Positions

Overview

  • Dr. Beierle received her undergraduate degree and medical degree from the University of North Dakota, graduating in 1989. She completed a general surgery internship at Baylor College of Medicine in Houston and subsequently completed her surgical residency at the University of Florida in 1996. She completed her pediatric surgery fellowship training in Philadelphia at St. Christopher’s Hospital for Children in 1998. Dr. Beierle came to the University of Alabama at Birmingham in 2009, after spending over nine years on the faculty at the University of Florida. She specializes in the surgical care of children and neonates with a special emphasis upon pediatric surgical oncology. She has an active basic science research laboratory that focuses on novel therapeutics for pediatric solid tumors. She has mentored a number of undergraduate students, medical students, residents and graduate students in her lab.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 PP2A activation alone and in combination with cisplatin decreases cell growth and tumor formation in human HuH6 hepatoblastoma cells 2019
    2019 Investigation of PP2A and Its Endogenous Inhibitors in Neuroblastoma Cell Survival and Tumor Growth 2019
    2018 Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 Expression 2018
    2018 FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts 2018
    2018 UAB30, a novel RXR agonist, decreases tumorigenesis and leptomeningeal disease in group 3 medulloblastoma patient-derived xenografts 2018
    2018 Pediatric patients with small-cell carcinoma of the ovary have similar survival to adults: A review of the national cancer database 2018
    2018 Systemic thrombolysis of an occlusive aortic thrombus in a neonate on extracorporeal membrane oxygenation 2018
    2018 Testicular tumors in prepubescent patients 2018
    2018 A novel retinoid X receptor agonist, UAB30, inhibits rhabdomyosarcoma cells in vitro 2018
    2018 Targeting PIM kinase as a therapeutic strategy in human hepatoblastoma 2018
    2018 Disparities in fertility-sparing surgery in adolescent and young women with stage I ovarian dysgerminoma 2018
    2018 Partial nephrectomy for nephroblastoma: A national cancer data base review 2018
    2018 Pediatric-protocol of multimodal therapy is associated with improved survival in AYAs and adults with rhabdomyosarcoma 2018
    2018 Socioeconomic disparities affect survival in malignant ovarian germ cell tumors in AYA population 2018
    2018 Pediatric anaplastic embryonal rhabdomyosarcoma: Targeted therapy guided by genetic analysis and a patient-derived xenograft study 2018
    2017 Newly Characterized Murine Undifferentiated Sarcoma Models Sensitive to Virotherapy with Oncolytic HSV-1 M002 2017
    2017 Open versus laparoscopic approach to gastric fundoplication in children with cardiac risk factors 2017
    2017 Whole exome sequencing identified sixty-five coding mutations in four neuroblastoma tumors 2017
    2017 Effects of socioeconomic status on children with well-differentiated thyroid cancer 2017
    2017 Breast Malignancies in Children: Presentation, Management, and Survival 2017
    2017 Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database 2017
    2017 Utilization of the NSQIP-Pediatric Database in Development and Validation of a New Predictive Model of Pediatric Postoperative Wound Complications 2017
    2017 Survival and surgical outcomes for pediatric head and neck melanoma 2017
    2017 The association between nephroblastoma-specific outcomes and high versus low volume treatment centers 2017
    2016 Effect of repeat dosing of engineered oncolytic herpes simplex virus on preclinical models of rhabdomyosarcoma 2016
    2016 Ileocolic and jejunal intussusceptions requiring surgical intervention in a pediatric patient with posttransplant lymphoproliferative disorder 2016
    2016 Targeting focal adhesion kinase suppresses the malignant phenotype in rhabdomyosarcoma cells 2016
    2016 Colorectal carcinoma in pediatric patients: A comparison with adult tumors, treatment and outcomes from the National Cancer Database 2016
    2016 Outcome assessment of renal replacement therapy in neonates 2016
