Positions

Overview

  • Dr. Inscho’s research focuses on understanding the regulation of renal microvascular function in healthy kidneys and in hypertension. Dr. Inscho earned his PhD in 1987 at the University of Cincinnati, College of Medicine. He received postdoctoral training at the University of Alabama at Birmingham and Tulane University School of Medicine and was a member of the Tulane University Department of Physiology faculty from 1989 through 2000. In 2001, he joined the Physiology faculty of the Medical College of Georgia as a Professor. He directed MCG’s MD/PhD program from 2004 to 2011 and served as the Interim Dean of the College of Graduate Studies from 2010-2012. Dr. Inscho has supported the scientific community by serving on numerous councils and committees including chairing peer-review AHA and NIH study sections and chairing the Research Committee for the Greater Southeast Affiliate of the American Heart Association. Dr. Inscho received the Harry Goldblatt Award for Cardiovascular Research (1998), the Hoechst Marion Rousell Young Scholars Award from the American Society of Hypertension (2000), and the Lewis K. Dahl Award for Hypertension Research (2008). His work has been continuously funded through investigator initiated grants from the local and national American Heart Associations, the National Kidney Foundation and the National Institutes of Health since 1991. Dr. Inscho serves on the Editorial Boards of prominent scientific journals related to renal physiology and hypertension and he has published over 115 peer-reviewed, original research papers, chapters and reviews.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Role for ovarian hormones in purinoceptor-dependent natriuresisBiology of Sex Differences.  11. 2020
    2020 Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role in renal microvascular pathophysiology in the Dahl salt-sensitive ratKidney International.  97:528-537. 2020
    2020 Extracellular nucleotides and P2 receptors in renal functionPhysiological Reviews.  100:211-269. 2020
    2020 Purinoceptors, renal microvascular function and hypertensionPhysiological Research.  69:353-369. 2020
    2019 Rho kinase inhibitors reduce voltage-dependent Ca2+ channel signaling in aortic and renal microvascular smooth muscle cells 2019
    2019 Antagonism of major histocompatibility complex class II invariant chain peptide during chronic lipopolysaccharide treatment rescues autoregulatory behavior 2019
    2019 Afferent arteriole responsiveness to endothelin receptor activation: Does sex matter? 11 Medical and Health Sciences 1103 Clinical SciencesBiology of Sex Differences.  10. 2019
    2018 Mechanisms of sphingosine-1-phosphate-mediated vasoconstriction of rat afferent arterioles 2018
    2017 Acute toll-like receptor 4 activation impairs rat renal microvascular autoregulatory behaviour 2017
    2016 "Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop 2016
    2016 Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats 2016
    2016 Metabolism of 13C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase 2016
    2015 Flow regulation of endothelin-1 production in the inner medullary collecting duct 2015
    2015 Flow regulation of endothelin-1 production in the inner medullary collecting duct 2015
    2015 Endothelin and the Renal MicrocirculationSeminars in Nephrology.  35:145-155. 2015
    2015 Endothelin contributes to blunted renal autoregulation observed with a high-salt diet 2015
    2015 Regulation of renal function and blood pressure control by P2 purinoceptors in the kidneyCurrent Opinion in Pharmacology.  21:82-88. 2015
    2014 High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism 2014
    2014 Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive ratsPLoS ONE.  9. 2014
    2014 Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension 2014
    2014 P2 receptors in renal autoregulation 2014
    2014 Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculatureJournal of the American Society of Nephrology.  25:1774-1785. 2014
