• Wyatt has been involved in the field of obesity, weight management and metabolism her entire career and personally struggled with her weight and maintaining a reduced healthy body weight earlier in her life. She is the co-founder and medical director for The State of Slim — a transformative weight loss program that specializes in long-term strategies for weight loss and transforming your life.

    Wyatt has more than 20 years of clinical experience in weight reduction using behavioral treatment, dietary therapy, physical activity interventions, weight loss medications, and surgery. She was the medical director for seasons four and five of ABC’s TV show Extreme Weight Loss and has spent much of her research career following more than 10,000 “successful losers” in the National Weight Control Registry to investigate what makes people successful during their weight loss journey.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study 2020
    2020 History of Cardiovascular Disease, Intensive Lifestyle Intervention, and Cardiovascular Outcomes in the Look AHEAD Trial 2020
    2019 Personalized nutrition: pretreatment glucose metabolism determines individual long-term weight loss responsiveness in individuals with obesity on low-carbohydrate versus low-fat dietInternational Journal of Obesity.  43:2037-2044. 2019
    2018 Harnessing centred identity transformation to reduce executive function burden for maintenance of health behaviour change: the Maintain IT modelHealth Psychology Review.  12:231-253. 2018
    2017 Equivalent reductions in body weight during the Beef WISE Study: beef's role in weight improvement, satisfaction and energyObesity Science and Practice.  3:298-310. 2017
    2016 Initial weight loss goals: have they changed and do they matter?Obesity Science and Practice.  2:154-161. 2016
    2015 Results of the exercise and nutrition to enhance recovery and good health for you (ENERGY) trial: A behavioral weight loss intervention in overweight or obese breast cancer survivorsJournal of Clinical Oncology.  33:3169-3176. 2015
    2014 Implications of Look AHEAD for clinical trials and clinical practice 2014
    2014 Low/no calorie sweetened beverage consumption in the National Weight Control Registry 2014
    2014 Changes in physical activity and sedentary behavior in a randomized trial of an internet-based versus workbook-based family intervention studyJournal of Physical Activity and Health.  11:348-358. 2014
    2014 Dietary habits and weight maintenance success in high versus low exercisers in the national weight control registryJournal of Physical Activity and Health.  11:1540-1548. 2014
    2014 Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: A secondary analysis of the Look AHEAD randomised clinical trialLancet Diabetes and Endocrinology.  2:801-809. 2014
    2014 The effects of water and non-nutritive sweetened beverages on weight loss during a 12-week weight loss treatment program 2014
    2013 Update on treatment strategies for obesityJournal of Clinical Endocrinology and Metabolism.  98:1299-1306. 2013
    2013 The importance of energy balanceEuropean Endocrinology.  9:111-115. 2013
    2013 The importance of energy balanceUS endocrinology.  9:27-31. 2013
    2012 Parental influence on child change in physical activity during a family-based intervention for child weight gain preventionJournal of Physical Activity and Health.  9:661-669. 2012
    2011 Obesity: Overview of an epidemicPsychiatric Clinics of North America.  34:717-732. 2011
    2011 Resistant starch and exercise independently attenuate weight regain on a high fat diet in a rat model of obesity 2011
    2010 Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat dietObstetrical and Gynecological Survey.  65:769-770. 2010
    2010 Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate dietAmerican Journal of Clinical Nutrition.  91:578-585. 2010
    2009 Effect of Moderate Diet-Induced Weight Loss and Weight Regain on Cardiovascular Structure and FunctionJournal of the American College of Cardiology.  54:2376-2381. 2009
    2009 Editorial: "Real world" obesity and weight management strategiesObesity and Weight Management.  5:143-144. 2009
    2009 Successful internet-based lifestyle change program on body weight and markers of metabolic healthObesity and Weight Management.  5:167-173. 2009
    2009 Exploiting social networks to mitigate the obesity epidemic 2009
