Positions

Overview

  • Dr. Pollock earned his Ph.D. degree in Physiology from the University of Cincinnati in 1983. He completed a post-doctoral fellowship at the University of North Carolina at Chapel Hill. He then spent two years as a Senior Scientist at the Institute for Circadian Physiology at Harvard University in Boston before taking a position in the Drug Discovery division of Abbott Laboratories in Chicago. In 1995, he accepted a faculty position in Vascular Biology Center at the Medical College of Georgia (now known as Augusta University) where he rose to the rank of Regents’ Professor. In 2010, he became the founding chief of the Section of Experimental Medicine in the Department of Medicine. In 2014, Dr. Pollock moved to UAB where he serves as Director of the Cardio-Renal Physiology and Medicine section in the UAB Department of Medicine whose charge it is to develop translational research and training programs. In 2016, he was named the James A Schafer NRTC Endowed Professor of Medicine.

    In 2015-2016, Dr. Pollock served as the 87th President of the American Physiological Society. Dr. Pollock is a fellow of the American Heart Association, the American Society of Nephrology and the American Physiological Society. He has served as Associate Editor for several journals including American Journal of Physiology: Regulatory, Integrative and Comparative Physiology and the Journal of the American Heart Association and is now serving as Editor-in-Chief of Comprehensive Physiology. He is also a founding member of the International Advisory Board on Endothelin who organize the bi-annual International Conferences on Endothelin. Dr. Pollock has also served on numerous NIH and AHA grant review committees. Dr. Pollock has also served as scientific advisor for several companies in the clinical development of endothelin antagonists including Speedel Pharmaceuticals, Abbott Laboratories, Pfizer Corporation, and Gilead Pharmaceuticals.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 A pilot study of the effect of atorvastatin on endothelial function and albuminuria in sickle cell disease.  American Journal of Hematology.  94:E299-E301. 2019
    2019 Diurnal Regulation of Renal Electrolyte Excretion: The Role of Paracrine Factors..  Annual Review of Physiology.  2019
    2019 Ethnic Differences in Nighttime Melatonin and Nighttime Blood Pressure: A Study in European Americans and African Americans.  American Journal of Hypertension.  32:968-974. 2019
    2019 SONAR propels endothelin A receptor antagonists to success.  Nature Reviews Nephrology.  15:461-462. 2019
    2019 Impact of ET-1 and sex in glomerular hyperfiltration in humanized sickle cell mice.  Clinical Science.  133:1475-1486. 2019
    2019 Tauroursodeoxycholic acid (TUDCA) abolishes chronic high salt-induced renal injury and inflammation.  Acta Physiologica Scandinavica.  226. 2019
    2019 Autonomic nerves and circadian control of renal function.  Autonomic Neuroscience: Basic and Clinical.  217:58-65. 2019
    2019 Combined hydroxyurea and ET A receptor blockade reduces renal injury in the humanized sickle cell mouse.  Acta Physiologica Scandinavica.  225. 2019
    2019 Afferent arteriole responsiveness to endothelin receptor activation: Does sex matter? 11 Medical and Health Sciences 1103 Clinical Sciences.  Biology of Sex Differences.  10. 2019
    2019 Angiotensin II receptor blocker attenuates stress pressor response in young adult African Americans.  Journal of Clinical Hypertension.  21:1191-1199. 2019
    2019 Hyperfiltration predicts long-term renal outcomes in humanized sickle cell mice.  Blood Advances.  3:1460-1475. 2019
    2018 Maternal separation enhances anticontractile perivascular adipose tissue function in male rats on a high-fat diet.  AJP - Regulatory, Integrative and Comparative Physiology.  315:R1085-R1095. 2018
    2018 Angiotensin II and the natriuretic and blood pressure response to mental stress in African Americans.  Ethnicity and Disease.  28:511-516. 2018
    2018 Endothelin type a receptors mediate pain in a mouse model of sickle cell disease.  Haematologica.  103:1124-1135. 2018
    2018 A more direct way to measure glomerular albumin permeability—even in human glomeruli!.  Kidney International.  93:1035-1037. 2018
    2018 Circadian regulation of renal function.  Free Radical Biology and Medicine.  119:93-107. 2018
    2018 Introduction to special issue: Circadian regulation of metabolism, redox signaling and function in health and disease.  Free Radical Biology and Medicine.  119:1-2. 2018
    2018 Diurnal pattern in skin Na+and water content is associated with salt-sensitive hypertension in ETBreceptor-deficient rats.  AJP - Regulatory, Integrative and Comparative Physiology.  314:R544-R551. 2018
    2018 Acute pressor response to psychosocial stress is dependent on endothelium-derived endothelin-1.  Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  7. 2018
    2018 Circadian regulation of kidney function: Finding a role for bmal1.  AJP - Renal Physiology.  314:F675-F678. 2018
    2018 High dietary sodium causes dyssynchrony of the renal molecular clock in rats.  AJP - Renal Physiology.  314:F89-F98. 2018
    2018 Natriuretic response to renal medullary endothelin B receptor activation is impaired in Dahl-salt sensitive rats on a high-fat diet.  Physiological Research.  67:S149-S154. 2018
    2018 Relation of urinary endothelin-1 to stress-induced pressure natriuresis in healthy adolescents.  Journal of the American Society of Hypertension.  12:34-41. 2018
    2017 The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection.  Scientific Reports.  7. 2017
    2017 Renal denervation attenuates hypertension but not salt sensitivity in ETB receptor-deficient rats.  AJP - Regulatory, Integrative and Comparative Physiology.  313:R425-R437. 2017
    2017 Interplay between renal endothelin and purinergic signaling systems.  AJP - Renal Physiology.  313:F666-F668. 2017
    2017 Long-term endothelin-a receptor antagonism provides robust renal protection in humanized sickle cell disease mice.  Journal of the American Society of Nephrology.  28:2443-2458. 2017
    2017 Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis.  AJP - Renal Physiology.  313:F361-F369. 2017
    2017 People and places: Meet the new committee chairs.  Physiologist.  60:219-222. 2017
