Selected Publications

Academic Article

Year Title Altmetric
2022 TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancerNature Communications.  13. 2022
2022 Integrated bioinformatic pipeline using whole-exome and RNAseq data to identify germline variants correlated with cancerSTAR Protocols.  3. 2022
2022 tRForest: a novel random forest-based algorithm for tRNA-derived fragment target predictionNAR Genomics and Bioinformatics.  4. 2022
2022 Function and Therapeutic Implications of tRNA Derived Small RNAsFrontiers in Molecular Biosciences.  9. 2022
2022 Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factorsCell Reports.  38. 2022
2022 Hpve6-usp46 mediated cdt2 stabilization reduces set8 mediated h4k20-methylation to induce gene expression changesCancers.  14. 2022
2021 tRForest: a novel random forest-based algorithm for tRNA-derived fragment target prediction 2021
2021 The tumor-suppressive long noncoding RNA DRAIC inhibits protein translation and induces autophagy by activating AMPKJournal of Cell Science.  134. 2021
2021 MicroDNA levels are dependent on MMEJ, repressed by c-NHEJ pathway, and stimulated by DNA damageNucleic Acids Research.  49:11787-11799. 2021
2021 Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors 2021
2021 De-stressing the T cells in need: Protection of transfer RNAs from fragmentation avoids overstressing T cellsScience.  372:683-684. 2021
2021 Atac-seq-based identification of extrachromosomal circular dna in mammalian cells and its validation using inverse pcr and fishBio-protocol.  11. 2021
2021 Germline Variants That Affect Tumor ProgressionTrends in Genetics.  37:433-443. 2021
2021 Germline variants predictive of tumor mutational burden and immune checkpoint inhibitor efficacyiScience.  24. 2021
2021 Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1ACell Reports.  34. 2021
2020 A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteinsJournal of Biological Chemistry.  295:16949-16959. 2020
2020 Noncanonical Roles of tRNAs: TRNA Fragments and beyondAnnual Review of Genetics.  54:47-69. 2020
2020 Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells 2020
2020 Re: Long Noncoding RNA DRAIC Inhibits Prostate Cancer Progression by Interacting with IKK to Inhibit NF-κB ActivationInvestigative urology.  204:622. 2020
2020 tRNA-derived fragments and microRNAs in the maternal-fetal interface of a mouse maternal-immune-activation autism modelRNA Biology.  17:1183-1195. 2020
2020 What Is Extrachromosomal Circular DNA and What Does It Do? 2020
2020 miR-206 family is important for mitochondrial and muscle function, but not essential for myogenesis in vitro 2020
2020 Bioinorganic hybrid bacteriophage for modulation of intestinal microbiota to remodel tumor-immune microenvironment against colorectal cancerScience Advances.  6. 2020
2020 ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell linesScience Advances.  6. 2020
2020 Long noncoding RNA DRAIC inhibits prostate cancer progression by interacting with IKK to inhibit NF-κB activationCancer Research.  80:950-963. 2020
2020 The pan-cancer landscape of prognostic germline variants in 10,582 patients 2020
2020 Identification and characterization of extrachromosomal circular DNA in maternal plasma 2020
2019 Angiogenin generates specific stress-induced tRNA halves and is not involved in tRF-3-mediated gene silencingJournal of Biological Chemistry.  294:16930-16941. 2019
2019 A Prognostic Signature for Lower Grade Gliomas Based on Expression of Long Non-Coding RNAsMolecular Neurobiology.  56:4786-4798. 2019
2019 Small extrachromosomal circular DNAs, microDNA, produce short regulatory RNAs that suppress gene expression independent of canonical promotersNucleic Acids Research.  47:4586-4596. 2019
2019 The germline variants rs61757955 and rs34988193 are predictive of survival in lower grade glioma patientsMolecular Cancer Research.  17:1075-1086. 2019
2019 Extrachromosomal circular DNA, microDNA, without canonical promoters produce short regulatory RNAs that suppress gene expression 2019
2019 Correction to: Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B and glioblastoma (Cell Death & Differentiation, (2014), 21, 5, (720-734), 10.1038/cdd.2013.196)Cell Death and Differentiation.  26:197. 2019
2018 The Germline Variants rs61757955 and rs34988193 are Predictive of Survival in Low Grade Glioma Patients 2018
2018 The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed CancersMolecular Cell.  72:823-835.e5. 2018
2018 LINC00152 promotes invasion through a 30'-hairpin structure and associates with prognosis in glioblastomaMolecular Cancer Research.  16:1470-1482. 2018
