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Elena Frolova Ph.D.
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efrolova@uab.edu
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Elena Frolova Ph.D.
Professor
Positions
Scientist (C)
,
Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC)
,
School of Medicine
Associate Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
Scientist (C)
,
Center for AIDS Research
,
School of Medicine
Professor (P)
,
Microbiology
,
Academic Joint Departments
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2022
Site-specific recognition of SARS-CoV-2 nsp1 protein with a tailored titanium dioxide nanoparticle - elucidation of the complex structure using NMR data and theoretical calculation†
2022
2022
Molecular Virology of Chikungunya Virus
.
Current Topics in Microbiology and Immunology
. 435:1-31.
2022
2021
1
H,
13
C and
15
N resonance assignment of the SARS-CoV-2 full-length nsp1 protein and its mutants reveals its unique secondary structure features in solution
.
PLoS ONE
. 16.
2021
2021
Natural and recombinant SARS-CoV-2 isolates rapidly evolve in vitro to higher infectivity through more efficient binding to heparan sulfate and reduced S1/S2 cleavage
.
Journal of Virology
. 95.
2021
2021
NAP1L1 and NAP1L4 binding to hypervariable domain of Chikungunya Virus nsP3 protein is bivalent and requires phosphorylation
.
Journal of Virology
. 95.
2021
2021
Natural isolate and recombinant SARS-CoV-2 rapidly evolve in vitro to higher infectivity through more efficient binding to heparan sulfate and reduced S1/S2 cleavage.
2021
2021
Optimized production and immunogenicity of an insect virus-based chikungunya virus candidate vaccine in cell culture and animal models
2021
2021
Structural and functional characterization of host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein
.
Journal of Virology
. 95.
2021
2020
Novel NMR Assignment Strategy Reveals Structural Heterogeneity in Solution of the nsP3 HVD Domain of Venezuelan Equine Encephalitis Virus
.
Molecules
. 25.
2020
2020
Hypervariable domain of nsP3 of eastern equine encephalitis virus is a critical determinant of viral virulence
.
Journal of Virology
. 94.
2020
2020
Mutations in hypervariable domain of venezuelan equine encephalitis virus nsP3 protein differentially affect viral replication
.
Journal of Virology
. 94.
2020
2019
Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein
.
Virology
. 537:130-142.
2019
2019
Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo
.
Virology
. 534:14-24.
2019
2019
Novel mutations in NSP2 abolish Chikungunya virus-induced transcriptional shutoff and make the virus less cytopathic without affecting its replication rates
.
Journal of Virology
. 93.
2019
2018
Multiple host factors interact with the hypervariable domain of chikungunya virus nsP3 and determine viral replication in cell-specific mode
.
Journal of Virology
. 92.
2018
2018
β-D-N
4
-Hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome
.
Journal of Virology
. 92.
2018
2018
Sindbis virus infection causes cell death by NSP2-induced transcriptional shutoff or by Nsp3-dependent translational shutoff
.
Journal of Virology
. 92.
2018
2017
Hypervariable domain of eastern equine encephalitis virus nsP3 redundantly utilizes multiple cellular proteins for replication complex assembly
.
Journal of Virology
. 91.
2017
2016
New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes
.
PLoS Pathogens
. 12.
2016
2016
Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode
.
Virology
. 487:230-241.
2016
2016
The SD1 subdomain of venezuelan equine encephalitis virus capsid protein plays a critical role in nucleocapsid and particle assembly
.
Journal of Virology
. 90:2008-2020.
2016
2015
IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon
.
PLoS Pathogens
. 11.
2015
2015
Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype
.
Journal of Virology
. 89:71-82.
2015
2014
Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs
2014
2014
Interferon-stimulated poly(ADP-ribose) polymerases are potent inhibitors of cellular translation and virus replication
.
Journal of Virology
. 88:2116-2130.
2014
2013
Hypervariable domain of nonstructural protein nsp3 of venezuelan equine encephalitis virus determines cell-specific mode of virus replication
.
Journal of Virology
. 87:7569-7584.
2013
2013
Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions
.
Journal of Virology
. 87:4202-4213.
2013
2013
Hypervariable Domains of nsP3 Proteins of New World and Old World Alphaviruses Mediate Formation of Distinct, Virus-Specific Protein Complexes
.
Journal of Virology
. 87:1997-2010.
2013
2013
Pseudoinfectious Venezuelan Equine Encephalitis Virus: A New Means of Alphavirus Attenuation
.
Journal of Virology
. 87:2023-2035.
2013
2013
The amino-terminal domain of alphavirus capsid protein is dispensable for viral particle assembly but regulates RNA encapsidation through cooperative functions of its subdomains
.
Journal of Virology
. 87:12003-12019.