    2013 Immunosuppression preserves renal autoregulatory function and microvascular P2X1 receptor reactivity in ANG II-hypertensive rats 2013
    2011 Endothelin and the renal vasculature.Contributions to Nephrology.  172:35-49. 2011
    2011 Endothelin and the renal vasculature 2011
    2011 Role of adenosine 5′-triphosphate in regulating renal microvascular function and in hypertensionHypertension.  58:333-340. 2011
    2011 P2X1 receptor-mediated vasoconstriction of afferent arterioles in angiotensin II-infused hypertensive rats fed a high-salt dietHypertension.  57:780-787. 2011
    2011 Physiology of endothelin and the kidneyComprehensive Physiology.  1:883-919. 2011
    2011 Regulation of blood pressure and salt homeostasis by endothelinPhysiological Reviews.  91:1-77. 2011
    2010 Interleukin 6 knockout prevents angiotensin II hypertension: Role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activationHypertension.  56:879-884. 2010
    2010 Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosisJournal of Pharmacology and Experimental Therapeutics.  334:430-438. 2010
    2010 P2X1 receptor blockade inhibits whole kidney autoregulation of renal blood flow in vivo 2010
    2010 Pentosan polysulfate treatment preserves renal autoregulation in ANG II-infused hypertensive rats via normalization of P2X 1 receptor activation 2010
    2010 Response to role of epithelial sodium channels in the renal myogenic response?Hypertension.  55. 2010
    2010 Clopidogrel, independent of the vascular P2Y12 receptor, improves arterial function in small mesenteric arteries from AngII-hypertensive ratsClinical Science.  118:463-471. 2010
    2010 p38 Mitogen-Activated Protein Kinase (MAPK) increases arginase activity and contributes to endothelial dysfunction in corpora cavernosa from angiotensin-II-treated mice 2010
    2009 Effect of epithelial sodium channel blockade on the myogenic response of rat juxtamedullary afferent arteriolesHypertension.  54:1062-1069. 2009
    2009 Purinoceptor regulation of renal tubular transport is coming of age 2009
    2009 Glomerular 20-HETE, EETs, and TGF-β1 in diabetic nephropathy 2009
    2009 Rho-kinase inhibition reduces pressure-mediated autoregulatory adjustments in afferent arteriolar diameter 2009
    2009 A true champion of Hungarian kidney research and nephrology education--tribute to László Rosivall.Acta Physiologica Hungarica.  96:375-382. 2009
    2009 ATP, P2 receptors and the renal microcirculationPurinergic Signalling.  5:447-460. 2009
    2009 Mysteries of renal autoregulationHypertension.  53:299-306. 2009
    2008 Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse 2008
    2007 Chemokine receptor 2b inhibition provides renal protection in angiotensin II-salt hypertensionHypertension.  50:1069-1076. 2007
    2007 P2X receptors as regulators of the renal microvasculatureTrends in Pharmacological Sciences.  28:646-652. 2007
    2007 Determination of adenosine effects and adenosine receptors in murine corpus cavernosumJournal of Pharmacology and Experimental Therapeutics.  322:678-685. 2007
    2007 Purinoceptors in the kidney 2007
    2007 P2 receptor regulation of [Ca2+]i in cultured mouse mesangial cells 2007
    2007 Attenuated vasoconstrictor responses to endothelin in afferent arterioles during a high-salt diet 2007
    2005 ET A and ET B receptors differentially modulate afferent and efferent arteriolar responses to endothelinBritish Journal of Pharmacology.  146:1019-1026. 2005
    2005 Calcium and chloride channel activation by angiotensin II-AT1 receptors in preglomerular vascular smooth muscle cells 2005
    2005 Impaired Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertensionHypertension.  46:562-568. 2005
    2005 TGF-β impairs renal autoregulation via generation of ROS 2005
    2005 L-type calcium channels, in the renal microcirculatory response to endothelin 2005
    2004 P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acidJournal of Pharmacology and Experimental Therapeutics.  311:1211-1217. 2004