2018 MUNC, an enhancer RNA upstream from the MYOD gene, induces a subgroup of myogenic transcripts in trans independently of MyoDMolecular and Cellular Biology.  38. 2018
2018 tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent mannerRNA.  24:1093-1105. 2018
2018 Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor CellsTrends in Genetics.  34:270-278. 2018
2017 ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand BreaksMolecular Cell.  68:61-75.e5. 2017
2017 Normal and cancerous tissues release extrachromosomal circular DNA (eccDNA) into the circulationMolecular Cancer Research.  15:1197-1205. 2017
2017 Global gene repression by Dicer-independent tRNA Fragments 2017
2017 Regulation of mammalian DNA replication via the ubiquitin-proteasome systemAdvances in Experimental Medicine and Biology.  1042:421-454. 2017
2016 Expression of lncRNAs in Low-Grade Gliomas and Glioblastoma Multiforme: An In Silico AnalysisPLoS Medicine.  13. 2016
2016 Two subunits of human ORC are dispensable for DNA replication and proliferationeLife.  5. 2016
2016 Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)Trends in Biochemical Sciences.  41:679-689. 2016
2016 A pro-metastatic tRNA pathwayCell.  165:1314-1315. 2016
2016 Biological processes discovered by high-throughput sequencingAmerican Journal of Pathology.  186:722-732. 2016
2016 A pan-cancer analysis of prognostic genesPeerJ.  2016. 2016
2015 Anindya duttaCurrent Biology.  25:R1112-R1114. 2015
2015 A pan-cancer analysis of prognostic genes 2015
2015 Sequential replication-coupled destruction at G1/S ensures genome stabilityGenes and Development.  29:1734-1746. 2015
2015 MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complexNature Communications.  6. 2015
2015 Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional ActivityCell Reports.  11:1749-1759. 2015
2015 The AAA+ proteins Pontin and Reptin enter adult age: From understanding their basic biology to the identification of selective inhibitorsFrontiers in Molecular Biosciences.  2. 2015
2015 The lncRNA DRAIC/PCAT29 locus constitutes a tumor-suppressive nexusMolecular Cancer Research.  13:828-838. 2015
2015 tRFdb: A database for transfer RNA fragmentsNucleic Acids Research.  43:D141-D145. 2015
2015 Initiation of replication in Xenopus egg extracts at a spatially defined originCell Cycle.  14:2391. 2015
2015 MUNC, a long noncoding RNA that facilitates the function of MyoD in skeletal myogenesisMolecular and Cellular Biology.  35:498-513. 2015
2015 The acetyltransferase Tip60 is a critical regulator of the differentiation-dependent amplification of human papillomavirusesJournal of Virology.  89:4668-4675. 2015
2014 CRL4Cdt2 E3 ubiquitin ligase and Proliferating Cell Nuclear Antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phaseJournal of Biological Chemistry.  289:23056-23064. 2014
2014 Novel anti-apoptotic MicroRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of Caspase 3, Caspase 9, and BimPLoS One.  9. 2014
2014 A new lncRNA, APTR, associates with and represses the CDKN1A/p21 promoter by recruiting polycomb proteinsPLoS One.  9. 2014
2014 Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cellsOncogene.  33:1448-1457. 2014
2014 The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regenerationGenes and Development.  28:491-501. 2014
2014 14-3-3 proteins play a role in the cell cycle by shielding Cdt2 from ubiquitin-mediated degradationMolecular and Cellular Biology.  34:4049-4061. 2014
2014 Long non-coding rnas as emerging regulators of differentiation, development, and diseaseTranscription.  5. 2014
2014 Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targetsJournal of Biology.  12. 2014
2014 Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastomaCell Death and Differentiation.  21:720-734. 2014
2013 Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damageJournal of Biological Chemistry.  288:30509-30514. 2013
2013 Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924Molecular Cancer Therapeutics.  12:1958-1967. 2013
2013 Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIAOncogene.  32:5017-5025. 2013
2013 MicroRNAs induced in melanoma treated with combination targeted therapy of Temsirolimus and BevacizumabJournal of Translational Medicine.  11. 2013
2013 Deubiquitination of tip60 by USP7 determines the activity of the p53-dependent apoptotic pathwayMolecular and Cellular Biology.  33:3309-3320. 2013
2013 Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2Cell Cycle.  12:2175-2182. 2013
