phase II Randomized Controlled Trial of Constraint-Induced Movement Therapy in Multiple Sclerosis. Part 1: Effects on Real-World Function 2018
    2018 Phase II Randomized Controlled Trial of Constraint-Induced Movement Therapy in Multiple Sclerosis. Part 2: Effect on White Matter Integrity 2018
    2018 The Pediatric SmartShoe: Wearable Sensor System for Ambulatory Monitoring of Physical Activity and Gait 2018
    2018 Rehabilitation of stroke patients with plegic hands: Randomized controlled trial of expanded Constraint-Induced Movement therapy 2018
    2018 Relation of white matter hyperintensities and motor deficits in chronic stroke 2018
    2017 Relation of depressive symptoms to outcome of CI movement therapy after stroke 2017
    2017 Video Game Rehabilitation for Outpatient Stroke (VIGoROUS): Protocol for a multi-center comparative effectiveness trial of in-home gamified constraint-induced movement therapy for rehabilitation of chronic upper extremity hemiparesis 2017
    2017 Assessing the amount of spontaneous real-world spoken language in aphasia: Validation of two methods 2017
    2017 Upper extremity motor training of a subject with initially motor complete chronic high tetraplegia using constraint-induced biofeedback therapy. 2017
    2016 Translation and cross cultural adaptation of the pediatric motor activity log-revised scale 2016
    2016 Airway management following repair of cervical tracheal injuries: A retrospective, multicenter study 2016
    2016 Change in movement-related cortical potentials following Constraint-Induced Movement Therapy (CIMT) after stroke 2016
    2014 Implications of CI therapy for visual deficit training 2014
    2014 Foreword for neuroplasticity and neurorehabilitation 2014
    2014 The functional significance of cortical reorganization and the parallel development of CI therapy 2014
    2014 An enhanced protocol for constraint-induced aphasia therapy II: A case series 2014
    2014 Diffusion tensor imaging study of the response to constraint-induced movement therapy of children with hemiparetic cerebral palsy and adults with chronic stroke 2014
    2014 Extensive cervical prevertebral haemorrhage with airway obstruction after low-energy hyperextension injury 2014
    2014 Importance for CP rehabilitation of transfer of motor improvement to everyday life 2014
    2014 Motor recovery from constraint induced movement therapy is not constrained by extent of tissue damage following stroke 2014
    2014 Research summit III proceedings on dosing in children with an injured brain or cerebral palsy: Executive summary 2014
    2014 Training model for promoting translation from research to clinical settings: University of Alabama at Birmingham training for constraint-induced movement therapy 2014
    2013 Constraint-induced movement therapy: A family of neurorehabilitation treatments that harnesses the plasticity of the central nervous system 2013
    2013 Promoting Acceptance of Efficacious Behavior Analysis Interventions by Clinical Communities: The Example of CI Therapy 2013
    2013 Method for enhancing real-world use of a more affected arm in chronic stroke: Transfer package of constraint-induced movement therapy 2013
    2013 Structural neuroplastic change after constraint-induced movement therapy in children with cerebral palsy 2013
    2013 Constraint-induced movement therapy for the lower extremities in multiple sclerosis: Case series with 4-year follow-up 2013
    2013 Constraint-induced movement therapy combined with conventional neurorehabilitation techniques in chronic stroke patients with plegic hands: A case series 2013
    2013 Constraint-induced movement therapy: A method for harnessing neuroplasticity to treat motor disorders 2013
    2012 Pediatric arm function test: Reliability and validity for assessing more-affected arm motor capacity in children with cerebral palsy 2012
    2012 The pediatric motor activity log-Revised: Assessing real-world arm use in children with cerebral palsy 2012
    2012 Brain parenchymal fraction predicts motor improvement following intensive task-oriented motor rehabilitation for chronic stroke 2012
    2012 Shaping-Induced Movement Therapy for lower extremity (SIMT) - A pilot study 2012
    2012 Parallels between use of constraint-induced movement therapy to treat neurological motor disorders and amblyopia training 2012
    2012 Atrophy of spared gray matter tissue predicts poorer motor recovery and rehabilitation response in chronic stroke 2012
    2012 The behavior-analytic origins of constraint-induced movement therapy: An example of behavioral neurorehabilitation 2012
    2011 A telerehabilitation platform for home-based automated therapy of arm function 2011
    2011 A telerehabilitation platform for home-based automated therapy of arm function. 2011
    2011 Treatment of congenital hemiparesis with pediatric constraint-induced movement therapy 2011
