Selected Publications

Academic Article

Year Title Altmetric
2022 Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell SignalingJournal of Virology.  96. 2022
2022 Site-specific recognition of SARS-CoV-2 nsp1 protein with a tailored titanium dioxide nanoparticle - elucidation of the complex structure using NMR data and theoretical calculation†Nanoscale Advances.  4:1527-1532. 2022
2022 Molecular Virology of Chikungunya VirusCurrent Topics in Microbiology and Immunology.  435:1-31. 2022
2021 1H, 13C and 15N resonance assignment of the SARS-CoV-2 full-length nsp1 protein and its mutants reveals its unique secondary structure features in solutionPLoS One.  16. 2021
2021 Natural and recombinant SARS-CoV-2 isolates rapidly evolve in vitro to higher infectivity through more efficient binding to heparan sulfate and reduced S1/S2 cleavageJournal of Virology.  95. 2021
2021 NAP1L1 and NAP1L4 binding to hypervariable domain of Chikungunya Virus nsP3 protein is bivalent and requires phosphorylationJournal of Virology.  95. 2021
2021 Natural isolate and recombinant SARS-CoV-2 rapidly evolve in vitro to higher infectivity through more efficient binding to heparan sulfate and reduced S1/S2 cleavage. 2021
2021 NAP1L1 and NAP1L4 binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein is bivalent and requires phosphorylation 2021
2021 Optimized production and immunogenicity of an insect virus-based chikungunya virus candidate vaccine in cell culture and animal modelsEmerging Microbes and Infections.  10:305-316. 2021
2021 Structural and functional characterization of host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 ProteinJournal of Virology.  95. 2021
2020 Novel NMR Assignment Strategy Reveals Structural Heterogeneity in Solution of the nsP3 HVD Domain of Venezuelan Equine Encephalitis VirusMolecules.  25. 2020
2020 Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein 2020
2020 Hypervariable domain of nsP3 of eastern equine encephalitis virus is a critical determinant of viral virulenceJournal of Virology.  94. 2020
2020 Mutations in hypervariable domain of venezuelan equine encephalitis virus nsP3 protein differentially affect viral replicationJournal of Virology.  94. 2020
2019 Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 proteinVirology.  537:130-142. 2019
2019 Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivoVirology.  534:14-24. 2019
2019 Novel mutations in NSP2 abolish Chikungunya virus-induced transcriptional shutoff and make the virus less cytopathic without affecting its replication ratesJournal of Virology.  93. 2019
2018 Multiple host factors interact with the hypervariable domain of chikungunya virus nsP3 and determine viral replication in cell-specific modeJournal of Virology.  92. 2018
2018 β-D-N 4 -Hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genomeJournal of Virology.  92. 2018
2018 Sindbis virus infection causes cell death by NSP2-induced transcriptional shutoff or by Nsp3-dependent translational shutoffJournal of Virology.  92. 2018
2017 Hypervariable domain of eastern equine encephalitis virus nsP3 redundantly utilizes multiple cellular proteins for replication complex assemblyJournal of Virology.  91. 2017
2016 New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication ComplexesPLoS Pathogens.  12. 2016
2016 Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent modeVirology.  487:230-241. 2016
2016 The SD1 subdomain of venezuelan equine encephalitis virus capsid protein plays a critical role in nucleocapsid and particle assemblyJournal of Virology.  90:2008-2020. 2016
2015 IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I InterferonPLoS Pathogens.  11. 2015
2015 Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotypeJournal of Virology.  89:71-82. 2015
2014 Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAsProceedings of the National Academy of Sciences of USA.  111:10708-10713. 2014
2014 Interferon-stimulated poly(ADP-ribose) polymerases are potent inhibitors of cellular translation and virus replicationJournal of Virology.  88:2116-2130. 2014
