Positions

Overview

  • Douglas “Doug” Moellering, Ph.D., is an Associate Professor at the University of Alabama at Birmingham, School of Health Professions, and Department of Nutrition Sciences. He also serves as the Director of the Bioanalytical Redox Biology (BARB) Core, serving multiple investigators in measuring functional mitochondrial physiology, bioenergetics, enzyme activity, markers of oxidative stress, and/or reactive oxygen species formation. Doug espouses and thinks education, either formal or informal, is meant to inspire us to think and positively influence a learner’s desire to ask questions and learn. Doug shares and disseminates knowledge from benchtop and clinical research not only in his published manuscripts and courses but to Birmingham and Alabama communities and has served as a representative on the One Great Community Council, which is the community engagement component for UAB’s Center for Clinical and Translational Science. He has been an invited speaker at local libraries to speak about Cities for Life for a Healthier Birmingham, through the American Academy of Family Physicians Foundation, the Birmingham-Jefferson Food Policy Summit, local schools and other organizations. The School of Health Professions recognized him with an award in 2018 for “Excellence in Service”.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Relationship between VO2max, cycle economy & mitochondrial respiration in untrained/trained.Journal of applied physiology: respiratory, environmental and exercise physiology2019
    2019 Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male miceGeroscience.  41:185-208. 2019
    2019 Chronic Inflammation in Rheumatoid Arthritis and Mediators of Skeletal Muscle Pathology and Physical Impairment: A ReviewArthritis Care and Research.  71:173-177. 2019
    2018 Age- and Genotype-Specific Effects of the Angiotensin-Converting Enzyme Inhibitor Lisinopril on Mitochondrial and Metabolic Parameters in Drosophila melanogasterInternational Journal of Molecular Sciences.  19. 2018
    2018 Fingernail and toenail clippings as a non-invasive measure of chronic cortisol levels in adult cancer survivorsCancer Causes and Control.  29:185-191. 2018
    2017 Potential Causes of Elevated REE after High-Intensity ExerciseMedicine and science in sports.  49:2414-2421. 2017
    2017 Associations of Mitochondrial Fatty Acid Oxidation with Body Fat in Premenopausal WomenJournal of Nutrition and Metabolism.  2017. 2017
    2016 Identification of small molecule inhibitors of human cytochrome c oxidase that target chemoresistant glioma cellsJournal of Biological Chemistry.  291:24188-24199. 2016
    2016 Detailed methods of two home-based vegetable gardening intervention trials to improve diet, physical activity, and quality of life in two different populations of cancer survivorsControlled Clinical Trials.  50:201-212. 2016
    2016 Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal AncestryCirculation: Cardiovascular Genetics.  9:26-36. 2016
    2016 BRCA1 Mutation Leads to Deregulated Ubc9 Levels which Triggers Proliferation and Migration of Patient-Derived High Grade Serous Ovarian Cancer and Triple Negative Breast Cancer Cells.Int J Chronic Dis Ther.  2:31-38. 2016
    2015 Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolismJournal of Immunology.  194:6082-6089. 2015
    2014 Use of HbA1c for diagnoses of diabetes and prediabetes: Comparison with diagnoses based on fasting and 2-Hr glucose values and effects of gender, race, and ageMetabolic Syndrome and Related Disorders.  12:258-268. 2014
    2014 Novel, high-intensity exercise prescription improves muscle mass, mitochondrial function, and physical capacity in individuals with Parkinson's diseaseJournal of applied physiology: respiratory, environmental and exercise physiology.  116:582-592. 2014
    2014 Carboxylated and uncarboxylated forms of osteocalcin directly modulate the glucose transport system and inflammation in adipocytesHormone and Metabolic Research.  46:341-347. 2014
    2014 Increased production of mitochondrial reactive oxygen species and reduced adult life span in an insecticide-resistant strain of Anopheles gambiaeBulletin of Entomological Research.  104:323-333. 2014
    2014 The progression of cardiometabolic disease: Validation of a new cardiometabolic disease staging system applicable to obesityObesity Research.  22:110-118. 2014
    2013 Erratum: Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload (Biochemical Journal (2013) 455 (157-167))Biochemical Journal.  456:147. 2013
    2013 Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overloadBiochemical Journal.  455:157-167. 2013
    2012 Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogasterBMC Genomics.  13. 2012
    2012 Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excessAJP - Endocrinology and Metabolism.  303. 2012
    2012 Skeletal muscle lipid peroxidation and insulin resistance in humansJournal of Clinical Endocrinology and Metabolism.  97. 2012
    2012 Ambient Temperature and Obesity.Current Obesity Reports.  1:26-34. 2012
    2011 Acquisition of chemoresistance in gliomas is associated with increased mitochondrial coupling and decreased ROS productionPLoS ONE.  6. 2011
    2011 The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: A complementary concept to Mendelian geneticsLaboratory Investigation.  91:1122-1135. 2011
    2010 Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: Role in glucose-induced insulin resistanceAJP - Endocrinology and Metabolism.  298. 2010