    2004 Role of interstitial ATP and adenosine in the regulation of renal hemodynamics and microvascular functionHypertension Research.  27:791-804. 2004
    2004 Age-related alterations in NOS and oxidative stress in mesenteric arteries from male and female rats 2004
    2004 Renal autoregulation in P2X1 knockout mice 2004
    2004 Elevated arterial pressure impairs autoregulation independently of AT 1 receptor activationJournal of Hypertension.  22:811-818. 2004
    2003 12-Hydroxyeicosatetraenoic acid participates in angiotensin II afferent arteriolar vasoconstriction by activating L-type calcium channelsJournal of Lipid Research.  44:2391-2399. 2003
    2003 Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior.Journal of Clinical Investigation.  112:1895-1905. 2003
    2003 Purinergic Receptors in the Glomerulus and Vasculature of the KidneyCurrent Topics in Membranes.  54:453-478. 2003
    2003 Modulation of renal microvascular function by adenosine 2003
    2003 Physiological role for P2X1 receptors in renal microvascular autoregulatory behaviorJournal of Clinical Investigation.  112:1895-1905. 2003
    2002 Adaptations of the renal microcirculation to hypertensionMicrocirculation.  9:315-328. 2002
    2002 P2 receptor-mediated afferent arteriolar vasoconstriction during calcium blockade. 2002
    2002 Comparative responses to α,β-methylene-ATP in cat pulmonary, mesenteric, and hindquarter vascular beds 2002
    2002 Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cellsJournal of Pineal Research.  32:112-119. 2002
    2002 P2 receptor-mediated afferent arteriolar vasoconstriction during calcium blockade 2002
    2001 The CYP450 hydroxylase pathway contributes to P2X receptor-mediated afferent arteriolar vasoconstriction. 2001
    2001 Calcium signaling pathways utilized by P2X receptors in freshly isolated preglomerular MVSMC. 2001
    2001 P2 receptors in regulation of renal microvascular function. 2001
    2001 Interactions of adenosine A1 and A2a receptors on renal microvascular reactivity. 2001
    2001 Calcium signaling pathways utilized by P2X receptors in freshly isolated preglomerular MVSMC 2001
    2001 Interactions of adenosine A1 and A2a receptors on renal microvascular reactivity 2001
    2001 P2 receptors in regulation of renal microvascular function 2001
    2001 The CYP450 hydroxylase pathway contributes to P2X receptor-mediated afferent arteriolar vasoconstriction 2001
    2000 Postglomerular vasoconstriction to angiotensin II and norepinephrine depends on intracellular calcium releaseGeneral Pharmacology.  34:409-415. 2000
    1999 Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsivenessBritish Journal of Pharmacology.  127:1399-1405. 1999
    1999 Extracellular uridine nucleotides initiate cytokine production by murine dendritic cellsCellular Immunology.  195:147-156. 1999
    1999 ATP-mediated Ca2+ signaling in preglomerular smooth muscle cells.American Journal of Physiology.  276:F450-F456. 1999
    1999 P2 purinoceptor saturation by adenosine triphosphate impairs renal autoregulation in dogsJournal of the American Society of Nephrology.  10:492-498. 1999
    1999 ATP-mediated Ca2+ signaling in preglomerular smooth muscle cells 1999
    1999 Afferent arteriolar vasodilation to the sulfonimide analog of 11,12- epoxyeicosatrienoic acid involves protein kinase AHypertension.  33:408-413. 1999
    1999 Candesartan cilexetil protects against loss of autoregulatory efficiency in angiotensin II-infused ratsJournal of the American Society of Nephrology.  10. 1999
    1999 Purinoceptor-mediated calcium signaling in preglomerular smooth muscle cellsHypertension.  33:195-200. 1999
    1998 Cyclooxygenase-2 participates in tubular flow-dependent afferent arteriolar tone: interaction with neuronal NOS.American Journal of Physiology.  275:F605-F612. 1998
    1998 Direct assessment of renal microvascular responses to P2-purinoceptor agonists.American Journal of Physiology.  274:F718-F727. 1998
    1998 Perfusion pressure dependent augmentation of afferent arteriolar vasoconstriction to increased distal nephron volume deliveryThe FASEB Journal.  12. 1998
