Positions

Overview

  • Dr. Pollock earned his Ph.D. degree in Physiology from the University of Cincinnati in 1983. He completed a post-doctoral fellowship at the University of North Carolina at Chapel Hill. He then spent two years as a Senior Scientist at the Institute for Circadian Physiology at Harvard University in Boston before taking a position in the Drug Discovery division of Abbott Laboratories in Chicago. In 1995, he accepted a faculty position in Vascular Biology Center at the Medical College of Georgia (now known as Augusta University) where he rose to the rank of Regents’ Professor. In 2010, he became the founding chief of the Section of Experimental Medicine in the Department of Medicine. In 2014, Dr. Pollock moved to UAB where he serves as Director of the Cardio-Renal Physiology and Medicine section in the UAB Department of Medicine whose charge it is to develop translational research and training programs. In 2016, he was named the James A Schafer NRTC Endowed Professor of Medicine.

    In 2015-2016, Dr. Pollock served as the 87th President of the American Physiological Society. Dr. Pollock is a fellow of the American Heart Association, the American Society of Nephrology and the American Physiological Society. He has served as Associate Editor for several journals including American Journal of Physiology: Regulatory, Integrative and Comparative Physiology and the Journal of the American Heart Association and is now serving as Editor-in-Chief of Comprehensive Physiology. He is also a founding member of the International Advisory Board on Endothelin who organize the bi-annual International Conferences on Endothelin. Dr. Pollock has also served on numerous NIH and AHA grant review committees. Dr. Pollock has also served as scientific advisor for several companies in the clinical development of endothelin antagonists including Speedel Pharmaceuticals, Abbott Laboratories, Pfizer Corporation, and Gilead Pharmaceuticals.
  • Selected Publications

    Book

    Year Title Altmetric
    2007 Contrasting actions of endothelin ETA and ETB receptors in cardiovascular disease.  Ed. 47.  2007

    Chapter

    Year Title Altmetric
    2013 Endothelin.  1473-1480. 2013
    2011 Endothelin in renal inflammation and hypertension.  160-170. 2011
    2011 Endothelin, nitric oxide, and reactive oxygen species in diabetic kidney disease.  149-159. 2011
    2006 Renal Endothelin.  1269-1275. 2006
    2006 Renal dysfunction in hypertension and obesity.  575-595. 2006

    Research Overview

  • For over 30 years, Dr. Pollock has conducted research on the renal mechanisms contributing to blood pressure regulation and renal disease. Dr. Pollock's lab has a wide range of expertise that includes chronic assessment of blood pressure (telemetry), hemodynamics, and renal function in rodent models of hypertension, diabetes, acute kidney injury, and chronic kidney disease. Dr. Pollock has provided considerable evidence through the years that the renal endothelin system is an important physiological regulator of sodium excretion and contributes to salt-dependent hypertension. He is currently Program Director of an NHLBI-funded Program Project Grant on the renal control of sodium excretion with a focus on renal autocrine and paracrine factors. His work specifically has begun to explore circadian control of renal function. Additional research interests include a long-standing collaboration with Dr. Jennifer Pollock in the area of stress in cardiovascular risk. More recently, he has several funded projects related to efforts to understand mechanisms responsible for sickle cell nephropathy.
  • Principal Investigator On