    2017 Sex-Specific Contributions of Endothelin to Hypertension.  Current Hypertension Reports.  20. 2017
    2017 Endothelin receptor-specific control of endoplasmic reticulum stress and apoptosis in the kidney.  Scientific Reports.  7. 2017
    2017 Activation of neuronal endothelin B receptors mediates pressor response through alpha-1 adrenergic receptors.  Physiological Reports.  5. 2017
    2016 Free radical scavenging decreases endothelin-1 excretion and glomerular albumin permeability during type 1 diabetes.  Physiological Reports.  4. 2016
    2016 Albuminuria is associated with endothelial dysfunction and elevated plasma endothelin-1 in sickle cell anemia.  PLoS ONE.  11. 2016
    2016 High salt intake increases endothelin B receptor function in the renal medulla of rats.  Life Sciences.  159:144-147. 2016
    2016 Ovarian hormones modulate endothelin A and B receptor expression.  Life Sciences.  159:148-152. 2016
    2016 Role of the endothelin system in sexual dimorphism in cardiovascular and renal diseases.  Life Sciences.  159:20-29. 2016
    2016 The Fourteenth International Conference on Endothelin (ET-14), Savannah, U.S.A..  Life Sciences.  159:2-9. 2016
    2016 The Third Tomoh Masaki Award (2015).  Life Sciences.  159:10-11. 2016
    2016 Activation of purinergic receptors (P2) in the renal medulla promotes endothelin-dependent natriuresis in male rats.  AJP - Renal Physiology.  311:F260-F267. 2016
    2016 Circadian regulation of cardiovascular and kidney function.  Experimental Physiology.  101:1022-1024. 2016
    2016 Endothelin.  Pharmacological Reviews.  68:357-418. 2016
    2016 Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats.  AJP - Renal Physiology.  310:F456-F465. 2016
    2016 Comprehensive Physiology: A tool for advanced education in physiology.  Advances in Physiology Education.  40:275-277. 2016
    2016 Endothelin-1 and the kidney: New perspectives and recent findings.  Current Opinion in Nephrology and Hypertension.  25:35-41. 2016
    2016 Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species.  British Journal of Pharmacology.  173:386-395. 2016
    2016 Loss of endothelin B receptor function impairs sodium excretion in a time- and sex-dependent manner.  AJP - Renal Physiology.  311:F991-F998. 2016
    2015 Endothelin-1 as a master regulator of whole-body Na+ homeostasis.  Federation proceedings.  29:4937-4944. 2015
    2015 Mentoring for Collaborations and Team Science.  Physiologist.  58. 2015
    2015 Endothelin and Renal Ion and Water Transport.  Seminars in Nephrology.  35:137-144. 2015
    2015 Angiotensin II is required to induce exaggerated salt sensitivity in Dahl rats exposed to maternal separation.  Physiological Reports.  3. 2015
    2015 ET-1 increases reactive oxygen species following hypoxia and high-salt diet in the mouse glomerulus.  Acta Physiologica Scandinavica.  213:722-730. 2015
    2015 Endothelin contributes to blunted renal autoregulation observed with a high-salt diet.  AJP - Renal Physiology.  309:F687-F696. 2015
    2015 Endothelium-derived ET-1 and the development of renal injury.  AJP - Regulatory, Integrative and Comparative Physiology.  309:R1071-R1073. 2015
    2015 High salt diet increases the pressor response to stress in female, but not male ETB-receptor-deficient rats.  Physiological Reports.  3. 2015
    2015 Interview with David Pollock.  Physiologist.  58:48-50. 2015
    2015 New Clues Towards Solving the Mystery of Endothelin and Blood Pressure Regulation.  Hypertension.  66:275-277. 2015
    2015 Physiologists can answer big questions.  News in Physiological Sciences.  30:402-403. 2015
    2015 What does peer review need?.  Physiologist.  58. 2015
    2014 Combined endothelin a blockade and chlorthalidone treatment in a rat model of metabolic syndrome.  Journal of Pharmacology and Experimental Therapeutics.  351:467-473. 2014
    2014 High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism.  AJP - Renal Physiology.  307. 2014
    2014 2013 Dahl Lecture American heart association council for high blood pressure research clarifying the physiology of endothelin.  Hypertension.  63. 2014
    2014 87th president of APS..  Physiologist.  57. 2014
    2014 APS leadership meets with NIGMS..  Physiologist.  57. 2014
    2014 Adverse childhood experiences are associated with detrimental hemodynamics and elevated circulating endothelin-1 in adolescents and young adults.  Hypertension.  64:201-207. 2014
    2014 Antihypertensive and anti-inflammatory actions of combined azilsartan and chlorthalidone in Dahl salt-sensitive rats on a high-fat, high-salt diet.  Clinical and Experimental Pharmacology and Physiology.  41:579-588. 2014
    2014 Editorial.  News in Physiological Sciences.  29:382-383. 2014
    2014 Guest editorial.  American Biology Teacher.  76:572-573. 2014
    2014 Indoleamine 2,3-dioxygenase inhibition alters the non-coding RNA transcriptome following renal ischemia-reperfusion injury.  Transplant Immunology.  30:140-144. 2014
    2014 Variable reactive hyperemia in normotensive strains of rat.  Physiological Reports.  2. 2014
    2013 L-citrulline protects from kidney damage in type 1 diabetic mice.  Frontiers in Immunology.  4. 2013
    2013 Reports of physiology's demise have been greatly exaggerated.  News in Physiological Sciences.  28:360-362. 2013
    2013 Sex differences in ET-1 receptor expression and Ca2+ signaling in the IMCD.  AJP - Renal Physiology.  305. 2013
    2013 Endothelin antagonists for diabetic and non-diabetic chronic kidney disease.  British Journal of Clinical Pharmacology.  76:573-579. 2013
    2013 Immunosuppression preserves renal autoregulatory function and microvascular P2X1 receptor reactivity in ANG II-hypertensive rats.  AJP - Renal Physiology.  304. 2013
    2013 Early life stress sensitizes the renal and systemic sympathetic system in rats.  AJP - Renal Physiology.  305. 2013
    2013 Renal collecting duct nos1 maintains fluid-electrolyte homeostasis and blood pressure.  Hypertension.  62:91-98. 2013
    2013 Endothelin ETB receptors contribute to sex differences in blood pressure elevation in angiotensin II hypertensive rats on a high-salt diet.  Clinical and Experimental Pharmacology and Physiology.  40:362-370. 2013
    2013 Endothelin, kidney disease, and hypertension.  Hypertension.  61:1142-1145. 2013