    1998 Neuronal nitric oxide synthase modulates rat renal microvascular function.American Journal of Physiology.  274:F516-F524. 1998
    1998 Calcium Mobilization Contributes to Pressure-Mediated Afferent Arteriolar VasoconstrictionHypertension.  31:421-428. 1998
    1998 Calcium mobilization contributes to pressure-mediated afferent arteriolar vasoconstriction.Hypertension.  31:421-428. 1998
    1998 Cyclooxygenase-2 participates in tubular flow-dependent afferent arteriolar tone: Interaction with neuronal NOS 1998
    1998 Direct assessment of renal microvascular responses to P2-purinoceptor agonists 1998
    1998 Interactive nitric oxide-angiotensin II influences on renal microcirculation in angiotensin II-induced hypertensionHypertension.  31:1255-1260. 1998
    1998 Neuronal nitric oxide synthase modulates rat renal microvascular function 1998
    1997 ATP and UTP have novel cAMP-mediated vasodilator activity in the hindlimb vascular bed of the catThe FASEB Journal.  11. 1997
    1997 ATP increases cytosolic CA2+ concentration in renal microvascular smooth muscle cells (MVSMC) through a thapsigargin-insensitive pathwayThe FASEB Journal.  11. 1997
    1997 Influence of angiotensin II on the autoregulatory stability of afferent arteriolar diameterThe FASEB Journal.  11. 1997
    1997 Neuronal nitric oxide synthase (nNOS) enhances efferent but not afferent arteriolar reactivity to angiotensin II (ANGII)The FASEB Journal.  11. 1997
    1997 Vascular responses to α,β methyl-ATP, a P2x selective agonist, are organ dependent in the catThe FASEB Journal.  11. 1997
    1997 Agonist-induced calcium regulation in freshly isolated renal microvascular smooth muscle cellsJournal of the American Society of Nephrology.  8:569-579. 1997
    1997 Afferent and efferent arteriolar vasoconstriction to angiotensin II and norepinephrine involves release of Ca2+ from intracellular storesHypertension.  29:222-227. 1997
    1997 Role of renal nerves in afferent arteriolar reactivity in angiotensin- induced hypertensionHypertension.  29:442-449. 1997
    1996 P2-purinoceptor characterization in rat juxtamedullary afferent arteriolesThe FASEB Journal.  10. 1996
    1996 Pressure-mediated vasoconstriction of juxtamedullary afferent arterioles involves P2-purinoceptor activation.American Journal of Physiology.  271:F1077-F1085. 1996
    1996 Extracellular ATP increases cytosolic calcium in cultured rat renal arterial smooth muscle cellsClinical and Experimental Pharmacology and Physiology.  23:503-507. 1996
    1996 Paracrine regulation of the renal microcirculationPhysiological Reviews.  76:425-536. 1996
    1996 Pressure-mediated vasoconstriction of juxtamedullary afferent arterioles involves P2-purinoceptor activation 1996
    1995 Calcium activation mechanisms in the renal microvascular response to extracellular ATP.American Journal of Physiology.  268:F876-F884. 1995
    1995 Calcium activation mechanisms in the renal microvascular response to extracellular ATP 1995
    1994 Autoregulation of afferent arteriolar blood flow in juxtamedullary nephrons.American Journal of Physiology.  267:F879-F887. 1994
    1994 Paracrine interactions regulating renal microcirculatory function 1994
    1994 Modulation of dihydropyridine receptors in vascular smooth muscle cells by membrane potential and cell proliferation 1994
    1994 Autoregulation of afferent arteriolar blood flow in juxtamedullary nephrons 1994
    1994 Autoregulation of afferent arteriolar blood flow in juxtamedullary nephronsAmerican Journal of Physiology.  267. 1994
    1994 Extracellular ATP in the regulation of renal microvascular functionThe FASEB Journal.  8:319-328. 1994
    1994 Renal arteriolar angiotensin responses during varied adenosine receptor activationHypertension.  23:I-114-I-119. 1994
    1992 EDRF-angiotensin II interactions in rat juxtamedullary afferent and efferent arterioles.American Journal of Physiology.  263:F900-F906. 1992
    1992 Effects of ATP on pre- and postglomerular juxtamedullary microvasculature.American Journal of Physiology.  263:F886-F893. 1992
