Selected Publications

Academic Article

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2016 "Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop 2016
2015 Endothelin and the Renal Microcirculation 2015
2015 Regulation of renal function and blood pressure control by P2 purinoceptors in the kidney 2015
2014 Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats 2014
2014 P2 receptors in renal autoregulation 2014
2014 Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature 2014
2011 Endothelin and the renal vasculature. 2011
2011 Role of adenosine 5′-triphosphate in regulating renal microvascular function and in hypertension 2011
2011 P2X1 receptor-mediated vasoconstriction of afferent arterioles in angiotensin II-infused hypertensive rats fed a high-salt diet 2011
2011 Physiology of endothelin and the kidney 2011
2011 Regulation of blood pressure and salt homeostasis by endothelin 2011
2010 Interleukin 6 knockout prevents angiotensin II hypertension: Role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation 2010
2010 Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis 2010
2010 Response to role of epithelial sodium channels in the renal myogenic response? 2010
2010 Clopidogrel, independent of the vascular P2Y12 receptor, improves arterial function in small mesenteric arteries from AngII-hypertensive rats 2010
2010 p38 Mitogen-Activated Protein Kinase (MAPK) increases arginase activity and contributes to endothelial dysfunction in corpora cavernosa from angiotensin-II-treated mice 2010
2009 Effect of epithelial sodium channel blockade on the myogenic response of rat juxtamedullary afferent arterioles 2009
2009 ATP, P2 receptors and the renal microcirculation 2009
2009 Mysteries of renal autoregulation 2009
2008 Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse 2008
2007 Chemokine receptor 2b inhibition provides renal protection in angiotensin II-salt hypertension 2007
2007 P2X receptors as regulators of the renal microvasculature 2007
2007 Determination of adenosine effects and adenosine receptors in murine corpus cavernosum 2007
2007 Purinoceptors in the kidney 2007
2005 ET A and ET B receptors differentially modulate afferent and efferent arteriolar responses to endothelin 2005
2005 Impaired Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertension 2005
2004 P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acid 2004
2004 Role of interstitial ATP and adenosine in the regulation of renal hemodynamics and microvascular function 2004
2004 Age-related alterations in NOS and oxidative stress in mesenteric arteries from male and female rats 2004
2004 Elevated arterial pressure impairs autoregulation independently of AT 1 receptor activation 2004
2003 12-Hydroxyeicosatetraenoic acid participates in angiotensin II afferent arteriolar vasoconstriction by activating L-type calcium channels 2003
2003 Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. 2003
2003 Purinergic Receptors in the Glomerulus and Vasculature of the Kidney 2003
2003 Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior 2003
2002 Adaptations of the renal microcirculation to hypertension 2002
2002 Comparative responses to α,β-methylene-ATP in cat pulmonary, mesenteric, and hindquarter vascular beds 2002
2002 Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cells 2002
2000 Postglomerular vasoconstriction to angiotensin II and norepinephrine depends on intracellular calcium release 2000
1999 Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness 1999
1999 Extracellular uridine nucleotides initiate cytokine production by murine dendritic cells 1999
1999 P2 purinoceptor saturation by adenosine triphosphate impairs renal autoregulation in dogs 1999
1999 Afferent arteriolar vasodilation to the sulfonimide analog of 11,12- epoxyeicosatrienoic acid involves protein kinase A 1999
1999 Candesartan cilexetil protects against loss of autoregulatory efficiency in angiotensin II-infused rats 1999
1999 Purinoceptor-mediated calcium signaling in preglomerular smooth muscle cells 1999
1998 Perfusion pressure dependent augmentation of afferent arteriolar vasoconstriction to increased distal nephron volume delivery 1998
1998 Calcium Mobilization Contributes to Pressure-Mediated Afferent Arteriolar Vasoconstriction 1998
1998 Calcium mobilization contributes to pressure-mediated afferent arteriolar vasoconstriction. 1998
1998 Interactive nitric oxide-angiotensin II influences on renal microcirculation in angiotensin II-induced hypertension 1998
1997 ATP and UTP have novel cAMP-mediated vasodilator activity in the hindlimb vascular bed of the cat 1997
1997 ATP increases cytosolic CA2+ concentration in renal microvascular smooth muscle cells (MVSMC) through a thapsigargin-insensitive pathway 1997
1997 Influence of angiotensin II on the autoregulatory stability of afferent arteriolar diameter 1997
1997 Neuronal nitric oxide synthase (nNOS) enhances efferent but not afferent arteriolar reactivity to angiotensin II (ANGII) 1997
1997 Vascular responses to α,β methyl-ATP, a P2x selective agonist, are organ dependent in the cat 1997
1997 Agonist-induced calcium regulation in freshly isolated renal microvascular smooth muscle cells 1997
1997 Afferent and efferent arteriolar vasoconstriction to angiotensin II and norepinephrine involves release of Ca2+from intracellular stores 1997
1997 Role of renal nerves in afferent arteriolar reactivity in angiotensin- induced hypertension 1997
1996 P2-purinoceptor characterization in rat juxtamedullary afferent arterioles 1996
1996 Extracellular ATP increases cytosolic calcium in cultured rat renal arterial smooth muscle cells 1996
1996 Paracrine regulation of the renal microcirculation 1996
1994 Extracellular ATP in the regulation of renal microvacular function 1994
1994 Paracrine interactions regulating renal microcirculatory function 1994
1994 Modulation of dihydropyridine receptors in vascular smooth muscle cells by membrane potential and cell proliferation 1994
1994 Renal arteriolar angiotensin responses during varied adenosine receptor activation 1994
1992 Attenuated afferent arteriolar response to acetylcholine in goldblatt hypertension 1992
1992 Perfusate composition modulates in vitro renal microvascular pressure responsiveness in a segment-specific manner 1992
1991 Influence of adenosine receptor blockade on renal function and renal autoregulation 1991
1991 Communication between the macula densa cells and the afferent arteriole 1991
1991 Determinants of renal microvascular autoregulatory behavior in normal and hypertensive rats 1991
1991 Juxtamedullary afferent arteriolar responses to P1 and P2 purinergic stimulation 1991
1990 Afferent arteriolar responsiveness to altered perfusion pressure in renal hypertension 1990
1989 The biological and immunological properties of fractionated atrial extracts from young and old rats 1989
1987 Age-related differences in the natriuretic and hypotensive properties of rat atrial extracts 1987
1986 Dissociation and enrichment of rat atrial myocytes containing atrial natriuretic factor (Anf) 1986
1984 Histamine H1 receptor antagonists inhibit autoregulation of renal blood flow in the dog 1984
1982 Histamine H1receptors and renal autoregulation 1982


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2000 Nonendothelial paracrine regulation of the renal microcirculation.  Ed. 9.  2000


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2008 The Renal Microcirculation.  550-683. 2008

Education And Training

  • Doctor of Philosophy in Physiology, Pathology, and Related Sciences, University of Cincinnati 1987
  • Full Name

  • Edward Inscho