    2013 APS election results.  Physiologist.  56:44. 2013
    2013 Early life stress induces renal dysfunction in adult male rats but not female rats.  AJP - Regulatory, Integrative and Comparative Physiology.  304. 2013
    2013 Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats.  Physiological Reports.  1:1-10. 2013
    2013 ET-1 actions in the kidney: Evidence for sex differences.  British Journal of Pharmacology.  168:318-326. 2013
    2013 Mycophenolate mofetil prevents high-fat diet–induced hypertension and renal glomerular injury in dahl SS rats.  Physiological Reports.  1:1-11. 2013
    2012 Frequency of edema in patients with pulmonary arterial hypertension receiving ambrisentan.  American Journal of Cardiology.  110:1373-1377. 2012
    2012 Loss of renal medullary endothelin B receptor function during salt deprivation is regulated by angiotensin II.  AJP - Renal Physiology.  303. 2012
    2012 Changing standard chow diet promotes vascular NOS dysfunction in Dahl S rats.  AJP - Regulatory, Integrative and Comparative Physiology.  302. 2012
    2012 New concepts in endothelin control of sodium balance.  Clinical and Experimental Pharmacology and Physiology.  39:104-110. 2012
    2011 ETA activation mediates angiotensin II-induced infiltration of renal cortical T cells.  Journal of the American Society of Nephrology.  22:2187-2192. 2011
    2011 Endothelin in renal inflammation and hypertension..  Contributions to Nephrology.  172:160-170. 2011
    2011 Endothelin, nitric oxide, and reactive oxygen species in diabetic kidney disease..  Contributions to Nephrology.  172:149-159. 2011
    2011 Early life stress enhances angiotensin II-mediated vasoconstriction by reduced endothelial nitric oxide buffering capacity.  Hypertension.  58:619-626. 2011
    2011 Erratum: Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat (Hypertension (2010) 56 (942-949)).  Hypertension.  58. 2011
    2011 Sex differences in renal medullary endothelin receptor function in angiotensin ii hypertensive rats.  Hypertension.  58:212-218. 2011
    2011 Distinct actions of endothelin A-selective versus combined endothelin A/B receptor antagonists in early diabetic kidney disease.  Journal of Pharmacology and Experimental Therapeutics.  338:263-270. 2011
    2011 Effects of spironolactone on cerebral vessel structure in rats with sustained hypertension.  American Journal of Hypertension.  24:708-715. 2011
    2011 Endothelin receptor A-specific stimulation of glomerular inflammation and injury in a streptozotocin-induced rat model of diabetes.  Diabetologia.  54:979-988. 2011
    2011 Physiology of endothelin and the kidney.  Comprehensive Physiology.  1:883-919. 2011
    2011 Flow regulation of collecting duct endothelin-1 production.  AJP - Renal Physiology.  300. 2011
    2011 Regulation of blood pressure and salt homeostasis by endothelin.  Physiological Reviews.  91:1-77. 2011
    2010 Cooperative role of ETA and ETB receptors in mediating the diuretic response to intramedullary hyperosmotic NaCl infusion.  AJP - Renal Physiology.  299. 2010
    2010 Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat.  Hypertension.  56:942-949. 2010
    2010 Immunosuppression with mycophenolate mofetil attenuates the development of hypertension and albuminuria in deoxycorticosterone acetate-salt hypertensive rats.  Clinical and Experimental Pharmacology and Physiology.  37:1016-1022. 2010
    2010 Sex differences in acute ANG II-mediated hemodynamic responses in mice.  AJP - Regulatory, Integrative and Comparative Physiology.  299. 2010
    2010 Contrasting effects of intervention with ETa and ETb receptor antagonists in hypertension induced by angiotensin II and high-salt diet.  Canadian Journal of Physiology and Pharmacology.  88:802-807. 2010
    2010 Endothelin activation of reactive oxygen species mediates stress-induced pressor response in dahl salt-sensitive prehypertensive rats.  Hypertension.  56:282-289. 2010
    2010 Dissecting the complex physiology of endothelin: New lessons from genetic models.  Hypertension.  56:31-33. 2010
    2010 Early life stress downregulates endothelin receptor expression and enhances acute stress-mediated blood pressure responses in adult rats.  AJP - Regulatory, Integrative and Comparative Physiology.  299. 2010
    2010 Introduction.  Canadian Journal of Physiology and Pharmacology.  88. 2010
    2010 Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury.  Kidney International.  78:374-381. 2010
    2009 Novel use of ultrasound to examine regional blood flow in the mouse kidney.  AJP - Renal Physiology.  297. 2009
    2009 Attenuation of experimental hepatopulmonary syndrome in endothelin B receptor-deficient rats.  AJP - Gastrointestinal and Liver Physiology.  296. 2009
    2009 Does targeting the lipophilic milieu provide advantages for an endothelin antagonist?.  Molecular Interventions.  9:75-78. 2009
    2009 Complications impair the usefulness and validity of the rat tail arteriovenous fistula model.  Kidney International.  76:916. 2009
    2009 Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis..  Hormone and Metabolic Research.  41:35-39. 2009
    2009 Contribution of endothelin A receptors in endothelin 1-dependent natriuresis in female rats..  Hypertension.  53:324-330. 2009
    2008 Role of endothelin-1 in clinical hypertension: 20 years on.  Hypertension.  52:452-459. 2008
    2008 Interleukin-1β, but not interleukin-6, enhances renal and systemic endothelin production in vivo.  AJP - Renal Physiology.  295. 2008
    2008 Collecting duct-derived endothelin regulates arterial pressure and Na excretion via nitric oxide.  Hypertension.  51:1605-1610. 2008
    2008 Renal medullary ETB receptors produce diuresis and natriuresis via NOS1.  AJP - Renal Physiology.  294. 2008
    2008 Dietary potassium supplementation improves vascular structure and ameliorates the damage caused by cerebral ischemia in normotensive rats.  Nutrition & Metabolism.  5. 2008
    2008 Influence of salt on subcellular localization of nitric oxide synthase activity and expression in the renal inner medulla.  Clinical and Experimental Pharmacology and Physiology.  35:120-125. 2008
    2008 Endothelin and NOS1/nitric oxide signaling and regulation of sodium homeostasis.  Current Opinion in Nephrology and Hypertension.  17:70-75. 2008
