• Elizabeth Sztul obtained a BS in Biology from Brooklyn College, CUNY, studying the ecology of marine arthropods and the renewing nature of the plant meristem. She initiated her graduate studies with a M.Sc. in Plant Physiology from University of Maryland, studying chloroplast biogenesis. She continued her graduate education in Cell Biology at Yale University School of Medicine, working on membrane trafficking pathways in the laboratory of Nobel Prize winner, Dr. George Palade, and was awarded a Ph.D. in 1984. She continued training as a Postdoctoral Fellow of the American Cancer Society in Human Genetics at Yale University School of Medicine, studying mitochondrial biogenesis in the laboratory of Dr. Leon Rosenberg. During her postdoctoral work at Yale, she was also a Visiting Scientist at the European Molecular Biology Laboratory in Heidelberg, Germany, in the laboratory of Dr. Kathryn Howell. She was appointed Assistant Professor of Molecular Biology at Princeton University (1989-1995), where she received the National Science Foundation Presidential Young Investigator Award. Dr. Sztul joined the faculty in the Department of Cell Biology at UAB as an Associate Professor in Fall of 1995 and was promoted to Full Professor in 2003. She is a member of the UAB Comprehensive Cancer Center, the Diabetes Center and the Fleming Cystic Fibrosis Center. She spent a sabbatical year (2000-01) at the Wellcome Center for Human Genetics in Oxford, United Kingdom, in the laboratory of Dr. Yvonne Jones, and another sabbatical year (2008-9) as a Program Director at the National Science Foundation. At the national level, she has served or serves multiple Scientific Advisory Panels, including those for the National Institute of Health, American Cancer Society, National Science Foundation, and the American Heart Association.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Imaging vesicle formation dynamics supports the flexible model of clathrin-mediated endocytosisNature Communications.  13. 2022
    2022 A Proximity biotinylation assay with a host protein bait reveals multiple factors modulating enterovirus replicationPLoS Pathogens.  18. 2022
    2021 Erratum: JAGN1, tetraspanins, and Erv proteins: is common topology indicative of common function in cargo sorting? (Am J Physiol Cell Physiol (2020) 319 (C667–C674) DOI: 10.1152/ajpcell.00436.2019) 2021
    2021 Modeling the dynamic behaviors of the COPI vesicle formation regulators, the small GTPase Arf1 and its activating Sec7 guanine nucleotide exchange factor GBF1 on Golgi membranesMolecular Biology of the Cell.  32:446-459. 2021
    2021 Enterovirus infection induces massive recruitment of all isoforms of small cellular arf GTPases to the replication organellesJournal of Virology.  95. 2021
    2020 Identification of p115 as a novel ACSL4 interacting protein and its role in regulating ACSL4 degradationJournal of Proteomics.  229. 2020
    2020 JAGN1, tetraspanins, and Erv proteins: Is common topology indicative of common function in cargo sorting? 2020
    2020 ARF family GTPases with links to cilia 2020
    2020 Regulating the regulators: role of phosphorylation in modulating the function of the GBF1/BIG family of Sec7 ARF-GEFsFEBS Letters.  594:2213-2226. 2020
    2019 The guanine nucleotide exchange factor GBF1 participates in rotavirus replicationJournal of Virology.  93. 2019
    2019 Promiscuity of the catalytic Sec7 domain within the guanine nucleotide exchange factor GBF1 in ARF activation, Golgi homeostasis, and effector recruitmentMolecular Biology of the Cell.  30:1523-1535. 2019
    2019 A redundant mechanism of recruitment underlies the remarkable plasticity of the requirement of poliovirus replication for the cellular ArfGEF GBF1Journal of Virology.  93. 2019
    2019 Arf GTPases and their GEFs and GAPS: Concepts and challengesMolecular Biology of the Cell.  30:1249-1271. 2019
    2018 Role of host cell secretory machinery in zika virus life cycleViruses.  10. 2018
    2018 Highly conserved motifs within the large Sec7 ARF guanine nucleotide exchange factor GBF1 target it to the Golgi and are critical for GBF1 activity 2018