2013 The MCM8-MCM9 complex Promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombinationMolecular and Cellular Biology.  33:1632-1644. 2013
2013 CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migrationMolecular Cell.  49:1147-1158. 2013
2013 The emergence of the conserved AAA+ ATPases pontin and reptin on the signaling landscapeScience Signaling.  6. 2013
2013 RVBs are required for assembling a functional TIP60 complexMolecular and Cellular Biology.  33:1163-1174. 2013
2013 The miR-99 family regulates the DNA damage response through its target SNF2HOncogene.  32:1164-1172. 2013
2013 Chromosomal structural variations during progression of a prostate epithelial cell line to a malignant metastatic state inactivate the NF2, NIPSNAP1, UGT2B17, and LPIN2 genesCancer Biology and Therapy.  14:840-852. 2013
2013 Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport 2013
2013 Genomic instability in cancerCold Spring Harbor perspectives in biology.  5. 2013
2013 Human Primpol1: A novel guardian of stalled replication forksEMBO Reports.  14:1032-1033. 2013
2012 Non-micro-short RNAs: The new kids on the blockMolecular Biology of the Cell.  23:4664-4667. 2012
2012 Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblastsJournal of Biological Chemistry.  287:40360-40370. 2012
2012 miR-26a is required for skeletal muscle differentiation and regeneration in miceGenes and Development.  26:2180-2191. 2012
2012 Extrachromosomal microDNAs and chromosomal microdeletions in normal tissuesScience.  335:82-86. 2012
2012 MicroRNAs regulate and provide robustness to the myogenic transcriptional networkCurrent Opinion in Pharmacology.  12:383-388. 2012
2012 The role of microRNAs in glioma initiation and progressionFrontiers in Bioscience-Landmark.  17:700-712. 2012
2011 The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) proteinJournal of Biological Chemistry.  286:30462-30470. 2011
2011 Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription (Genome Research (2011) 21, (377-389))Genome Research.  21:1561. 2011
2011 DNA replication: Mammalian treslin-topBP1 interaction mirrors yeast Sld3-Dpb11Current Biology.  21. 2011
2011 Rad18 emerges as a critical regulator of the Fanconi anemia pathwayCell Cycle.  10:2415. 2011
2011 Rad18 emerges as a critical regulator of the Fanconi anemia pathway.Cell Cycle.  10:2414-2415. 2011
2011 Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4 Cdt2 ubiquitin ligase complexMolecular and Cellular Biology.  31:3136-3145. 2011
2011 MicroRNA-378 targets the myogenic repressor MyoR during myoblast differentiationJournal of Biological Chemistry.  286:19431-19438. 2011
2011 Nuclear scaffold attachment sites within ENCODE regions associate with actively transcribed genesPLoS One.  6. 2011
2011 The effect of the intra-S-phase checkpoint on origins of replication in human cellsGenes and Development.  25:621-633. 2011
2011 Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcriptionGenome Research.  21:377-389. 2011
2011 miR-206 and -486 induce myoblast differentiation by downregulating Pax7 (Molecular and Cellular Biology (2010) 31, 1, (203-214))Molecular and Cellular Biology.  31:1329. 2011
2011 miR-99 family of microRNAs suppresses the expression of prostate-specific antigen and prostate cancer cell proliferationCancer Research.  71:1313-1324. 2011
2011 CRL4Cdt2: Master coordinator of cell cycle progression and genome stabilityCell Cycle.  10:241-249. 2011
2011 Molecular requirements for transformation of fallopian tube epithelial cells into serous carcinomaNeoplasia.  13:899-911. 2011
2011 miR-206 and -486 induce myoblast differentiation by downregulating Pax7Molecular and Cellular Biology.  31:203-214. 2011
2010 NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cellsCancer Research.  70:10310-10320. 2010
2010 CRL4Cdt2 regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradationMolecular Cell.  40:9-21. 2010
2010 Detection of DNA fusion junctions for BCR-ABL translocations by Anchored ChromPET 2010
2010 Evaluation of EVI1 and EVI1s (Δ324) as potential therapeutic targets in ovarian cancerGynecologic Oncology.  118:189-195. 2010
2010 MiR-322/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25AMolecular Biology of the Cell.  21:2138-2149. 2010
2010 Destabilization of TIP60 by Human Papillomavirus E6 Results in Attenuation of TIP60-Dependent Transcriptional Regulation and Apoptotic PathwayMolecular Cell.  38:700-711. 2010
2010 Genomic study of replication initiation in human chromosomes reveals the influence of transcription regulation and chromatin structure on origin selectionMolecular Biology of the Cell.  21:393-404. 2010