    2009 Mouse Strains with Differential Cardiovascular Disease Susceptibilities Have Significantly Different Measures of Mitochondrial Function and DamageFree Radical Biology and Medicine.  47:S57-S58. 2009
    2008 Effect of exercise and calorie restriction on biomarkers of aging in miceAJP - Regulatory, Integrative and Comparative Physiology.  294. 2008
    2007 Reply: 'Second generation antipsychotic drugs: Is there a common mechanism in the development of obesity?' [2]Neuropsychopharmacology.  32:2433-2434. 2007
    2007 Atypical antipsychotic drugs directly impair insulin action in adipocytes: Effects on glucose transport, lipogenesis, and antilipolysisNeuropsychopharmacology.  32:765-772. 2007
    2005 Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cellsAJP - Heart and Circulatory Physiology.  289. 2005
    2004 Human glutamate cysteine ligase gene regulation through the electrophile response elementFree Radical Biology and Medicine.  37:1152-1159. 2004
    2004 Regulation of endothelial glutathione by ICAM-1: Implications for inflammationFederation proceedings.  18:1321-1323. 2004
    2004 Proteomic analysis of skeletal muscle mitochondria reveal decreases in complex I and IV of the electron transport chainFree Radical Biology and Medicine.  37:S27-S27. 2004
    2004 Redox signalling: From nitric oxide to oxidized lipidsBiochemical Society Symposia.  71:107-120. 2004
    2003 Cytoprotection against oxidative stress and the regulation of glutathione synthesisBiological Chemistry.  384:527-537. 2003
    2003 The differential modification of mitochondrial proteins by nitroxyl and nitric oxideFree Radical Biology and Medicine.  35:S97-S97. 2003
    2002 Activation of c-Jun N-terminal kinase and apoptosis in endothelial cells mediated by endogenous generation of hydrogen peroxideBiological Chemistry.  383:693-701. 2002
    2002 Inhibition of mitochondrial protein synthesis results in increased endothelial cell susceptibility to nitric oxide-induced apoptosisProceedings of the National Academy of Sciences.  99:6643-6648. 2002
    2002 Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: Protection against quinone-mediated oxidative stressBiochemical Journal.  362:51-59. 2002
    2002 ICAM-1 modulates GCLC expression and GSH localization within endothelial cellsFree Radical Biology and Medicine.  33:S345-S345. 2002
    2002 Induction of glutamate-cysteine ligase by oxidized lipids is mediated through antioxidant responsive element (ARE)Free Radical Biology and Medicine.  33:S354-S355. 2002
    2002 Nitric oxide and cellular respiration at low oxygen tension: A study on bovine aortic endothelial cells.Free Radical Biology and Medicine.  33:S400-S400. 2002
    2001 Endothelial NOS-dependent activation of c-Jun NH(2)- terminal kinase by oxidized low-density lipoprotein.AJP - Heart and Circulatory Physiology.  281:H2705-H2713. 2001
    2001 Endothelial NOS-dependent activation of c-Jun NH2-terminal kinase by oxidized low-density lipoproteinAJP - Heart and Circulatory Physiology.  281. 2001
    2001 Endothelial NOS-dependent activation of c-Jun NH2-terminal kinase by oxidized low-density lipoproteinAJP - Heart and Circulatory Physiology.  281. 2001
    2001 Biphasic effects of 15-deoxy-Δ12,14-prostaglandin J2 on glutathione induction and apoptosis in human endothelial cellsArteriosclerosis, Thrombosis, and Vascular Biology.  21:1846-1851. 2001
    2001 Biphasic effects of cyclopentenone prostaglandins on glutathione induction and apoptosis in endothelial cells: insights into the cell signaling pathways initiated by oxidized phospholipidsFree Radical Biology and Medicine.  31:S57-S57. 2001
    2001 Effect of inhibition of mitochondrial protein synthesis on nitric oxide dependent apoptosisFree Radical Biology and Medicine.  31:S106-S106. 2001
    2000 Cell signaling by reactive nitrogen and oxygen species in atherosclerosisFree Radical Biology and Medicine.  28:1780-1794. 2000
    1999 Effects of pyrrolidine dithiocarbamate on endothelial cells: Protection against oxidative stressFree Radical Biology and Medicine.  26:1138-1145. 1999
    1999 The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: A role for γ-glutamylcysteine synthetase and γ-glutamyl transpeptidaseFEBS Letters.  448:292-296. 1999
    1999 Shear stress induces expression of 1-glutamylcysteine synthetase (GCS) genes.Federation proceedings.  13:A129-A129. 1999
    1998 Nitric oxide-dependent induction of glutathione synthesis through increased expression of γ-glutamylcysteine synthetaseArchives of Biochemistry and Biophysics.  358:74-82. 1998
    1998 A novel cellular mechanism for the antioxidant effects of the NF kappa B inhibitor pyrrolidine dithiocarbamate.Free Radical Biology and Medicine.  25:S15-S15. 1998
    1997 Formation of the NO donors glyceryl mononitrate and glyceryl mononitrite from the reaction of peroxynitrite with glycerolBiochemical Journal.  328:517-524. 1997
    1997 L-arginine protects against xanthine oxidase-dependent vascular injury in hypercholesterolemic rabbitsCirculation.  96:2327-2327. 1997
    1997 Nitric oxide, free radicals and cell signalling in cardiovascular diseaseBiochemical Society Transactions.  25. 1997
    1997 The interplay of nitric oxide and peroxynitrite with signal transduction pathways: Implications for diseaseSeminars in Perinatology.  21:351-366. 1997
    1992 EARLY TREATMENT OF SPONTANEOUSLY HYPERTENSIVE RATS (SHR) WITH THE ANGIOTENSIN (AII) CONVERTING-ENZYME-INHIBITOR CAPTOPRIL (CAP) PREVENTS THE SUBSEQUENT DEVELOPMENT OF HYPERTENSION AND DECREASES CENTRAL AII RESPONSESFederation proceedings.  6:A945-A945. 1992

