• Wyatt has been involved in the field of obesity, weight management and metabolism her entire career and personally struggled with her weight and maintaining a reduced healthy body weight earlier in her life. She is the co-founder and medical director for The State of Slim — a transformative weight loss program that specializes in long-term strategies for weight loss and transforming your life.

    Wyatt has more than 20 years of clinical experience in weight reduction using behavioral treatment, dietary therapy, physical activity interventions, weight loss medications, and surgery. She was the medical director for seasons four and five of ABC’s TV show Extreme Weight Loss and has spent much of her research career following more than 10,000 “successful losers” in the National Weight Control Registry to investigate what makes people successful during their weight loss journey.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study 2020
    2020 History of Cardiovascular Disease, Intensive Lifestyle Intervention, and Cardiovascular Outcomes in the Look AHEAD Trial 2020
    2019 The Impact of Timing of Exercise Initiation on Weight Loss: An 18-Month Randomized Clinical Trial 2019
    2019 Personalized nutrition: pretreatment glucose metabolism determines individual long-term weight loss responsiveness in individuals with obesity on low-carbohydrate versus low-fat diet 2019
    2019 Physical Activity Energy Expenditure and Total Daily Energy Expenditure in Successful Weight Loss Maintainers 2019
    2018 No consistent evidence of a disproportionately low resting energy expenditure in long-term successful weight-loss maintainers 2018
    2018 Effects of consuming a high-protein diet with or without soy protein during weight loss and maintenance: a non-inferiority, randomized clinical efficacy trial 2018
    2018 Harnessing centred identity transformation to reduce executive function burden for maintenance of health behaviour change: the Maintain IT model 2018
    2018 Hunger, food cravings, and diet satisfaction are related to changes in body weight during a 6-month behavioral weight loss intervention: The beef WISE study 2018
    2018 Objectively Measured Physical Activity and Sedentary Behavior in Successful Weight Loss Maintainers 2018
    2017 Equivalent reductions in body weight during the Beef WISE Study: beef's role in weight improvement, satisfaction and energy 2017
    2017 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial 2017
    2016 Impact of a behavioral weight loss intervention on comorbidities in overweight and obese breast cancer survivors 2016
    2016 Initial weight loss goals: have they changed and do they matter? 2016
    2016 Erratum: Low/No calorie sweetened beverage consumption in the national weight control registry (Obesity (2014) 22 (2244-2251)) 2016
    2016 The effects of water and non-nutritive sweetened beverages on weight loss and weight maintenance: A randomized clinical trial 2016
    2015 Results of the exercise and nutrition to enhance recovery and good health for you (ENERGY) trial: A behavioral weight loss intervention in overweight or obese breast cancer survivors 2015
    2015 Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial 2015
    2015 Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: The look AHEAD study 2015
    2014 Implications of Look AHEAD for clinical trials and clinical practice 2014
    2014 Low/no calorie sweetened beverage consumption in the National Weight Control Registry 2014
    2014 Changes in physical activity and sedentary behavior in a randomized trial of an internet-based versus workbook-based family intervention study 2014
    2014 Dietary habits and weight maintenance success in high versus low exercisers in the national weight control registry 2014
    2014 Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: A secondary analysis of the Look AHEAD randomised clinical trial 2014
    2014 The effects of water and non-nutritive sweetened beverages on weight loss during a 12-week weight loss treatment program 2014
    2013 The myth of healthy obesity 2013
    2013 The importance of energy balance 2013
    2013 Similar effects on cognitive performance during high- and low-carbohydrate obesity treatment 2013
    2013 The importance of energy balance 2013
    2013 A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II) 2013
    2013 Update on treatment strategies for obesity 2013
    2013 Endothelial function and weight loss: Comparison of low-carbohydrate and low-fat diets 2013
    2013 Reducing breast cancer recurrence with weight loss, a vanguard trial: The Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial 2013
    2012 Cluster analysis of the national weight control registry to identify distinct subgroups maintaining successful weight loss 2012
    2012 Energy balance and obesity 2012
    2012 Comparative effects of low-carbohydrate high-protein versus low-fat diets on the kidney 2012
    2012 Relationship between treatment preference and weight loss in the context of a randomized controlled trial 2012
    2012 Parental influence on child change in physical activity during a family-based intervention for child weight gain prevention 2012
    2011 Obesity: Overview of an epidemic 2011
    2011 Change in food cravings, food preferences, and appetite during a low-carbohydrate and low-fat diet 2011
    2011 Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regain 2011
    2011 Resistant starch and exercise independently attenuate weight regain on a high fat diet in a rat model of obesity 2011
    2011 Physical activity patterns using accelerometry in the national weight control registry 2011
    2010 Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet 2010
    2010 Pedometer-measured physical activity and health behaviors in U.S. adults 2010
    2010 Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: A randomized trial 2010