2013 Hypervariable domain of nonstructural protein nsp3 of venezuelan equine encephalitis virus determines cell-specific mode of virus replicationJournal of Virology.  87:7569-7584. 2013
2013 Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virionsJournal of Virology.  87:4202-4213. 2013
2013 Hypervariable Domains of nsP3 Proteins of New World and Old World Alphaviruses Mediate Formation of Distinct, Virus-Specific Protein ComplexesJournal of Virology.  87:1997-2010. 2013
2013 Pseudoinfectious Venezuelan Equine Encephalitis Virus: A New Means of Alphavirus AttenuationJournal of Virology.  87:2023-2035. 2013
2013 The amino-terminal domain of alphavirus capsid protein is dispensable for viral particle assembly but regulates RNA encapsidation through cooperative functions of its subdomainsJournal of Virology.  87:12003-12019. 2013
2012 New PARP gene with an anti-alphavirus functionJournal of Virology.  86:8147-8160. 2012
2012 Evasion of the innate immune response: The old world alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase IIJournal of Virology.  86:7180-7191. 2012
2012 Early events in alphavirus replication determine the outcome of infectionJournal of Virology.  86:5055-5066. 2012
2011 Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution.Journal of Virology.  85:8022-8036. 2011
2011 Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotypeJournal of Virology.  85:4363-4376. 2011
2011 Conservation of a packaging signal and the Vira genome RNA packaging mechanism in alphavirus evolutionJournal of Virology.  85:8022-8036. 2011
2010 Functional sindbis virus replicative complexes are formed at the plasma membraneJournal of Virology.  84:11679-11695. 2010
2010 Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin α/β that obstructs nuclear pore complex functionJournal of Virology.  84:4158-4171. 2010
2010 Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid proteinJournal of Virology.  84:10004-10015. 2010
2009 Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcriptionJournal of Virology.  83:9031-9044. 2009
2008 Different types of nsP3-containing protein complexes in sindbis virus-infected cellsJournal of Virology.  82:10088-10101. 2008
2008 IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cellsVirology.  377:160-169. 2008
2008 A new role for ns polyprotein cleavage in Sindbis virus replicationJournal of Virology.  82:6218-6231. 2008
2008 Venezuelan equine encephalitis virus capsid protein inhibits nuclear import in mammalian but not in mosquito cellsJournal of Virology.  82:4028-4041. 2008
2007 Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcriptionJournal of Virology.  81:13552-13565. 2007
2007 Comparative analysis of the alphavirus-based vectors expressing Rift Valley fever virus glycoproteinsVirology.  366:212-225. 2007
2007 Development of Sindbis viruses encoding nsP2/GFP chimeric proteins and their application for studying nsP2 functioningJournal of Virology.  81:5046-5057. 2007
2007 The old world and new world alphaviruses use different virus-specific proteins for induction of transcriptional shutoffJournal of Virology.  81:2472-2484. 2007
2006 Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcriptionJournal of Virology.  80:5686-5696. 2006
2006 Formation of nsP3-specific protein complexes during Sindbis virus replicationJournal of Virology.  80:4122-4134. 2006
2006 Expression patterns of Wnt genes during development of an anterior part of the chicken eyeDevelopmental Dynamics.  235:496-505. 2006
2005 Inhibition of transcription and translation in Sindbis virus-infected cellsJournal of Virology.  79:9397-9409. 2005
2004 PKR-dependent and -independent mechanisms are involved in translational shutoff during sindbis virus infectionJournal of Virology.  78:8455-8467. 2004
2004 The expression pattern of opticin during chicken embryogenesisGene Expression Patterns.  4:335-338. 2004
2002 Roles of nonstructural protein nsP2 and alpha/beta interferons in determining the outcome of Sindbis virus infectionJournal of Virology.  76:11254-11264. 2002