    2010 Measurement structure of the wolf motor function test: Implications for motor control theory 2010
    2010 The EXCITE stroke trial: Comparing early and delayed constraint-induced movement therapy 2010
    2010 The measurement of upper extremity learned nonuse in progressive multiple sclerosis 2010
    2010 Turkish adaptation of motor activity log-28 2010
    2009 Minimal detectable change scores for the wolf motor function test 2009
    2009 Improvement after constraint-induced movement therapy is independent of infarct location in chronic stroke patients 2009
    2009 A Method for Standardizing Procedures in Rehabilitation: Use in the Extremity Constraint Induced Therapy Evaluation Multisite Randomized Controlled Trial 2009
    2008 Constraint-Induced Movement therapy can improve hemiparetic progressive multiple sclerosis. Preliminary findings 2008
    2008 MRI infarction load and CI therapy outcomes for chronic post-stroke hemiparesis 2008
    2008 Recovery effect of constraint-induced movement therapy on supper extremity activity of stroke patients with hemiparasis 2008
    2008 Poststroke cerebral peduncular atrophy correlates with a measure of corticospinal tract injury in the cerebral hemisphere 2008
    2008 Remodeling the brain: plastic structural brain changes produced by different motor therapies after stroke. 2008
    2008 Retention of upper limb function in stroke survivors who have received constraint-induced movement therapy: the EXCITE randomised trial 2008
    2007 Extending the Constraint-Induced Movement Therapy (CIMT) approach to cognitive functions: Constraint-Induced Aphasia Therapy (CIAT) of chronic aphasia 2007
    2007 Pediatric CI therapy for stroke-induced hemiparesis in young children 2007
    2007 Constraint-induced movement therapy during early stroke rehabilitation 2007
    2006 Autonomously adapting robotic assistance for rehabilitation therapy 2006
    2006 Definition and classification of negative motor signs in childhood 2006
    2006 Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: The EXCITE randomized clinical trial 2006
    2006 The Motor Activity Log-28: Assessing daily use of the hemiparetic arm after stroke 2006
    2006 Constraint-induced movement therapy: Characterizing the intervention protocol 2006
    2006 Neuroplasticity and constraint-induced movement therapy 2006
    2006 The learned nonuse phenomenon: Implications for rehabilitation 2006
    2006 A telerehabilitation approach to delivery of constraint-induced movement therapy 2006
    2006 A treatment for a chronic stroke patient with a plegic hand combining CI therapy with conventional rehabilitation procedures: Case report 2006
    2006 Cognitive assessment for CI therapy in the outpatient clinic 2006
    2006 Constraint-Induced Movement therapy: Answers and questions after two decades of research 2006
    2006 Contribution of the shaping and restraint components of Constraint-Induced Movement therapy to Treatment Outcome 2006
    2006 Employment in households with stroke after Constraint-Induced Movement therapy 2006
    2006 The influence of neuropsychological characteristics on the use of CI therapy with persons with traumatic brain injury 2006
    2006 A placebo-controlled trial of constraint-induced movement therapy for upper extremity after stroke 2006
    2006 Functional reorganization and recovery after constraint-induced movement therapy in subacute stroke: Case reports 2006
    2005 Use of CI therapy for improving motor ability after chronic cns damage: A development prefigured by Paul Bach-y-Rita 2005
    2005 Constraint-induced movement therapy for recovery of upper-limb function following traumatic brain injury 2005
    2005 Reliability and validity of the upper-extremity motor activity log-14 for measuring real-world arm use 2005
    2005 The EXCITE trial: Attributes of the Wolf Motor Function Test in patients with subacute stroke 2005
    2005 AutoCITE: Automated delivery of CI therapy with reduced effort by therapists 2005
    2005 Implications of the learned nonuse formulation for measuring rehabilitation outcomes: Lessons from constraint-induced movement therapy 2005
    2005 Distributed form of constraint-induced movement therapy improves functional outcome and quality of life after stroke 2005
    2004 Rapid functional plasticity in the primary somatomotor cortex and perceptual changes after nerve block 2004
    2004 Constraint-induced movement therapy for chronic stroke hemiparesis and other disabilities 2004
    2004 Harnessing brain plasticity through behavioral techniques to produce new treatments in neurorehabilitation 2004
    2004 Automated Constraint-Induced Therapy Extension (AutoCITE) for movement deficits after stroke. 2004
    2004 Efficacy of Constraint-Induced Movement Therapy for Children with Cerebral Palsy with Asymmetric Motor Impairment 2004
