Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Mutations in hypervariable domain of venezuelan equine encephalitis virus nsP3 protein differentially affect viral replication 2020
2019 Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein 2019
2019 Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo 2019
2019 Novel mutations in NSP2 abolish Chikungunya virus-induced transcriptional shutoff and make the virus less cytopathic without affecting its replication rates 2019
2019 Combination of ribosome and phage display for fast selection of high affinity VHH antibody fragments 2019
2019 Molecular Virology of Chikungunya Virus. 2019
2018 Multiple host factors interact with the hypervariable domain of chikungunya virus nsP3 and determine viral replication in cell-specific mode 2018
2018 β-D-N 4 -Hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome 2018
2018 Chimeric antigen receptor expression in natural killer cell line NK-92 by transduction with lentiviral particles pseudotyped with the surface glycoproteins of the measles virus vaccine strain 2018
2018 Sindbis virus infection causes cell death by NSP2-induced transcriptional shutoff or by Nsp3-dependent translational shutoff 2018
2018 Therapeutic strategies for targeting cancer stem cells 2018
2017 Hypervariable domain of eastern equine encephalitis virus nsP3 redundantly utilizes multiple cellular proteins for replication complex assembly 2017
2016 New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes 2016
2016 Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode 2016
2016 Role of PDLIM4 and c-Src in Breast Cancer Progression 2016
2016 The SD1 subdomain of venezuelan equine encephalitis virus capsid protein plays a critical role in nucleocapsid and particle assembly 2016
2015 IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon 2015
2015 Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype 2015
2014 Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs 2014
2014 Interferon-stimulated poly(ADP-ribose) polymerases are potent inhibitors of cellular translation and virus replication 2014
2013 Hypervariable domain of nonstructural protein nsp3 of venezuelan equine encephalitis virus determines cell-specific mode of virus replication 2013
2013 Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions 2013
2013 Hypervariable Domains of nsP3 Proteins of New World and Old World Alphaviruses Mediate Formation of Distinct, Virus-Specific Protein Complexes 2013
2013 Pseudoinfectious Venezuelan Equine Encephalitis Virus: A New Means of Alphavirus Attenuation 2013
2013 The amino-terminal domain of alphavirus capsid protein is dispensable for viral particle assembly but regulates RNA encapsidation through cooperative functions of its subdomains 2013
2012 New PARP gene with an anti-alphavirus function 2012
2012 Evasion of the innate immune response: The old world alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase II 2012
2012 Early events in alphavirus replication determine the outcome of infection 2012
2011 Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution. 2011
2011 Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype 2011
2010 Functional sindbis virus replicative complexes are formed at the plasma membrane 2010
2010 Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin α/β that obstructs nuclear pore complex function 2010
2010 Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid protein 2010
2009 Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription 2009
2008 Different types of nsP3-containing protein complexes in sindbis virus-infected cells 2008
2008 IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells 2008
2008 A new role for ns polyprotein cleavage in Sindbis virus replication 2008
2008 Venezuelan equine encephalitis virus capsid protein inhibits nuclear import in mammalian but not in mosquito cells 2008
2007 Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcription 2007
2007 Comparative analysis of the alphavirus-based vectors expressing Rift Valley fever virus glycoproteins 2007
2007 Development of Sindbis viruses encoding nsP2/GFP chimeric proteins and their application for studying nsP2 functioning 2007
2007 The old world and new world alphaviruses use different virus-specific proteins for induction of transcriptional shutoff 2007
2006 Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcription 2006
2006 Formation of nsP3-specific protein complexes during Sindbis virus replication 2006
2006 Expression patterns of Wnt genes during development of an anterior part of the chicken eye 2006
2005 Inhibition of transcription and translation in Sindbis virus-infected cells 2005
2004 PKR-dependent and -independent mechanisms are involved in translational shutoff during sindbis virus infection 2004
2004 The expression pattern of opticin during chicken embryogenesis 2004
2002 Roles of nonstructural protein nsP2 and alpha/beta interferons in determining the outcome of Sindbis virus infection 2002
2000 The expression pattern of a novel Deltex homologue during chicken embryogenesis 2000
1999 Binding of the glucose-dependent Mig1p repressor to the GAL1 and GAL4 promoters in vivo: Regulation by glucose and chromatin structure 1999
1997 Packaging Signals in Alohaviruses 1997
1997 Sindbis virus replicons and sindbis virus: Assembly of chimeras and of particles deficient in virus RNA 1997
1995 Ribozyme mimics as catalytic antisense reagents 1995
1994 Sequence-Specific Cleavage of HIV mRNA by a Ribozyme Mimic 1994
1994 Inhibition of the in vitro translation of the influenza virus protein NP mRNA by derivatives of an antisense oligodeoxynucleotide 1994
1993 Influence of 3'- and 5'-terminal reactive groups of primer on its initiating properties in the polymerization reaction 1993
1993 Comparison of interactions of 5′-derivatives of deoxyoctathymidylate with human DNA polymerize α and HIV reverse transcriptase 1993
1993 Porphyrin derivatives of oligonucleotides. I. Synthesis of oligonucleotide derivatives bearing 2,4-di(alpha-(2-hydroxyethoxy)ethyl)- deuteroporphyrin IX or a metal complex of it and study of the oxidative modification of DNA by these derivatives 1993
1993 Oxidative degradation of nucleic acids 1993
1993 Kinetic study of the addressed modification by hemin derivatives of oligonucleotides 1993
1992 Oligonucleotide derivatives inhibit influenza virus RNA transcription 1992
1991 5′-Derivatives of oligonucleotides as primers of DNA polymerization catalyzed by AMV reverse transcriptase and Klenow fragment of DNA polymerase 1 1991
1991 Affinity chromatography of DNA fragments and oligonucleotides blocked by internucleotide phosphates 1991
1991 Hydroxyl radical generation by oligonucleotide derivatives of anthracycline antibiotic and synthetic quinone 1991
1991 New porphyrin-linked oligonucleotide derivatives for sequence-specific chemical modification of DNA. 1991
1991 Photoactivatabu Porphyrin Oligonucleotide Derivatives For Sequence Specific Ceemical Modification And Cleavage Of Dna 1991
1991 Suppression of transcription and translation of the influenza virus RNAs by oligonucleotide derivatives 1991
1990 Porphyrin-linked oligonucleotides. Synthesis and sequence-specific modification of ssDNA 1990
1989 Hydroxyl radical generation and DNA strand scission mediated by natural anticancer and synthetic quinones 1989
1988 Complementary-addressed modification of a single-stranded DNA fragment with an iron-porphyrin oligonucleotide derivative 1988
1987 Prokaryotic and eukaryotic DNA-polymerase. I. The role of internucleotide phosphate groups in the binding of a primer with the enzyme 1987
1987 The influence of the bases noncomplementary to the template on the efficiency of the interaction of the primers with the human placenta DNA-polymerase α 1987

Principal Investigator On

Investigator On

Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, Novosibirsk State University 1992
  • Master's Level Degree in Biochemistry, Novosibirsk State University 1985
  • Bachelor's Level Degree in Biochemistry, Novosibirsk State University 1984

    • Full Name

  • Elena Frolova