Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancer 2019
2019 Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx 2019
2019 Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer 2019
2019 Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation 2019
2018 Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 Expression 2018
2018 Gene Expression Profiling of Advanced Penile Squamous Cell Carcinoma Receiving Cisplatin-based Chemotherapy Improves Prognostication and Identifies Potential Therapeutic Targets 2018
2018 Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors 2018
2018 Composition and richness of the serum microbiome differ by age and link to systemic inflammation 2018
2018 Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors 2018
2018 Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) study 2018
2017 Targeting RNA-polymerase I in both chemosensitive and chemoresistant populations in epithelial ovarian cancer 2017
2017 The crystal structure of the Yersinia pestis iron chaperone YiuA reveals a basic triad binding motif for the chelated metal 2017
2017 The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia 2017
2017 Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing 2017
2017 Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion 2017
2017 Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2 2017
2017 MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer 2017
2017 Pdgfrb is a direct regulatory target of TGFβ signaling in atrioventricular cushion mesenchymal cells 2017
2017 Enhanced Hematopoietic Stem Cell Self-Renewal-Promoting Ability of Clonal Primary Mesenchymal Stromal/Stem cells Versus Their Osteogenic Progeny 2017
2017 Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targets 2017
2017 Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinoma 2017
2016 Kinase gene expression profiling of metastatic clear cell renal cell carcinoma tissue identifies potential new therapeutic targets 2016
2016 A microscopic landscape of the invasive breast cancer genome 2016
2016 PCM-07COMPARATIVE GENOMICS: THE DOG AS A TRANSLATIONAL MODEL FOR MENINGIOMA 2016
2016 Silencing of CD24 enhances the PRIMA-1-induced restoration of mutant p53 in prostate cancer cells 2016
2016 Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes. 2016
2016 The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models 2016
2016 Surveying the serologic proteome in a tissue-specific kras(G12D) knockin mouse model of pancreatic cancer 2016
2016 The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function 2016
2016 ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the breast 2016
2015 Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing 2015
2015 High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypes 2015
2015 KIFC1 is a novel potential therapeutic target for breast cancer 2015
2015 KAP1 promotes proliferation and metastatic progression of breast cancer cells 2015
2015 N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells 2015
2015 Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survival 2015
2015 FOXP3 controls an MIR-146/NF-κB negative feedback loop that inhibits apoptosis in breast cancer cells 2015
2015 S100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinase 2015
2015 A Genomic Profile of the Immune Response to Stroke With Implications for Stroke Recovery 2015
2015 Altered blood proteome in girls with high urine concentrations of bisphenol a, genistein, mono-ethyl hexylphthalate and mono-benzyl phthalate. 2015
2015 Gene expression profile of human lung epithelial cells chronically exposed to single-walled carbon nanotubes 2015
2015 SEMA6D expression and patient survival in breast invasive carcinoma 2015
2014 Altered serine/threonine kinase activity in schizophrenia 2014
2014 Transient knockdown of SULT4A1 induces upregulation of phototransduction proteins 2014
2014 Alterations in the rat serum proteome induced by prepubertal exposure to bisphenol A and genistein 2014
2014 Comprehensive kinase profiling to classify clear cell (cc)-renal cell carcinoma (RCC). 2014
2014 Integrated comprehensive high-throughput kinomics profiling and whole exome sequencing of penile squamous cell cancer (PSCC). 2014
2014 Inhibition of sult4a1 expression induces up-regulation of phototransduction gene expression in 72-hour postfertilization zebrafish larvae 2014
