Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behaviorMatrix Biology.  65:104-118. 2018
2017 Transancestral mapping and genetic load in systemic lupus erythematosusNature Communications.  8. 2017
2017 Young adult and usual adult body mass index and multiple myeloma risk: A pooled analysis in the international multiple myeloma consortium (IMMC)Cancer Epidemiology, Biomarkers and Prevention.  26:876-885. 2017
2017 Recent trends in multiple myeloma incidence and survival by age, race, and ethnicity in the United StatesBlood Advances.  1:282-287. 2017
2016 A meta-analysis of multiple myeloma risk regions in African and European ancestry populations identifies putatively functional lociCancer Epidemiology, Biomarkers and Prevention.  25:1609-1618. 2016
2016 Killer cell immunoglobulin-like receptors are associated with common variable immune deficiency pathogenesisJournal of Allergy and Clinical Immunology.  138:1495-1498. 2016
2016 Impact of marital status, insurance status, income, and race/ethnicity on the survival of younger patients diagnosed with multiple myeloma in the United StatesCancer.  122:3183-3190. 2016
2016 Family history of hematologic malignancies and risk of multiple myeloma: differences by race and clinical featuresCancer Causes and Control.  27:81-91. 2016
2016 Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNAAnnals of the Rheumatic Diseases.  75:242-252. 2016
2014 Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcriptionAmerican Journal of Human Genetics.  94:586-598. 2014
2014 Complementary and alternative medicine use in African Americans with rheumatoid arthritisArthritis Care and Research.  66:180-189. 2014
2014 Genetic variants associated with methotrexate efficacy and toxicity in early rheumatoid arthritis: Results from the treatment of early aggressive rheumatoid arthritis trialThe Pharmacogenomics Journal.  14:48-53. 2014
2014 Brief report: A polymorphism in TLR2 is associated with arterial thrombosis in a multiethnic population of patients with systemic lupus erythematosusArthritis and Rheumatology.  66:1882-1887. 2014
2014 End-stage renal disease in African Americans with lupus nephritis is associated with APOL1Arthritis and Rheumatology.  66:390-396. 2014
2014 Fcγ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African AmericansArthritis and Rheumatology.  66:1291-1299. 2014
2014 Host genetics and immune control of HIV-1 infection: Fine mapping for the extended human MHC region in an African cohortGenes and Immunity.  15:275-281. 2014
2014 Lupus risk variants in the PXK locus alter B-cell receptor internalizationFrontiers in Genetics.  5. 2014
2013 Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4PLoS Genetics.  9. 2013
2013 Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody ProductionPLoS Genetics.  9. 2013
2013 Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in AsiansArthritis and Rheumatism.  65:211-215. 2013
2012 Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosusArthritis and Rheumatism.  64:3695-3705. 2012
2012 Evidence of genetic susceptibility to infectious mononucleosis: A twin studyEpidemiology and Infection.  140:2089-2095. 2012
2012 Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populationsArthritis and Rheumatism.  64:3687-3694. 2012
2012 Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestriesAnnals of the Rheumatic Diseases.  71:1809-1814. 2012
2012 Genetic risk factors for thrombosis in systemic lupus erythematosusJournal of Rheumatology.  39:1603-1610. 2012
2011 Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groupsArthritis and Rheumatism.  63:2755-2763. 2011
2011 Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosusArthritis and Rheumatism.  63:2049-2057. 2011
2011 Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21Arthritis and Rheumatism.  63:1689-1697. 2011
2011 Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibilityPLoS Genetics.  7. 2011
2011 Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.PLoS Genetics.  7:e1002079. 2011
2011 Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosusNature Genetics.  43:253-258. 2011
2011 Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic studyAmerican Journal of Human Genetics.  88:83-91. 2011
2010 Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African AmericansArthritis Care and Research.  62:3547-3553. 2010
2010 Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologistsCancer Causes and Control.  21:1857-1866. 2010
2010 Measurement of erythrocyte methotrexate polyglutamate levels: Ready for clinical use in rheumatoid arthritis?Current Rheumatology Reports.  12:342-347. 2010
2009 Erratum: Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing (Genes and Immunity (2009) vol. 10 (457-469) 10.1038/gene.2009.27)Genes and Immunity.  10:606. 2009
2009 Identification of new SLE-associated genes with a two-step Bayesian study designGenes and Immunity.  10:446-456. 2009
2009 Fcγ receptors: Structure, function and role as genetic risk factors in SLEGenes and Immunity.  10:380-389. 2009
2009 Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived populationGenes and Immunity.  10:531-538. 2009
2009 Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicingGenes and Immunity.  10:457-469. 2009
2009 Genetic associations of LYN with systemic lupus erythematosusGenes and Immunity.  10:397-403. 2009
2008 Approaches to complex pathways in molecular epidemiology: Summary of a special conference of the american association for cancer researchCancer Research.  68:10028-10030. 2008
2008 Risk factors for classical Kaposi sarcoma in a population-based case-control study in sicilyCancer Epidemiology, Biomarkers and Prevention.  17:3435-3443. 2008
2008 Genetic variation in the CRP promoter: Association with systemic lupus erythematosusHuman Molecular Genetics.  17:1147-1155. 2008
2008 Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African AmericansGenes and Immunity.  9:187-194. 2008
2007 Common variants in genes that mediate immunity and risk of multiple myelomaInternational Journal of Cancer.  120:2715-2722. 2007
2006 Haplotypes of IL6 and IL10 and susceptibility to human T lymphotropic virus type I infection among childrenJournal of Infectious Diseases.  194:1565-1569. 2006
2006 Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcomaCancer.  107:2282-2290. 2006
2006 Host immunogenetics and control of human herpesvirus-8 infectionJournal of Infectious Diseases.  193:1054-1062. 2006
2006 Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunityCancer Epidemiology, Biomarkers and Prevention.  15:926-934. 2006
2005 Correlates of Human Herpesvirus-8 DNA detection among adults in Italy without Kaposi sarcomaInternational Journal of Epidemiology.  34:1110-1117. 2005
2005 A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcomaCancer Epidemiology, Biomarkers and Prevention.  14:633-637. 2005

