Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Optimized production and immunogenicity of an insect virus-based chikungunya virus candidate vaccine in cell culture and animal models 2021
2021 Structural and functional characterization of host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein.  Journal of Virology.  95. 2021
2020 Novel NMR Assignment Strategy Reveals Structural Heterogeneity in Solution of the nsP3 HVD Domain of Venezuelan Equine Encephalitis Virus.  Molecules.  25. 2020
2020 Hypervariable domain of nsP3 of eastern equine encephalitis virus is a critical determinant of viral virulence.  Journal of Virology.  94. 2020
2020 Mutations in hypervariable domain of venezuelan equine encephalitis virus nsP3 protein differentially affect viral replication.  Journal of Virology.  94. 2020
2019 Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein.  Virology.  537:130-142. 2019
2019 Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo.  Virology.  534:14-24. 2019
2019 Novel mutations in NSP2 abolish Chikungunya virus-induced transcriptional shutoff and make the virus less cytopathic without affecting its replication rates.  Journal of Virology.  93. 2019
2019 Molecular Virology of Chikungunya Virus..  Current Topics in Microbiology and Immunology.  2019
2018 Multiple host factors interact with the hypervariable domain of chikungunya virus nsP3 and determine viral replication in cell-specific mode.  Journal of Virology.  92. 2018
2018 β-D-N 4 -Hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome.  Journal of Virology.  92. 2018
2018 Sindbis virus infection causes cell death by NSP2-induced transcriptional shutoff or by Nsp3-dependent translational shutoff.  Journal of Virology.  92. 2018
2017 Hypervariable domain of eastern equine encephalitis virus nsP3 redundantly utilizes multiple cellular proteins for replication complex assembly.  Journal of Virology.  91. 2017
2016 New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes.  PLoS Pathogens.  12. 2016
2016 Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode.  Virology.  487:230-241. 2016
2016 The SD1 subdomain of venezuelan equine encephalitis virus capsid protein plays a critical role in nucleocapsid and particle assembly.  Journal of Virology.  90:2008-2020. 2016
2015 IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon.  PLoS Pathogens.  11. 2015
2015 Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype.  Journal of Virology.  89:71-82. 2015
2014 Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs 2014
2014 Interferon-stimulated poly(ADP-ribose) polymerases are potent inhibitors of cellular translation and virus replication.  Journal of Virology.  88:2116-2130. 2014
2013 Hypervariable domain of nonstructural protein nsp3 of venezuelan equine encephalitis virus determines cell-specific mode of virus replication.  Journal of Virology.  87:7569-7584. 2013
2013 Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions.  Journal of Virology.  87:4202-4213. 2013
2013 Hypervariable Domains of nsP3 Proteins of New World and Old World Alphaviruses Mediate Formation of Distinct, Virus-Specific Protein Complexes.  Journal of Virology.  87:1997-2010. 2013
2013 Pseudoinfectious Venezuelan Equine Encephalitis Virus: A New Means of Alphavirus Attenuation.  Journal of Virology.  87:2023-2035. 2013
2013 The amino-terminal domain of alphavirus capsid protein is dispensable for viral particle assembly but regulates RNA encapsidation through cooperative functions of its subdomains.  Journal of Virology.  87:12003-12019. 2013
2012 New PARP gene with an anti-alphavirus function.  Journal of Virology.  86:8147-8160. 2012
2012 Evasion of the innate immune response: The old world alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase II.  Journal of Virology.  86:7180-7191. 2012
2012 Early events in alphavirus replication determine the outcome of infection.  Journal of Virology.  86:5055-5066. 2012
2011 Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution..  Journal of Virology.  85:8022-8036. 2011
2011 Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype.  Journal of Virology.  85:4363-4376. 2011
2010 Functional sindbis virus replicative complexes are formed at the plasma membrane.  Journal of Virology.  84:11679-11695. 2010
2010 Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin α/β that obstructs nuclear pore complex function.  Journal of Virology.  84:4158-4171. 2010
2010 Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid protein.  Journal of Virology.  84:10004-10015. 2010
2009 Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription.  Journal of Virology.  83:9031-9044. 2009
2008 Different types of nsP3-containing protein complexes in sindbis virus-infected cells.  Journal of Virology.  82:10088-10101. 2008
2008 IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells.  Virology.  377:160-169. 2008
2008 A new role for ns polyprotein cleavage in Sindbis virus replication.  Journal of Virology.  82:6218-6231. 2008
2008 Venezuelan equine encephalitis virus capsid protein inhibits nuclear import in mammalian but not in mosquito cells.  Journal of Virology.  82:4028-4041. 2008
2007 Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcription.  Journal of Virology.  81:13552-13565. 2007