2014 MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship of miR-152 and DNA methyltranferase 1 2014
2014 Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer 2014
2013 DNA from dead cancer cells induces TLR9-mediated invasion and inflammation in living cancer cells 2013
2013 LRRK2 secretion in exosomes is regulated by 14-3-3 2013
2013 RNA-seq analyses of gene expression in the microsclerotia of Verticillium dahliae 2013
2013 Antioxidation of decellularized stem cell matrix promotes human synovium-derived stem cell-based chondrogenesis 2013
2012 A cloud computing system to quickly implement new microarray data pre-processing methods 2012
2012 Low TLR9 expression defines an aggressive subtype of triple-negative breast cancer 2012
2012 Sex hormone-dependent attenuation of EAE in a transgenic mouse with astrocytic expression of the RNA regulator HuR 2012
2012 Gene profiling of muscle specific VEGF deficient mice: Linking angiogenesis to metabolism? 2012
2012 Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable Stage III colorectal adenocarcinomas 2012
2011 Differential gene expression in the adrenals of normal and anencephalic fetuses and studies focused on the fras-1-related extracellular matrix protein (FREM2) gene 2011
2011 Influence of aging and hemorrhage injury on Sirt1 expression: Possible role of myc-Sirt1 regulation in mitochondrial function 2011
2011 GenDrux: A biomedical literature search system to identify gene expression-based drug sensitivity in breast cancer 2011
2011 Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury 2011
2011 Gene expression profiling in soybean under aluminum stress: genes differentially expressed between Al-tolerant and Al-sensitive genotypes 2011
2010 Identification of aluminum responsive genes in Al-tolerant soybean line PI 416937 2010
2010 Mechanisms of magnesium amelioration of aluminum toxicity in soybean at the gene expression level 2010
2010 A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: In vitro and in vivo activity and mechanisms of action 2010
2010 Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition 2010
2010 Molecular profiling of the developing mouse axial skeleton: A role for Tgfbr2 in the development of the intervertebral disc 2010
2010 Hypoxia-induced alteration of mitochondrial genes in cardiomyocytes: Role of Bnip3 and Pdk1 2010
2010 Upregulation of chemokine (C-C motif) ligand 20 in adult epidermal keratinocytes in direct current electric fields 2010
2009 Turning access™ into a web-enabled secure information system for clinical trials 2009
2009 Breast cancer metastasis suppressor 1 coordinately regulates metastasis-associated microRNA expression 2009
2009 The prolyl isomerase Pin1 regulates the NF-B signaling pathway and interleukin-8 expression in glioblastoma 2009
2009 Tumoristatic effects of endostatin in prostate cancer is dependent on androgen receptor status 2009
2009 Late Developmental Plasticity in the T Helper 17 Lineage 2009
2008 A guided approach for personalized information search and visualization 2008
2008 Transcriptional response of dermal fibroblasts in direct current electric fields 2008
2008 Level of expression of the nonmutant Ferrochelatase allele is a determinant of biochemical phenotype in a mouse model of erythropoietic protoporphyria. 2008
2006 Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity 2006
2006 Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agents 2006
2005 Personalized online information search and visualization 2005
2005 Development and analyses of CPT-11 resistant sublines of human colorectal adenocarcinoma cell line, SW-948 2005
2004 Wireless local area network in a prehospital environment 2004
1997 Induction of Cell Cycle Arrest and B Cell Terminal Differentiation by CDK Inhibitor p18 INK4c and IL-6 1997
1993 Potentials for Targeting Hepatoma with Anti-Ferritin (IgG)-Daunomycin Immunoconjugate: In Vitro and In Vivo Studies 1993
1991 Specific Experimental Radioimmunotherapy and Chemoimmunotherapy of Hepatoma Grafts in Nude Mice 1991
1991 The Biodistribution and (gamma-image of 131-I-Labeled Anti-Ferritin-Daunomycin Immunoconjugate in the Engrafted Nude Mice 1991
1991 The Biodistribution of 125-I-Labeled Anti-Ferritin (IgG) Daunomycin Immunoconjugate in Hepatoma Engrafted Nude Mice 1991
1990 The Spleen PFC Changes Induced by Tritiated-Water in LACA Mice 1990

