Positions

Overview

  • Dr. Standaert was named the John N. Whitaker Professor & Chair of Neurology in 2012. Prior to that, he was appointed the John T. and Juanelle D. Strain Endowed Chair by the Board of Trustees of the University of Alabama system, which he held for five years. He received his M.D. and Ph.D. degrees from Washington University in St. Louis in medicine and pharmacology in 1988. He completed a one-year internship in medicine at Jewish Hospital of St. Louis in 1989 and a three-year neurology residency in 1992 at the University of Pennsylvania. He completed a three-year research and clinical fellowship in neurology (movement disorders) at Harvard Medical School Massachusetts General Hospital in 1995. Dr. Standaert is licensed to practice medicine in the states of Massachusetts and Alabama and was board certified in 1993 by the American Board of Psychiatry and Neurology. Dr. Standaert's clinical teaching has consisted of: serving as an attending physician on the MGH Neurology inpatient service, one month each year; teaching residents, fellows and medical students in the Movement Disorders clinic on a weekly basis; and teaching in Resident's clinic about once a month. Classroom teaching has consisted of serving as member of the Core Faculty for Harvard Health Sciences Technology Pharmacology course (HST150) and a lecturer for the Harvard Medical School Human Neuroscience and Behavior course. Dr. Standaert serves as Director of the Center for Neurodegeneration and Experimental Therapeutics, Director of the Division of Movement Disorders in the Department of Neurology, Director of the American Parkinson Disease Association (APDA) Advanced Center for Parkinson Research, and Director of the UAB Bachmann-Straus Dystonia and Parkinson’s Disease Center of Excellence. He sees many patients in a weekly clinic and oversees many clinical trials for new treatments in Parkinson’s disease.
  • Research Overview

  • My laboratory is working on understanding both the root causes of Parkinson disease (PD) as well as the origin of the disabling symptoms that appear after long term treatment of the disease. The lab has a strong translational orientation – our goal is to accelerate the delivery of new therapies for Parkinson disease to the patients who desperately need them. A primary focus of the laboratory is understanding the role of the protein alpha-synuclein in PD pathophysiology, and searching for novel approaches for protecting the brain from the effects of excess alpha-synuclein. We use a variety of cellular and rodent models, and are exploring the effects of several chaperone molecules, including those derived from open-ended screens in simple non-mammalian systems. A related interest is the role of neuroinflammation in PD. In human PD, there is a marked brain inflammatory response. Recent work in the Standaert lab using mouse models has led to the idea that this inflammation may be triggered directly by the presence of excess alpha-synuclein. The response involves both microglia as well as the adaptive immune system, and both components may be targets of therapies to prevent or retard the disease. We are also exploring the effect of levodopa on brain function in PD. Levodopa remains the most effective existing treatment, but long-term therapy leads to many unwanted side effects (“wearing off” and “dyskinesia”). The Standaert lab has shown that many of the effects result from abnormal synaptic plasticity in the basal ganglia, and mislocalization of glutamate receptor systems. Recently, we found that the mechanisms responsible for the maintenance of this aberrant plasticity are likely the result of levodopa-induced epigenetic modifications.
  • Principal Investigator On