2007 Comparative analysis of the alphavirus-based vectors expressing Rift Valley fever virus glycoproteins.  Virology.  366:212-225. 2007
2007 Development of Sindbis viruses encoding nsP2/GFP chimeric proteins and their application for studying nsP2 functioning.  Journal of Virology.  81:5046-5057. 2007
2007 The old world and new world alphaviruses use different virus-specific proteins for induction of transcriptional shutoff.  Journal of Virology.  81:2472-2484. 2007
2006 Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcription.  Journal of Virology.  80:5686-5696. 2006
2006 Formation of nsP3-specific protein complexes during Sindbis virus replication.  Journal of Virology.  80:4122-4134. 2006
2006 Expression patterns of Wnt genes during development of an anterior part of the chicken eye.  Developmental Dynamics.  235:496-505. 2006
2005 Inhibition of transcription and translation in Sindbis virus-infected cells.  Journal of Virology.  79:9397-9409. 2005
2004 PKR-dependent and -independent mechanisms are involved in translational shutoff during sindbis virus infection.  Journal of Virology.  78:8455-8467. 2004
2004 The expression pattern of opticin during chicken embryogenesis.  Gene Expression Patterns.  4:335-338. 2004
2002 Roles of nonstructural protein nsP2 and alpha/beta interferons in determining the outcome of Sindbis virus infection.  Journal of Virology.  76:11254-11264. 2002
2000 The expression pattern of a novel Deltex homologue during chicken embryogenesis.  Mechanisms of Development.  92:285-289. 2000
1999 Binding of the glucose-dependent Mig1p repressor to the GAL1 and GAL4 promoters in vivo: Regulation by glucose and chromatin structure.  Nucleic Acids Research.  27:1350-1358. 1999
1997 Packaging Signals in Alohaviruses.  Journal of Virology.  71:248-258. 1997
1997 Sindbis virus replicons and sindbis virus: Assembly of chimeras and of particles deficient in virus RNA.  Journal of Virology.  71:2819-2829. 1997
1995 Ribozyme mimics as catalytic antisense reagents.  Applied Biochemistry and Biotechnology.  54:43-56. 1995
1994 Sequence-Specific Cleavage of HIV mRNA by a Ribozyme Mimic.  Journal of the American Chemical Society.  116:5981-5982. 1994
1994 Inhibition of the in vitro translation of the influenza virus protein NP mRNA by derivatives of an antisense oligodeoxynucleotide.  Molecular Biology.  28:307-312. 1994
1993 Influence of 3'- and 5'-terminal reactive groups of primer on its initiating properties in the polymerization reaction.  Molecular Biology.  27:781-789. 1993
1993 Comparison of interactions of 5′-derivatives of deoxyoctathymidylate with human DNA polymerize α and HIV reverse transcriptase 1993
1993 Porphyrin derivatives of oligonucleotides. I. Synthesis of oligonucleotide derivatives bearing 2,4-di(alpha-(2-hydroxyethoxy)ethyl)- deuteroporphyrin IX or a metal complex of it and study of the oxidative modification of DNA by these derivatives.  Bioorganicheskaia khimiia.  19:439-454. 1993
1993 Oxidative degradation of nucleic acids.  Russian Chemical Reviews.  62. 1993
1993 Kinetic study of the addressed modification by hemin derivatives of oligonucleotides.  Biochimie.  75:5-11. 1993
1992 Oligonucleotide derivatives inhibit influenza virus RNA transcription.  Molecular Biology.  26:635-644. 1992
1991 5′-Derivatives of oligonucleotides as primers of DNA polymerization catalyzed by AMV reverse transcriptase and Klenow fragment of DNA polymerase 1.  FEBS Letters.  281:111-113. 1991
1991 Affinity chromatography of DNA fragments and oligonucleotides blocked by internucleotide phosphates.  Bioorganicheskaia khimiia.  17:232-240. 1991
1991 Hydroxyl radical generation by oligonucleotide derivatives of anthracycline antibiotic and synthetic quinone.  Chemico-Biological Interactions.  77:325-339. 1991
1991 New porphyrin-linked oligonucleotide derivatives for sequence-specific chemical modification of DNA..  Nucleic Acids Symposium Series.  286. 1991
1991 Photoactivatabu Porphyrin Oligonucleotide Derivatives For Sequence Specific Ceemical Modification And Cleavage Of Dna 1991
1991 Suppression of transcription and translation of the influenza virus RNAs by oligonucleotide derivatives 1991
1990 Porphyrin-linked oligonucleotides. Synthesis and sequence-specific modification of ssDNA.  FEBS Letters.  269:101-104. 1990
1989 Hydroxyl radical generation and DNA strand scission mediated by natural anticancer and synthetic quinones.  FEBS Letters.  242:397-400. 1989
1988 Complementary-addressed modification of a single-stranded DNA fragment with an iron-porphyrin oligonucleotide derivative.  Bioorganicheskaia khimiia.  14:551-554. 1988
1987 Prokaryotic and eukaryotic DNA-polymerase. I. The role of internucleotide phosphate groups in the binding of a primer with the enzyme.  Bioorganicheskaia khimiia.  13:45-57. 1987
1987 The influence of the bases noncomplementary to the template on the efficiency of the interaction of the primers with the human placenta DNA-polymerase α.  Molecular Biology.  21:1193-1200. 1987
Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein

Principal Investigator On

Investigator On

Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, Novosibirsk State University 1992
  • Master's Level Degree in Biochemistry, Novosibirsk State University 1985
  • Bachelor's Level Degree in Biochemistry, Novosibirsk State University 1984

    • Full Name

  • Elena Frolova