Research Overview

  • -Informatics services for high throughput data including microarray and next generation sequencing (NGS)
    -Integration of Medical Informatics and Bioinformatics through data mining and information system development
    -Application of gene expression profiles for personalized medicine
  • Investigator On

  • Coronary Artery Risk Development In Young Adults (CARDIA) Study-Coordinating Center  awarded by NIH - National Institutes of Health/DHHS 2018 - 2024
  • Coronary Artery Risk Development In Young Adults (CARDIA) Study-Coordinating Center  awarded by NIH - National Institutes of Health/DHHS 2018 - 2024
  • Epigenetic Regulation of Cardiac Neural Crest Cell Development  awarded by American Heart Association 2019 - 2022
  • Critical Roles of CHD7 During Mouse Cardiogenesis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2022
  • Remodeling and Spacing Factor 1 in Histone H2A Ubiquitination-Mediated Gene Silencing  awarded by National Institute of General Medical Sciences/NIH/DHHS 2019 - 2021
  • 3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Biostatistics/Bioinformatics Shared Resource  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Dietary Intervention of Non-Classical Wnt Signaling  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • COMPLETED - Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Biostatistics/Bioinformatics Shared Resource  awarded by National Cancer Institute/NIH/DHHS 2016 - 2020
  • Ph1 of HSV G207 and Radiation to Treat Pediatric Brain Tumors IND16294 (12/10/14)  awarded by Food & Drug Administration 2016 - 2020
  • Epigenome Editing for Targeted Reactivation of X- Linked FOXP3 to Treat Breast Cancers  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2017 - 2019
  • Mid-South Transdisciplinary Collaborative Center for Health Disparities Research  awarded by NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES/NIH/DHHS 2012 - 2019
  • Trans-Omics for Precision Medicine (TOPMed) Data Coordinating Center (DCC)  awarded by UNIVERSITY OF WASHINGTON 2018
  • Pilot Study of HSV G207 Alone or with Radiation in Children with Recurrent Brain Tumors  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE 2015 - 2018
  • Targeting MELK-Mediated EZH2 Signaling in Glioma Stem Cells  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2018
  • Functions of CHD7 in Regulating Cardiogenesis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2018
  • Roles of Semaphorin Signaling in Breast Cancer Racial Disparities  awarded by National Cancer Institute/NIH/DHHS 2015 - 2018
  • Coronary Artery Risk Development in Young Adults (CARDIA) Study - Coordinating Center  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2013 - 2018
  • RANK Signaling in Osteoclast Differentiation and Function  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2018
  • SULT4A1 in Zebrafish Development  awarded by National Institute of General Medical Sciences/NIH/DHHS 2015 - 2018
  • UAB / UMN SPORE in Pancreatic Cancer  awarded by National Cancer Institute/NIH/DHHS 2010 - 2017
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • UAB / UMN SPORE in Pancreatic Cancer - Core C  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Combinational Environmental Chemicals Altering Susceptibility for Mammary Cancer  awarded by National Institute of Environmental Health Sciences/NIH/DHHS 2010 - 2016
  • Active - Biostatistics and Bioinformatics - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2013 - 2016
  • Active - Proteomics - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Evaluation pf Clinically-ready Oncolytic HSV in Pediatric Brain Tumors  awarded by HYUNDAI HOPE ON WHEELS 2013 - 2015
  • Whole Exome and Comprehensive Kinomics Analysis of Penile Squamous Cell Carcinoma  awarded by Conquer Cancer Foundation of ASCO 2014 - 2015
  • Engineered HSV for the Treatment of Malignant Glioma  awarded by National Cancer Institute/NIH/DHHS 2009 - 2015
  • Engineered HSV for the Treatment of Malignant Glioma - Core A. Administrative Core  awarded by National Cancer Institute/NIH/DHHS 2009 - 2015
  • Targeting Pediatric Medulloblastoma with Engineered Herpes Simplex Virus  awarded by RALLY FOUNDATION 2013 - 2014
  • Longitudinal Studies of Coronary Heart Disease Risk Factors in Young Adults (CARDIA) - Coordinating Center  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2010 - 2013
  • Full Name

  • Dongquan Chen
  • Fax

  • 205-934-4262