Positions

Overview

  • Dr. Xing received her medical degree in 1995 and a Masters in Pathophysiology in 1998 from Xian Medical University, Xian, China. In 2001 she received her Ph.D. in Pathology and Pathophysiology from Peking University, Beijing, China. She then came to UAB as a postdoctoral fellow in the Program of Vascular Biology & Hypertension and in 2008 she was promoted to Assistant Professor. She has authored or co-authored 15 papers published in peer-reviewed journals and has received many honors from national societies.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis. 2022
    2022 Dietary salt initiates redox signaling between endothelium and vascular smooth muscle through NADPH oxidase 4.  Redox Biology.  52. 2022
    2021 Prolyl endopeptidase contributes to early neutrophilic inflammation in acute myocardial transplant rejection.  JCI Insight.  6. 2021
    2019 Induced pluripotent stem cell-derived endothelial cells attenuate lipopolysaccharide-induced acute lung injury.  Journal of Applied Physiology.  127:444-456. 2019
    2017 Haploinsufficiency of the Transcription Factor Ets-1 Is renoprotective in dahl salt-sensitive rats.  Journal of the American Society of Nephrology.  28:3239-3250. 2017
    2017 Induced pluripotent stem cell-derived endothelial cells overexpressing interleukin-8 receptors a/b and/or c-c chemokine receptors 2/5 inhibit vascular injury response.  Stem Cells Translational Medicine.  6:1168-1177. 2017
    2017 Assessment of vascular function in low socioeconomic status preschool children: a pilot study.  Journal of the American Society of Hypertension.  11:101-109. 2017
    2016 Calreticulin Regulates Neointima Formation and Collagen Deposition following Carotid Artery Ligation.  Journal of Vascular Research.  52:306-320. 2016
    2016 Targeted delivery of human iPS-ECs overexpressing IL-8 receptors inhibits neointimal and inflammatory responses to vascular injury in the rat 2016
    2015 Estrogen and cardiovascular disease: Is timing everything?.  American Journal of the Medical Sciences.  350:27-35. 2015
    2014 Inhibiting C-reactive protein for the treatment of cardiovascular disease: Promising evidence from rodent models.  Mediators of Inflammation.  2014. 2014
    2014 Targeted delivery of pulmonary arterial endothelial cells overexpressing interleukin-8 receptors attenuates monocrotaline-induced pulmonary vascular remodeling 2014
    2013 Endothelial cell transfusion ameliorates endothelial dysfunction in 5/6 nephrectomized rats 2013
    2013 Endothelial cells overexpressing IL-8 receptor reduce cardiac remodeling and dysfunction following myocardial infarction 2013
    2012 Role of the transcription factor erythroblastosis virus E26 oncogen homolog-1 (ETS-1) as mediator of the renal proinflammatory and profibrotic effects of angiotensin II.  Hypertension.  60:1226-1233. 2012
    2012 Acute O-GlcNAcylation prevents inflammation-induced vascular dysfunction 2012
    2012 Estrogen modulates NFκB signaling by enhancing IκBα levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-β.  PLoS One.  7. 2012
    2012 Endothelial cells overexpressing interleukin-8 receptors reduce inflammatory and neointimal responses to arterial injury.  Circulation.  125:1533-1541. 2012
    2011 Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling 2011
    2011 cGMP inhibits TGF-β signaling by sequestering Smad3 with cytosolic β2-tubulin in pulmonary artery smooth muscle cells 2011
    2011 O-GlcNAc modification of nfκb p65 inhibits tnf-α-induced inflammatory mediator expression in rat aortic smooth muscle cells.  PLoS One.  6. 2011
    2011 Transforming growth factor-β inhibits myocardial PPARγ expression in pressure overload-induced cardiac fibrosis and remodeling in mice.  Journal of Hypertension.  29:1810-1819. 2011
    2010 C-reactive protein-mediated vascular injury requires complement 2010
    2010 The transcription factor ETS-1 mediates proinflammatory responses and neointima formation in carotid artery endoluminal vascular injury.  Hypertension.  55:1381-1388. 2010
    2010 Inhibition of transforming growth factor-β signaling induces left ventricular dilation and dysfunction in the pressure-overloaded heart 2010
    2009 Estrogen and mechanisms of vascular protection 2009
    2008 Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury 2008
    2008 Atrial natriuretic peptide inhibits transforming growth factor β-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts.  Circulation Research.  102:185-192. 2008
    2008 Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats.  Biogerontology.  9:139-151. 2008
    2008 Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (FcγRI)-dependent.  American Journal of Pathology.  172:22-30. 2008
    2007 Estrogen modulates TNF-α-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-β activation 2007
    2007 Aged rats lose vasoprotective and anti-inflammatory actions of estrogen in injured arteries 2007
    2006 Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodeling.  Life Sciences.  79:1357-1365. 2006
    2006 Dominant negative mutation of the TGF-β eceptor blocks hypoxia-induced pulmonary vascular remodeling.  Journal of Applied Physiology.  100:564-571. 2006
    2006 Proteasomal inhibition: A novel pathway for prevention of atherosclerosis and restenosis.  Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry.  3:345-352. 2006
    2004 Estrogen modulates inflammatory mediator expression and neutrophil chemotaxis in injured arteries.  Circulation.  110:1664-1669. 2004
    2004 Estradiol and Progestins Differentially Modulate Leukocyte Infiltration after Vascular Injury.  Circulation.  109:234-241. 2004
    2004 Angiotensin II induced upregulation of G alpha q/11, phospholipase C beta 3 and extracellular signal-regulated kinase 1/2 via angiotensin II type 1 receptor 2004
    2004 Angiotensin II induced upregulation of G alpha q/11, phospholipase C beta 3 and extracellular signal-regulated kinase 1/2 via angiotensin II type 1 receptor 2004
    2003 Hormone replacement therapy and inflammation: Interactions in cardiovascular disease.  Hypertension.  42:657-663. 2003
    2002 Regulation of angiotensin II on Gαq/11 protein of vascular smooth muscle cell and its underlying mechanism.  Chinese Science Bulletin.  47:1369-1372. 2002
    2002 Platelet-derived growth factor receptor-β in myocyte was upregulated by angiotensin II.  Chinese Science Bulletin.  47:1015-1018. 2002
    2002 Role of platelet-derived growth factor receptor-mediated signal transduction in myocardial hypertrophy of spontaneously hypertensive rats. 2002

    Research Overview

  • Dr. Xing’s research has focused on fundamental mechanisms of the vascular injury response and their modulation by estrogen (E2) and protein O-GlcNAc modification. Experiments are conducted to test the hypothesis that O-GlcNAc modification of proteins plays a mechanistic role in the anti-inflammatory/vasoprotective action of glucosamine and estrogen and that the anti-inflammatory/vasoprotective effects of estrogen are mediated by estrogen receptor-beta dependent inhibition of NFκB in the setting of acute vascular injury.

    • Principal Investigator On

    Investigator On

    Education And Training

  • Doctor of Philosophy Level Degree in Pathology/Human and Animal, Peking University 2001

    • Full Name

  • Dongqi Xing