Research Overview

  • Molecular and Genetic Epidemiology of Immune-Mediated Clinical Phenotypes - The research conducted in Dr. Brown’s laboratory is mainly targeted to advance the understanding of aberrant immune function common to inflammatory-mediated chronic diseases, such as select autoimmune diseases as well as multiple myeloma and related precursor states, each with underlying B cell pathology. Within this purview, she uses a multidisciplinary functional genomics approach to explore pathways involved in chronic immune perturbation, inflammation as modifiers of disease, and B cell homeostasis. The objective of this research is to identify and validate molecular biomarkers, which may be used to target high-risk populations to improve disease surveillance and modify therapeutic intervention leading to significant reductions in morbidity and mortality associated with advanced stage disease.

    Keywords - multiple myeloma, autoimmune, lupus, genetics, genomics, epidemiology
  • Principal Investigator On

  • A Genome Wide Admixture Scan of Multiple Myeloma in African-Americans  awarded by University of Southern California
  • A Genome-Wide Methylation Study of Epigenetic Contributions to Multiple Myeloma  awarded by National Cancer Institute/NIH/DHHS
  • A Genome-Wide Methylation Study of Multiple Myeloma  awarded by HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY
  • Association of Genetic and Autoantibody Signatures with SLE Clinical Course  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Characterization of the Lupus Nephritis microRNAome  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Cancer Control and Population Sciences Program  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Cancer Control and Population Sciences Program  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Cancer Control and Population Sciences Program  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Cancer Control and Population Sciences Program  awarded by National Cancer Institute/NIH/DHHS
  • Contribution of Omics to Plasma Cell Proliferative Disorders  awarded by NEW YORK UNIVERSITY SCHOOL OF MEDICINE
  • Epigenetic contribution to the excess risk of MGUS in African Americans  awarded by National Cancer Institute/NIH/DHHS
  • Mayo/UAB Epidemiology of CLL Collaboration  awarded by MAYO CLINIC
  • Molecular Characterization of Myeloma and Related Asymptomatic Precursor States  awarded by National Cancer Institute/NIH/DHHS
  • Mutographs Differentiating the Racial and Temporal Incidence of Multiple Myeloma  awarded by NEW YORK UNIVERSITY SCHOOL OF MEDICINE
  • Program Project in the Genetics of SLE - Project 4 (A Genetic Risk Profile on Longitudinal SLE Cohorts)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Rheumatic Diseases Core Center: Pilot Project - P & F 3  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • The Role of Exosome Heparanase and miRNAs as Biomarkers for Myeloma  awarded by National Cancer Institute/NIH/DHHS
  • Investigator On