  • Timing of Sodium Intake and Nocturnal Sodium Excretion and Blood Pressure in Obese African Americans  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2024
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - AD Supplement: Salt-Dependent Hypertension and the Central Clock  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Admin Core  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 1 = Circadian Control of Sodium Excretion  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 2 = Integrated Control of Endothelin Production in the Collecting Duct  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Research Supplement to Promote Diversity  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Role of Renal Sensory Nerves in Mediating Hypertension  awarded by American Heart Association 2019 - 2020
  • Collecting Duct Bmal1 And Circadian Control Of Sodium Excretion  awarded by American Heart Association 2018 - 2020
  • Primary Cilia Function in Sickle Cell Nephropathy  awarded by American Physiological Society 2017 - 2019
  • Stress Related Mechanisms of Hypertension Risk - Core A  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA) 2014 - 2019
  • Stress Related Mechanisms of Hypertension Risk - Project 3  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA) 2014 - 2019
  • The Role of Endothelin-1 in Sickle Cell Disease  awarded by AUGUSTA UNIVERSITY - NEW 2014 - 2019
  • Evaluation of Human Variants in Disease Models for End Stage Renal Disease  awarded by HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY 2015 - 2018
  • The Role of Endothelin in Sickle Cell Nephropathy  awarded by ASN FOUNDATION FOR KIDNEY RESEARCH 2016 - 2018
  • Extrarenal Control of Na+ Homeostasis and Blood Pressure by Endothelin-1  awarded by American Heart Association (Southeast Affiliate) 2015 - 2018
  • Endothelin and Circadian Fluid Electrolyte Control  awarded by American Heart Association (Southeast Affiliate) 2015 - 2017
  • Sex Differences in Renal Endothelin and Purinergic Systems: Modulation by Ovarian Hormones  awarded by American Heart Association (Southeast Affiliate) 2015 - 2017
  • Endothelin Control of Renal Hemodynamic and Excretory Function  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Core A - Administrative Core  awarded by NIH - National Institutes of Health/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Core B - Analytical Core  awarded by NIH - National Institutes of Health/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Core C - Animal Core  awarded by NIH - National Institutes of Health/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Project 1 - Renal Endothelin Receptor-Specific Function in Angiotension II-Dependent Hypertension  awarded by NIH - National Institutes of Health/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Project 2 - Receptor Specific Mechanisms of Endothelin Control of the Renal Microcirculation  awarded by NIH - National Institutes of Health/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Project 3 - Endothelin-Dependent NOS Activation  awarded by NIH - National Institutes of Health/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Project 4 - Collecting Duct Endothelin and Sodium Homeostasis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2016
  • Endothelin in Sodium Homeostatis and Hypertension  awarded by American Heart Association (Southeast Affiliate) 2014 - 2016
  • Investigator On

  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 3 = HDAC-Mediated Regulation of Endothelin and Nitric Oxide  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • The Role Of Endothelin-1 In Tubular Injury In Sickle Cell Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2021
  • Mechanisms of Salt-Dependent Shifts in Blood Pressure Rhythms  awarded by American Heart Association 2019 - 2021
  • Sex Differences in Renal Sodium Handling  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2021
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center - Novel Mechanisms of Salt-Sensitivity and Diurnal Blood Pressure Rhythm - Project 3  awarded by American Heart Association 2015 - 2020
  • Stress Related Mechanisms of Hypertension Risk  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA) 2014 - 2019
  • Sex-Differences in Renal Sodium Handling  awarded by American Heart Association 2018 - 2019
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center  awarded by American Heart Association 2015 - 2019
  • Renal Vascular Function in ARPKD  awarded by PKD Foundation for Research in Polycystic Kidney Disease 2016 - 2019
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group 2017 - 2018
  • Endothelin: Mechanisms in Hypertension and Obesity  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2017
  • The Cytokines, MCP-1 and TGF-Beta, Mediate Renal Autoregulatory Impairment  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2016
  • Teaching Overview

  • Dr. Pollock has many years of classroom experience teaching graduate and medical physiology with a particular focus on water and electrolyte homeostasis and renal physiology and pharmacology. At the Medical College of Georgia, Dr. Pollock served as Chair of the Graduate Curriculum Committee and Program Director of the Vascular Biology Graduate Program. He has led problem based learning programs in medical schools at the University of North Carolina at Chapel Hill, the Medical College of Georgia, and the University of Alabama at Birmingham.

    Dr. Pollock has mentored over 30 PhD students and post-doctoral fellows and over 42 medical and undergraduate students. He has also served on over 20 additional PhD thesis committees. He has served on many NIH and AHA grant review committees that have focused on training applications and directed the T32-funded institutional training program for over 10 years while at the Medical College of Georgia. Dr. Pollock currently serves as the training co-director for an AHA funded Strategically Focused Research Network in Hypertension.
  • Education And Training

  • Doctor of Philosophy in Physiology, Pathology and Related Sciences, University of Cincinnati 1983
  • Full Name

  • David Pollock