    2008 TNF-α inhibition reduces renal injury in DOCA-salt hypertensive rats.  AJP - Regulatory, Integrative and Comparative Physiology.  294. 2008
    2007 Chemokine receptor 2b inhibition provides renal protection in angiotensin II-salt hypertension.  Hypertension.  50:1069-1076. 2007
    2007 EndothelinA (ETA) and ETB receptor-mediated regulation of nitric oxide synthase 1 (NOS1) and NOS3 isoforms in the renal inner medulla.  Acta Physiologica Scandinavica.  191:329-336. 2007
    2007 Selective and mixed endothelin receptor antagonism in cardiovascular disease.  Trends in Pharmacological Sciences.  28:573-579. 2007
    2007 Intact female stroke-prone hypertensive rats lack responsiveness to mineralocorticoid receptor antagonists.  AJP - Regulatory, Integrative and Comparative Physiology.  293. 2007
    2007 Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat.  AJP - Heart and Circulatory Physiology.  293. 2007
    2007 Sex and sex hormones influence the development of albuminuria and renal macrophage infiltration in spontaneously hypertensive rats.  AJP - Regulatory, Integrative and Comparative Physiology.  293. 2007
    2007 Effect of chronic IL-6 infusion on acute pressor responses to vasoconstrictors in mice.  AJP - Heart and Circulatory Physiology.  293. 2007
    2007 Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation.  AJP - Heart and Circulatory Physiology.  293. 2007
    2007 Spironolactone improves structure and increases tone in the cerebral vasculature of male spontaneously hypertensive stroke-prone rats.  Microvascular Research.  73:198-205. 2007
    2007 Attenuated vasoconstrictor responses to endothelin in afferent arterioles during a high-salt diet.  AJP - Renal Physiology.  292. 2007
    2007 Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension.  Vascular Pharmacology.  46:144-151. 2007
    2007 A high-potassium diet reduces infarct size and improves vascular structure in hypertensive rats.  AJP - Regulatory, Integrative and Comparative Physiology.  292. 2007
    2007 Acute increases of renal medullary osmolality stimulate endothelin release from the kidney.  AJP - Renal Physiology.  292. 2007
    2007 Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism.  Journal of the American Society of Nephrology.  18:143-154. 2007
    2006 Exaggerated cardiovascular stress responses and impaired β-adrenergic-mediated pressor recovery in obese Zucker rats.  Hypertension.  48:1109-1115. 2006
    2006 Increased reactive oxygen species contributes to kidney injury in mineralocorticoid hypertensive rats.  Journal of Physiology and Pharmacology.  57:343-357. 2006
    2006 Clarifying endothelin type B receptor function.  Hypertension.  48:211-212. 2006
    2006 Multi-center study: The biochemical efficacy, safety and tolerability of a new α1-proteinase inhibitor, Zemaira.  COPD: Journal of Chronic Obstructive Pulmonary Disease.  3:17-23. 2006
    2006 Contribution of prostanoid TP receptors to the pressor and intrarenal haemodynamic response to endothelin.  Clinical and Experimental Pharmacology and Physiology.  33:253-257. 2006
    2006 In vivo evidence for endothelin-1-mediated attenuation of α1-adrenergic stimulation.  AJP - Heart and Circulatory Physiology.  290. 2006
    2006 Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes.  AJP - Regulatory, Integrative and Comparative Physiology.  290. 2006
    2006 How does endothelin induce vascular oxidative stress in mineralocorticoid hypertension?.  Clinical Science.  110:205-206. 2006
    2006 Hypertension after experimental cerebral ischemia: Candesartan provides neurovascular protection.  Journal of Hypertension.  24:535-539. 2006
    2005 An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats.  Journal of Cardiovascular Pharmacology.  46:842-848. 2005
    2005 ET A and ET B receptors differentially modulate afferent and efferent arteriolar responses to endothelin.  British Journal of Pharmacology.  146:1019-1026. 2005
    2005 Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta.  Journal of Pharmacology and Experimental Therapeutics.  315:1058-1064. 2005
    2005 Endothelin-1 activation of JAK2 in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species.  Vascular Pharmacology.  43:310-319. 2005
    2005 Endothelin and oxidative stress in the vascular system.  Current Vascular Pharmacology.  3:365-367. 2005
    2005 Fructose feeding increases insulin resistance but not blood pressure in Sprague-Dawley rats.  Hypertension.  46:806-811. 2005
    2005 Peroxisome proliferator-activated receptor-α activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade.  Hypertension.  46:366-371. 2005
    2005 Endogenous endothelin attenuates the pressor response to acute environmental stress via the ETA receptor.  AJP - Heart and Circulatory Physiology.  288. 2005
    2005 Endothelin, angiotensin, and oxidative stress in hypertension.  Hypertension.  45:477-480. 2005
    2005 L-type calcium channels, in the renal microcirculatory response to endothelin.  AJP - Renal Physiology.  288. 2005
    2005 Sexual dimorphism in renal production of prostanoids in spontaneously hypertensive rats.  Hypertension.  45:406-411. 2005
    2005 Tactics for vascular protection after acute ischemic stroke.  Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy.  25:387-395. 2005
    2005 NADPH oxidase inhibition attenuates oxidative stress but not hypertension produced by chronic ET-1.  Hypertension.  45:283-287. 2005
    2005 An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension..  Hypertension.  46:975-981. 2005
    2005 Posttranslational regulation of NO synthase activity in the renal medulla of diabetic rats.  AJP - Renal Physiology.  288. 2005
    2004 Arterial pressure response to the antioxidant tempol and ETB receptor blockade in rats on a high-salt diet.  Hypertension.  44:770-775. 2004
    2004 ETA receptor blockade attenuates hypertension and decreases reactive oxygen species in ETB receptor-deficient rats.  Journal of Cardiovascular Pharmacology.  44. 2004
    2004 Targets for vascular protection after acute ischemic stroke.  Stroke.  35:2220-2225. 2004
    2004 Reduced NOS3 Phosphorylation Mediates Reduced NO/cGMP Signaling in Mesenteric Arteries of Deoxycorticosterone Acetate-Salt Hypertensive Rats.  Hypertension.  43:1080-1085. 2004