    2004 Automated constraint-induced therapy extension (AutoCITE) for movement deficits after stroke 2004
    2004 Constraint-induced movement therapy for chronic stroke hemiparesis and other disabilities. 2004
    2003 Factor analysis of bowel symptoms in US and Italian populations 2003
    2003 Pediatric Constraint-Induced Movement Therapy for a Young Child With Cerebral Palsy: Two Episodes of Care 2003
    2003 Constraint-Induced Movement therapy: Bridging from the primate laboratory to the stroke rehabilitation laboratory 2003
    2003 Erratum: Constraint-induced therapy in stroke: Magnetic-stimulation motor maps and cerebral activation (Neurorehabilitation and Neural Repair (March 2003) 17:1) 2003
    2003 Constraint-induced movement therapy: Bridging from the primate laboratory to the stroke rehabilitation laboratory 2003
    2003 New developments in stroke rehabilitation based on behavioral and neuroscientific principles: Constraint-induced therapy 2003
    2003 Constraint-induced therapy in stroke: Magnetic-stimulation motor maps and cerebral activation 2003
    2003 Improved motor recovery after stroke and massive cortical reorganization following Constraint-Induced Movement Therapy 2003
    2003 Methods for a Multisite Randomized Trial to Investigate the Effect of Constraint-Induced Movement Therapy in Improving Upper Extremity Function among Adults Recovering from a Cerebrovascular Stroke 2003
    2002 Expansion of the tonotopic area in the auditory cortex of the blind 2002
    2002 Coherence of gamma-band EEG activity as a basis for associative learning 2002
    2002 Pallidal deep brain stimulation in patients with cervical dystonia and severe cervical dyskinesias with cervical myelopathy 2002
    2002 Longer versus shorter daily constraint-induced movement therapy of chronic hemiparesis: An exploratory study 2002
    2002 New treatments in neurorehabiliation founded on basic research 2002
    2002 Sensory motor retuning: A behavioral treatment for focal hand dystonia of pianists and guitarists 2002
    2001 Chronic thalamic stimulation for treatment of dystonic paroxysmal nonkinesigenic dyskinesia 2001
    2001 Constraint-induced movement therapy to enhance recovery after stroke. 2001
    2001 Constraint-induced therapy approach to restoring function after neurological injury 2001
    2001 Constraint-induced therapy of chronic aphasia after stroke 2001
    2001 The reliability of the wolf motor function test for assessing upper extremity function after stroke 2001
    2000 Erratum: Progressive transneuronal changes in the brainstem and thalamus after long-term dorsal rhizotomies in adult macaque monkeys (Journal of Neuroscience (May 15,2000) (3884-3899)) 2000
    2000 A neural substrate for nonpainful phantom limb phenomena 2000
    2000 Progressive transneuronal changes in the brainstem and thalamus after long-term dorsal rhizotomies in adult macaque monkeys 2000
    2000 Differential activation in somatosensory cortex for different discrimination tasks 2000
    2000 Objective measurement of functional upper-extremity movement using accelerometer recordings transformed with a threshold filter 2000
    2000 Rapid functional plasticity of the somatosensory cortex after finger amputation 2000
    2000 Treatment-induced cortical reorganization after stroke in humans 2000
    2000 Treatment-induced cortical reorganization in stroke patients 2000
    1999 A fourth author responds 1999
    1999 New discovery equals change in clinical practice 1999
    1999 Decrease in phantom limb pain associated with prosthesis-induced increased use of an amputation stump in humans 1999
    1999 Effect of CI therapy on movement-related brain potentials 1999
    1999 Relation of accelerometer and EMG recordings for the measurement of upper extremity movement 1999
    1999 Constraint-induced Movement Therapy: A new family of techniques with broad application to physical rehabilitation - A clinical review 1999
    1999 The thought translation device: A neurophysiological approach to communication in total motor paralysis 1999
    1999 A spelling device for the paralysed 1999
    1999 Plasticity in the motor system related to therapy-induced improvement of movement after stroke 1999
    1999 Constraint-induced movement therapy - Results of a behavioral psychology training program for motor rehabilitation of stroke patients 1999
    1999 Cortical reorganization in tinnitus 1999
    1999 Coherence of gamma-band EEG activity as a basis for associative learning 1999
    1999 Constraint-induced movement therapy for focal hand dystonia in musicians 1999
    1999 Constraint-induced movement therapy [1] (multiple letters) 1999
    1999 Constraint-induced movement therapy for motor recovery in chronic stroke patients 1999
    1999 Development of cortical reorganization in the somatosensory cortex of adult Braille students. 1999