    Chapter

    Year Title Altmetric
    2000 Cytoprotective mechanisms of nitric oxide: the role of cell signaling.  191-199. 2000

    Research Overview

  • Doug’s collaborative research interests support accumulating evidence that many chronic diseases involve mitochondrial dysfunction, retrograde redox mitochondrial signaling and free radical-mediated tissue injury. His research focus includes energy metabolism, mitochondrial physiology, redox biology, exercise and nutrition, psychosocial life stress and their contributions to health & wellness, health disparities, cardiometabolic disease, diabetes, obesity, cancer, and aging. Model systems include in vitro cell culture, yeast, Drosophila melanogaster, rodents, fish, and human translational research. One of the current projects involves investigating the adverse effects of life stress, including discrimination, and dietary choices that may contribute to increased levels of oxidative stress, cardiometabolic disease risk and obesity.
  • Teaching Overview

  • Teaching is Doug’s passion, extends far beyond the classroom or eLearning platform, and occurs anytime information, ideas, or beliefs are explained and interpreted in a way that inspires and facilitates a better way of thinking or understanding otherwise complex concepts or lessons. Doug is actively engaged in undergraduate, graduate and postdoctoral training through mentoring. He teaches an undergraduate course in nutrition and metabolism, multiple sections of graduate courses, and embraces pedagogy. He thinks that there is no end to education; it is a process where we move fluidly between student and teacher based on our acquisition and dissemination of knowledge, our respect for the process, and our ability to share it effectively and accurately with others. In this light, some things he embraces to be the best teacher possible include: a love of learning, possessing an insatiable curiosity and imagination, comprehension and respect for his field of knowledge and expertise, and ensuring that the didactic process is done in a positive, meaningful, easily comprehensible, and inspirational way.
  • Education And Training

  • Doctor of Philosophy in Pathology Residency Program, University of Alabama at Birmingham 2003
  • Full Name

  • Douglas Moellering