    2004 Soluble Epoxide Hydrolase Inhibition Protects the Kidney from Hypertension-Induced Damage.  Journal of the American Society of Nephrology.  15:1244-1253. 2004
    2004 Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli.  AJP - Renal Physiology.  286. 2004
    2004 Low-flow vascular remodeling in the metabolic syndrome X.  AJP - Heart and Circulatory Physiology.  286. 2004
    2004 Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria.  Obesity Research.  12:1278-1289. 2004
    2003 Omapatrilat increases renal endothelin in deoxycorticosterone acetate-salt hypertensive rats.  Vascular Pharmacology.  40:253-259. 2003
    2003 Endothelin-1 gene LYS198ASN polymorphism and blood pressure reactivity.  Hypertension.  42:494-499. 2003
    2003 Enalapril attenuates endothelin-1-induced hypertension via increased kinin survival.  AJP - Heart and Circulatory Physiology.  284. 2003
    2003 Functional role of ETB receptors in the renal medulla.  Hypertension.  41:1359-1363. 2003
    2003 Targeting sources of superoxide and increasing nitric oxide bioavailability in hypertension.  Current Opinion in Investigational Drugs.  4:282-290. 2003
    2003 Unique endothelin receptor binding in kidneys of ETB receptor deficient rats.  AJP - Regulatory, Integrative and Comparative Physiology.  284. 2003
    2003 Down-regulation of soluble guanylyl cyclase in the inner medulla of DOCA-salt hypertensive rats.  Vascular Pharmacology.  40:155-160. 2003
    2003 Salt-Sensitive Hypertension After Exposure to Angiotensin Is Associated With Inability to Upregulate Renal Epoxygenases.  Hypertension.  42:775-780. 2003
    2002 Decreased endothelin binding and [Ca2+]i signaling in microvessels of DOCA-salt hypertensive rats.  Journal of Hypertension.  20:1799-1805. 2002
    2002 Plasma endothelin-1 release during acute stress: Role of ethnicity and sex.  Psychosomatic Medicine.  64:707-713. 2002
    2002 Renal endothelin in chronic angiotensin II hypertension.  AJP - Regulatory, Integrative and Comparative Physiology.  283. 2002
    2002 Functional NOS 1 in the rat mesenteric arterial bed.  AJP - Heart and Circulatory Physiology.  283. 2002
    2002 Role of ET-1 receptor binding and [Ca2+]i in contraction of coronary arteries from DOCA-salt hypertensive rats.  AJP - Heart and Circulatory Physiology.  282. 2002
    2002 Dissecting the genetic architecture of the cardiovascular and renal stress response.  Biological Psychology.  61:73-95. 2002
    2001 EtB receptor-deficient rats exhibit reduced contraction to ET-1 despite an increase in ETA receptors.  AJP - Heart and Circulatory Physiology.  281. 2001
    2001 Urinary excretion of vasoactive factors are correlated to sodium excretion.  American Journal of Hypertension.  14:1003-1006. 2001
    2001 Evidence for endothelin involvement in the response to high salt.  AJP - Renal Physiology.  281. 2001
    2001 Contrasting pharmacological ETB receptor blockade with genetic ETB deficiency in renal responses to big ET-1.  Physiological Genomics.  2001:39-43. 2001
    2001 Endothelin-1-induced vasoconstriction is inhibited during erection in rats.  AJP - Regulatory, Integrative and Comparative Physiology.  281. 2001
    2001 Endothelin antagonists in the treatment of renal failure.  Current Opinion in Investigational Drugs.  2:513-520. 2001
    2001 Enhanced endothelin-1 response and receptor expression in small mesenteric arteries of insulin-resistant rats.  AJP - Heart and Circulatory Physiology.  280. 2001
    2001 Contrasting pharmacological ETB receptor blockade with genetic ETB deficiency in renal responses to big ET-1..  Physiological Genomics.  6:39-43. 2001
    2001 Exercise in sickle cell anemia: Effect on inflammatory and vasoactive mediators.  Endothelium.  8:147-155. 2001
    2000 Combined effects of AT1 and ETA receptor antagonists, candesartan, and A-127722 in DOCA-salt hypertensive rats.  General Pharmacology.  34:337-342. 2000
    2000 Endothelin inhibits thick ascending limb chloride flux via ET(B) receptor-mediated NO release.  AJP - Renal Physiology.  279. 2000
    2000 Shear stress-mediated NO production in inner medullary collecting duct cells.  AJP - Renal Physiology.  279. 2000
    2000 Receptor-specific influence of endothelin-1 in the erectile response of the rat.  AJP - Regulatory, Integrative and Comparative Physiology.  279. 2000
    2000 Renal endothelin in hypertension.  Current Opinion in Nephrology and Hypertension.  9:157-164. 2000
    2000 Upregulation of endothelin B receptors in kidneys of DOCA-salt hypertensive rats.  AJP - Renal Physiology.  278. 2000
    2000 Arterial pressure response to endothelin-1 and sarafotoxin 6c in rescued endothelin-B-deficient rats.  Journal of Cardiovascular Pharmacology.  36. 2000
    2000 Racial differences in endothelin-1 at rest and in response to acute stress in adolescent males.  Hypertension.  35:722-725. 2000
    1999 Increased nitric oxide synthase-3 expression in kidneys of deoxycorticosterone acetate-salt hypertensive rats.  Journal of the American Society of Nephrology.  10:2283-2289. 1999
    1999 Combined treatment with ibuprofen and the AT1 receptor antagonist candesartan in young spontaneously hypertensive rats.  Journal of the American Society of Nephrology.  10. 1999
    1998 Hypertensive response to chronic NO synthase inhibition is different in Sprague-Dawley rats from two suppliers.  AJP - Regulatory, Integrative and Comparative Physiology.  275. 1998
    1998 Coronary vascular reactivity is improved by endothelin A receptor blockade in DOCA-salt hypertensive rats.  AJP - Regulatory, Integrative and Comparative Physiology.  274. 1998
    1998 ET(A) receptor blockade attenuates the hypertension but not renal dysfunction in DOCA-salt rats.  AJP - Regulatory, Integrative and Comparative Physiology.  275. 1998
    1998 Role of endothelin ET(A) receptors in the hypertension produced by 4- day L-nitroarginine methyl ester and cyclosporine treatment.  European Journal of Pharmacology.  346:43-50. 1998
    1997 Chronic blockade of ETA receptors with A-127722 attenuates hypertension without effect on renal function in DOCA-salt rats.  Federation proceedings.  11. 1997
    1997 ET(A) receptor blockade prevents hypertension associated with exogenous endothelin-1 but not renal mass reduction in the rat.  Journal of the American Society of Nephrology.  8:1054-1060. 1997