2010 CRL4Cdt2 E3 Ubiquitin Ligase Monoubiquitinates PCNA to Promote Translesion DNA SynthesisMolecular Cell.  37:143-149. 2010
2009 The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1Journal of Biological Chemistry.  284:34179-34188. 2009
2009 Microarray analysis of DNA replication timingMethods in Molecular Biology.  556:191-203. 2009
2009 Yeast genome analysis identifies chromosomal translocation, gene conversion events and several sites of Ty element insertionNucleic Acids Research.  37:6454-6465. 2009
2009 A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)Genes and Development.  23:2639-2649. 2009
2009 RVB1/RVB2: Running Rings around Molecular BiologyMolecular Cell.  34:521-533. 2009
2009 The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions.Journal of Molecular Evolution.  68:587-602. 2009
2009 Surface treatment of pure and PEG-4000 blended fibroin films and their characterizations as matrices for in vitro fibroblast culture.Journal of Biomaterials Applications.  23:497-517. 2009
2009 MicroRNAs in cancerAnnual Review of Pathology: Mechanisms of Disease.  4:199-227. 2009
2009 P21 in cancer: Intricate networks and multiple activitiesNature Reviews Cancer.  9:400-414. 2009
2008 Architecture of the Pontin/Reptin Complex, Essential in the Assembly of Several Macromolecular ComplexesFolding & design.  16:1511-1520. 2008
2008 PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complexGenes and Development.  22:2496-2506. 2008
2008 The Immortal Strand Hypothesis: How Could It Work?Cell.  133:21-23. 2008
2008 Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damageMolecular and Cellular Biology.  28:2690-2700. 2008
2008 Human Cdt1 lacking the evolutionarily conserved region that interacts with MCM2-7 is capable of inducing re-replicationJournal of Biological Chemistry.  283:6817-6825. 2008
2007 Mechanisms to control rereplication and implications for cancerCurrent Opinion in Cell Biology.  19:663-671. 2007
2007 UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: A basis for the regulation of FANCD2 monoubiquitinationMolecular and Cellular Biology.  27:8421-8430. 2007
2007 The Origin Recognition Complex Localizes to Telomere Repeats and Prevents Telomere-Circle FormationCurrent Biology.  17:1989-1995. 2007
2007 ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replicationJournal of Biological Chemistry.  282:30357-30362. 2007
2007 Mcm10 and And-1/CTF4 recruit DNA polymerase α to chromatin for initiation of DNA replicationGenes and Development.  21:2288-2299. 2007
2007 Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot projectNature.  447:799-816. 2007
2007 Pan-S replication patterns and chromosomal domains defined by genome-tiling arrays of ENCODE genomic areasGenome Research.  17:865-876. 2007
2007 The tumor suppressor microRNA let-7 represses the HMGA2 oncogeneGenes and Development.  21:1025-1030. 2007
2007 Autocatalytic phosphorylation of CDK2 at the activating Thr160Cell Cycle.  6:843-852. 2007
2007 APC/C - The master controller of origin licensing?Cell Division.  2. 2007
2007 The APC/C inhibitor, Emi1, is essential for prevention of rereplicationGenes and Development.  21:184-194. 2007
2007 Chaotic license for genetic instability and cancerNature Genetics.  39:10-11. 2007
2006 Regulation of S phaseResults and problems in cell differentiation.  42:31-63. 2006
2006 Targeted comparative RNA interference analysis reveals differential requirement of genes essential for cell proliferationMolecular Biology of the Cell.  17:4837-4845. 2006
2006 Activation of fanconi anemia pathway in cells with re-replicated DNACell Cycle.  5:2306-2309. 2006
2006 Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cellsMolecular Cancer Therapeutics.  5:2310-2316. 2006
2006 Muscle-specific microRNA miR-206 promotes muscle differentiation 2006
2006 UBE2T Is the E2 in the Fanconi Anemia Pathway and Undergoes Negative AutoregulationMolecular Cell.  23:589-596. 2006
2006 An ATR- and BRCA1-mediated fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplicationMolecular and Cellular Biology.  26:4601-4611. 2006
2006 MicroRNAs: Small but potent oncogenes or tumor suppressors 2006
2006 CDK2-activating kinase (CAK): More questions than answersCell Cycle.  5:1123-1124. 2006
2006 p130-Angiomotin associates to actin and controls endothelial cell shape 2006
2006 PCNA is a cofactor for CDT1 degradation by CUL4/DDB1-mediated N-terminal ubiquitinationJournal of Biological Chemistry.  281:6246-6252. 2006