    2018 Commonly used trafficking blocks disrupt ARF1 activation and the localization and function of specific Golgi proteinsMolecular Biology of the Cell.  29:937-947. 2018
    2018 The ARF guanine nucleotide exchange factor GBF1 is targeted to Golgi membranes through a PIP-binding domainJournal of Cell Science.  131. 2018
    2017 CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cellsJournal of Cell Science.  130:4155-4167. 2017
    2017 Finding your inner modeler: An NSF-sponsored workshop to introduce cell biologists to modeling/computational approaches.Cellular Logistics.  7:e1382669. 2017
    2017 How can biological modeling help cell biology?Cellular Logistics.  7:e1404780. 2017
    2017 The Arf activator GBF1 localizes to plasma membrane sites involved in cell adhesion and motility.Cellular Logistics.  7:e1308900. 2017
    2016 Oligomerization of the Sec7 domain Arf guanine nucleotide exchange factor GBF1 is dispensable for Golgi localization and function but regulates degradation 2016
    2016 Toll-like receptor 4 engagement mediates prolyl endopeptidase release from airway epithelia via exosomesAmerican Journal of Respiratory Cell and Molecular Biology.  54:359-369. 2016
    2016 Expression of epitope-tagged proteins in mammalian cells in cultureMethods in Molecular Biology.  1474:3-24. 2016
    2015 Phospholipase C γ1 regulates early secretory trajficking and cell migration via interaction with p115Molecular Biology of the Cell.  26:2263-2278. 2015
    2015 p115-SNARE Interactions: A Dynamic Cycle of p115 Binding Monomeric SNARE Motifs and Releasing Assembled BundlesTraffic.  16:148-171. 2015
    2015 Characterization of intracellular aggresomes by fluorescent microscopyMethods in Molecular Biology.  1258:307-317. 2015
    2014 Monitoring endosomal trafficking of the g protein-coupled receptor somatostatin receptor 3Methods in Enzymology.  534:261-280. 2014
    2014 Novel effects of Brefeldin A (BFA) in signaling through the insulin receptor (IR) pathway and regulating FoxO1-mediated transcription.Cellular Logistics.  4:e27732. 2014
    2014 Regulating the large Sec7 ARF guanine nucleotide exchange factors: The when, where and how of activationCellular and Molecular Life Sciences.  71:3419-3438. 2014
    2014 Rewiring of cellular membrane homeostasis by picornavirusesJournal of Virology.  88:9478-9489. 2014
    2013 Role of mTOR downstream effector signaling molecules in Francisella tularensis internalization by murine macrophagesPLoS One.  8. 2013
    2013 Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2-, AP-1-, and Rab22-dependent stepsMolecular Biology of the Cell.  24:1735-1748. 2013
    2013 A role for cargo in Arf-dependent adaptor recruitmentJournal of Biological Chemistry.  288:14788-14804. 2013
    2013 The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN)Journal of Biological Chemistry.  288:11532-11545. 2013
    2013 ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cellsJournal of Ovarian Research.  6. 2013
    2013 Haploinsufficiency of the Sec7 Guanine Nucleotide Exchange Factor Gea1 Impairs Septation in Fission YeastPLoS One.  8. 2013
    2013 Nobel Prize for Cellular Logistics!Cellular Logistics.  3:e27194. 2013
    2013 Studying membrane trafficking in the worm C. elegans by RNA interferenceMethods in Cell Biology.  118:51-68. 2013
    2012 The pleckstrin homology (PH) domain of the Arf exchange factor Brag2 is an allosteric binding siteJournal of Biological Chemistry.  287:24273-24283. 2012
    2012 Identification of a functional domain within the p115 tethering factor that is required for Golgi ribbon assembly and membrane traffickingJournal of Cell Science.  125:1896-1909. 2012
    2012 Tethering factor P115: a new model for tether-SNARE interactions.BioArchitecture.  2:175-180. 2012
    2011 Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activationJournal of Biological Chemistry.  286:36898-36906. 2011
    2011 Endosomal trafficking of the G protein-coupled receptor somatostatin receptor 3Biochemical and Biophysical Research Communications.  413:555-560. 2011