    1997 Atrial natriuretic factors: The treatment of the future or a false hope?.  Blood Purification.  15:292-304. 1997
    1997 Beneficial effect of ET(A) receptor blockade in a rat model of radiocontrast-induced nephropathy.  Renal Failure.  19:753-761. 1997
    1996 ET, receptor blockade prevents hypertension associated with exogenous et-1 but not renal mass reduction in the rat.  Federation proceedings.  10. 1996
    1996 Hypertension induced by subchronic treatment with l-name is prevented by eta receptor blockade in the rat.  Federation proceedings.  10. 1996
    1996 ET(A) receptor blockade potentiates the bronchoconstrictor response to ET-1 in the guinea pig airway.  Biochemical and Biophysical Research Communications.  225:225-231. 1996
    1995 Endothelin receptors and calcium signaling.  Federation proceedings.  9:1196-1204. 1995
    1995 Prevention by blockade of angiotensin subtype1‐receptors of the development of genetic hypertension but not its heritability.  British Journal of Pharmacology.  115:557-562. 1995
    1994 Biochemical Characterization of Endothelin Receptors Following Renal Ischemia in the Rat.  Endothelium.  2:223-228. 1994
    1994 ETA receptor‐mediated responses to endothelin‐1 and big endothelin‐1 in the rat kidney.  British Journal of Pharmacology.  111:729-732. 1994
    1993 Angiotensin II receptor blockade improves renal function in rats with reduced renal mass.  Journal of Pharmacology and Experimental Therapeutics.  267:657-663. 1993
    1993 In vivo characterization of a phosphoramidon-sensitive endothelin-converting enzyme in the rat.  European Journal of Pharmacology.  231:459-464. 1993
    1993 Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition.  Hypertension.  21:660-666. 1993
    1993 Atrial natriuretic peptides in the treatment of acute renal failure.  Renal Failure.  15:439-449. 1993
    1993 Effect of the Endothelin ETA Receptor Antagonist, BQ-123, on Pressor Responses to Endothelin Family Peptides.  Endothelium.  1:55-59. 1993
    1993 Evidence for endothelin-induced renal vasoconstriction independent of ET(A) receptor activation.  American Journal of Physiology.  264. 1993
    1993 Surgery and Plasma Infusion Increase Circulating Immunoreactive Endothelin in the Anesthetized Rat.  Endothelium.  1:123-126. 1993
    1992 Rhamnose moiety of phosphoramidon is not required for in vivo inhibition of endothelin converting enzyme.  Biochemical and Biophysical Research Communications.  186:1146-1150. 1992
    1992 Small Atrial Natriuretic Peptide Analogs: Design, Synthesis, and Structural Requirements for Guanylate Cyclase Activation.  Journal of Medicinal Chemistry.  35:808-816. 1992
    1992 Beneficial effect of the ANF analog a68828 on recovery from ischemic acute renal failure.  Renal Failure.  14:141-146. 1992
    1991 Comparison of the hemodynamic effects of endothelin-1 and big endothelin-1 in the rat.  Biochemical and Biophysical Research Communications.  179:1122-1126. 1991
    1991 Effect of acute renal denervation and ANF on renal function in adult spontaneously hypertensive rats.  American Journal of Physiology.  261. 1991
    1991 Effect of the ANF analog A68828 in cisplatin-induced acute renal failure.  Journal of Pharmacology and Experimental Therapeutics.  257:1179-1183. 1991
    1991 Evidence for metalloprotease involvement in the in vivo effects of big endothelin 1.  American Journal of Physiology.  261. 1991
    1991 Perspectives on Renal Blood Flow Autoregulation.  Proceedings of the Society for Experimental Biology and Medicine.  198:800-805. 1991
    1991 Renal response to 7 days of lower body positive pressure in squirrel monkeys.  American Journal of Physiology.  260. 1991
    1990 Beneficial effect of the atrial natriuretic factor analog A68828 in postischemic acute renal failure.  Journal of Pharmacology and Experimental Therapeutics.  255:1166-1169. 1990
    1990 Native tubular fluid attenuates ANF-induced inhibition of tubuloglomerular feedback.  AJP - Renal Physiology.  258. 1990
    1990 Tubuloglomerular feedback and blood flow autoregulation during DA1-induced renal vasodilation.  AJP - Renal Physiology.  258. 1990
    1990 Exaggerated natriuretic response to atrial natriuretic factor in rats developing spontaneous hypertension.  Hypertension.  16:72-79. 1990
    1988 Altered reactivity of tubuloglomerular feedback in the spontaneously hypertensive rat.  Fernstrom Foundation Series.  11:297-312. 1988
    1988 Does atrial natriuretic peptide inhibit tubuloglomerular feedback? Results of free-flow and microperfusion studies in the rat.  Fernstrom Foundation Series.  11:465-467. 1988
    1986 Effect of atrial natriuretic factor on renal hemodynamics in the rat.  American Journal of Physiology - Renal Fluid and Electrolyte Physiology.  251. 1986
    1986 Dissociation of urinary kallikrein activity and salt and water excretion in the rat.  American Journal of Physiology - Renal Fluid and Electrolyte Physiology.  250. 1986
    1985 Abnormalities in kallikrein excretion in spontaneously hypertensive rats.  American Journal of Physiology - Renal Fluid and Electrolyte Physiology.  17. 1985
    1985 Abnormalities in kallikrein excretion in spontaneously hypertensive rats.  American Journal of Physiology - Renal Fluid and Electrolyte Physiology.  17. 1985
    1985 Lower atrial natriuretic activity in the newborn versus adult rat.  Mineral and Electrolyte Metabolism.  11:41-44. 1985
    1984 Influence of dietary sodium on the natriuretic activity of atrial tissue.  Mineral and Electrolyte Metabolism.  10:337-342. 1984
    1984 Relation between urinary kallikrein excretion and renal arterial pressure in spontaneously hypertensive rats.  Federation proceedings.  43. 1984
    1983 Effect of atrial extract on renal function in the rat.  Clinical Science.  65:47-55. 1983
    1983 Failure of atrial myocardial extract to inhibit renal na+, k -atpase.  Kidney and Blood Pressure Research.  6:295-299. 1983
    1983 Failure of atrial myocardial extract to inhibit renal na+, k -atpase.  Kidney and Blood Pressure Research.  6:295-299. 1983
    1982 Hemodynamic effects of a new histamine H2 receptor agonist (impromidine) and antagonist (ranitidine).  Pharmacological research communications.  14:605-612. 1982
    1981 Hemodynamic effects of a new histamine H2 receptor agonist (impromidine) and antagonist (ranitidine).  Federation proceedings.  40. 1981