    2016 Preclinical evaluation of UAB30 in pediatric renal and hepatic malignancies 2016
    2016 Risk factors for stricture formation after esophageal atresia repair 2016
    2016 Factors associated with mortality in pediatric vs adult nasopharyngeal carcinoma 2016
    2016 Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex viruses 2016
    2016 Cell proliferation in neuroblastoma 2016
    2015 Cancer stem cells and their interaction with the tumor microenvironment in neuroblastoma 2015
    2015 Surgical management and morbidity of pediatric magnet ingestions 2015
    2015 Pediatric cancer gone viral. Part I: Strategies for utilizing oncolytic herpes simplex virus-1 in children 2015
    2015 Pediatric cancer gone viral. Part II: Potential clinical application of oncolytic herpes simplex virus-1 in children 2015
    2015 Preclinical evaluation of a novel RXR agonist for the treatment of neuroblastoma 2015
    2015 Focal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival 2015
    2015 Pediatric papillary thyroid cancer > 1 cm: Is total thyroidectomy necessary? 2015
    2015 Primary malignant pulmonary tumors in children: A review of the national cancer data base 2015
    2015 Erratum: [γ 1 34.5-deleted HSV-1-expressing human cytomegalovirus IRS1 gene kills human glioblastoma cells as efficiently as wild-type HSV-1 in normoxia or hypoxia (Gene Therapy) (2015) 22: 348-355] 2015
    2015 Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma 2015
    2015 Routine utilization of Single-Incision Pediatric Endosurgery (SIPES): A 5-year institutional experience 2015
    2015 Single-incision pediatric endosurgery (SIPES) splenectomy: what dictates the need for additional ports? 2015
    2015 γ 1 34.5-deleted HSV-1-expressing human cytomegalovirus IRS1 gene kills human glioblastoma cells as efficiently as wild-type HSV-1 in normoxia or hypoxia 2015
    2014 Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines 2014
    2014 Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of pediatric solid tumors 2014
    2014 Extraction of esophageal foreign bodies in children: Rigid versus flexible endoscopy 2014
    2014 FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors 2014
    2014 Parathyroid carcinoma in more than 1,000 patients: A population-level analysis 2014
    2014 Role of laparoscopy in the prevention and in the treatment of adhesions 2014
    2014 The interaction between FAK, MYCN, p53 and Mdm2 in neuroblastoma 2014
    2014 Utility of immature granulocyte percentage in pediatric appendicitis 2014
    2013 Neonatal spiradenoma 2013
    2013 Preclinical Evaluation of Engineered Oncolytic Herpes Simplex Virus for the Treatment of Neuroblastoma 2013
    2013 Laparoscopic cholecystectomy for biliary dyskinesia in children: Frequency increasing 2013
    2013 Mentoring in pediatric oncology: A report from the children's oncology group young investigator committee 2013
    2013 FAK inhibition decreases cell invasion, migration and metastasis in MYCN amplified neuroblastoma 2013
    2013 Single incision pediatric endosurgery (SIPES) appendectomy - Is obesity a contraindication? 2013
    2013 Cell survival signaling in neuroblastoma 2013
    2013 Single-incision pediatric endosurgery for ovarian pathology 2013
    2013 FAK inhibition decreases hepatoblastoma survival both in vitro and in vivo 2013
    2012 Angiodysplasia (vascular malformations) of the colon presenting as an acute abdomen 2012
    2012 Feasibility of single-incision pediatric endosurgery for treatment of appendicitis in 415 children 2012
    2012 Laparoscopic surgery in children with congenital heart disease 2012
    2012 Targeting pediatric cancer stem cells with oncolytic virotherapy. 2012
    2011 MYCN, neuroblastoma and focal adhesion kinase (FAK) 2011
    2010 Inhibition of focal adhesion kinase and Src increases detachment and apoptosis in human neuroblastoma cell lines 2010
    2010 Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma 2010
    2010 All-terrain vehicle safety in Florida: Is legislation really the answer? 2010
    2010 Targeting Focal Adhesion Kinase in Neuroblastoma 2010
    2009 Infectious risk to ventriculo-peritoneal shunts from gastrointestinal surgery in the pediatric population 2009
    2009 Equestrian injuries in children 2009