  • Private Grant  awarded by ABBVIE INC 2020 - 2024
  • Private Grant  awarded by ABBVIE INC 2020 - 2024
  • Private Grant  awarded by ABBVIE INC 2019 - 2024
  • The Parkinson's Progression Marker's Initiative (PPMI)  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2010 - 2023
  • Contribution of the Interaction Between Synuclein and Tau in the Pathophysiology of Dementia with Lewy Bodies  awarded by National Institute on Aging/NIH/DHHS 2018 - 2023
  • Innate and Adaptive Immunity in Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • Innate and Adaptive Immunity in Parkinson Disease - Core A: Administrative Core  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • Innate and Adaptive Immunity in Parkinson Disease - Project 1: Role of Innate Immune Cells in Human Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • Innate and Adaptive Immunity in Parkinson Disease - Project 3: LRRK2 Mediated Macrophage Responses in PD  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • Private Grant  awarded by ABBVIE INC 2021 - 2023
  • Identification and Rescue of Striatal Circuit Abnormalities in Models of GNAL Dystonia  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2019 - 2022
  • Interactions of Gut Microbiome, Genetic Susceptibility and Environmental Factors in Parkinson's Disease  awarded by DOD - Department of Defense 2018 - 2022
  • UAB Research and Education Program in Neuroscience  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2017 - 2022
  • UAB Training Program in Neuroscience  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2017 - 2022
  • UAB Cannabidiol Program  awarded by ALABAMA DEPARTMENT OF COMMERCE 2014 - 2022
  • The Edmond J. Safra Fellowship in Movement Disorders 2019 Program  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2019 - 2022
  • Alabama Project on Alzheimer Disease and Related Disorders  awarded by ALABAMA INNOVATION FUND 2020 - 2021
  • Border-Associated Macrophages in an Alpha-Synuclein Overabundance Model of Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2021
  • Role of T cells in an Alpha-Synuclein Mediated Mouse Model of Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2021
  • APDA Advanced Center for Parkinson Disease Research at UAB  awarded by American Parkinson Disease Association 2008 - 2021
  • The Role of T Cells in Inflammation-induced Neurodegeneration  awarded by American Parkinson Disease Association 2019 - 2021
  • UAB Neuroscience Core Center - Core B: Molecular Detection and Stereology Core  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2021
  • Private Grant  awarded by ABBVIE INC 2016 - 2020
  • University of Alabama at Birmingham_The Edumond J. Safra Fellowship in Movement Disorders 2017  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2017 - 2020
  • MJFF Emerging Targets Committee Membership  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2016 - 2020
  • Role of HLA/MHCII in Parkinson's Disease Pathogenesis  awarded by Emory University 2015 - 2020
  • Molecular Etiology of Early Onset Torsion Dystonia  awarded by MASSACHUSETTS GENERAL HOSPITAL 2015 - 2020
  • The Edmond J. Safra Visiting Nurse Faculty Program at the Parkinson Disease Foundation  awarded by National Parkinson Foundation, Inc. 2017 - 2019
  • The Edmond J. Safra Fellowship in Movement Disorders  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2016 - 2019
  • UAB Bachmann-Straus Dystonia and Parkinson's Disease Center of Excellence  awarded by Bachmann-Strauss Dystonia & Parkinson Foundation, Inc 2013 - 2018
  • Genetics of Levodopa Induced Dyskinesia  awarded by 23ANDME, INC. 2017 - 2018
  • Innate and Adaptive Immunity in Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2018