    1999 Effects of constraint-induced movement therapy on patients with chronic motor deficits after stroke: A replication 1999
    1999 Language support program for thought-translation-devices 1999
    1998 Alteration of digital representations in somatosensory cortex in focal hand dystonia 1998
    1998 Reorganization of auditory cortex in tinnitus 1998
    1998 Thermal and EMG biofeedback learning in nonhuman primates 1998
    1998 Motor cortex plasticity during constraint,induced movement therapy in stroke patients 1998
    1998 Constraint-induced movement therapy: A new approach to treatment in physical rehabilitation 1998
    1998 Perceptual correlates of changes in cortical representation of fingers in blind multifinger Braille readers 1998
    1998 Plasticity of plasticity? Changes in the pattern of perceptual correlates of reorganization after amputation 1998
    1998 Cortical reorganization and phantom phenomena in congenital and traumatic upper-extremity amputees 1998
    1998 Changed perceptions in Braille readers [9] 1998
    1998 Conditioned gamma band coherence between visual and somatosensory brain areas after differential conditioning of painful stimuli 1998
    1998 Constraint-induced (CI) movement therapy in patients treated according to German rehabilitation programs 1998
    1998 Expansion of cortical hand representation and tactile sensory thresholds in blind Braille readers: A link between cortical organization and perception 1998
    1997 Input-increase and input-decrease types of cortical reorganization after upper extremity amputation in humans 1997
    1997 The relationship of phantom limb pain to other phantom limb phenomena in upper extremity amputees 1997
    1997 Constraint-induced movement therapy for motor recovery after stroke 1997
    1997 Accelerometers in rehabilitation: Objective measurement of extremity use at home. 1997
    1997 Constraint induced movement techniques to facilitate upper extremity use in stroke patients 1997
    1997 Constraint-induced movement therapy for motor recovery after stroke. 1997
    1997 Effects of regional anesthesia on phantom limb pain are mirrored in changes in cortical reorganization 1997
    1997 The arm motor ability test: Reliability, validity, and sensitivity to change of an instrument for assessing disabilities in activities of daily living 1997
    1996 Biofeedback treatment of Raynaud's disease 1996
    1996 Factor analysis of gastrointestinal symptoms [5] 1996
    1996 Impact of irritable bowel syndrome on quality of life 1996
    1996 Reorganizational and perceptional changes after amputation 1996
    1995 Cortical reorganization in human amputees and mislocalization of painful stimuli to the phantom limb 1995
    1995 Irritable bowel syndrome defined by factor analysis gender and race comparisons 1995
    1995 Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation 1995
    1995 Coping with irritable bowel syndrome IBS): Analgesic and other medication use by IBS patients and IBS non-consulter 1995
    1995 Spontaneous swallowing rate and emotional state - Possible mechanism for stress-related gastrointestinal disorders 1995
    1995 Increased cortical representation of the fingers of the left hand in string players 1995
    1995 Resolution of chronic cluster headache after resection of a tentorial meningioma: Case report 1995
    1994 Effectiveness of broad spectrum approaches to relapse prevention in severe alcoholism: A long-term, randomized, controlled trial of transcendental meditation, EMG biofeedback and electronic neurotherapy 1994
    1994 Extensive reorganization of the somatosensory cortex in adult humans after nervous system injury 1994
    1993 Technique to improve chronic motor deficit after stroke 1993
    1992 Chronic deafferentation in monkeys differentially affects nociceptive and nonnociceptive pathways distinguished by specific calcium-binding proteins and down-regulates γ-aminobutyric acid type A receptors at thalamic levels 1992
    1991 Massive cortical reorganization after sensory deafferentation in adult macaques 1991
    1991 PETA Account Disputed 1991
    1980 Effect of slide projections and tape-recorded suggestions on thermal biofeedback training 1980
    1980 Some anatomical observations following chronic dorsal rhizotomy in monkeys 1980
    1979 Electrophysiologic evidence that deafferentation by dorsal rhizotomy abolishes afferent inputs to segmental levels of the spinal cord in the monkey 1979
    1978 Biofeedback in the treatment of vasoconstrictive syndromes 1978
    1978 Some methodological considerations in thermal biofeedback training 1978
    1978 Comparison of the performance of deafferented and intact monkeys on continuous and fixed ratio schedules of reinforcement 1978
    1977 Abstracts of papers presented at the Eighth Annual Meeting of the Biofeedback Society of America 1977