    2010 The elephant in the room 2010
    2010 Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate diet 2010
    2009 Effect of Moderate Diet-Induced Weight Loss and Weight Regain on Cardiovascular Structure and Function 2009
    2009 Using the Energy Gap to Address Obesity: A Commentary 2009
    2009 Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss 2009
    2009 The Obesity Epidemic 2009
    2009 Editorial: "Real world" obesity and weight management strategies 2009
    2009 Successful internet-based lifestyle change program on body weight and markers of metabolic health 2009
    2009 Exploiting social networks to mitigate the obesity epidemic 2009
    2009 A small-changes approach reduces energy intake in free-living humans 2009
    2008 International strategies to address obesity 2008
    2008 Dietary fat increases energy intake across the range of typical consumption in the United States 2008
    2008 Physical activity patterns in the national weight control registry 2008
    2008 Weight loss in a community initiative that promotes decreased energy intake and increased physical activity and dairy consumption: Calcium weighs-in 2008
    2007 Does insulin concentration modify the outcome of dietary intervention in young adults with obesity? Commentary 2007
    2007 The medical cost of cardiometabolic risk factor clusters in the United States 2007
    2007 Using telehealth to increase participation in weight maintenance programs 2007
    2007 Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size 2007
    2007 America on the Move 2007
    2007 Over the counter orlistat: What will your patients want to know? 2007
    2007 Small changes in dietary sugar and physical activity as an approach to preventing excessive weight gain: The America on the move family study 2007
    2007 Three-year weight change in successful weight losers who lost weight on a low-carbohydrate diet 2007
    2007 Diets do work 2007
    2007 Relationship of Body Mass Index With Outcomes After Coronary Artery Bypass Graft Surgery 2007
    2007 The role of physical activity in producing and maintaining weight loss 2007
    2007 The role of public policy in treating the epidemic of global obesity 2007
    2007 Physical activity in U.S. adults with diabetes and at risk for developing diabetes, 2003 2007
    2007 Impact of cardiometabolic risk factor clusters on health-related quality of life in the U.S. 2007
    2007 Productivity costs associated with cardiometabolic risk factor clusters in the United States 2007
    2007 Step-counter determined walking in youth in Colorado. 2007
    2006 Small changes: A big idea for addressing obesity 2006
    2006 Physical activity in prevention and management of obesity and type-2 diabetes. 2006
    2006 A family-based approach to preventing excessive weight gain 2006
    2006 Is it OK to call children obese? 2006
    2006 Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats 2006
    2006 Are the eating and exercise habits of successful weight losers changing? 2006
    2006 Are health care professionals advising patients with diabetes or at risk for developing diabetes to exercise more? 2006
    2005 Clinical Case Report 2005
    2005 Role of physical activity in preventing and treating obesity 2005
    2005 Carbohydrate-controlled diets: Are they safe and effective? 2005
    2005 Obesity, inactivity, and the prevalence of diabetes and diabetes-related cardiovascular comorbidities in the U.S. 2000-2002 2005
    2005 Clinical Case Report 2005
    2005 A Colorado statewide survey of walking and its relation to excessive weight 2005
    2005 Clinical Case Report 2005
    2005 Lessons from Patients Who Have Successfully Maintained Weight Loss 2005
    2005 Clinical Q & A 2005
    2005 Obesity: Overview of an epidemic 2005
    2005 The National Weight Control Registry: Is it useful in helping deal with our obesity epidemic? 2005
    2005 Weight maintenance: What's missing? 2005
    2005 What role for weight-loss medication? 2005
    2005 Why We Need Obesity Management 2005
    2004 Should low-carbohydrate diets be recommended for weight loss? 2004
    2004 Using electronic step counters to increase lifestyle physical activity: Colorado on the Move 2004
    2004 Hormones & you: patient information page. Hormones and obesity. 2004
    2004 What role for weight-loss medication?: Weighing the pros and cons for obese patients 2004
    2003 A randomized trial of a low-carbohydrate diet for obesity 2003
    2003 How much physical activity is enough to prevent unhealthy weight gain? Outcome of the IASO 1st stock conference and consensus statement 2003
    2003 Obesity and the environment: Where do we go from here? 2003
    2003 The prevalence of obesity 2003
    2002 Outpatient management of obesity: A primary care perspective 2002
    2002 From instinct to intellect: The challenge of maintaining healthy weight in the modern world 2002
    2002 Let's get serious about promoting physical activity 2002
    2002 Long-term weight loss and breakfast in subjects in the National Weight Control Registry 2002
    2002 Office evaluation of the obese patient 2002
    2000 Genetic and environmental contributions to obesity 2000
    1999 Relapse in obesity treatment: Biology or behavior? 1999
    1999 Resting energy expenditure in reduced-obese subjects in the National Weight Control Registry 1999


    Year Title Altmetric
    2013 Obesity: Overview of treatments and interventions.  445-464. 2013
    2012 Obesity: Epidemiology, etiology, and prevention.  771-785. 2012
    2012 Correlates of Successful Maintenance of Weight Loss 2012

    Research Overview

  • Obesity
    Physical activity
    Weight loss and regulation
    Internal medicine
  • Education And Training

  • Doctor of Medicine, Baylor College of Medicine 1993
  • Bachelor of Arts in Microbiology, University of Texas System : Austin 1989
  • Full Name

  • Holly Wyatt