  • Innate and Adaptive Immunity in Parkinson Disease - Core A: Administrative Core  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2018
  • Innate and Adaptive Immunity in Parkinson Disease - Project 3: Role of Myeloid Cells in Human Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2018
  • Clinician-Input Study: How the Fox Insight Mobile Application can Influence Treatment and Care (CIS-PD)  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2016 - 2017
  • UAB Research and Education Program in Neurology, Neurosurgery, and Neuropathology  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2012 - 2017
  • Private Grant  awarded by ACERTA PHARMA B.V. 2014 - 2016
  • Genetic Susceptibility and Epigenetic Modulation in Levodopa Induced Dyskinesia  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2016
  • Evaluation of the Effects of a Novel Nicotinic Agonist, AZD1446, on Neurochemical and Electrophysiologic Endpoints in DYT1 Mouse Models.  awarded by Dystonia Medical Research Foundation 2015 - 2016
  • Cholinergic and Dopaminergic Mechanisms in Mouse Models of Dystonia  awarded by Mount Sinai School of Medicine 2015 - 2016
  • Private Grant  awarded by SANGAMO BIOSCIENCES, INC. 2013 - 2016
  • Role of MicroRNAs in Modulating Inflammation in Alpha-Syn Mediated Models of PD  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2016
  • Private Grant  awarded by ABBVIE INC 2012 - 2016
  • Validation of the Class II MHC Transactivator (CIITA) in Models of PD  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2014 - 2016
  • Private Grant  awarded by ABBVIE INC 2010 - 2015
  • Molecular Etiology of Early Onset Torsin Dystonia  awarded by MASSACHUSETTS GENERAL HOSPITAL 2009 - 2015
  • UAB PD Neuroprotection Clinical Trial Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2014
  • Role of MHC II Proteins in Parkinson's Related Inflammation  awarded by RJG FOUNDATION 2011 - 2014
  • Role of Complement in Alpha-Synuclein Based Models of Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2011 - 2014
  • Private Grant  awarded by Solvay Pharmaceuticals, Inc. 2010 - 2014
  • Private Grant  awarded by ABBOTT LABORATORIES 2009 - 2014
  • Genetic and Enviromental Risk Factors for Progressive Supranuclear Palsy (PSP)  awarded by University of Louisville 2006 - 2013
  • A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Doses of Aplindore MR (1, 3, and 6 mg Twice Daily) in Patients with Early Parkinson Disease  awarded by University of Rochester 2009 - 2013
  • Developing an Adenoviral Vector Platform for Selective Gene Delivery to Neurons  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2009 - 2013
  • 2012 HDSA Center of Excellence Grant  awarded by Huntington's Disease Society of America, Inc. 2011 - 2012
  • Private Grant  awarded by ABBOTT LABORATORIES 2008 - 2012
  • Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)  awarded by MASSACHUSETTS GENERAL HOSPITAL 2011
  • Private Grant  awarded by TEVA NEUROSCIENCE, INC. 2010 - 2011
  • HD Program of Excellence at the University of Alabama at Birmingham  awarded by Huntington's Disease Society of America, Inc. 2011
  • Biomarkers and Immunotherapy for Parkinson's Disease  awarded by UNIVERSITY OF NEBRASKA 2010 - 2011
  • Effects of Coenzyme Q10 in PSP, A Multicenter, Randomized, Placebo-Controlled, Double Blind Study  awarded by LAHEY CLINIC, INC. 2008 - 2011
  • Effects of Selective Inactivation of the DYT1 Gene on Cholinergic Function  awarded by Bachmann-Strauss Dystonia & Parkinson Foundation, Inc 2009 - 2010
  • APDA Advanced Center for Parkinson Disease Research at UAB  awarded by American Parkinson Disease Association 2007 - 2008
  • Investigator On