    1977 Suggestion as an aid to self-regulation of hand temperature 1977
    1976 Feedback-aided self-regulation of skin temperature with a single feedback locus - I. Acquisition and reversal training 1976
    1976 Movement in nonhciman primates deprived of somatosensory feedback 1976
    1975 Diminution of early environmental control through perinatal and prenatal somatosensory deafferentation 1975
    1975 Deafferentation in monkeys: Pointing at a target without visual feedback 1975
    1974 Use of sensory recombination and somatosensory deafferentation techniques in the investigation of sensory-motor integration. 1974
    1973 A nonsurgical method for restraining the head during behavioral tests in primates 1973
    1973 Behavioral development after forelimb deafferentation on day of birth in monkeys with and without blinding 1973
    1973 Prism adaptation: Control of intermanual transfer by distribution of practice 1973
    1973 Somatic evoked response recording: An adequate test of deafferentation? 1973
    1972 Summated cortical evoked response testing in the deafferented primate 1972
    1970 Experimental Studies of Toxic Factors in Uremic Encephalopathy 1970
    1966 Deafferentation in monkeys: Effect on conditioned grasp response 1966
    1965 Simple and discriminative tactile conditioned responses following removal of primate frontal agranular cortex. 1965
    1965 Acquisition of a trace-conditioned avoidance response after deafferentation of the responding limb 1965
    1964 Conditioned behavior following sensory isolation in primates. 1964
    1963 Avoidance conditioning in the absence of relevant proprioceptive and exteroceptive feed back 1963
    1963 Movements in monkeys with deafferented forelimbs 1963
    1962 Effect of motor cortex ablations on conditioned flexion response in the monkey. 1962
    1961 Tactile conditioning after motor cortex ablations. 1961
    1959 Conditioned response following deafferentation in the monkey. 1959
    1958 Effect of deafferentation on a conditioned avoidance response 1958


    Year Title Altmetric
    2017 Constraint-Induced Movement Therapy: When Efficacious Motor Therapy Meets Progressive Disease.  143-155. 2017
    2015 Constraint-Induced Aphasia Therapy: A Neuroscience-Centered Translational Method.  1025-1034. 2015
    2015 Constraint-induced movement therapy for restoration of upper-limb function: Introduction.  573-585. 2015
    2015 The use of constraint-induced movement therapy (CI therapy) to promote motor recovery following stroke.  401-416. 2015
    2010 You can teach an old dog new tricks: Harnessing neuroplasticity after brain injury in older adults.  104-129. 2010
    2009 Constraint-induced movement therapy for restoration of upper-limb function: Introduction.  301-308. 2009
    2009 Cortical Reorganization and the Rehabilitation of Movement by CI Therapy After Neurological Injury 2009

    Research Overview

  • Based on research Dr. Taub conducted with deafferented monkeys, his laboratory developed the neurorehabilitation technique termed Constraint-Induced therapy or CI therapy. Over the past 20 years, Dr. Taub and collaborators have used a CI Therapy approach to develop successful treatments for the motor deficit resulting from damage to the central nervous system in a number of conditions that had previously proved refractory to treatment: stroke in the chronic phase, traumatic brain injury in the chronic phase, cerebral palsy of varied etiologies, multiple sclerosis, and focal hand dystonia in musicians. The CI Therapy approach has also been used to improve speech expression and comprehension in patients with post-stroke aphasia.

    In addition to his work on translating the deafferented monkey research into clinical interventions with rigorous evidence of efficacy, Dr. Taub has also conducted considerable research applying functional and structural neuroimaging techniques to study neuroplasticity in humans after brain injury, which has resulted in publications in Science and Nature, among other prominent outlets. Among the more striking results to emerge recently from his laboratory is a voxel-based morphometry (VBM) analysis of structural magnetic resonance images (MRIs) before and after upper-extremity CI therapy in chronic stroke survivors, showing a profuse increase in amount of grey matter in brain areas related to arm control and learning. Work is now ongoing to identify the microstructural and cellular basis of this grey matter change using magnetic resonance spectroscopy (MRS).

    In October 2014 the CI Therapy Research Group was honored to host a visit by the Dalai Lama; Dr. Taub participated in a symposium/dialog with him on “Neuroplasticity and Healing.”

    Behavioral neuroscience, behavioral medicine, neurorehabilitation, neural plasticity
  • Education And Training

  • Doctor of Philosophy in Psychology, New York University 1970
  • Full Name

  • Edward Taub