    2011 COPII and COPI traffic at the ER-Golgi interfacePhysiology.  26:348-364. 2011
    2011 The Garz Sec7 domain guanine nucleotide exchange factor for Arf regulates salivary gland development in Drosophila.Cellular Logistics.  1:69-76. 2011
    2011 ArfGAP1 promotes COPI vesicle formation by facilitating coatomer polymerization.Cellular Logistics.  1:139-154. 2011
    2011 Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and AtaxiaNeurobiology of Disease.  41:11-22. 2011
    2010 Transient expression of epitope-tagged proteins in mammalian cellsMethods in Molecular Biology.  657:43-61. 2010
    2009 Role of vesicle tethering factors in the ER-Golgi membrane trafficFEBS Letters.  583:3770-3783. 2009
    2009 Listeria monocytogenes ActA-mediated escape from autophagic recognitionNature Cell Biology.  11:1233-1240. 2009
    2009 ER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagyEuropean Journal of Cell Biology.  88:215-226. 2009
    2008 Depletion of β-COP reveals a role for COP-I in compartmentalization of secretory compartments and in biosynthetic transport of caveolin-1 2008
    2008 Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomesJournal of Virology.  82:5054-5067. 2008
    2008 Cystic fibrosis transmembrane conductance regulator trafficking is mediated by the COPI coat in epithelial cellsJournal of Biological Chemistry.  283:833-839. 2008
    2007 Activation of ADP-ribosylation factor regulates biogenesis of the ATP7A-containing trans-Golgi network compartment and its Cu-induced trafficking 2007
    2007 Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein traffickingJournal of Cell Science.  120:3929-3940. 2007
    2007 Dynein-dependent transport of the Hantaan virus nucleocapsid protein to the endoplasmic reticulum-Golgi intermediate compartmentJournal of Virology.  81:8634-8647. 2007
    2007 Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy 2007
    2006 SNARE status regulates tether recruitment and function in homotypic COPII vesicle fusionJournal of Biological Chemistry.  281:38825-38833. 2006
    2006 Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivoNature Cell Biology.  8:1143-1148. 2006
    2006 On and off membrane dynamics of the endoplasmic reticulum-golgi tethering factor p115 in vivoMolecular Biology of the Cell.  17:2996-3008. 2006
    2006 Role of tethering factors in secretory membrane traffic 2006
    2005 Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine proteinNeurobiology of Disease.  20:656-665. 2005
    2005 Nuclear aggresomes form by fusion of PML-associated aggregatesMolecular Biology of the Cell.  16:4905-4917. 2005
    2005 Golgi tethering factors 2005
    2005 P115 interacts with the GLUT4 vesicle protein, IRAP, and plays a critical role in insulin-stimulated GLUT4 translocationMolecular Biology of the Cell.  16:2882-2890. 2005
    2005 Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1Traffic.  6:374-385. 2005
    2004 h-ERES-y in ER-Golgi transportDevelopmental Cell.  7:6-8. 2004
    2003 Mutations in COCH that result in non-syndromic autosomal dominant deafness (DFNA9) affect matrix deposition of cochlinHuman Genetics.  113:406-416. 2003
    2003 ADP-ribosylation factor/COPI-dependent events at the endoplasmic reticulum-Golgi interface are regulated by the guanine nucleotide exchange factor GBF1Molecular Biology of the Cell.  14:2250-2261. 2003
    2003 COPI recruitment is modulated by a Rab1b-dependent mechanismMolecular Biology of the Cell.  14:2116-2127. 2003
    2003 The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factorEMBO Reports.  4:320-325. 2003
    2003 Traffic-independent function of the Sar1p/COPII machinery in proteasomal sorting of the cystic fibrosis transmembrane conductance regulator 2003
    2003 Membrane targeting of p115 phosphorylation mutants and their effects on Golgi integrity and secretory trafficEuropean Journal of Cell Biology.  82:411-420. 2003
    2002 A novel type of regulation of the vimentin intermediate filament cytoskeleton by a Golgi proteinEuropean Journal of Cell Biology.  81:391-401. 2002