2006 Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activationJournal of Biological Chemistry.  281:6253-6260. 2006
2005 Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cellsGenes and Development.  19:2827-2836. 2005
2005 Right place, right time, and only once: Replication initiation in metazoansCell.  123:13-24. 2005
2005 Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activationJournal of Biological Chemistry.  280:27624-27630. 2005
2005 Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phaseJournal of Biological Chemistry.  280:23416-23423. 2005
2005 Preventing re-replication of chromosomal DNANature Reviews Molecular Cell Biology.  6:476-486. 2005
2005 Temporal profile of replication of human chromosomes 2005
2005 Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiationJournal of Biological Chemistry.  280:16635-16641. 2005
2005 DNA replication and progression through S phaseOncogene.  24:2827-2843. 2005
2005 Cellular checkpoint mechanisms monitoring proper initiation of DNA replicationJournal of Biological Chemistry.  280:6253-6256. 2005
2005 Geminin-Cdt1 balance is critical for genetic stabilityMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  569:111-121. 2005
2005 DNA replication and genomic instabilityAdvances in Experimental Medicine and Biology.  570:249-279. 2005
2005 Nuclear localization of RFC40 by RIα: A link between cellular signaling and proliferationCancer Biology and Therapy.  4:444-445. 2005
2004 Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complexMolecular Cell.  16:465-477. 2004
2004 The ENCODE (ENCyclopedia of DNA Elements) ProjectScience.  306:636-640. 2004
2004 Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpointMolecular and Cellular Biology.  24:7140-7150. 2004
2004 A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibitionMolecular Cell.  15:245-258. 2004
2004 The destruction box of human Geminin is critical for proliferation and tumor growth in human colon cancer cellsOncogene.  23:58-70. 2004
2003 Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cellsJournal of Biological Chemistry.  278:44312-44319. 2003
2003 p21-dependent Inhibition of Colon Cancer Cell Growth by Mevastatin Is Independent of Inhibition of G1 Cyclin-dependent KinasesJournal of Biological Chemistry.  278:43586-43594. 2003
2003 Erratum: A p53-dependent checkpoint pathway prevents rereplication (Molecular Cell (April 2003) 11 (997-1008))Molecular Cell.  11:1415. 2003
2003 A p53-dependent checkpoint pathway prevents rereplicationMolecular Cell.  11:997-1008. 2003
2003 Inhibition of cdk2 activating phosphorylation by mevastatinJournal of Biological Chemistry.  278:4840-4846. 2003
2003 Geminin and p53: deterrents to rereplication in human cancer cells.Cell Cycle.  2:282-285. 2003
2002 Origin recognition complex and the initiation of DNA replicationChemtracts.  15:533-543. 2002
2002 DNA replication in eukaryotic cellsAnnual Review of Biochemistry.  71:333-374. 2002
2002 Expression of geminin as a marker of cell proliferation in normal tissues and malignanciesAmerican Journal of Pathology.  161:267-273. 2002
2002 Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45Molecular Cell.  9:233-240. 2002
2001 Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus 2001
2001 Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by GemininCell.  106:287-296. 2001
2001 Architecture of the Human Origin Recognition ComplexJournal of Biological Chemistry.  276:29067-29071. 2001
2001 Mutational analysis of the Cy motif from p21 reveals sequence degeneracy and specificity for different cyclin-dependent kinasesMolecular and Cellular Biology.  21:4868-4874. 2001
2001 Multiple Mechanisms Regulate Subcellular Localization of Human CDC6Journal of Biological Chemistry.  276:26947-26954. 2001
2001 Requirement of CDC45 for postimplantation mouse developmentMolecular and Cellular Biology.  21:4598-4603. 2001
2001 Rvb1p and Rvb2p are Essential Components of a Chromatin Remodeling Complex that Regulates Transcription of over 5% of Yeast GenesJournal of Biological Chemistry.  276:16279-16288. 2001
2001 A bipartite substrate recognition motif for cyclin-dependent kinasesJournal of Biological Chemistry.  276:1993-1997. 2001
2000 Inhibition of eukaryotic DNA replication by geminin binding to Cdt1Science.  290:2309-2312. 2000
2000 Proteasome inhibitors alter the orderly progression of DNA synthesis during S-phase in HeLa cells and lead to rereplication of DNAExperimental Cell Research.  261:271-283. 2000
2000 Identification and characterization of the human ORC6 homologJournal of Biological Chemistry.  275:34983-34988. 2000