    Book

    Year Title Altmetric
    2007 Contrasting actions of endothelin ETA and ETB receptors in cardiovascular disease.  Ed. 47.  2007

    Chapter

    Year Title Altmetric
    2013 Endothelin.  1473-1480. 2013
    2011 Endothelin in renal inflammation and hypertension.  160-170. 2011
    2011 Endothelin, nitric oxide, and reactive oxygen species in diabetic kidney disease.  149-159. 2011
    2006 Renal Endothelin.  1269-1275. 2006
    2006 Renal dysfunction in hypertension and obesity.  575-595. 2006

    Research Overview

  • For over 30 years, Dr. Pollock has conducted research on the renal mechanisms contributing to blood pressure regulation and renal disease. Dr. Pollock's lab has a wide range of expertise that includes chronic assessment of blood pressure (telemetry), hemodynamics, and renal function in rodent models of hypertension, diabetes, acute kidney injury, and chronic kidney disease. Dr. Pollock has provided considerable evidence through the years that the renal endothelin system is an important physiological regulator of sodium excretion and contributes to salt-dependent hypertension. He is currently Program Director of an NHLBI-funded Program Project Grant on the renal control of sodium excretion with a focus on renal autocrine and paracrine factors. His work specifically has begun to explore circadian control of renal function. Additional research interests include a long-standing collaboration with Dr. Jennifer Pollock in the area of stress in cardiovascular risk. More recently, he has several funded projects related to efforts to understand mechanisms responsible for sickle cell nephropathy.