2013
2012
New PARP gene with an anti-alphavirus function
.
Journal of Virology
. 86:8147-8160.
2012
2012
Evasion of the innate immune response: The old world alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase II
.
Journal of Virology
. 86:7180-7191.
2012
2012
Early events in alphavirus replication determine the outcome of infection
.
Journal of Virology
. 86:5055-5066.
2012
2011
Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution.
.
Journal of Virology
. 85:8022-8036.
2011
2011
Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype
.
Journal of Virology
. 85:4363-4376.
2011
2011
Conservation of a packaging signal and the Vira genome RNA packaging mechanism in alphavirus evolution
.
Journal of Virology
. 85:8022-8036.
2011
2010
Functional sindbis virus replicative complexes are formed at the plasma membrane
.
Journal of Virology
. 84:11679-11695.
2010
2010
Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin α/β that obstructs nuclear pore complex function
.
Journal of Virology
. 84:4158-4171.
2010
2010
Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid protein
.
Journal of Virology
. 84:10004-10015.
2010
2009
Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription
.
Journal of Virology
. 83:9031-9044.
2009
2008
Different types of nsP3-containing protein complexes in sindbis virus-infected cells
.
Journal of Virology
. 82:10088-10101.
2008
2008
IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells
.
Virology
. 377:160-169.
2008
2008
A new role for ns polyprotein cleavage in Sindbis virus replication
.
Journal of Virology
. 82:6218-6231.
2008
2008
Venezuelan equine encephalitis virus capsid protein inhibits nuclear import in mammalian but not in mosquito cells
.
Journal of Virology
. 82:4028-4041.
2008
2007
Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcription
.
Journal of Virology
. 81:13552-13565.
2007
2007
Comparative analysis of the alphavirus-based vectors expressing Rift Valley fever virus glycoproteins
.
Virology
. 366:212-225.
2007
2007
Development of Sindbis viruses encoding nsP2/GFP chimeric proteins and their application for studying nsP2 functioning
.
Journal of Virology
. 81:5046-5057.
2007
2007
The old world and new world alphaviruses use different virus-specific proteins for induction of transcriptional shutoff
.
Journal of Virology
. 81:2472-2484.
2007
2006
Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcription
.
Journal of Virology
. 80:5686-5696.
2006
2006
Formation of nsP3-specific protein complexes during Sindbis virus replication
.
Journal of Virology
. 80:4122-4134.
2006
2006
Expression patterns of Wnt genes during development of an anterior part of the chicken eye
.
Developmental Dynamics
. 235:496-505.
2006
2005
Inhibition of transcription and translation in Sindbis virus-infected cells
.
Journal of Virology
. 79:9397-9409.
2005
2004
PKR-dependent and -independent mechanisms are involved in translational shutoff during sindbis virus infection
.
Journal of Virology
. 78:8455-8467.
2004
2004
The expression pattern of opticin during chicken embryogenesis
.
Gene Expression Patterns
. 4:335-338.
2004
2002
Roles of nonstructural protein nsP2 and alpha/beta interferons in determining the outcome of Sindbis virus infection
.
Journal of Virology
. 76:11254-11264.
2002
2000
The expression pattern of a novel Deltex homologue during chicken embryogenesis
.
Mechanisms of Development
. 92:285-289.
2000
1999
Binding of the glucose-dependent Mig1p repressor to the GAL1 and GAL4 promoters in vivo: Regulation by glucose and chromatin structure
.
Nucleic Acids Research
. 27:1350-1358.
1999
1997
Packaging Signals in Alohaviruses
.
Journal of Virology
. 71:248-258.
1997
1997
Sindbis virus replicons and sindbis virus: Assembly of chimeras and of particles deficient in virus RNA
.
Journal of Virology
. 71:2819-2829.
1997
1995
Ribozyme mimics as catalytic antisense reagents
.
Applied Biochemistry and Biotechnology
. 54:43-56.
1995
1994
Sequence-Specific Cleavage of HIV mRNA by a Ribozyme Mimic
.
Journal of the American Chemical Society
. 116:5981-5982.
1994
1994
Inhibition of the in vitro translation of the influenza virus protein NP mRNA by derivatives of an antisense oligodeoxynucleotide
.
Molecular Biology
. 28:307-312.
1994
1993
Influence of 3'- and 5'-terminal reactive groups of primer on its initiating properties in the polymerization reaction
.
Molecular Biology
. 27:781-789.
1993
1993
Comparison of interactions of 5′-derivatives of deoxyoctathymidylate with human DNA polymerize α and HIV reverse transcriptase
1993
1993
Porphyrin derivatives of oligonucleotides. I. Synthesis of oligonucleotide derivatives bearing 2,4-di(alpha-(2-hydroxyethoxy)ethyl)- deuteroporphyrin IX or a metal complex of it and study of the oxidative modification of DNA by these derivatives
.