  • Active - Major Program Leader - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Genome-Wide Association Study in African-Americans With Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Genomics of Lupus  awarded by Oklahoma Medical Research Foundation (OMRF)
  • HLA Region and KIR Genomics in Common Variable Immune Deficiency  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Heparanase In Tumor Progression, Metastasis and Chemoresistance  awarded by National Cancer Institute/NIH/DHHS
  • Heparanase Regulation of Myeloma Metastasis: Mechanism and Therapy  awarded by National Cancer Institute/NIH/DHHS
  • Inhibition of Herpes Simplex Viruses Type 2 by Tenofovir  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Program Project in the Genetics of SLE  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • UAB Multidisciplinary Clinical Research Center (P60)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Understanding the Immune Microenvironment of Light Chain (AL) Amyloidosis  awarded by Amyloidosis Foundation
  • Teaching Activities

  • EPI610 - Prin of Epidemiologic Research (Fall Term 2014)
  • EPI695 - Epidemiology Seminar (Fall Term 2008)
  • EPI695 - Epidemiology Seminar (Spring Term 2008)
  • EPI695 - Epidemiology Seminar (Spring Term 2009)
  • EPI697 - Internship (Fall Term 2014)
  • EPI697 - Internship (Spring Term 2009)
  • EPI697 - Internship (Spring Term 2010)
  • EPI697 - Internship (Spring Term 2011)
  • EPI697 - Internship (Summer Term 2009)
  • EPI697 - Internship (Summer Term 2013)
  • EPI698 - Directed Research (Fall Term 2010)
  • EPI698 - Directed Research (Fall Term 2012)
  • EPI698 - Directed Research (Fall Term 2014)
  • EPI698 - Directed Research (Spring Term 2008)
  • EPI698 - Directed Research (Spring Term 2009)
  • EPI698 - Directed Research (Spring Term 2011)
  • EPI699 - Project Research (Fall Term 2010)
  • EPI699 - Project Research (Fall Term 2013)
  • EPI699 - Project Research (Spring Term 2011)
  • EPI699 - Project Research (Spring Term 2013)
  • EPI699 - Project Research (Spring Term 2014)
  • EPI699 - Project Research (Summer Term 2010)
  • EPI699 - Project Research (Summer Term 2013)
  • EPI788 - Prin/Meth Molecular Epidem (Summer Term 2008)
  • EPI788 - Prin/Meth Molecular Epidem (Summer Term 2009)
  • EPI788 - Prin/Meth Molecular Epidem (Summer Term 2011)
  • EPI788 - Prin/Meth Molecular Epidem (Summer Term 2013)
  • EPI790 - Doctoral Seminar (Fall Term 2012)
  • EPI795 - Epidemiology Seminar (Fall Term 2008)
  • EPI795 - Epidemiology Seminar (Spring Term 2008)
  • EPI795 - Epidemiology Seminar (Spring Term 2009)
  • EPI798 - Doctoral Directed Research (Fall Term 2010)
  • EPI798 - Doctoral Directed Research (Fall Term 2011)
  • EPI798 - Doctoral Directed Research (Fall Term 2013)
  • EPI798 - Doctoral Directed Research (Fall Term 2014)
  • EPI798 - Doctoral Directed Research (Spring Term 2011)
  • EPI798 - Doctoral Directed Research (Spring Term 2012)
  • EPI798 - Doctoral Directed Research (Spring Term 2013)
  • EPI798 - Doctoral Directed Research (Summer Term 2009)
  • EPI798 - Doctoral Directed Research (Summer Term 2011)
  • EPI798 - Doctoral Directed Research (Summer Term 2012)
  • EPI798 - Doctoral Directed Research (Summer Term 2013)
  • EPI798 - Doctoral Directed Research (Summer Term 2014)
  • EPI799 - Dissertation Research (Fall Term 2012)
  • EPI799 - Dissertation Research (Spring Term 2013)
  • EPI799 - Dissertation Research (Summer Term 2012)
  • Education And Training

  • Doctor of Philosophy in Epidemiology, Johns Hopkins University 2004
  • Master of Public Health in Epidemiology, Oregon Health Sciences University 2003
  • Bachelor of Science or Mathematics in Biology, University of Oregon 1992
  • Full Name

  • Elizabeth Brown