    2002 Hassles with taking out the garbage: Aggravating aggresomesTraffic.  3:388-396. 2002
    2002 Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and αB-crystallin to aggresomesJournal of Biochemistry.  131:593-603. 2002
    2001 A novel interaction of the Golgi complex with the vimentin intermediate filament cytoskeleton 2001
    2001 The p115-interactive Proteins GM130 and Giantin Participate in Endoplasmic Reticulum-Golgi TrafficJournal of Biological Chemistry.  276:2693-2700. 2001
    2001 Distinct epitopes on formiminotransferase cyclodeaminase induce autoimmune liver cytosol antibody type 1Hepatology.  34:494-501. 2001
    2001 Role Of Golgi Matrix Proteins In Regulating Secretory Traffic. 2001
    2000 Human cytomegalovirus pp28 (UL99) localizes to a cytoplasmic compartment which overlaps the endoplasmic reticulum-Golgi-intermediate compartmentJournal of Virology.  74:3842-3851. 2000
    2000 Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminusJournal of Biological Chemistry.  275:10196-10201. 2000
    2000 Accumulation of virion tegument and envelope proteins in a stable cytoplasmic compartment during human cytomegalovirus replication: Characterization of a potential site of virus assemblyJournal of Virology.  74:975-986. 2000
    2000 The membrane transport factor p115 recycles only between homologous compartments in intact heterokaryonsEuropean Journal of Cell Biology.  79:229-239. 2000
    1999 ER to Golgi transport: Requirement for p115 at a pre-Golgi VTC stage 1999
    1999 Monoclonal antibodies as context-specific reagents: Differential antigen reactivity of MAb 58K-9 during immunoprecipitation, immunoblotting, and immunofluorescence analysesHybridoma.  18:479-485. 1999
    1999 Characterization and dynamics of aggresome formation by a cytosolic GFP- chimera 1999
    1999 Brefeldin A (BFA) disrupts the organization of the micuotubule and the actin cytoskeletonsEuropean Journal of Cell Biology.  78:1-14. 1999
    1998 Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa proteinJournal of Biological Chemistry.  273:33825-33834. 1998
    1998 The membrane transport factor TAP/p115 cycles between the Golgi and earlier secretory compartments and contains distinct domains required for its localization and function 1998
    1997 Free-flow electrophoretic analysis of endosome subpopulations of rat hepatocytesElectrophoresis.  18:2516-2522. 1997
    1997 Experimentally induced changes in the endocytic traffic of P-glycoprotein alter drug resistance of cancer cells.American Journal of Physiology.  273:C687-C702. 1997
    1997 Experimentally induced changes in the endocytic traffic of P- glycoprotein alter drug resistance of cancer cells 1997
    1996 A novel Ca2+-binding protein, p22, is required for constitutive membrane trafficJournal of Biological Chemistry.  271:10183-10187. 1996
    1995 Transcytosis-associated protein (TAP)/p115 is a general fusion factor required for binding of vesicles to acceptor membranes 1995
    1994 Basolateral to apical transcytosis in polarized cells is indirect and involves BFA and trimeric G protein sensitive passage through the apical endosome 1994
    1993 A coat protein required for transcytotic traffic exists as a multimeric complexEuropean Journal of Cell Biology.  61:184-188. 1993
    1993 Brefeldin a causes a defect in secretion in Saccharomyces cerevisiaeJournal of Biological Chemistry.  268:3040-3043. 1993
    1993 Control of protein traffic between distinct plasma membrane domains. Requirement for a novel 108,000 protein in the fusion of transcytotic vesicles with the apical plasma membraneJournal of Biological Chemistry.  268:1876-1885. 1993
    1992 Targeting and fusion in vesicular transportTrends in Cell Biology.  2:381-386. 1992
    1992 Transcytotic vesicle fusion with plasma membraneMethods in Enzymology.  219:44-51. 1992
    1991 Erratum: Sequence analysis, biogenesis, and mitochondrial import of the α-subunit of rat liver propionyl-CoA carboxylase (The Journal of Biological Chemistry, Vol. 264 (1989) 12680-12685)Journal of Biological Chemistry.  266:4660. 1991