    • Principal Investigator On

  • Timing of Sodium Intake and Nocturnal Sodium Excretion and Blood Pressure in Obese African Americans  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2024
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - AD Supplement: Salt-Dependent Hypertension and the Central Clock  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Admin Core  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 1 = Circadian Control of Sodium Excretion  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 2 = Integrated Control of Endothelin Production in the Collecting Duct  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Research Supplement to Promote Diversity  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Role of Renal Sensory Nerves in Mediating Hypertension  awarded by American Heart Association 2019 - 2020
  • Collecting Duct Bmal1 And Circadian Control Of Sodium Excretion  awarded by American Heart Association 2018 - 2020
  • Primary Cilia Function in Sickle Cell Nephropathy  awarded by American Physiological Society 2017 - 2019
  • Stress Related Mechanisms of Hypertension Risk - Core A  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA) 2014 - 2019
  • Stress Related Mechanisms of Hypertension Risk - Project 3  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA) 2014 - 2019
  • The Role of Endothelin-1 in Sickle Cell Disease  awarded by AUGUSTA UNIVERSITY - NEW 2014 - 2019
  • Evaluation of Human Variants in Disease Models for End Stage Renal Disease  awarded by HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY 2015 - 2018
  • The Role of Endothelin in Sickle Cell Nephropathy  awarded by ASN FOUNDATION FOR KIDNEY RESEARCH 2016 - 2018
  • Extrarenal Control of Na+ Homeostasis and Blood Pressure by Endothelin-1  awarded by American Heart Association (Southeast Affiliate) 2015 - 2018
  • Endothelin and Circadian Fluid Electrolyte Control  awarded by American Heart Association (Southeast Affiliate) 2015 - 2017
  • Sex Differences in Renal Endothelin and Purinergic Systems: Modulation by Ovarian Hormones  awarded by American Heart Association (Southeast Affiliate) 2015 - 2017
  • Endothelin Control of Renal Hemodynamic and Excretory Function  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Core A - Administrative Core  awarded by NIH - National Institutes of Health/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Core B - Analytical Core  awarded by NIH - National Institutes of Health/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Core C - Animal Core  awarded by NIH - National Institutes of Health/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Project 1 - Renal Endothelin Receptor-Specific Function in Angiotension II-Dependent Hypertension  awarded by NIH - National Institutes of Health/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Project 2 - Receptor Specific Mechanisms of Endothelin Control of the Renal Microcirculation  awarded by NIH - National Institutes of Health/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Project 3 - Endothelin-Dependent NOS Activation  awarded by NIH - National Institutes of Health/DHHS 2014 - 2016
  • Endothelin Control of Renal Hemodynamic and Excretory Function - Project 4 - Collecting Duct Endothelin and Sodium Homeostasis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2016
  • Endothelin in Sodium Homeostatis and Hypertension  awarded by American Heart Association (Southeast Affiliate) 2014 - 2016

    • Investigator On

  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 3 = HDAC-Mediated Regulation of Endothelin and Nitric Oxide  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • The Role Of Endothelin-1 In Tubular Injury In Sickle Cell Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2021
  • Mechanisms of Salt-Dependent Shifts in Blood Pressure Rhythms  awarded by American Heart Association 2019 - 2021
  • Sex Differences in Renal Sodium Handling  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2021
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center - Novel Mechanisms of Salt-Sensitivity and Diurnal Blood Pressure Rhythm - Project 3  awarded by American Heart Association 2015 - 2020
  • Stress Related Mechanisms of Hypertension Risk  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA) 2014 - 2019
  • Sex-Differences in Renal Sodium Handling  awarded by American Heart Association 2018 - 2019
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center  awarded by American Heart Association 2015 - 2019
  • Renal Vascular Function in ARPKD  awarded by PKD Foundation for Research in Polycystic Kidney Disease 2016 - 2019
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group 2017 - 2018
  • Endothelin: Mechanisms in Hypertension and Obesity  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2017
  • The Cytokines, MCP-1 and TGF-Beta, Mediate Renal Autoregulatory Impairment  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2016

    • Teaching Overview

  • Dr. Pollock has many years of classroom experience teaching graduate and medical physiology with a particular focus on water and electrolyte homeostasis and renal physiology and pharmacology. At the Medical College of Georgia, Dr. Pollock served as Chair of the Graduate Curriculum Committee and Program Director of the Vascular Biology Graduate Program. He has led problem based learning programs in medical schools at the University of North Carolina at Chapel Hill, the Medical College of Georgia, and the University of Alabama at Birmingham.

    Dr. Pollock has mentored over 30 PhD students and post-doctoral fellows and over 42 medical and undergraduate students. He has also served on over 20 additional PhD thesis committees. He has served on many NIH and AHA grant review committees that have focused on training applications and directed the T32-funded institutional training program for over 10 years while at the Medical College of Georgia. Dr. Pollock currently serves as the training co-director for an AHA funded Strategically Focused Research Network in Hypertension.

    • Teaching Activities

    Education And Training

  • Doctor of Philosophy in Physiology, Pathology and Related Sciences, University of Cincinnati 1983

    • Full Name

  • David Pollock