    2007 Over the counter orlistat: What will your patients want to know?Childhood Obesity.  3:204-209. 2007
    2007 Small changes in dietary sugar and physical activity as an approach to preventing excessive weight gain: The America on the move family studyPediatrics (Spanish Edition).  120. 2007
    2007 Three-year weight change in successful weight losers who lost weight on a low-carbohydrate diet 2007
    2007 Diets do workChildhood Obesity.  3:153-154. 2007
    2007 Relationship of Body Mass Index With Outcomes After Coronary Artery Bypass Graft SurgeryAnnals of Thoracic Surgery.  84:10-16. 2007
    2007 The role of physical activity in producing and maintaining weight lossNature Reviews Endocrinology.  3:518-529. 2007
    2007 Physical activity in U.S. adults with diabetes and at risk for developing diabetes, 2003Diabetes Care.  30:203-209. 2007
    2006 Physical activity in prevention and management of obesity and type-2 diabetes. 2006
    2006 A family-based approach to preventing excessive weight gain 2006
    2006 Is it OK to call children obese?Childhood Obesity.  2:131-132. 2006
    2006 Are health care professionals advising patients with diabetes or at risk for developing diabetes to exercise more?Diabetes Care.  29:543-548. 2006
    2005 Obesity, inactivity, and the prevalence of diabetes and diabetes-related cardiovascular comorbidities in the U.S. 2000-2002Diabetes Care.  28:1599-1603. 2005
    2005 A Colorado statewide survey of walking and its relation to excessive weightMedicine and Science in Sports and Exercise.  37:724-730. 2005
    2005 Clinical Case ReportChildhood Obesity.  1:65-67. 2005
    2005 Lessons from Patients Who Have Successfully Maintained Weight LossChildhood Obesity.  1:56-61. 2005
    2004 Using electronic step counters to increase lifestyle physical activity: Colorado on the MoveJournal of Physical Activity and Health.  1:181-190. 2004
    2003 Obesity and the environment: Where do we go from here?Science.  299:853-855. 2003
    2003 The prevalence of obesityPrimary Care: Clinics in Office Practice.  30:267-279. 2003
    2002 Let's get serious about promoting physical activityAmerican Journal of Clinical Nutrition.  75:449-450. 2002
    2002 Long-term weight loss and breakfast in subjects in the National Weight Control Registry 2002
    2002 Office evaluation of the obese patientClinics in Family Practice.  4:351-367. 2002
    2002 Outpatient management of obesity: A primary care perspective 2002
    2000 Genetic and environmental contributions to obesityMedical Clinics of North America.  84:333-346. 2000
    A randomized trial of a low-carbohydrate diet for obesityNew England Journal of Medicine.  348:2082-2090.
    America on the MoveMedical Clinics of North America.  91:1079-1089.
    Change in food cravings, food preferences, and appetite during a low-carbohydrate and low-fat diet
    Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: The look AHEAD study
    Clinical Case ReportChildhood Obesity.  1:108-110.
    Clinical Case ReportChildhood Obesity.  1:163-165.
    Clinical Q & AChildhood Obesity.  1:20.
    Cluster analysis of the national weight control registry to identify distinct subgroups maintaining successful weight loss
    Dietary fat increases energy intake across the range of typical consumption in the United States
    Does insulin concentration modify the outcome of dietary intervention in young adults with obesity? CommentaryNature Reviews Endocrinology.  3:802-803.
    Effects of consuming a high-protein diet with or without soy protein during weight loss and maintenance: a non-inferiority, randomized clinical efficacy trialObesity Science and Practice.  4:357-366.
    Endothelial function and weight loss: Comparison of low-carbohydrate and low-fat diets
    Energy balance and obesityCirculation.  126:126-132.
    Erratum: Low/No calorie sweetened beverage consumption in the national weight control registry (Obesity (2014) 22 (2244-2251))
    Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regain
    From instinct to intellect: The challenge of maintaining healthy weight in the modern worldObesity Reviews.  3:69-74.
    Hormones & you: patient information page. Hormones and obesity.Journal of Clinical Endocrinology and Metabolism.  89.
    Hunger, food cravings, and diet satisfaction are related to changes in body weight during a 6-month behavioral weight loss intervention: The beef WISE study