2000 The expression pattern of a novel Deltex homologue during chicken embryogenesisMechanisms of Development.  92:285-289. 2000
1999 Binding of the glucose-dependent Mig1p repressor to the GAL1 and GAL4 promoters in vivo: Regulation by glucose and chromatin structureNucleic Acids Research.  27:1350-1358. 1999
1997 Packaging Signals in AlohavirusesJournal of Virology.  71:248-258. 1997
1997 Sindbis virus replicons and sindbis virus: Assembly of chimeras and of particles deficient in virus RNAJournal of Virology.  71:2819-2829. 1997
1995 Ribozyme mimics as catalytic antisense reagentsApplied Biochemistry and Biotechnology.  54:43-56. 1995
1994 Sequence-Specific Cleavage of HIV mRNA by a Ribozyme MimicJournal of the American Chemical Society.  116:5981-5982. 1994
1994 Inhibition of the in vitro translation of the influenza virus protein NP mRNA by derivatives of an antisense oligodeoxynucleotideMolecular Biology.  28:307-312. 1994
1993 Influence of 3'- and 5'-terminal reactive groups of primer on its initiating properties in the polymerization reactionMolecular Biology.  27:781-789. 1993
1993 Comparison of interactions of 5′-derivatives of deoxyoctathymidylate with human DNA polymerize α and HIV reverse transcriptaseMolecular Biology Reports: an international journal on molecular and cellular biology.  18:43-47. 1993
1993 Porphyrin derivatives of oligonucleotides. I. Synthesis of oligonucleotide derivatives bearing 2,4-di(alpha-(2-hydroxyethoxy)ethyl)- deuteroporphyrin IX or a metal complex of it and study of the oxidative modification of DNA by these derivativesBioorganicheskaia khimiia.  19:439-454. 1993
1993 Oxidative degradation of nucleic acidsRussian Chemical Reviews.  62. 1993
1993 Kinetic study of the addressed modification by hemin derivatives of oligonucleotidesBiochimie.  75:5-11. 1993
1992 Oligonucleotide derivatives inhibit influenza virus RNA transcriptionMolecular Biology.  26:635-644. 1992
1991 5′-Derivatives of oligonucleotides as primers of DNA polymerization catalyzed by AMV reverse transcriptase and Klenow fragment of DNA polymerase 1FEBS Letters.  281:111-113. 1991
1991 Affinity chromatography of DNA fragments and oligonucleotides blocked by internucleotide phosphatesBioorganicheskaia khimiia.  17:232-240. 1991
1991 Hydroxyl radical generation by oligonucleotide derivatives of anthracycline antibiotic and synthetic quinoneChemico-Biological Interactions.  77:325-339. 1991
1991 New porphyrin-linked oligonucleotide derivatives for sequence-specific chemical modification of DNA.Nucleic Acids Symposium Series.  286. 1991
1991 Photoactivatabu Porphyrin Oligonucleotide Derivatives For Sequence Specific Ceemical Modification And Cleavage Of DnaNucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication.  10:641-643. 1991
1991 Suppression of transcription and translation of the influenza virus RNAs by oligonucleotide derivativesNucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication.  10:645-647. 1991
1990 Porphyrin-linked oligonucleotides. Synthesis and sequence-specific modification of ssDNAFEBS Letters.  269:101-104. 1990
1989 Hydroxyl radical generation and DNA strand scission mediated by natural anticancer and synthetic quinonesFEBS Letters.  242:397-400. 1989
1988 Complementary-addressed modification of a single-stranded DNA fragment with an iron-porphyrin oligonucleotide derivativeBioorganicheskaia khimiia.  14:551-554. 1988
1987 Prokaryotic and eukaryotic DNA-polymerase. I. The role of internucleotide phosphate groups in the binding of a primer with the enzymeBioorganicheskaia khimiia.  13:45-57. 1987
1987 The influence of the bases noncomplementary to the template on the efficiency of the interaction of the primers with the human placenta DNA-polymerase αMolecular Biology.  21:1193-1200. 1987

Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, Novosibirsk State University 1992
  • Master's Level Degree in Biochemistry, Novosibirsk State University 1985
  • Bachelor's Level Degree in Biochemistry, Novosibirsk State University 1984
  • Full Name

  • Elena Frolova