  • Integrating Genomic Risk Assessment for Chronic Disease Management in a Diverse Population  awarded by National Human Genome Research Institute/NIH/DHHS 2020 - 2025
  • Adaptive Immunity in the Etiology and Progression of Parkinson’s Disease  awarded by RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. - NEW 2020 - 2023
  • UAB Alzheimer's Disease Research Center  awarded by National Institute on Aging/NIH/DHHS 2020 - 2023
  • Cytokine Production by Adaptive Immune Cells from Patients with Parkinson’s Disease: Response to Diverse Biological Stimuli  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2020 - 2023
  • Innate and Adaptive Immunity in Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • Interactions of Gut Microbiome, Genetic Susceptibility and Environmental Factors in Parkinson's Disease  awarded by DOD - Department of Defense 2018 - 2022
  • Parkinson Disease Genetics in the Black American Population  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2021 - 2022
  • UAB Neuroscience Core Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2021
  • Center for Translational Research on Aging and Mobility  awarded by National Institute on Aging/NIH/DHHS 2014 - 2021
  • Center for Translational Research on Aging and Mobility - Core B: Pilot Core  awarded by National Institute on Aging/NIH/DHHS 2014 - 2021
  • Role of Alpha Synuclein in PINK1-linked Parkinson's Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2020
  • National Resource Center for High-Impact Clinical Trials in Medical Rehabilitation: Admin Oversight Component  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2015 - 2020
  • National Resource Center for High-Impact Clinical Trials in Medical Rehabilitation: Pilot Projects Component  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2015 - 2020
  • Rehabilitation Research Resource to Enhance Clinical Trials (REACT)  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2015 - 2020
  • Diagnosis of Parkinson's Disease Using Diffusion Tensor Imaging  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2020
  • Private Grant  awarded by GW RESEARCH LTD. 2014 - 2018
  • Private Grant  awarded by GW RESEARCH LTD. 2014 - 2018
  • Exosome LRRK2 in Predicting Parkinson Disease Phenotypes  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2018
  • Causes, Treatment, and Prevention of Corticobasal Degeneration  awarded by University of California, San Francisco 2014 - 2018
  • Private Grant  awarded by AVID RADIOPHARMACEUTICALS 2014 - 2018
  • Striatal Modulation of Epigenetic DNA Demethylation in Reward Learning  awarded by National Institute on Drug Abuse/NIH/DHHS 2016 - 2018
  • Modeling X-Linked Dystonia Parkinsonism Using BAC Transgenesis  awarded by MASSACHUSETTS GENERAL HOSPITAL 2015 - 2018
  • The Role of the JAK/STAT Pathway in Human Parkinson's Disease  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2017 - 2018
  • The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD Patients  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2012 - 2017
  • Interdisciplinary Training in Pathobiology and Rehabilitation Medicine  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2012 - 2017
  • LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2012 - 2016
  • Mechanisms of Frontotemporal Dementia Like Behavior in Progranulin Deficient Mice  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2016
  • Training Program in the Neurobiology of Cognition and Cognitive Disorders  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2016
  • Mechanisms of LRRK2 Mediated Neurotoxicity  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2010 - 2016
  • Targeting the JAK/STAT Pathway in the Treatment of Parkinson's Disease  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2015 - 2016
  • Fox Investigation for New Discovery of Biomarkers (BioFIND)  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2014 - 2015
  • The Role of Astrocytes in Huntington's Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2010 - 2015
  • Collaborative MS Research Center Award  awarded by National Multiple Sclerosis Society 2009 - 2015
  • Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)  awarded by MASSACHUSETTS GENERAL HOSPITAL 2014 - 2015
  • Role of Microglial LRRK2 in Inflammation  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2012 - 2015
  • Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)  awarded by MASSACHUSETTS GENERAL HOSPITAL 2011 - 2014
  • Targeting the JAK/STAT Pathway in the Treatment of Parkinson's Disease  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2012 - 2014
  • Role of 14-3-3 Proteins in Alpha-Synuclein-Induced Neurotoxicity  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2008 - 2013
  • Private Grant  awarded by ASTRAZENECA AB 2013
  • DMRF Clinical Fellowship Training Program  awarded by Dystonia Medical Research Foundation 2012 - 2013
  • 14-3-3s as Regulators of LRRK2 Toxicity  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2011 - 2013
  • Private Grant  awarded by ALLON THERAPEUTICS 2010 - 2013
  • The Effects of Lower and High Frequency Unilateral STN DBS on Sleep in Parkinson's Disease  awarded by American Sleep Medicine Foundation 2011 - 2012
  • Private Grant  awarded by ADDEX PHARMA SA 2011 - 2012
  • Education And Training

  • Doctor of Philosophy in Pharmacology, Washington University/St. Louis 1988
  • Doctor of Medicine, Washington University/St. Louis 1982
  • Jewish Hospital of St. Louis, Internship 1989
  • Jewish Hospital of St. Louis, Internship 1989
  • University of Pennsylvania Hospital, Residency 1992
  • University of Pennsylvania, Residency 1992
  • Massachusetts General Hospital, Postdoctoral Fellowship 1995
  • Full Name

  • David Standaert