    Impact of Combined Hormonal Contraceptive Use on Weight Loss: A Secondary Analysis of a Behavioral Weight-Loss Trial
    Impact of a behavioral weight loss intervention on comorbidities in overweight and obese breast cancer survivorsSupportive Care in Cancer.  24:3285-3293.
    Impact of cardiometabolic risk factor clusters on health-related quality of life in the U.S.
    Intensive Weight Loss Intervention and Cancer Risk in Adults with Type 2 Diabetes: Analysis of the Look AHEAD Randomized Clinical Trial
    International strategies to address obesityObesity Reviews.  9:41-47.
    No consistent evidence of a disproportionately low resting energy expenditure in long-term successful weight-loss maintainersAmerican Journal of Clinical Nutrition.  108:658-666.
    Obesity: Overview of an epidemicPsychiatric Clinics of North America.  28:1-23.
    Objectively Measured Physical Activity and Sedentary Behavior in Successful Weight Loss Maintainers
    Pedometer-measured physical activity and health behaviors in U.S. adultsMedicine and Science in Sports and Exercise.  42:1819-1825.
    Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats
    Productivity costs associated with cardiometabolic risk factor clusters in the United StatesValue in Health.  10:443-450.
    Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trialDiabetologia.  58:1803-1813.
    Reducing breast cancer recurrence with weight loss, a vanguard trial: The Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) TrialContemporary Clinical Trials.  34:282-295.
    Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss
    Relapse in obesity treatment: Biology or behavior?American Journal of Clinical Nutrition.  69:1064-1065.
    Relationship between treatment preference and weight loss in the context of a randomized controlled trial
    Role of physical activity in preventing and treating obesity
    Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist sizeJournal of Agricultural and Food Chemistry.  55:10050-10054.
    Should low-carbohydrate diets be recommended for weight loss?
    Similar effects on cognitive performance during high- and low-carbohydrate obesity treatment
    Small changes: A big idea for addressing obesityChildhood Obesity.  2:227-231.
    The Impact of Timing of Exercise Initiation on Weight Loss: An 18-Month Randomized Clinical Trial
    The National Weight Control Registry: Is it useful in helping deal with our obesity epidemic?
    The Obesity EpidemicClinics in Chest Medicine.  30:415-444.
    The effects of water and non-nutritive sweetened beverages on weight loss and weight maintenance: A randomized clinical trial
    The elephant in the roomObesity and Weight Management.  6:103-104.
    The medical cost of cardiometabolic risk factor clusters in the United States
    The myth of healthy obesityAnnals of Internal Medicine.  159:789-790.
    The role of public policy in treating the epidemic of global obesityClinical Pharmacology and Therapeutics.  81:772-775.
    Using telehealth to increase participation in weight maintenance programs
    Using the Energy Gap to Address Obesity: A CommentaryJournal of The American Dietetic Association.  109:1848-1853.
    Weight loss in a community initiative that promotes decreased energy intake and increased physical activity and dairy consumption: Calcium weighs-inJournal of Physical Activity and Health.  5:28-44.
    Weight maintenance: What's missing?Journal of The American Dietetic Association.  105:63-66.
    What role for weight-loss medication?Sendrom -Istanbul-.  17:18-27.
    What role for weight-loss medication?: Weighing the pros and cons for obese patientsPostgraduate Medicine.  115.
    Why We Need Obesity ManagementChildhood Obesity.  1:1.


    Year Title Altmetric
    2013 Obesity: Overview of treatments and interventions.  445-464. 2013
    2012 Obesity: Epidemiology, etiology, and prevention.  771-785. 2012
    2012 Correlates of Successful Maintenance of Weight Loss 2012

    Research Overview

  • Obesity
    Physical activity
    Weight loss and regulation
    Internal medicine
  • Investigator On

    Education And Training

  • Doctor of Medicine, Baylor College of Medicine 1993
  • Bachelor of Arts in Microbiology, University of Texas System : Austin 1989
  • Full Name

  • Holly Wyatt