    1991 Protein traffic between distinct plasma membrane domains: Isolation and characterization of vesicular carriers involved in transcytosisCell.  64:81-89. 1991
    1990 Exocytic transport vesicles generated in vitro from the trans-Golgi network carry secretory and plasma membrane proteins 1990
    1989 Translocation of precursor proteins into the mitochondrial matrix occurs through an environment accessible to aqueous perturbantsJournal of Cell Science.  94:695-701. 1989
    1989 Sequence analysis, biogenesis, and mitochondrial import of the α-subunit of rat liver propionyl-CoA carboxylaseJournal of Biological Chemistry.  264:12680-12685. 1989
    1989 Synthetic transit peptides inhibit import and processing of mitochondrial precursor proteinsJournal of Biological Chemistry.  264:9552-9558. 1989
    1988 Import of the malate dehydrogenase precursor by mitochondria. Cleavage within leader peptide by matrix protease leads to formation of intermediate-sized formJournal of Biological Chemistry.  263:12085-12091. 1988
    1987 Localization of Na+,K+-ATPase α-subunit to the sinusoidal and lateral but not canalicular membranes of rat hepatocytes 1987
    1987 Import of rat ornithine transcarbamylase precursor into mitochondria: Two-step processing of the leader peptide 1987
    1986 Phosphorylation of the rat hepatic polymeric IgA receptor 1986
    1985 Biogenesis of the polymeric IgA receptor in rat hepatocytes. II. localization of its intracellular forms by cell fractionation studies 1985
    1985 Biogenesis of the polymeric IgA receptor in rat hepatocytes: I. kinetic studies of its intracellular forms 1985
    1984 Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver 1984
    1983 Intracellular and transcellular transport of secretory component and albumin in rat hepatocytes 1983


    Year Title Altmetric
    2006 In Vitro Techniques.  201-378. 2006

    Research Overview

  • Molecular regulation of membrane traffic in eukaryotic cells

    Cross-talk between exocytic traffic, ER quality control and proteosomal degradation

    Cellular toxicity caused by aggregation of misfolded proteins

    Traffic-dependent activation of transcription factors
  • Teaching Activities

  • 01-235 - CMB3 CELLS (Fall Term 2007)
  • 01-235 - CMB3 CELLS (Fall Term 2009)
  • CB740 - Research in Cell Biology (Fall Term 2007)
  • CB740 - Research in Cell Biology (Fall Term 2008)
  • CB740 - Research in Cell Biology (Fall Term 2009)
  • CB740 - Research in Cell Biology (Fall Term 2010)
  • CB740 - Research in Cell Biology (Fall Term 2011)
  • CB740 - Research in Cell Biology (Fall Term 2012)
  • CB740 - Research in Cell Biology (Fall Term 2013)
  • CB740 - Research in Cell Biology (Spring Term 2008)
  • CB740 - Research in Cell Biology (Spring Term 2009)
  • CB740 - Research in Cell Biology (Spring Term 2010)
  • CB740 - Research in Cell Biology (Spring Term 2011)
  • CB740 - Research in Cell Biology (Spring Term 2012)
  • CB740 - Research in Cell Biology (Spring Term 2013)
  • CB747 - Cell Biology Seminar (Fall Term 2011)
  • CB747 - Cell Biology Seminar (Fall Term 2012)
  • CB747 - Cell Biology Seminar (Fall Term 2013)
  • CB747 - Cell Biology Seminar (Fall Term 2014)
  • CB747 - Cell Biology Seminar (Fall Term 2015)
  • CB747 - Cell Biology Seminar (Spring Term 2011)
  • CB747 - Cell Biology Seminar (Spring Term 2012)
  • CB747 - Cell Biology Seminar (Spring Term 2013)
  • CB747 - Cell Biology Seminar (Spring Term 2014)
  • CB747 - Cell Biology Seminar (Spring Term 2015)
  • CMB730 - CMB III Cells (Fall Term 2007)
  • GBS709 - Basic Bio Organization (Fall Term 2010)
  • GBS709 - Basic Bio Organization (Fall Term 2011)
  • GBS709 - Basic Bio Organization (Fall Term 2012)
  • GBS709 - Basic Bio Organization (Fall Term 2013)
  • GBS709 - Basic Bio Organization (Fall Term 2014)
  • GBS709 - Basic Bio Organization (Fall Term 2015)
  • GBS709 - Basic Bio Organization (Fall Term 2016)
  • GBS709 - Basic Bio Organization (Fall Term 2017)
  • GBS709 - Basic Bio Organization (Fall Term 2018)
  • Full Name

  • Elizabeth Sztul