    1992 Attenuated afferent arteriolar response to acetylcholine in goldblatt hypertensionHypertension.  19:785-789. 1992
    1992 EDRF-angiotensin II interactions in rat juxtamedullary afferent and efferent arteriolesAmerican Journal of Physiology.  263. 1992
    1992 Effects of ATP on pre- and postglomerular juxtamedullary microvasculatureAmerican Journal of Physiology.  263. 1992
    1992 Perfusate composition modulates in vitro renal microvascular pressure responsiveness in a segment-specific mannerMicrovascular Research.  43:347-351. 1992
    1991 Influence of adenosine receptor blockade on renal function and renal autoregulationJournal of the American Society of Nephrology.  2:991-999. 1991
    1991 Communication between the macula densa cells and the afferent arterioleKidney International1991
    1991 Determinants of renal microvascular autoregulatory behavior in normal and hypertensive ratsKidney International1991
    1991 Juxtamedullary afferent arteriolar responses to P1 and P2 purinergic stimulationHypertension.  17:1033-1037. 1991
    1990 Prostaglandin influences on afferent arteriolar responses to vasoconstrictor agonists.American Journal of Physiology.  259:F157-F163. 1990
    1990 Afferent arteriolar responsiveness to altered perfusion pressure in renal hypertensionHypertension.  15:748-752. 1990
    1990 Arterial pressure effects on preglomerular microvasculature of juxtamedullary nephronsAmerican Journal of Physiology.  258. 1990
    1990 Arterial pressure effects on preglomerular microvasculature of juxtamedullary nephrons.American Journal of Physiology.  258:F94-102. 1990
    1990 Prostaglandin influences on afferent arteriolar responses to vasoconstrictor agonistsAmerican Journal of Physiology.  259. 1990
    1989 The biological and immunological properties of fractionated atrial extracts from young and old ratsLife Sciences.  45:2333-2342. 1989
    1988 Direct evaluation of the microvascular actions of ANP in juxtamedullary nephrons.American Journal of Physiology.  254:F440-F444. 1988
    1988 Direct evaluation of the microvascular actions of ANP in juxtamedullary nephronsAmerican Journal of Physiology.  254. 1988
    1987 Age-related differences in the natriuretic and hypotensive properties of rat atrial extractsEndocrinology.  121:1662-1670. 1987
    1986 Dissociation and enrichment of rat atrial myocytes containing atrial natriuretic factor (Anf) 1986
    1984 Histamine H1 receptor antagonists inhibit autoregulation of renal blood flow in the dogCirculation Research.  54:527-535. 1984
    1982 Histamine H1 receptors and renal autoregulationThe FASEB Journal.  41. 1982

    Book

    Year Title Altmetric
    2000 Nonendothelial paracrine regulation of the renal microcirculation.  Ed. 9.  2000

    Chapter

    Year Title Altmetric
    2008 The Renal Microcirculation.  550-683. 2008

    Investigator On

  • Interdisciplinary Training In Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2024
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 1 = Circadian Control of Sodium Excretion  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 3 = HDAC-Mediated Regulation of Endothelin and Nitric Oxide  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2021
  • Sex Differences in Renal Sodium Handling  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2021
  • Sphingosine-1-Phosphate in Renal Microvascular Dysfunction of Ischemia-Reperfusion Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2021
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center - Novel Mechanisms of Salt-Sensitivity and Diurnal Blood Pressure Rhythm - Project 3  awarded by American Heart Association 2015 - 2020
  • Sex-Differences in Renal Sodium Handling  awarded by American Heart Association 2018 - 2019
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center  awarded by American Heart Association 2015 - 2019
  • Education And Training

  • Doctor of Philosophy in Physiology, Pathology, and Related Sciences, University of Cincinnati 1987
  • Full Name

  • Edward Inscho