    2009 Ketone bodies inhibit the viability of human neuroblastoma cells 2009
    2008 Pediatric basal cell carcinoma: case reports and literature review 2008
    2008 Focal adhesion kinase expression in human neuroblastoma: immunohistochemical and real-time PCR analyses 2008
    2008 Traumatic aortic injuries in the pediatric population 2008
    2008 Pulmonary surgery in cystic fibrosis 2008
    2008 TAE226 inhibits human neuroblastoma cell survival 2008
    2008 Ashes, embers, and coals: Significant sources of burn-related morbidity in children 2008
    2008 Mesenteric lipoblastoma: a rare location in children 2008
    2007 Hydrofluoric acid burn in a child from a compressed air duster 2007
    2007 The use of Seprafilm® in pediatric surgical patients 2007
    2007 N-MYC regulates focal adhesion kinase expression in human neuroblastoma 2007
    2006 Differential response of neuroblastoma cells to TRAIL is independent of PI3K/AKT 2006
    2006 Pediatric Surgical Issues in Meconium Disease and Cystic Fibrosis 2006
    2006 Recurrent pneumonia in children: A case report and approach to diagnosis 2006
    2005 VEGF-mediated survivin expression in neuroblastoma cells 2005
    2005 Exhaust system burn injuries in children 2005
    2004 Administration of prenatal betamethasone suppresses the adrenal-hypophyseal axis in newborns with congenital diaphragmatic hernia 2004
    2004 Artificial rearing of mouse pups: Development of a mouse pup in a cup model 2004
    2004 Expression of VEGF receptors in cocultured neuroblastoma cells 2004
    2004 Extracorporeal membrane oxygenation combined with endovascular embolization for management of neonatal high-output cardiac failure secondary to intracranial arteriovenous fistula: Case report 2004
    2004 Animal models for intestinal tissue engineering 2004
    2003 Neuroblastoma, apoptosis, and growth factors 2003
    2003 Twenty years of progress in congenital diaphragmatic hernia at the University of Florida 2003
    2003 Analysis of Gene Expression Patterns in Human Postburn Hypertrophic Scars 2003
    2003 Pediatric sand aspiration: Case report and literature review 2003
    2003 Differential expression of Bcl-2 and Bax may enhance neuroblastoma survival 2003
    2003 VEGF receptors are differentially expressed by neuroblastoma cells in culture 2003
    2002 Small watercraft injuries in children 2002
    2002 Caspase 3 expression is altered in a coculture model of neuroblastoma 2002
    2002 Competency-based student self-assessment on a surgery rotation 2002
    2002 Insulin-like growth factor-I protects neuroblastoma against starvation-induced apoptosis and is associated with increased Bcl-2 expression 2002
    2002 VEGF upregulates BCL-2 expression and is associated with decreased apoptosis in neuroblastoma cells 2002
    2001 Gastrointestinal foreign bodies 2001
    2001 VEGF is upregulated in a neuroblastoma and hepatocyte coculture model 2001
    2000 Neuroblastoma and hepatocyte coculture conditioned media alter apoptosis 2000
    2000 Free fluid on abdominal computed tomography scan after blunt trauma does not mandate exploratory laparotomy in children 2000
    1999 Fas-mediated induction of hepatocyte apoptosis in a neuroblastoma and hepatocyte coculture model 1999
    1998 Gastrointestinal perforation after pediatric orthotopic liver transplantation 1998
    1998 Gastrointestinal surgery in cystic fibrosis 1998
    1996 Hepatic tumor necrosis factor-α production and distant organ dysfunction in a murine model of obstructive jaundice 1996
    1996 In utero lung growth of fetal sheep with diaphragmatic hernia and tracheal stenosis 1996
    1995 PEG-BP-30 monotherapy attenuates the cytokine-mediated inflammatory cascade in baboon Escherichia coli septic shock 1995

    Chapter

    Year Title Altmetric
    2010 Focal adhesion kinase with the interacting proteins and signaling in cancer.  275-305. 2010
    2007 Surgical management of complications of burn injury.  502-512. 2007

    Education And Training

  • Baylor College of Medicine, Internship 1990
  • St. Christopher's Hospital for Children, Residency 1998
  • University of Florida/Shands Hospital, Residency 1996
  • Full Name

  • Elizabeth Beierle Chen