Bioorganicheskaia khimiia
. 19:439-454.
1993
1993
Oxidative degradation of nucleic acids
.
Russian Chemical Reviews
. 62.
1993
1993
Kinetic study of the addressed modification by hemin derivatives of oligonucleotides
.
Biochimie
. 75:5-11.
1993
1992
Oligonucleotide derivatives inhibit influenza virus RNA transcription
.
Molecular Biology
. 26:635-644.
1992
1991
5′-Derivatives of oligonucleotides as primers of DNA polymerization catalyzed by AMV reverse transcriptase and Klenow fragment of DNA polymerase 1
.
FEBS Letters
. 281:111-113.
1991
1991
Affinity chromatography of DNA fragments and oligonucleotides blocked by internucleotide phosphates
.
Bioorganicheskaia khimiia
. 17:232-240.
1991
1991
Hydroxyl radical generation by oligonucleotide derivatives of anthracycline antibiotic and synthetic quinone
.
Chemico-Biological Interactions
. 77:325-339.
1991
1991
New porphyrin-linked oligonucleotide derivatives for sequence-specific chemical modification of DNA.
.
Nucleic Acids Symposium Series
. 286.
1991
1991
Photoactivatabu Porphyrin Oligonucleotide Derivatives For Sequence Specific Ceemical Modification And Cleavage Of Dna
1991
1991
Suppression of transcription and translation of the influenza virus RNAs by oligonucleotide derivatives
1991
1990
Porphyrin-linked oligonucleotides. Synthesis and sequence-specific modification of ssDNA
.
FEBS Letters
. 269:101-104.
1990
1989
Hydroxyl radical generation and DNA strand scission mediated by natural anticancer and synthetic quinones
.
FEBS Letters
. 242:397-400.
1989
1988
Complementary-addressed modification of a single-stranded DNA fragment with an iron-porphyrin oligonucleotide derivative
.
Bioorganicheskaia khimiia
. 14:551-554.
1988
1987
Prokaryotic and eukaryotic DNA-polymerase. I. The role of internucleotide phosphate groups in the binding of a primer with the enzyme
.
Bioorganicheskaia khimiia
. 13:45-57.
1987
1987
The influence of the bases noncomplementary to the template on the efficiency of the interaction of the primers with the human placenta DNA-polymerase α
.
Molecular Biology
. 21:1193-1200.
1987
NAP1L1 and NAP1L4 binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein is bivalent and requires phosphorylation
Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein
Research
Principal Investigator On
Alphavirus nsP3 Protein: Roles of Intrinsically Disordered Region in Virus Replication and Pathogenesis
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
HTS Assay for Identification of Small Molecule Inhibitors of Venezuelan Equine Encephalitis
awarded by
SOUTHERN RESEARCH INSTITUTE
Mechanistic Role of ns2 Protein in Evasion of Innate Immune Response by Alphaviruses
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Multiple Functions of VEEV nsP3 in Virus Replication
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Sindbis Nonstructural Protein nsP2: Interaction with Cellular Proteins
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Investigator On
Development of a Ribonucleoside Analog to Treat VEEV Infections
awarded by
Emory University
Mechanism of Alphavirus Packaging: Designing of Pseudoinfectious Viruses
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Mechanistic Understanding of SH3 Domain-containing Protein Function in Alphavirus Replication
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
New Generation of Efficient Vaccines Against Encephalitogenic Alphaviruses
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Revolutionary Eilat-based Chikungunya Vaccine Vector
awarded by
UNIVERSITY OF TEXAS MEDICAL BRANCH (GALVESTON)
Single Round Infection Chikungunya Virus as a New Vaccine Candidate
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
The Molecular Basis of VEEV Pathogenesis
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Teaching
Teaching Activities
GBS762 - Virology (Spring Term 2011)
GBS762 - Virology (Spring Term 2012)
GBS762 - Virology (Spring Term 2013)
GBS762 - Virology (Spring Term 2014)
GBS762 - Virology (Spring Term 2015)
GBS762 - Virology (Spring Term 2016)
GBS762 - Virology (Spring Term 2017)
GBS762 - Virology (Spring Term 2018)
GBS762 - Virology (Spring Term 2019)
GBS762 - Virology (Spring Term 2020)
Background
Education And Training
Doctor of Philosophy Level Degree in Biochemistry,
Novosibirsk State University
1992
Master's Level Degree in Biochemistry,
Novosibirsk State University
1985
Bachelor's Level Degree in Biochemistry,
Novosibirsk State University
1984
Contact
Full Name
Elena
Frolova