2000 Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteinsJournal of Biological Chemistry.  275:35233-35241. 2000
2000 Evaluation of cyclin expression in testicular germ cell tumors: Cyclin E correlates with tumor type, advanced clinical stage, and pulmonary metastasisModern Pathology.  13:667-672. 2000
1999 BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domainFEBS Letters.  460:93-98. 1999
1999 The metazoan origin recognition complexFrontiers in Bioscience.  4:d805-815. 1999
1999 The metazoan origin recognition complex.Frontiers in Bioscience-Landmark.  4. 1999
1999 latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutantNeuron.  23:45-54. 1999
1998 In vivo cyclin e expression as a marker for early cervical neoplasiaModern Pathology.  11:1238-1246. 1998
1998 An eukaryotic RuvB-like protein (RUVBL1) essential for growthJournal of Biological Chemistry.  273:27786-27793. 1998
1998 ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseasesJournal of Biological Chemistry.  273:27137-27145. 1998
1998 Cyclin A and MIB1 (Ki67) as markers of proliferative activity in primary renal neoplasmsModern Pathology.  11:963-966. 1998
1998 The human homolog of Saccharomyces cerevisiae CDC45Journal of Biological Chemistry.  273:18205-18209. 1998
1998 The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repairJournal of Biological Chemistry.  273:1453-1461. 1998
1998 Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phaseMolecular and Cellular Biology.  18:2758-2767. 1998
1998 Regulation of S phase.Results and problems in cell differentiation.  22:35-55. 1998
1997 Identification of HsORC4, a member of the human origin of replication recognition complexJournal of Biological Chemistry.  272:28247-28251. 1997
1997 p21(CIP1) and Cdc25A: Competition between an inhibitor and an activator of cyclin-dependent kinasesMolecular and Cellular Biology.  17:4338-4345. 1997
1996 p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex 1996
1996 Expression of cell cycle-regulated proteins in prostate cancerCancer Research.  56:4159-4163. 1996
1996 Dissection of functional domains of the human DNA replication protein complex replication protein AJournal of Biological Chemistry.  271:17190-17198. 1996
1996 Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53Oncogene.  12:2661-2668. 1996
1996 A 39 amino acid fragment of the cell cycle regulator p21 is sufficient to bind PCNA and partially inhibit DNA replication in vivoNucleic Acids Research.  24:1727-1733. 1996
1996 Cyclin-binding motifs are essential for the function of p21(CIP1)Molecular and Cellular Biology.  16:4673-4682. 1996
1996 Phosphorylation of human replication protein A by the DNA-dependent protein kinase is involved in the modulation of DNA replicationNucleic Acids Research.  24:3107-3112. 1996
1995 Cyclins as markers of tumor proliferation: Immunocytochemical studies in breast cancer 1995
1995 Separate domains of p21 involved in the inhibition of Cdk kinase and PCNANature.  374:386-388. 1995
1995 Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complexMolecular and Cellular Biology.  15:3119-3128. 1995
1993 Inhibition of DNA replication factor RPA by p53Nature.  365:79-82. 1993
1993 Trans-plication factors?Current Biology.  3:709-712. 1993
1992 DNA replication and the cell cycle.Ciba Foundation symposium.  170. 1992
1992 cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication 1992
1990 Serum and v-src increase the level of a CCAAT-binding factor required for transcription from a retroviral long terminal repeatGenes and Development.  4:243-254. 1990
1990 Serum independence of transcription from the promoter of an avian retrovirus in v-src-transformed cells is a primary, intracellular effect of increased tyrosine phosphorylation 1990
1988 Phosphorylation of serum response factor, a factor that binds to the serum response element of the c-FOS enhancer 1988
1988 The putative trans-activator in the MA(gag) region of Rous sarcoma virus is not required for cell transformationJournal of Virology.  62:4767-4769. 1988
1985 Partial nucleotide sequence of Rous sarcoma virus-29 provides evidence that the original Rous sarcoma virus was replication defectiveJournal of Virology.  55:728-735. 1985


Year Title Altmetric
1997 Initiation of DNA replication in eukaryotic cells.  Ed. 13.  1997

Education And Training

  • Doctor of Philosophy in Biology / Biological Sciences, The Rockefeller University 1989
  • Bachelor of Medicine & Surgery (MBBS), 1981
  • Full Name

  • Anindya Dutta